ライフサイエンスコーパス: myelination

1 role in oligodendrocyte development and CNS myelination.

2 antly reduces oligodendrocyte maturation and myelination.

3 the role of calcineurin in Schwann cells and myelination.

4 g of the molecular mechanisms underlying CNS myelination.

5 essential to define their specific roles in myelination.

6 lity, excitability-associated disorders, and myelination.

7 revealed disruption of the initial stages of myelination.

8 leukodystrophies with 'normal' developmental myelination.

9 dendroglial HIFalpha-regulated developmental myelination.

10 t axonal localization both before and during myelination.

11 N-glycan branching markedly inhibits primary myelination.

12 retains it in the axons of neurons fated for myelination.

13 ruptions in fiber orientation, integrity and myelination.

14 t HIFalpha-regulated OPC differentiation and myelination.

15 on, while reduced cell size led to decreased myelination.

16 cterized by deficient central nervous system myelination.

17 th essential physiological processes such as myelination.

18 ie between P20 and P25, coinciding with peak myelination.

19 for mechanistic unraveling of developmental myelination.

20 so represents a novel mechanism for adaptive myelination.

21 in Schwann cells has detrimental effects on myelination.

22 s a required component of activity-dependent myelination.

23 uts are percentage (%) neurite density and % myelination.

24 l use behavior, potentially via dysregulated myelination.

25 tures that are thought to be associated with myelination.

26 s and show structural differences related to myelination.

27 ical for oligodendrocyte differentiation and myelination.

28 emote MTX exposure blocks activity-regulated myelination.

29 lopment and behavior in infancy by promoting myelination.

30 differentiation, and a persistent deficit in myelination.

31 RG1) type III regulate Schwann cell fate and myelination.

32 and impacted on the rate of SC migration and myelination.

33 that are characterized by reduced levels of myelination.

34 ors and G protein-coupled receptors, control myelination.

35 on.Axon-glial communication is important for myelination.

36 nal metabolic support and activity-dependent myelination.

37 oligodendrocyte morphology and capacity for myelination.

38 ion regulators in cooperation with SOX10 for myelination.

39 ndifferentiated SCs incompatible with normal myelination.

40 physiological functions, such as during axon myelination.

41 together with Schwann cells at the onset of myelination.

42 immature SCs to initiate differentiation and myelination.

43 entral candidate mediator of activity-driven myelination.

44 godendrocytes disturbed normal developmental myelination.

45 rexpression in CNS co-cultures did not alter myelination.

46 study the role of GABAergic signaling during myelination.

47 nd increased oligodendrocyte development and myelination.

48 cerebral organoids, which expedited in situ myelination.

49 es that make contact with axons and initiate myelination.

50 portant for human white matter expansion and myelination.

51 and reduced white matter volume with delayed myelination.

52 ate Ca(2+) signaling and OPC development and myelination.

53 ion in oligodendrocytes during developmental myelination.

54 differentiation and a delay in initiation of myelination.

55 of NAA as a lipid precursor during postnatal myelination.

56 ed the effects of CnB ablation on peripheral myelination after birth in both male and female mice.

57 translatable strategy for efficient de novo myelination after CNS injury.

58 Here we examined mechanisms controlling myelination after injury and during axon regeneration in

59 luded synaptic proteins at dendritic spines, myelination along axons, and presynaptic densities at do

60 Here, we report that segmental myelination along neocortical interneuron axons is stron

61 An open question remains whether myelination also contributes to information processing i

62 We relate this deficit to impaired myelination and aberrant synapse formation in the cochle

63 usion that mTOR regulates both initiation of myelination and axon wrapping by targeting cytoskeletal

64 Although developmental myelination and axonal coverage by endogenous oligodendr

65 A small-molecule TrkB agonist rescues both myelination and cognitive impairment after MTX chemother

66 ied depending on activity levels, and axonal myelination and conduction velocity exhibited no adaptat

67 We show that the mutants have reduced myelination and defective Purkinje cell development.

68 Both children had delayed myelination and development, organomegaly, and hypopigme

69 ion of the proteoglycan decorin and promotes myelination and differentiation of oligodendrocyte precu

