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1  enabling the reduction of membrane-inserted mycobactin.
2 cells of the deferri form of the siderophore mycobactin.
3    Mutant strain LUN9 produced no detectable mycobactin.
4 was not known to participate in synthesis of mycobactin.
5 l dimycocerosates, phenolic glycolipids, and mycobactins.
6 nown as MbtA involved in biosynthesis of the mycobactins.
7 btA which is involved in biosynthesis of the mycobactins.
8 ted in the cell wall of M. tuberculosis: the mycobactins.
9 n-binding molecules, and to transfer iron to mycobactins.
10 e termed exochelin (an excreted product) and mycobactin (a cell-associated product).
11                         Structurally related mycobactins affect the growth of both mycobacterial and
12 rain produced measurable amounts of excreted mycobactin, although both excreted exochelin (the mycoba
13 angstrom into the periplasm is essential for mycobactin and bedaquiline efflux by MmpL4 and MmpL5.
14 l, and the organism imports this metal using mycobactin and carboxymycobactin siderophores.
15 synthesize iron chelating siderophores named mycobactin and carboxymycobactin to extract intracellula
16 t of tuberculosis, produces the siderophores mycobactin and carboxymycobactin.
17 es of MbtG in converting deoxymycobactins to mycobactin and in promoting M. tuberculosis growth.
18      In contrast, although the expression of mycobactin and iron ABC transport operons is highly upre
19 uces two classes of siderophore, lipid-bound mycobactin and water-soluble carboxymycobactin(2,3).
20 n low-iron medium and that secretion of both mycobactins and carboxymycobactins is drastically reduce
21 M. tuberculosis uses the siderophores called mycobactins and carboxymycobactins.
22 y, we demonstrated the presence of 1 or both mycobactins and/or tuberculosinyladenosine in serum and
23  several biosynthetic pathways (pyrimidines, mycobactin, and polyketides); genes that encode enzymes
24                                              Mycobactins are small-molecule iron chelators (sideropho
25 for the biosynthesis of the core scaffold of mycobactin based on sequence analysis.
26 icroscopy structures of MmpL4 and identify a mycobactin binding site, which is accessible from the cy
27  tuberculosis and establishes the enzymes of mycobactin biosynthesis as novel targets for the develop
28 osis catalyzes the initial transformation in mycobactin biosynthesis by converting chorismate to sali
29 cyl-AMP ligase (MbtA), the first gene in the mycobactin biosynthesis gene cluster, providing a possib
30   MbtA catalyzes the first committed step of mycobactin biosynthesis in Mycobacterium tuberculosis (M
31 he mbt cluster to evaluate the importance of mycobactin biosynthesis in the growth and virulence of M
32 ting enzyme MbtA catalyzes the first step of mycobactin biosynthesis in two half-reactions: activatio
33  novel lead compounds 44 and 49 as potential mycobactin biosynthesis inhibitors against mycobacteria.
34 rmore, a succinct discussion on non-specific mycobactin biosynthesis inhibitors and the Trojan horse
35 nes for iron scavenging has led to a revised mycobactin biosynthesis model.
36 n vivo essentiality makes this less explored mycobactin biosynthesis pathway a promising endogenous t
37                                          The mycobactin biosynthesis pathway, conserved only among th
38 te synthase MbtI catalyzes the first step of mycobactin biosynthesis through the conversion of the pr
39  which is responsible for the second step of mycobactin biosynthesis, exhibited potent antitubercular
40 erium tuberculosis, which is responsible for mycobactin biosynthesis.
41 orthologue of the Mycobacterium tuberculosis mycobactin biosynthetic gene mbtE.
42 s and order of action of enzymes through the mycobactin biosynthetic pathway.
43 licyl-AMP ligase (MbtA), a key enzyme in the mycobactin biosynthetic pathway.
44 he absence of Esx-3, mycobacteria synthesize mycobactin but are unable to use the bound iron and are
45 synthetic standards to natural mycobacterial mycobactins by nuclear magnetic resonance and mass spect
46 hed on the epsilon-amino group of the lysine mycobactin core, which is transferred by MbtK.
47 luster, providing a possible explanation for mycobactin dependence of Map; and Map-specific sequences
48 tant (MtbDeltambtE) was unable to synthesize mycobactins, displayed an altered colony morphology, and
49 sition, and Mtb iron-chelating siderophores, mycobactin, have been known since 1965.
50 ost and the environment, these organisms use mycobactin, high-affinity iron-binding molecules.
