ライフサイエンスコーパス: mutation rate

1 (an order of magnitude higher than the point mutation rate).

2 DNA mismatch repair that confer an elevated mutation rate.

3 d by a combination of stem cell dynamics and mutation rate.

4 implying a correlation between d (N) and the mutation rate.

5 ribution of Polepsilon errors to the genomic mutation rate.

6 replication is associated with an increased mutation rate.

7 ng sets of three individuals to estimate the mutation rate.

8 e, we show that QnrB increases the bacterial mutation rate.

9 r, with a frequency close to the spontaneous mutation rate.

10 ns than expected from the average background mutation rate.

11 gly depend on the assumed mutagen-associated mutation rate.

12 y and repeatedly alternate with decreases in mutation rate.

13 sponse against a virus with an extraordinary mutation rate.

14 ltimate elimination of a genetic modifier of mutation rate.

15 acterized by an approximate 50% beta-catenin mutation rate.

16 10-100x higher than the in vivo replication mutation rate.

17 uses DNA replication stress and an increased mutation rate.

18 control the decision, rather than to a high mutation rate.

19 ggesting that chromatin structure may affect mutation rate.

20 nitude higher than the corresponding genetic mutation rates.

21 continued to be generated at roughly stable mutation rates.

22 as those thought to have the highest overall mutation rates.

23 ow coverage and could handle a wide range of mutation rates.

24 ad of TE copies, which rapidly leads to high mutation rates.

25 a strategy based on exploration of different mutation rates.

26 it this relationship to infer microsatellite mutation rates.

27 ot chromatin enriched, and exhibit increased mutation rates.

28 size and distribution, and display elevated mutation rates.

29 tured, conserved, and contain low synonymous mutation rates.

30 t STRs by comparing observed versus expected mutation rates.

31 sis-specific gene expression levels and TP53 mutation rates.

32 s ( approximately 30 kb) associated with low mutation rates.

33 were mutated significantly above background mutation rates.

34 ancer, and the stem-cell and transition-cell mutation rates.

35 riminating hosts are reached with reasonable mutation rates.

36 ting sample- and feature-specific background mutation rates.

37 ment or ionizing radiation results in higher mutation rates.

38 constraints such as gene gain, gene loss and mutation rates.

39 effects that they provide, rather than their mutation rates.

40 ite selection and how A3 mutagenesis impacts mutation rates.

41 riability arising from increased genome-wide mutation rates.

42 cuss their implications for the evolution of mutation rates.

43 vity pathways were enriched in BCs with high mutation rates.

44 eral orders of magnitude higher than de novo mutation rates (1 in 10,000,000 or 100,000,000 base pair

45 pring whole genome sequencing, we estimate a mutation rate (3.38 x 10(-6) per bp per generation) that

46 RC, and found an unexpectedly high effective mutation rate, 7.1 x 10(-7) The curve of subclonal mutat

47 of tumor cells exceeds the reciprocal of the mutation rate, a circumstance relevant to even the small

48 Age-adjusted mutation rates (AAMRs) in 61 women and 61 men from the U

49 We found that the mitochondrial and nuclear mutation rates across a waterlouse species' genome incre

50 d mini-satellites and can be used to compare mutation rates across chromosomes.

51 ed to antibiotics transiently increase their mutation rates (adaptive mutability), thus improving the

52 were significantly elevated in BCs with high mutation rates (all p < 0.01), indicating strong immunog

53 enetic rates of change, much as evolutionary mutation rate along a lineage, vary during lifetime.

54 on characteristics known to influence local mutation rate and a series of enrichment filters in orde

55 Its low mutation rate and ability to grow on defined media allow

56 for confounding effects, such as background mutation rate and ancestry.

