ライフサイエンスコーパス: myelinated

1 cytoskeleton organization and are generally myelinated.

2 gested about 57% of penile nerve fibers were myelinated.

3 proximately 1 mum in diameter if they become myelinated.

4 derlying axonal bundles become progressively myelinated.

5 , in which practically all axons are already myelinated.

6 thin during childhood but instead gets more myelinated.

7 xon diameters than PV+ cells, and are rarely myelinated.

8 onding to fast temporal frequencies are more myelinated.

9 ections of cholera toxin subunit B (CTB) for myelinated A fibers and isolectin B4 (IB4) for unmyelina

10 Large diameter sensory myelinated (Abeta) fibres are more frequently involved,

11 hereas sensory modalities conveyed by thinly myelinated Adelta fibers were less sensitive to chemothe

12 ogeneous group of disorders affecting thinly myelinated Adelta-fibres and unmyelinated C-fibres.

13 e more frequently involved, but motor, small myelinated (Adelta), unmyelinated (C) or autonomic fibre

14 PERK activation in oligodendrocytes of fully myelinated adult mice had minimal effects on morphology

15 t but that increases in internodal length of myelinated adult nerve axons do not result in either def

16 able model of motoneurons, interneurons, and myelinated afferent fibers for antagonistic ankle muscle

17 istinct, 200-kD neurofilament-immunopositive myelinated afferent fibers, a subpopulation of which did

18 rans-synaptically through the recruitment of myelinated afferent fibers.

19 d and high-frequency AP conduction along the myelinated afferent nerves, and loss of function of thes

20 minae I-II with normal unmyelinated and thin myelinated afferents labeled with calcitonin gene-relate

21 In myelinated afferents, nodal length increased postoperati

22 emerge unmyelinated from the eye and become myelinated after passage through the optic nerve lamina

23 unonegative nerves are strikingly similar to myelinated airway afferents, the cough receptor, and smo

24 in relation to neuropathological changes in myelinated and demyelinated hippocampi from postmortem M

25 As (miRNAs), we compared miRNA profiles from myelinated and demyelinated hippocampi from postmortem M

26 pression and C3 activation were increased in myelinated and demyelinated MS hippocampi, mainly in the

27 Engraftment of human GPCs in normally myelinated and immunodeficient mice resulted in humanize

28 pe resolution, parabrachiothalamic axons are myelinated and make large boutons, forming multiple asym

29 hGCs interact with myelinated and non-myelinated axons through the formatio

30 revealing differentiable fatty acyl pools in myelinated and nonmyelinated regions.

31 rves, ERK1/2 phosphorylation was observed in myelinated and nonmyelinating SCs.

32 The auditory system is heavily myelinated and operates at the upper limits of action po

33 AAVrh10 has higher tropic affinity to large myelinated and small peptidergic sensory neurons that in

34 gical and functional studies to assess large myelinated and small unmyelinated axons in the db/db typ

35 rate that GFRalpha3 expression is similar in myelinated and unmyelinated adult sensory neurons, sugge

36 lectrical and pharmacological stimulation of myelinated and unmyelinated axons, respectively.

37 unmyelinated fibers, despite a loss in both myelinated and unmyelinated axons.

38 erve increased mitochondrial traffic in both myelinated and unmyelinated axons.

39 action potential conduction velocity in both myelinated and unmyelinated central axons can be bidirec

40 ics of neurofilament transport in contiguous myelinated and unmyelinated segments of axons in long-te

41 long-distance (>25 mm) regeneration of both myelinated and unmyelinated sensory axons with topograph

42 CTb was found in both myelinated and unmyelinated vagal axons and terminals in

43 ncreased myelination with about 40% of axons myelinated, and an enhanced locomotor function (score of

44 The radiate commissural axons are thick and myelinated, and they exit the dorsal acoustic stria of t

45 nections, dense projections from the frontal myelinated area (FM), and moderate projections from S2 a

46 ssive MS is mainly due to the higher rate of myelinated axon degeneration, coupled to the lower capac

47 omprises the paranodal barriers required for myelinated axon domain organization.

48 tor marker; CGRP), and/or neurofilament 200 (myelinated axon marker; NF200).