51 fer from each other and from water insoluble mycobactins in polarity, which is dependent primarily up
52 on transferrin, transferred iron to desferri-mycobactins in the cell wall of live bacteria.
53 ing proteins and transferring it to desferri-mycobactins in the cell wall of the bacterium.
54 ns but not iron transferrin transfer iron to mycobactins in the cell wall underscores the importance
55      This study highlights the importance of mycobactins in the growth and virulence of M. tuberculos
56      However, the biological significance of mycobactins in the growth of this pathogen and in diseas
57 dge, these are the first rationally designed mycobactin inhibitors to demonstrate an excellent in viv
58  of all 109 isolates were confirmed by using mycobactin J dependence and characterization of five wel
59   Exogenous addition of sodium propionate or Mycobactin J restored PDIM/PGL production in the Deltamb
60 ented with 1% egg yolk emulsion, 4 microg of mycobactin J, and 0.5% pyruvate (12B/EMP) for use in con
61  in the presence of a panel of siderophores (mycobactin J, deferrioxamine B, acinetoferrin, and nanno
62 sed solid medium was also used that included mycobactin J, pyruvate, and VAN but excluded the egg yol
63 iciency as the more costly, native chelator, mycobactin J.
64 stimulating growth than the native chelator, mycobactin J.
65 7H11 (M7H11) with hemoglobin, and M7H11 with mycobactin J.
66 presenting protein led to the discovery of a mycobactin-like compound, dideoxymycobactin (DDM).
67 ysis of CD1a cocrystallized with a synthetic mycobactin lipopeptide at 2.8 A resolution further revea
68 spectroscopy studies suggested that the LUN8 mycobactin may have an altered fatty acid side chain.
69 osis) produces two aryl-capped siderophores, mycobactin (MBT) and carboxymycobactin (cMBT), to chelat
70                            The production of mycobactin (MBT) by Mycobacterium tuberculosis is essent
71             Here we show that, surprisingly, mycobactin or carboxymycobactin did not rescue the low-i
72 d type when the medium was supplemented with mycobactins or when MtbDeltambtE was genetically complem
73  assays show that IrtAB has a preference for mycobactin over carboxymycobactin as its substrate.
74 ther each of nine mbt genes was required for mycobactin production and to examine the conservation of
75  essential nature of each of these genes for mycobactin production has been lacking.
76                              Cell-associated mycobactin production in the mutants appeared to be norm
77 ine mbt genes investigated are essential for mycobactin production.
78 olate, and the siderophores enterobactin and mycobactin, respectively.
79 nsporters, MmpL4 and MmpL5, are required for mycobactin secretion and drug efflux.
80 K, a conserved acyl-transferase required for mycobactin siderophore synthesis and virulence, was requ
81                                          The mycobactin siderophore system is present in many Mycobac
82  mutations lead to altered concentrations of mycobactin siderophores and acylated sulfoglycolipids.
83 s-specific, small molecules as biomarkers: 2 mycobactin siderophores and tuberculosinyladenosine.
84 the incorporation of salicylic acid into the mycobactin siderophores.
85 rium tuberculosis survival in cells requires mycobactin siderophores.
86 tins because of their structural relation to mycobactin siderophores.
87 tion of the iron-dependent regulator (ideR), mycobactin synthase B (mbtB), or mycobactin synthase G (
88 tor (ideR), mycobactin synthase B (mbtB), or mycobactin synthase G (mbtG).
89  forms a complex with MmpL4, indicating that mycobactin synthesis and export are coupled.
90 o acids with homology to the MbtH protein of mycobactin synthesis in Mycobacteria tuberculosis; no fu
91                       A modular synthesis of mycobactin T and its N-acetyl analogue is reported in a
92 ydroxylamine with stearyl fluoride furnished mycobactin T in 65% yield.
93                                  The gallium mycobactin T-N-acetyl derivative (GaMbT-NAc) structure w
94 hain on the core structure of exochelins and mycobactins, the principal determinant of their polarity
95 um tuberculosis secretes siderophores called mycobactins to scavenge iron from the human host.
96 logues that partially mimic the structure of mycobactin, to address the requirement of novel therapeu
97 rculosis, generates a salicyl-capped peptide mycobactin under iron-stress conditions in host macropha
98 ty that the transfer iron from exochelins to mycobactins was influenced by their polarity, we investi
99 riction and that these microvesicles contain mycobactin, which can serve as an iron donor and support
100 the first committed biosynthetic step of the mycobactins, which are important virulence factors assoc
101 -reconstituted IrtAB is sufficient to import mycobactins, which are then reduced by the siderophore i

 
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