57 o extract important key information, such as mutation rate and conserved single-nucleotide polymorphi

58 Origin of these variants, including de novo mutation rate and extent of founder versus recurrent var

59 tify 76 gene-drug interactions based on both mutation rate and fitness and find that these parameters

60 caling branch lengths to absolute time using mutation rate and generation time, multispecies coalesce

61 tations in HRR genes can result in increased mutation rate and genomic rearrangements, and are associ

62 Like other RNA viruses, CHIKV has a high mutation rate and is capable of rapid intrahost diversif

63 Owing to a high mutation rate and low levels of recombination of mitroch

64 Neurospora crassa has the highest mutation rate and mutational burden of any non-viral lif

65 l and two asexual populations with increased mutation rate and observe maintenance of beneficial muta

66 ified an inverse plastic association between mutation rate and population density at 1 locus in 1 spe

67 ows how optimal control strategies depend on mutation rate and population size of the pathogen, and h

68 events, we estimate genome-wide germline ME mutation rate and selective constraint and demonstrate t

69 Here, we quantify the mutation rate and spectrum in Saccharomyces cerevisiae b

70 , but to what extent the environment impacts mutation rate and spectrum is poorly understood.

71 lthy tissue and cancer, allows inferring the mutation rate and the cell survival/death rate per divis

72 of a few genes, irrespective of genome size, mutation rate and the sophistication of trait distorters

73 lution has been whether differences exist in mutation rate and/or mutation spectra among HIV types (i

74 hese responses over time owing to their high mutation rates and antigenic flexibility.

75 As mutation rates and burdens climbed, lifespan steadily er

76 d for virus host adaptation.IMPORTANCE Rapid mutation rates and correspondingly high levels of intra-

77 er of this Red King effect, whereas relative mutation rates and generation times have little effect.

78 GC-bias in molecular analysis, and find that mutation rates and genetic distances are estimated under

79 and can act as sentinels indicating elevated mutation rates and increased risk of cancer.

80 cer mutation profiles revealed lower overall mutation rates and more frequent mutations in RHOB and c

81 ental temperature increases accelerate plant mutation rates and particularly accelerate the rate of i

82 arity-determining region loops, high somatic mutation rates and polyreactivity.

83 ncreasing environmental temperature on plant mutation rates and relative impact on specific mutationa

84 asis of a new Bayesian framework to estimate mutation rates and selection coefficients from populatio

85 Here we estimate germline mutation rates and spectra in six multi-sibling mouse pe

86 To test predictions, mutation rates and targets were determined for each path

87 that plasmid-borne QnrB increases bacterial mutation rates and that genetic changes can alleviate th

88 ith other MSeq-analysed tumour types reveals mutation rates and their timing to determine phylogeneti

89 lts show that the populations with increased mutation rate, and capable of sexual recombination, outp

90 process, namely, effective population size, mutation rate, and distribution of selection coefficient

91 rved across influenza A serotypes, has a low mutation rate, and is essential for viral entry and repl

92 With this ABC we infer recombination rate, mutation rate, and recombination tract length of Bacillu

93 ocus, inequality of mating-type frequencies, mutation rate, and selection on this relationship.

94 xcision, regulating phenotypes of virulence, mutation rate, and terminal differentiation in multicell

95 ticular, NGS has yielded direct estimates of mutation rates, and an unbiased and calibrated molecular

96 impaired replication and fitness, increased mutation rates, and attenuated virulence in vivo Despite

97 Sexual recombination and mutation rate are theorized to play different roles in a

98 e results demonstrate that recombination and mutation rates are intimately linked.

99 Taken together, these results show that mutation rates are no higher than normal stem cells, ess

100 do not present any characteristics of a high mutation rate, are scattered across the genome and the c

101 than others due to differences in background mutation rates arising from various forms of infidelity

102 leosome maps and find substantially elevated mutation rates around translationally stable ('strong')

103 f cancer driver genes rely primarily on high mutation rates as evidence for gene selection in tumors.

104 in weakly discriminating hosts, the required mutation rates, assuming a single locus, are untenably h

105 hod is motivated by the observation that the mutation rate at megabase scale and the local mutational

106 creased dNTP concentrations and an increased mutation rate at the CAN1 locus compared to wild type ye

107 gression and stability, leading to increased mutation rates at highly transcribed loci.