49 Distal myelinated axon outgrowth after 4 weeks was quantified u

50 ary conductive component to accurately model myelinated axon physiology and saltatory conduction.

51 their myelin sheaths to fully understand how myelinated axon plasticity contributes to neuronal circu

52 fies a mechanism selectively contributing to myelinated axon regeneration, and point out the role of

53 rd, expression of Nogo-A was associated with myelinated axon tracts and upregulated in oligodendrocyt

54 vier is a functionally important site on the myelinated axon where sodium channels are clustered and

55 components of the nodes of Ranvier and other myelinated axonal domains in sensory neurons cultured al

56 hese interactions are mediated by long-range myelinated axonal fiber bundles, collectively termed as

57 size dramatically increased the frequency of myelinated axonal segments.

58 at GlcNAc6ST-1 modulates PNS myelination and myelinated axonal survival through the GlcNAc-6-O-sulfat

59 duced Ca(2+) influx, some active in normally-myelinated axons (T-type channels, NCX), others active o

60 ronal processes, permitting us to survey all myelinated axons (the projectome).

61 d an important decrease in the percentage of myelinated axons and a substantial increase in the mean

62 a significant decrease in the percentage of myelinated axons and a substantial increase in the mean

63 distance-dependent ephaptic coupling between myelinated axons and between fascicles as well.

64 affecting auditory ganglion cells and their myelinated axons and dendrites; and (iv) central neural

65 ny cell adhesion molecules are present along myelinated axons and in myelinating glia, but functional

66 zed by small reductions in the percentage of myelinated axons and minor changes in the g-ratio of mye

67 al role of the Nfasc gene in the function of myelinated axons and reveals further redundancy in the m

68 in hypomyelination (i.e., reduced number of myelinated axons and thinner myelin profiles), as well a

69 ortant axonal domains.SIGNIFICANCE STATEMENT Myelinated axons are constricted at nodes of Ranvier, re

70 Myelinated axons are constricted at nodes of Ranvier.

71 Myelinated axons are patterned into discrete and often-r

72 ry both in the nerve size and the density of myelinated axons at 7 months in almost half of the optic

73 n serves to compartmentalize the membrane of myelinated axons at specific locations that are determin

74 Thus, individual anatomical parameters of myelinated axons can be tuned to optimize pathways invol

75 Myelinated axons can conduct sustained trains of impulse

76 substantial increase in the mean g-ratio of myelinated axons compared with controls.

77 Imaging of neurofilament transport in mature myelinated axons ex vivo reveals that neurofilament poly

78 otypic improvement in transplanted shi/shis, myelinated axons exhibited faster conduction, lower acti

79 s (Kv1 channels) within the nodal complex of myelinated axons following injury.

80 Oligodendrocytes and myelinated axons have been identified as major targets o

81 relates of this adjacent injury in surviving myelinated axons have not been previously defined.

82 Myelinated axons histologically measured using BLFB were

83 nerve fibres and significant degeneration of myelinated axons in both the distal sural nerve and nerv

84 duction of mature oligodendrocyte number and myelinated axons in gpr56 zebrafish mutants.

85 ccess to the nanostructural dynamics of live myelinated axons in health and disease.

86 diameter of the axon plus myelin sheath) of myelinated axons in regions subject to significant NPC-d

87 eostasis, we asked whether the disruption to myelinated axons in slc12a2b/NKCC1b mutants is affected

88 nique for high-resolution in vivo imaging of myelinated axons in the brain, spinal cord and periphera

89 struction, and failure to produce adequately myelinated axons in the central nervous system (CNS).

90 ure oligodendrocytes and a reduced number of myelinated axons in the corpus callosum and optic nerves

91 elin basic protein, and decreased numbers of myelinated axons in the corpus callosum.

92 also established the feasibility of imaging myelinated axons in the human cerebral cortex.

93 particularly from the brainstem, and more SC-myelinated axons in the implants and improvement in hind

94 otein and a reduction in the total number of myelinated axons in the lesion.

95 domains (the paranode and juxtaparanode) of myelinated axons in the pathology of acquired, inflammat

96 not lose unmyelinated fibres in the skin or myelinated axons in the sural nerve and toe after vincri

97 ice displayed abnormal myelination and fewer myelinated axons in the white matter despite elevated OP

98 flected light, enabling nanoscale imaging of myelinated axons in their natural living state.

