ライフサイエンスコーパス: mutational pattern

1 anscriptomic anomalies and a hitherto unseen mutational pattern.

2 sociated with unique expression profiles and mutational patterns.

3 tational challenges in analysing the complex mutational patterns.

4 evolution is not a consequence of underlying mutational patterns.

5 s combined to Cmu or Cgamma showed identical mutational patterns.

6 rning tools exist for detecting HRD based on mutational patterns.

7 n the importance and interpretation of these mutational patterns.

8 diverse bacterial species and find distinct mutational patterns.

9 Each subgroup has distinguishing mutational patterns, aberrant somatic hypermutation rate

10 Here, we characterize somatic mutational patterns across mouse tissues deficient in th

11 Tumor mitochondrial genomes show distinct mutational patterns and are disproportionately enriched

12 molecular and evolutionary principles to map mutational patterns and model interactions between cells

13 h an 11q23/KMT2A rearrangement have distinct mutational patterns and outcomes depending on the fusion

14 We identify haplotype-specific mutational patterns and several mutational hotspots, inc

15 sion subtypes identified positively selected mutational patterns and suggested that angiogenesis in t

16 The framework explores DNA context-dependent mutational patterns and underlying somatic cancer mutage

17 ity in background mutation rate can confound mutational patterns, and the presence of highly mutated

18 utagenesis in opposing directions, the final mutational patterns appear to be dictated by the efficie

19 In lung cancers, the p53 mutational patterns are different between smokers and no

20 for de novo discovery of mutually exclusive mutational patterns are limited because the heterogeneit

21 Our findings suggest that mutational patterns are often shared across myeloid mali

22 cies in cancers may result in characteristic mutational patterns, as exemplified by deficiency of BRC

23 ous recombination pathway; (ii) dominant T>G mutational pattern associated with a high mutational loa

24 Kataegis, a further mutational pattern associated with APOBEC deregulation,

25 of cloned env sequences revealed no specific mutational pattern associated with reduced susceptibilit

26 y analysing human cancer genomes we identify mutational patterns associated with aging.

27 or clinical use in this setting and describe mutational patterns associated with neutralization escap

28 des an unprecedented opportunity to identify mutational patterns associated with smoking.

29 To analyze and compare K-ras mutational patterns between colorectal tissues at differ

30 imary study objective was to compare genomic mutational patterns between EOCRC and LOCRC, stratified

31 ly affected gene in CH, we observed distinct mutational patterns between the FD and age/sex-matched c

32 human populations and have characterized the mutational patterns by direct observation of 731 meioses

33 genic processes often produce characteristic mutational patterns called mutational signatures.

34 with Ks, suggesting that methylation-induced mutational patterns can explain some of the variation in

35 We found significant differences in mutational patterns, chromosomal instability, and gene e

36 Mutational patterns confirm that the interleukin-6-JAK1-

37 Cancer samples lacking SA2 display mutational patterns consistent with loss of this pathway

38 findings, combined with our demonstration of mutational patterns consistent with similar priming even

39 In summary, specific mutational patterns define different risk of developing

40 BeWith in providing novel information about mutational patterns, driver genes, and pathways.

41 ently non-processive, accounting for complex mutational patterns during TMEJ.

42 interfaces with high confidence using solely mutational patterns extracted from prokaryotic genomes.

43 uggest that discontinuous LOH is a signature mutational pattern for oxidative damage and further sugg

44 The mutational pattern for the TP53 tumour suppressor gene i

45 icted with good accuracy, including expected mutational patterns for BRCA1/2, MSH3/6, TP53, and CDK12

46 ns (PAHs) found in CS coincides with the p53 mutational pattern found in lung cancer, and PAHs have t

47 Significantly, the mutational pattern found overlaps oxidative damage hot s

48 re, we show that HPV-associated SNSCC shares mutational patterns found in HPV-associated cervical and

49 increased mutability 10-fold and changed the mutational pattern from predominantly insertions to main

50 that accounts for local variation in neutral mutational patterns further improves our predictions.

51 Furthermore, the mutational pattern giving rise to diversification in the

52 Knowledge of mutational patterns has expanded significantly, but link

53 The distinct mutational patterns identified in BM specimens compared

54 cr-DNA binding pattern is similar to the p53 mutational pattern in human lung cancer.

55 Variant A.27 is characterized by a mutational pattern in the spike gene that includes the L

56 he impact of these distinct responses on RAS mutational patterning in vivo, all four alleles were glo

57 ation and dN/dS analyses suggest that unique mutational patterns in alpha2 and insertions in the V1-t

58 Investigations of VH gene mutational patterns in B-cell tumors are often performed

59 , revealing distinct strain distribution and mutational patterns in bacterial species.

60 chanisms of aging, yet little is known about mutational patterns in different brain cell types.

61 Our study highlights characteristic mutational patterns in GZL associated with presentation

62 es in esophageal adenocarcinomas and complex mutational patterns in liver cancer.

63 gies that infer epistatic relationships from mutational patterns in natural or experimental evolution

64 ences using probabilistic models of expected mutational patterns in pairwise sequence alignments.