108 tases with both robust read-through and high mutation rates at m(1)A sites.

109 86% detected donor template release and 99% mutation rate being observed at the donor loci and the g

110 ost likely due to the extreme variability in mutation rates between individuals.

111 at maternal age at conception influences the mutation rate both because of the accumulation of damage

112 Heritable silencing does not impact mutation rate but drives population size expansion and r

113 cumulation of PCNA on DNA and also increases mutation rate, but it has been unclear if the two effect

114 Bacteria often respond with elevated mutation rates, but little evidence exists of stable euk

115 proven to be very efficient with regards to mutation rates, but the precise insertion of exogenous D

116 eir offspring, increasing the per generation mutation rate by 4.27 x 10(-10) per base pair per year.

117 duals and (2) estimating regional background mutation rates by regressing the varying local mutation

118 Our results suggest that mutation rates can evolve markedly over short evolutiona

119 Modeling shows that elevated mutation rates can influence evolution under demographic

120 Like other RNA viruses with high mutation rates, CHIKV produces populations of geneticall

121 recurrent mutations, providing insights into mutation rates, clonality and the genomic architecture a

122 al simulations show that a substantial virus mutation rate combined with high virus transmission prob

123 m 16 tumours showed 4 to 100 times increased mutation rates compared to healthy development and subst

124 accounted for other known factors affecting mutation rate, controlling for population density can re

125 The acceleration of mutation rates correlates with increased guanine-cytosin

126 re mutation is less common, tumors with high mutation rates demonstrate aggressive phenotypes and att

127 e rate of environmental change or decreasing mutation rate, demonstrating that both factors act via t

128 A growing body of evidence supports mutation rate dependence on the local DNA sequence conte

129 Mutation rate did not impact survival although high muta

130 lied to analyze the genome-wide somatic gene mutation rate difference between lung adenocarcinoma (LU

131 We evaluated ancestry effects on mutation rates, DNA methylation, and mRNA and miRNA expr

132 conception explains most of the variation in mutation rate: Each additional year of paternal age in h

133 rapidity of replication coupled with a high mutation rate enables HIV to evade selective pressures i

134 that it provides a reasonable per nucleotide mutation rate estimate when mice come from the colony nu

135 nd thereby explain observed discrepancies in mutation rates estimated by Luria-Delbruck fluctuation t

136 Our mutation rate estimates for baboons raise a further puzz

137 r population density can reduce variation in mutation-rate estimates by 93%.

138 In addition, we employ a novel approach to mutation rate estimation based on the observed genetic v

139 mutagenesis, and do strains with high innate mutation rate evolve faster?

140 Neuroblastoma has a low mutation rate for the p53 gene.

141 close to its known wild-type mutation rate; mutation rates for additional organisms were also found

142 Based on the mutation rates for Ebola virus given its natural sequenc

143 nce of selective pressures that lead to high mutation rates for engineered bacteria.

144 G, and sole loss of Pol theta attenuated the mutation rates for O (6)-nBu-dG and O (6)-pyridyloxobuty

145 Also, the mutation rates for Wnt pathway and MAPK pathway were cal

146 The germline mutation rate has been extensively studied and has been

147 imary methods for estimating the genome-wide mutation rate have been counting de novo mutations in pa

148 ng to identify these burdened regions due to mutation rate heterogeneity across the genome and across

149 Although in plants intra-organismic mutation rate heterogeneity is poorly resolved, the same

150 ar short-lived ones (e.g., petals), and that mutation rate heterogeneity should be deterministic with

151 a Gamma-Poisson mixture model to capture the mutation-rate heterogeneity across different individuals

152 owed association with CRC and a high somatic mutation rate in cancer tissues.

153 nation of one signal, an increased TCC-->TTC mutation rate in Europeans, indicates a burst of mutatio

154 he number of hotspot motifs, and perhaps the mutation rate in general, is expected to decay over time

155 to leukemic transformation by increasing the mutation rate in hematopoietic stem/progenitor cells (HS

156 vel, which have limited power due to the low mutation rate in most genes.