99 onal activity regulates oligodendrocytes and myelinated axons in vivo, with a focus on the timing of

100 The precise and remarkable subdivision of myelinated axons into molecularly and functionally disti

101 Conduction in myelinated axons involves substantial ion movements that

102 cise fine-tuning of conduction along already-myelinated axons may also be mediated by alterations to

103 In peripheral myelinated axons of mammalian spinal motor neurons, Ca(2

104 ury, when nerve repair is normally advanced, myelinated axons of MEK1DD mutants demonstrated higher r

105 we quantitatively examined K(v)7 channels in myelinated axons of rat neocortical pyramidal neurons us

106 sm in humans to test whether alcohol damages myelinated axons of the prefrontal cortex.

107 to analyze neurofilament transport in mature myelinated axons of tibial nerves from male and female m

108 We previously reported that pain and myelinated axons regenerating through a Y-shaped nerve g

109 tion potential initiation and propagation in myelinated axons require ion channel clustering at axon

110 Rapid action potential propagation in myelinated axons requires Na(+) channel clustering at no

111 es of Ranvier are the myelin-free gaps along myelinated axons that allow fast communication between n

112 Herceptin also increased the number of myelinated axons that regenerated 4 weeks after immediat

113 hGCs interact with myelinated and non-myelinated axons through the formation of pseudopodia.

114 etylcholinesterase (AChE) and the density of myelinated axons throughout postnatal development in the

115 ankyrin-spectrin protein complexes exist in myelinated axons to cluster Na(+) channels at nodes of R

116 Finally, oligodendrocytes and myelinated axons were analyzed using stereology and cohe

117 that the functional capacity of the heavily myelinated axons were preferentially compromised, leadin

118 eduction in major myelin proteins, 30% fewer myelinated axons, a 33% decrease in myelin thickness, an

119 icient mice of both sexes and found that, in myelinated axons, alphaII spectrin forms a periodic cyto

120 y describe the organization of myelin and of myelinated axons, as well as the functions of myelin in

121 own that white matter, primarily composed of myelinated axons, can also be dynamically regulated by a

122 In myelinated axons, it also enhances myelin thickness thro

123 ence of cerebral oedema, loss of neurons and myelinated axons, microglial proliferation and reactive

124 found at greater densities in large-diameter myelinated axons, suggesting that nodes are particularly

125 channels at nodes of Ranvier, a hallmark of myelinated axons, underlies effective saltatory conducti

126 axon-myelin interface, and the integrity of myelinated axons.

127 preferential degeneration of large-diameter myelinated axons.

128 anges were accompanied by reduced numbers of myelinated axons.

129 cal for fast action potential propagation in myelinated axons.

130 d filaments that extend longitudinally along myelinated axons.

131 substantial increase in the mean g-ratio of myelinated axons.

132 med in one case revealed subtotal absence of myelinated axons.

133 a general marker of damage to large-caliber myelinated axons.

134 mechanism of current flux minimization along myelinated axons.

135 ial for effective saltatory conduction along myelinated axons.

136 astructurally, and occurred in virtually all myelinated axons.

137 a substantial reduction in the percentage of myelinated axons.

138 ction algorithm to identify and characterize myelinated axons.

139 apid propagation of the nerve impulses along myelinated axons.

140 establish functional membrane domains along myelinated axons.

141 e morphological features of unmyelinated and myelinated axons.

142 f unmyelinated sensory axons and a subset of myelinated axons.

143 ural activity in endogenous unmyelinated and myelinated axons.

144 ebral cortex contains significant amounts of myelinated axons.

145 the number of surviving oligodendrocytes and myelinated axons.

146 er dorsal-root ganglion (L-DRG) neurons with myelinated axons.

147 rapid propagation of action potentials along myelinated axons.

148 ate-like junctions of peripheral and central myelinated axons.

149 microglia were found to structurally damage myelinated axons.

150 ed axons and minor changes in the g-ratio of myelinated axons.

151 them toward a close spatial association with myelinated axons.

152 ic protein highly expressed in large calibre myelinated axons.

153 ct myelin lipid composition and stability of myelinated axons.

