ライフサイエンスコーパス: myelin proteolipid protein

1 y different encephalitogenic determinants of myelin proteolipid protein.

2 n the X chromosome which codes for the major myelin proteolipid protein.

3 ncoding a mutant form of the DM20 isoform of myelin proteolipid protein.

4 As a major component of CNS myelin, proteolipid protein 1 (Plp1) is indispensable fo

5 cell hybridoma stimulated by a set of three myelin proteolipid protein 139-151 altered peptide ligan

6 tide (Q144) from an autoantigenic peptide of myelin proteolipid protein 139-151 by a single amino aci

7 on in the frequency and effector function of myelin proteolipid proteins 139-151/I-A(s)-tetramer(+) c

8 ases in the amounts of myelin basic protein, myelin proteolipid protein, and 2',3'-cyclic nucleotide

9 ted proteins including myelin basic protein, myelin proteolipid protein, and 2'3'-cyclic nucleotide 3

10 ity, associates with myelin proteins such as myelin proteolipid protein, and assembles lipid-rich mic

11 patients and are specific for two different myelin proteolipid protein-derived peptides presented by

12 isease, we show here that the immunodominant myelin proteolipid protein epitope (PLP(178-191)) elicit

13 that T-cell responses to the immunodominant myelin proteolipid protein epitope (PLP139-151) did not

14 mimic (HI574-586) of an immunodominant self-myelin proteolipid protein epitope (PLP139-151) induced

15 Th1 cells reactive to myelin proteolipid protein expressed more H1R and less H

16 Although the myelin proteolipid protein gene (Plp1) is highly express

17 t with axons, and subsequently expressed the myelin proteolipid protein gene, initiating remyelinatio

18 ing regulates cell surface expression of the myelin proteolipid protein in cultured oligodendrocytes

19 The major intrinsic membrane protein of myelin, proteolipid protein, interacts with rafts in oli

20 We have found that the myelin proteolipid protein is critical to regulating OPC

21 entrations of myelin-specific proteins (MBP, myelin proteolipid protein, MAG, and 2',3'-cyclic nucleo

22 immunized for disease with encephalitogenic myelin proteolipid protein peptide 139 to 151, and analy

23 Collectively, these results indicate that myelin proteolipid protein peptide-specific CD8+ CTL may

24 A protein complex containing the myelin proteolipid protein (PLP) and alphav integrin mod

25 Mutated HSP proteins include myelin proteolipid protein (PLP) and axon-enriched prote

26 a systematic epitope mapping of responses to myelin proteolipid protein (PLP) as well as assaying res

27 ope-mapping series of 265 12-mer peptides of myelin proteolipid protein (PLP) by patients with isolat

28 The myelin proteolipid protein (PLP) gene (i.e., the PLP/DM2

29 meric genes containing portions of the mouse myelin proteolipid protein (PLP) gene fused to the lacZ

30 uorescent protein (EGFP) driven by the mouse myelin proteolipid protein (PLP) gene promoter have been

31 specific for an encephalitogenic peptide of myelin proteolipid protein (PLP) peptide 139-151 (HSLGKW

32 We used myelin proteolipid protein (PLP) peptide 139-151 and its

33 In B10.S mice immunized with myelin proteolipid protein (PLP) peptide 139-151, both P

34 TCR) (5B6) specific for the encephalitogenic myelin proteolipid protein (PLP) peptide 139-151, on the

35 oimmune encephalomyelitis (EAE) induced with myelin proteolipid protein (PLP) peptide 139-151, wherea

36 gnize peptides derived from sequences of the myelin proteolipid protein (PLP) presented by HLA class

37 oimmune encephalomyelitis (EAE) induced with myelin proteolipid protein (PLP) residues 139-151 (HSLGK

38 e immunized with the p139-151 determinant of myelin proteolipid protein (PLP) were transfected with a

39 gies to intervene in autoimmune responses to myelin proteolipid protein (PLP), encephalitogenic epito

40 g a conundrum with regard to the function of myelin proteolipid protein (PLP), one of the major prote

41 ar change when a tetraspan membrane protein, myelin proteolipid protein (PLP), replaced the type I in

42 A new role for the myelin proteolipid protein (PLP), the most abundant prot

43 -2(s)) mice, which are highly susceptible to myelin proteolipid protein (PLP)-induced experimental au

44 ntal autoimmune encephalomyelitis (EAE) with myelin proteolipid protein (PLP).

45 ium-binding proteins, and, surprisingly, the myelin proteolipid protein (PLP).

46 ap with 22 MS-associated proteins, including myelin proteolipid protein (PLP).

47 ive CD4+CD25-Foxp3- T cells specific for the myelin proteolipid protein (PLP)139-151 peptide can be c

48 modified multitransmembrane domain proteins, myelin proteolipid protein (PLP, 30 kDa) and DM-20 (26 k

49 We also provide evidence that myelin proteolipid protein (PLP/DM-20)-positive cells in

50 combined with an autoantigenic peptide from myelin proteolipid protein (PLP; PLP(139-151)) and used

51 6b, bore significant homology with the major myelin proteolipid protein, PLP/DM20.

52 mpassing the immunodominant encephalitogenic myelin proteolipid protein (PLP139-151) epitope.

53 encoding a minigene for residues 139-151 of myelin proteolipid protein (PLP139-151), a pathogenic se

54 treatment of oligomerized T cell epitope of myelin proteolipid protein (PLP139-151).

55 de encompassing the extracellular domains of myelin proteolipid protein (PLPECD).

56 Finally, we show that myelin proteolipid protein-specific autoreactive T cells

57 ences were remarkably similar to that of the myelin proteolipid protein were previously isolated.