157 es, but much less is known about the somatic mutation rate in multicellular organisms, which remains

158 stematic profiling of the somatic background mutation rate in protein-coding mononucleotide microsate

159 Recent work suggests that the underlying mutation rate in PSCs is low, although they also seem to

160 somatic tissue, selection can favor a higher mutation rate in the early segregating soma than in germ

161 ate the prevalence of the signaling pathways mutation rate in the Gastrointestinal (GI) tract cancers

162 a mechanistic explanation for the increased mutation rate in the POLD1-R689W-expressing cells.

163 Here, we present an estimate of the de novo mutation rate in the rhesus macaque (Macaca mulatta) usi

164 e present a pedigree-based estimation of the mutation rate in this species.

165 We further identified a marginal increase in mutation rate in tumors in African Americans with increa

166 e the variation with tissue stiffness of the mutation rate in tumors.

167 Here we show that the mutation rate in two human embryonic stem cell lines der

168 s germline mutation signatures and modulates mutation rates in a gene-specific manner, maintaining DN

169 anelle DNA polymerase suitable for elevating mutation rates in chloroplasts and mitochondria.

170 iation together with experimentally measured mutation rates in colorectal tissues and proliferation r

171 under drug treatment and underestimation of mutation rates in fluctuation tests.

172 cular, the selection model captures elevated mutation rates in functionally important sites using mul

173 We conclude that germline mutation rates in healthy young adults may provide a mea

174 Germline mutation rates in humans have been estimated for a varie

175 cilia genes were found selectively with high mutation rates in LUSC, possibly implying the importance

176 Here, we present data on somatic mutation rates in mice and humans, obtained by sequencin

177 ational signatures and estimation of somatic mutation rates in single cells.

178 , resulting in one of the lowest spontaneous mutation rates in the body.

179 anization has been suggested to affect local mutation rates in the genome.

180 ke the first direct comparison with germline mutation rates in these two species.

181 e six brain mini-GCNs showed markedly higher mutation rates in tumors relative to matched sets of ran

182 requencies for multiple loci, microsatellite mutation rates in wild-type and Msh2-deficient epitheliu

183 We tested whether germline autosomal mutation rates in young adults predict their remaining s

184 genetic variants that raise the genome-wide mutation rate - in asexual populations is often describe

185 stems evolving under strong linkage and high mutation rates, including viruses and cancer cells.

186 This defect results in a moderate mutation rate increase in typical genes, and a larger in

187 The mutation rate increased synergistically when the POLD1-R

188 Spontaneous base substitution mutation rates increased sevenfold upon the disruption o

189 We show that, in yeast, the mutation rate increases synergistically when a Polepsilo

190 t causes strong synergistic increases in the mutation rate, indicating that Pole-P301R errors are cor

191 ests have suggested that the influenza virus mutation rate is 2.7 x 10(-6) - 3.0 x 10(-5) substitutio

192 Mutation rate is about twice as large as the migration r

193 During cell division, the spontaneous mutation rate is expressed as the probability of mutatio

194 Yet, its mutation rate is higher than that of viruses like HIV, f

195 This effect of temperature on the mutation rate is not limited to Arabidopsis, as we obser

196 A higher deleterious mutation rate is observed in the pericentromeric regions

197 However, the mutation rate is reduced by >50% in cells cultured under

198 fferent culture conditions on the underlying mutation rate is unknown.

199 MPORTANCE Because influenza virus has a high mutation rate, many cells are infected by mutated virion

200 at the intra-individual level and found that mutation rates may differ by gene sequence length but no

201 Additionally, analyses using indirect mutation rate measurements have yielded contradictory an

202 find that genomic features missing from our mutation-rate model likely operate on a megabase length

203 ls no significant differences in the overall mutation rate, mutation signatures, specific recurrent p

204 00), the CMR is close to its known wild-type mutation rate; mutation rates for additional organisms w

205 s study therefore provides insights into the mutation rates, mutational processes and developmental o

206 er genomic alterations, including low coding mutation rates, mutational signatures consistent with ag

207 er 550 generations, the strain exhibited the mutation rate of >/=1.3 x 10(-8) single nucleotide subst

208 We estimated an average mutation rate of 0.58 x 10(-8) per base pair per generat

209 five postzygotic cleavages and calculated a mutation rate of 1.3 mutations per division per cell.