154 ine structures including cortical layers and myelinated axons.

155 of myelin proteins and in the percentage of myelinated axons.

156 preferential degeneration of large-diameter myelinated axons.

157 nd efficient action potential propagation in myelinated axons.

158 ature oligodendrocytes and normal numbers of myelinated axons; however, myelin thickness was signific

159 ning the segregation of axonal domains along myelinated axons; however, the proteins required to orga

160 Not all axons are myelinated, but mechanisms directing myelination of spec

161 ma-immunoreactive interneurons suggests that myelinated, but not unmyelinated, LTMRs play a critical

162 electrically active axons are preferentially myelinated by glial cells, and if so, whether axo-glial

163 on markedly amplified mechanical currents in myelinated, CGRP-negative neurons projecting to muscle.

164 Following inflammation of the hindpaw, myelinated, CGRP-positive neurons projecting to the paw

165 d brain, discrete nuclei form interconnected myelinated circuits that control song acquisition and pr

166 a computational model of a single mammalian myelinated cochlear nerve fiber coupled to a stimulator-

167 Moreover, in pHERV-W ENV-stimulated myelinated cocultures, microglia were found to structura

168 Evoked action potentials in the myelinated corpus callosum projections of Msh2-null mice

169 nificantly differed between demyelinated and myelinated cortex (p < 0.001).

170 , in the strong coupling regime, relevant to myelinated dendritic trees, the spike train statistics c

171 Unmyelinated epidermal nerve fiber and myelinated dermal nerve fiber densities were quantified

172 on in certain sensory neurons, which possess myelinated distal dendritic tree-like arbors with excita

173 -term engrafted glial-restricted progenitors myelinated dysmyelinated adult mouse brains within one m

174 traepidermal nerve fibers and intrapapillary myelinated endings remained unchanged, but the caliber o

175 unchanged, but the caliber of intrapapillary myelinated endings was increased.

176 traepidermal nerve fibers and intrapapillary myelinated endings was reduced.

177 betic mice, resulted in significantly higher myelinated fiber densities and conduction velocities con

178 ld be determined along an extended length of myelinated fiber in the physiological condition.

179 titative stereologic analysis showed reduced myelinated fiber length and density.

180 that the IC and MGC exhibit relatively high myelinated fiber length density (MFLD) values at birth a

181 ignificantly reduced the ratio of abnormally myelinated fibers (p = 0.00148) and secondary inflammati

182 aPOZ mice are impaired in the maintenance of myelinated fibers and are a promising model for studying

183 ly large myelinated fibers, bortezomib small myelinated fibers and cisplatin damaged all types of mye

184 portance of sensory input in the building of myelinated fibers and suggest that this activity-depende

185 Sensory modalities that involved large Abeta myelinated fibers and unmyelinated C fibers were most af

186 Striking color patterns unique to individual myelinated fibers are generated that facilitate their tr

187 osarcoma, and irregularity and disruption of myelinated fibers in areas infiltrated by oligodendrogli

188 f IQCJ-SCHIP1 in vivo by studying peripheral myelinated fibers in Schip1 knock-out mutant mice.

189 The mean number of myelinated fibers in the sural nerve was significantly l

190 In addition, most of the fine myelinated fibers projecting from the corpus callosum in

191 Myelinated fibers showed caliber reduction and nodal elo

192 The contribution of injury to myelinated fibers that was observed at P18 is probably a

193 ed fibers and cisplatin damaged all types of myelinated fibers to a similar degree.

194 We found evidence for two classes of myelinated fibers within the pinniped optic nerve, those

195 ect on neurite outgrowth and regeneration of myelinated fibers without affecting unmyelinated DRG neu

196 itaxel and vincristine affected mostly large myelinated fibers, bortezomib small myelinated fibers an

197 eous observation of neuronal cell bodies and myelinated fibers, we were able to correlate subnuclear

198 se novel connective tissues are comprised of myelinated fibers, with reduced myelin basic protein lev

199 l regions for action potential conduction in myelinated fibers.

200 out affecting other structural properties of myelinated fibers.

201 red to vehicle, suggesting more functionally myelinated fibers.