65 We then determined mutational patterns in single melanocyte cell clones by

66 Recombinatorial and mutational patterns in the clonal immunoglobulin (Ig) of

67 sequences of these antibodies show clustered mutational patterns in the complementarity determining r

68 es may influence HBeAg seroconversion rates, mutational patterns in the precore (PC) and core promote

69 Allele-specific RAS co-mutational patterns included an enrichment in NTRK3 and

70 ognition by Rlm7 is governed by more complex mutational patterns, including gene loss or drastic modi

71 A damage response genes based on genome-wide mutational patterns, including structural variants, inde

72 The mutational patterns indicate strong selection for ligand

73 Mutational patterns indicative of rapid viral population

74 There was apparent clustering of mutational patterns into either an IgMD/IgG3/IgA set or

75 The mutational pattern is consistent with dG to dT transvers

76 The observed mutational pattern is consistent with two distinct mecha

77 utation rate at megabase scale and the local mutational patterns jointly contribute to distinguishing

78 Since our model captures mutational patterns linked to clinical heterogeneity, we

79 We review and compare how these mutational patterns manifest in these two distinct virus

80 Notably, neither mutational patterns nor gene expression profiles differ

81 ithfully reproduce the complex multi-residue mutational patterns observed in natural sequences due to

82 e imposed bias of Ag-mediated selection, the mutational pattern of 37 nonproductively rearranged VH g

83 To address this, the mutational patterns of a large panel of productive V(H)D

84 Based on mutational patterns of anticodon loops of tRNAs encoded

85 The mutational patterns of cancer genomes allow conclusions

86 quencing studies are beginning to reveal the mutational patterns of genes in various cancers, identif

87 outcome of patients with HBV-induced ALF and mutational patterns of HBV variants, which might contrib

88 Regional and subtype-specific mutational patterns of HIV-1 transmitted drug resistance

89 mic variations, we compared the rate and the mutational patterns of putative driver genes that are re

90 e further show major differences between the mutational patterns of the mitochondrial and nuclear gen

91 type and HLA-B* 57/5801 epitope-specific Gag mutational patterns of the transmitted virus and not to

92 due to molecular drivers associated with the mutational patterns of these polyC/G repeats, rather tha

93 to SVs in the human genome in terms of their mutational patterns, population genetics, functional con

94 These combinatorial mutational patterns provide guiding information for the

95 l clusters provides insight into the complex mutational patterns required for HIV-1 protease inhibito

96 The observed mutational pattern resembles the deamination signature o

97 Complex mutational patterns resulted in convergent PNG shifts in

98 The mutational patterns revealed recurrent evolution of biof

99 DNA methylation also may explain the unusual mutational patterns seen in A. mellifera that lead to AT

100 Mutational patterns showed that residues 297 and 372, wh

101 acaques and knock-in mice that exhibited the mutational patterns, structural characteristics, or neut

102 In addition, the observed mutational patterns suggest candidates of new cosequenci

103 y mutated gene in our cohort, IGLL5, shows a mutational pattern suggestive of activation-induced cyti

104 rriers are mosaic for repeat size, but these mutational patterns tend to be well conserved when compa

105 tingly, some spontaneous mutants exhibited a mutational pattern that is characteristic of oxidative m

106 , and 76.1% of all kataegic events exhibited mutational patterns that are associated with the activat

107 es), we identify three distinct 'foreground' mutational patterns that are defined by cell-to-cell str

108 We have addressed this question by comparing mutational patterns that are linked to the manifestation

109 Single-cell genomes are also revealing the mutational patterns that arise from biological processes

110 vidual sites and uncovering several striking mutational patterns that arise from unknown mechanisms.

111 C repeat instability describing two types of mutational patterns that can be partitioned by transcrip

112 Understanding the mutational patterns that define the maturation pathways

113 We observed a diversity of combinatorial mutational patterns that generally do not cluster within

114 es, and revealed complementarity of specific mutational patterns that has not previously been identif

115 Tumor-derived IgG V genes exhibited mutational patterns that were consistent with antigenic

116 th sequencing additionally revealed original mutational patterns, the strong specificity of which mig

117 Despite extensive investigation, the mutational pattern they provoke in eukaryotic cells rema

118 tudies into the etiologies and mechanisms of mutational patterns uncovered in cancers.

119 Analysis of mutational patterns unique to exonuclease domain mutant

120 However, certain combinatorial mutational patterns violate these simple rules and demon

121 Unlike the Tm clones where the replacement mutational pattern was similar to that seen for synonymo

122 The mutational pattern was strikingly nonrandom, with somati

123 Two distinct zidovudine-resistance mutational patterns were noted.

124 Clear mutational patterns were observed that both pointed to k

125 ans- and (+)-cis-adducts also show a similar mutational pattern with a more even mixture of G --> T,

126 load and neoantigen burden; and (iii) C>A/T mutational pattern with evidence of an aging imprint.

127 nd (-)-cis-adducts show a remarkably similar mutational pattern with G --> A mutations predominating

128 ly consisted of short fragments with complex mutational patterns, with a repair topology that deviate

129 rus at the whole-genome level, (ii) in-depth mutational patterns within 511 viruses detected during a

130 The underlying forces that shape mutational patterns within any type of cancer have been

131 EC3B (A3B) has been correlated with kataegic mutational patterns within multiple cancer types.

132 ty, HLA concordance, race and ethnicity, and mutational patterns within the clustering and noncluster