210 ith high parental relatedness, we estimate a mutation rate of 1.45 +/- 0.05 x 10(-8) per base pair pe

211 We measured an overall mutation rate of 1.8 x 10(-4) s/n/r for PR8 (H1N1) and 2

212 elic mutation rate of 44.4% and a homozygous mutation rate of 11.1%, representing a significant impro

213 The mutation rate of 13 subjects having no signs but positiv

214 of 562 mutational changes, translating to a mutation rate of 2.20 x 10-3 (95% CI 1.94 x 10-3 to 2.48

215 We have achieved a biallelic mutation rate of 44.4% and a homozygous mutation rate of

216 ture (ST; 23 degrees C) is associated with a mutation rate of 7 x 10(-9) base substitutions per site

217 The average mutation rate of affected colonic epithelial cells is 2.

218 Due to the high sequence diversity and mutation rate of HIV-1, viral isolates are often resista

219 me cases, fast evolution depends on the high mutation rate of one or few loci with short tandem repea

220 Measurement of the mutation rate of PGCs in culture revealed that 2.7 x 10(

221 By contrast, the mutation rate of the EF-1a gene was higher than COI, and

222 rate pedigree data, we estimated the de novo mutation rate of the horse MSY and showed that various m

223 However, the high mutation rate of this obstinate cancer type renders it s

224 develop a method for estimating the relative mutation rates of duplications and substitutions, as wel

225 ood computational framework for inference of mutation rates of individual cancer subclones using sing

226 to estimate P -values while controlling the mutation rates of individual patients and genes similar

227 iants; a model that incorporates the varying mutation rates of the basic mutation types explains anot

228 e-based estimates of the dependence of human mutation rates on sex and age.

229 Evaluation of mutation rates on the level of subclones rather than ind

230 pressed during spermatogenesis display lower mutation rates on the transcribed strand and have low di

231 ic exposure and DNA repair deficiency alters mutation rates or signatures in 41% of experiments, reve

232 r the tree is calibrated with pedigree-based mutation rates or with fossils.

233 s based on attributes such as gene function, mutation rates, or network features perform poorly.

234 While this has often been attributed to low mutation rates, other factors have been described, inclu

235 diting exhibited substantial fluctuations in mutation rate over time with episodic bursts of mutation

236 t can be biased by selection and by changing mutation rates over time.

237 icantly higher than the estimated background-mutation rate (p = 2.46 x 10(-6)).

238 S) studies have estimated the human germline mutation rate per basepair per generation (~1.2 x 10(-8)

239 We estimated a mutation rate per generation in baboons of 0.57x10-8 per

240 them now requires not only a slowdown of the mutation rate per generation in humans but also in baboo

241 We find the point mutation rate per generation to differ by 3.6-fold among

242 the effective population size and mu is the mutation rate per site per generation), which explains s

243 This trend renders the mutation rate per year more constant than that per gener

244 nces between species in mutation spectra, in mutation rates per cell division, and in the parental bi

245 ind that in vitro callus tissue has a higher mutation rate (per unit time) than the wild-grown compar

246 mutagenesis or repair are required for this mutation-rate plasticity.

247 frican populations, suggesting that the high mutation rates play dominant roles in producing the low

248 e of rapid host adaptation, a relatively low mutation rate, pleiotropy, and/or a lack of selective ch

249 nants of evolutionary rate: generation time, mutation rate, population size, and the intensity of nat

250 natural bedrock radioactivity influence the mutation rate possibly through the accumulation of oxida

251 ore, the presence of HORT1 explains the high mutation rates resulting in many variations of pigmentat

252 s to counterbalance aggressiveness of a high mutation rate, resulting in similar survival rates to lo

253 RNA viruses typically have high mutation rates, resulting in frequent production of prot

254 the nuclear genome, the yeast mitochondrial mutation rate rises with the growth rate, consistent wit

255 Sex linkage can affect mutation rates, selection, and drift, and our results su

256 s neutralized by specific antisera and had a mutation rate similar to conventional virus growth techn

257 es via a low-fidelity polymerase with a high mutation rate; strong conservation of individual nucleot

258 are limited to diseases associated with high mutation rate such as cancer.