202 affected individuals showed a severe loss of myelinated fibres and abnormalities in the paranodal jun

203 The assembly of myelinated fibres and nodes of Ranvier is mediated by a

204 Immunofluorescence staining of myelinated fibres from two affected individuals showed a

205 ls because the organization and abundance of myelinated fibres in this region make the RVM a challeng

206 ce-labelling of paranodal proteins of dermal myelinated fibres revealed disruption of paranodal archi

207 Loss of large-myelinated fibres was a uniform feature in a total of 21

208 Studies of myelinated fibres, however, show that voltage-gated sodi

209 ed by immunofluorescence labelling of dermal myelinated fibres.

210 suggest that lateral VTC likely becomes more myelinated from childhood to adulthood, affecting the co

211 Although large, myelinated group A fibers, in particular Abeta-fibers, h

212 In contrast, myelinated hair mechanoreceptive afferents proportionall

213 irst biomimetic microphysiological system of myelinated human peripheral nerve which can be used for

214 r, we found that cortex was thicker and more myelinated in genetic voxels of face areas, while it was

215 of face areas, while it was thinner and less myelinated in genetic voxels of place areas.

216 d approximately 47% of large fiber axons are myelinated in les spinal cord.

217 in-positive (PV) interneurons are frequently myelinated in the cerebral cortex.

218 ascending (CoPA) neurons are among the first myelinated in the zebrafish CNS.

219 uctural plasticity has come to light for the myelinated infrastructure of the nervous system.

220 d that Ube3a is expressed monoallelically in myelinated large-diameter neurons and biallelically in u

221 ssed from the maternally inherited allele in myelinated large-diameter sensory neurons and biallelica

222 Type I afferents are myelinated, larger diameter neurons that send a single d

223 t DOR activation at the central terminals of myelinated mechanoreceptors depresses synaptic input to

224 opioid receptor (DOR), which is expressed by myelinated mechanoreceptors that form Meissner corpuscle

225 nsient neurons are large- or medium-diameter myelinated mechanoreceptors that form the Merkel cell-ne

226 y discriminable but similar deficits in well myelinated mice in which glial cells cannot fully suppor

227 The Ca(2+) that enters myelinated motor axons during normal activity is likely

228 sin-positive synapses or mtHSP70 was seen in myelinated MS hippocampi, further pointing toward a link

229 tional ordering of membrane compounds in the myelinated nerve fiber by means of polarized Raman micro

230 ermal nerve fiber density, as well as dermal myelinated nerve fiber density, which persisted througho

231 inal pigment epithelium degeneration (2.5%), myelinated nerve fiber layer (1.3%), and internal limiti

232 erest because the global effects of aging on myelinated nerve fibers are more complex and profound th

233 Approximately 80 percent of myelinated nerve fibers throughout the central and perip

234 Although the development of myelinated nerve fibers was not impaired, Miz1DeltaPOZ m

235 sequential nodal and axonal injury of intact myelinated nerve fibers, recapitulating pathologic featu

236 ction, it had no effect on measures of large myelinated nerve fibers, specifically sural or sciatic n

237 sent a new method to quantify differences in myelinated nerve fibers.

238 the action potential propagating elements of myelinated nerve fibers.

239 adhesion molecules, such as MAG, present in myelinated nerve fibers.

240 14 cutaneous nerve biopsies revealed loss of myelinated nerve fibres (86%), increased regenerative cl

241 o myelinate developing nerve and to maintain myelinated nerve in adulthood.

242 ciated glycolipids essential for maintaining myelinated nerve integrity.

243 Rapid nerve conduction in myelinated nerves requires the clustering of voltage-gat

244 Fast, saltatory conduction in myelinated nerves requires the clustering of voltage-gat

245 an be regenerated during nerve conduction on myelinated nerves, ion channel mechanisms underlying the

246 response protein 2) transcription factors in myelinated nerves.

247 aps through the nodes of Ranvier (NRs) along myelinated nerves.

248 induced alteration of paranodal junctions in myelinated neuronal culture.

249 t that mechanical sensitization can occur in myelinated neurons after inflammation.

250 the slowing of conduction velocity in large myelinated neurons and a lack of understanding of the ba

251 Nodes of Ranvier in the axons of myelinated neurons are exemplars of the specialized cell

252 A second channel found in larger myelinated neurons, Nav1.6, subsequently evolved resista

253 nd the marrow cavity were each innervated by myelinated (NF200+) sensory neurons, and unmyelinated (N

254 nclude a small population of CGRP-expressing myelinated nociceptors that we now identify as the somat

255 d particularly the morphologically distinct, myelinated, nodose-derived mechanoreceptors described in

256 When myelinated optic nerves from conditional NMDA receptor m

257 sis of their axons revealed that the initial myelinated part gives rise to several unmyelinated small

258 In myelinated peripheral axons, Kv1 potassium channels are

259 12 status displayed improved conductivity in myelinated peripheral nerves after vitamin B-12 treatmen

260 ced consistent improvements in conduction in myelinated peripheral nerves; the sensory latency of bot

261 d partly by early-born neurons destined to a myelinated phenotype participate in fating late-born RUN

262 myelinated retinal nerve fiber layer and the myelinated post-laminar axons, as well as olygodendrocyt

263 preparation for detailed investigation and a myelinated preparation for validation, we report that it

264 e interneurons appear to receive exclusively myelinated primary afferents in type II synaptic glomeru

265 That only myelinated primary afferents were found to contact PKCga

266 found that MASS1 protein is enriched in the myelinated regions of the superior and inferior collicul

267 tra-axonal diffusion microenvironment; while myelinated regions showed no changes.

268 De, perpendicular in both premyelination and myelinated regions, indicative of both intra- and extra-

269 observations that V3d and PO/V6 are densely myelinated relative to adjacent cortex and share similar

270 etermines whether an individual axon becomes myelinated remains unknown.

271 hich reveal remarkable bilateral symmetry in myelinated reticulospinal and lateral line afferent axon

272 driving axonal wrapping by unmyelinated and myelinated Schwann cells and enhancing myelin protein sy

273 Analyses of gene expression arrays of large myelinated sciatic nerves from pioglitazone-treated anim

274 fied profiles, including a new pattern where myelinated segments are interspersed with long, unmyelin

275 The myelinated segments contained more neurofilaments and ha

276 ARTN promotes robust regeneration of large, myelinated sensory afferents.

277 between db/db and db/+ mice studies of large myelinated sensory and motor nerves.

278 morphology of small unmyelinated as well as myelinated sensory axons and relate such changes to soma

279 ozygote mice already have reduced numbers of myelinated sensory axons at 1.5 months and lose more axo

280 chanism to suppress the hyperexcitability of myelinated sensory axons that follows nerve injury.

281 nly stimulates robust regeneration of large, myelinated sensory axons to the brainstem, but also prom

282 ment-200, which is commonly used to identify myelinated sensory axons within organs.

283 cells of C3 nerves serves to prevent loss of myelinated sensory axons, particularly in distal nerves,

284 associated with hyperexcitability in damaged myelinated sensory axons, which begins to normalise over

285 modalities mediated by both unmyelinated and myelinated sensory axons.

286 P), peptidergic nociceptors (PEP), and large myelinated sensory neurons (LM) under both control and i

287 low morphological and Ca(2+) changes in live myelinated spinal axons acutely following injury.

288 de novo ensheathment of approximately 30% of myelinated spinal axons at injury epicenter 3 months aft

289 ), primarily localized by Perls' staining to myelinated structures.

290 ctional recovery are usually worse for large myelinated than for small sensory axons.

291 ciation cortical areas were thicker and less myelinated than primary cortical areas at 14 y.

292 Neonatally engrafted hiPSC OPCs robustly myelinated the brains of myelin-deficient shiverer mice

293 mentations are then used to track volumes of myelinated tissues in the regions of the central brain s

294 Conversely, the distribution of myelinated tracts along the length of axons has been ass

295 hus, microglia and low-grade inflammation of myelinated tracts emerged as the trigger of a previously

296 ain by the predominant (95%) large-diameter, myelinated type I afferents, each of which is postsynapt

297 ate to activate AMPA-type receptors on these myelinated type-I neurons, which carry the neuronal sign

298 l recovery is accompanied by preservation of myelinated white matter and motor neurons and an increas

299 Myelinated white matter supports the speed of electrical

300 mouse optic nerve, which is a pure and fully myelinated WM tract, aging axons are larger, have thicke