259 s a continuous concern for viruses with high mutation rates such as influenza.

260 evolution in cases of substantially elevated mutation rates, such as stress-induced mutagenesis in mi

261 binding residues had a significantly higher mutation rate than other parts of the protein.

262 enotypic markers give a more precise view of mutation rate than previously believed: having accounted

263 r detection relies on unbiased models of the mutation rate that also capture rate variation from unch

264 equine encephalitis virus (VEEV), have high mutation rates that allow for rapid adaptation to select

265 ternative class of approaches for estimating mutation rates that avoids these limitations is based on

266 The estimated mutation rate - the lowest among vertebrates analyzed to

267 Alternatively, assuming a fixed mutation rate, the generation time increases over the la

268 mature unloading of PCNA generally increases mutation rate, the mutator phenotype of elg1Delta is att

269 utoimmunity may be attributed to rapid viral mutation rates, the cyclical periodicity of viruses(7) a

270 diversity ratios, as a result of male-biased mutation rates, the equilibrium X:A ratio of effective p

271 ring human and chimpanzee genomes to measure mutation rates, the proposed method allows us to find ch

272 ameters, for instance, the scaled population mutation rate Theta=4N e mu for diploids or Theta=2N e m

273 grees C) is highly mutagenic, increasing the mutation rate to 12 x 10(-9) SNV frequency is approximat

274 We estimate the simultaneous MNV germline mutation rate to be 1.78 x 10(-10) mutations per base pa

275 We extend our site-specific model of the mutation rate to include the additional variance from th

276 ighlight the need for direct measurements of mutation rates to clarify CHIKV fidelity phenotypes.IMPO

277 ons, and using our precise context-dependent mutation rates to predict long-term evolutionary pattern

278 aluation of the clinical implications of HPV mutation rates, transmission, clearance, and persistence

279 s, suggesting that when subject to increased mutation rates, transposons are then more rapidly inacti

280 Paradoxically, cancers with high ARID1A mutation rates typically lack copy number alterations (C

281 The model does not require increase in mutation rate under G-CSF treatment and agrees with age

282 ion rates were defined as the top 10% of the mutation rate, utilizing TCGA and METABRIC transcriptomi

283 with plant longevity, we conclude that some mutation rate variation between tissues is consistent wi

284 e-specific mutational signatures, long-range mutation rate variation, and position-specific impact me

285 s a substantial influence on the large-scale mutation-rate variations observed in human cancers.

286 The mutation rate was 67 of 1032 patients (6.5%).

287 The SLC12A2 de novo mutation rate was demonstrated to be significantly eleva

288 he combined effect of the drug and mutant on mutation rate was greater than predicted.

289 The observed mutation rate was in agreement with rates previously det

290 with age, but a progressive increase in the mutation rate was observed at higher Gleason scores.

291 oad due to lethal mutations (i.e. the lethal mutation rate), we manipulate thousands of individual pa

292 Using an improved model of human mutation rates, we classify human protein-coding genes a

293 Tumors with high mutation rates were associated with APOBEC3B and homolog

294 High mutation rates were defined as the top 10% of the mutati

295 Mutation rates were unable to be determined because the

296 The viral mutation rates were variable between patients but did no

297 evolution may be facilitated by an effective mutation rate which increases as each prior mutation inc

298 nowing or accounting for the highly variable mutation rate, which can vary by over three orders of ma

299 cancer, or on the assumed mutagen-associated mutation rate, within the generally-accepted ranges test

300 iation and expanded estimation of background mutation rates, yet fewer computational tools exist for