70 l genes whose expression was enriched during myelination and further investigated hepatoma-derived gr

71 ane fusion in zebrafish during developmental myelination and investigated expression and localization

72 ying aged-related SNHL by impairing cochlear myelination and lowering cochlear adenosine levels or bl

73 APOE-amyloid-beta effects converge to alter myelination and lysosomal gene expression, which then co

74 PR56/ADGRG1 regulates central nervous system myelination and melanoma progression by interacting with

75 drocyte signatures suggested impaired axonal myelination and metabolic adaptation to neuronal degener

76 tin organizer, is essential for Schwann cell myelination and myelin regeneration after nerve injury.

77 and GlcNAc as critical regulators of primary myelination and myelin repair and suggest that oral GlcN

78 opment, however, its functions in peripheral myelination and myelin repair remain elusive.

79 ogenitor cells, GPR56 controls developmental myelination and myelin repair.

80 ns for our understanding of both PNS and CNS myelination and myelin repair.

81 teolipid protein (PLP), result in failure of myelination and neurological dysfunction in the X-chromo

82 neural stem cell therapies to restore normal myelination and protect axons in patients with PLP1 gene

83 nerve conduction velocities, improvement of myelination and reduced inflammation in lumbar roots and

84 Selection of the correct targets for myelination and regulation of myelin sheath growth are e

85 NS) and central (CNS) nervous systems during myelination and remyelination in a cuprizone-induced dem

86 of interest in central nervous system (CNS) myelination and remyelination, and we sought to investig

87 ice cultures, Treg accelerated developmental myelination and remyelination, even in the absence of ov

88 , a key transcription factor for PNS and CNS myelination and remyelination, to drag Sox10 out of the

89 t FA synthesis in OLs plays key roles in CNS myelination and remyelination.

90 erentiation inhibitors to control peripheral myelination and repair.

91 utation mouse model of severe PMD, increased myelination and restored nerve conduction velocity, moto

92 standing of HIFalpha-regulated developmental myelination and suggest the potential of intervening wit

93 eurological phenotype results from decreased myelination and the accumulation of locally produced neu

94 , the mechanisms by which activity regulates myelination and the extent to which myelin plasticity co

95 ubiquitination as essential for Schwann cell myelination and unravels new disease-relevant links betw

96 cal studies of schizophrenia are deficits in myelination and white matter integrity; however, direct

97 ly and negatively impacts programs governing myelination, and acts on myelinating oligodendrocyte (OL

98 ormalized psychosine concentration, improved myelination, and attenuated inflammation in both the CNS

99 , including evolutionary expansion, cortical myelination, and cerebral blood flow.

100 ontal measures of morphometry, intracortical myelination, and functional connectivity with affective

101 er by promoting oligodendroglial maturation, myelination, and functional recovery after perinatal bra

102 een intracortical and subjacent white matter myelination, and individual differences in regional GWC

103 e used to study oligodendrocyte development, myelination, and interactions with other major cell type

104 tin nucleation, plays a critical role in CNS myelination, and its absence leads to several myelin abn

105 of the disease with failure of developmental myelination, and more recently, in severely affected pat

106 s in the mutant mouse cortex are involved in myelination, and mutant mice had reduced mature oligoden

107 preserved oligodendrocyte maturation, axonal myelination, and neurofunction.

108 in function, including oxidative metabolism, myelination, and neurotransmitter synthesis.

109 nformation through differences in cell size, myelination, and the expression of distinct receptors an

110 s of glial cells, significant disruptions in myelination, and thereby cognitive and behavioral disabi

111 s family in organogenesis, neurodevelopment, myelination, angiogenesis, and cancer progression.

112 e data highlight the functional role of mPFC myelination as critical determinant of the avoidance res

113 n and myelination, both during developmental myelination as well as during myelin regeneration.

114 We found evidence that neurogenesis and myelination-as well as genes expressed in the synapse, a

115 nt enrichment of overlapping DEGs and common myelination-associated pathways.

116 he function and maturation of OLs to promote myelination.Axon-glial communication is important for my

117 Differential myelination between intracortical and subjacent white ma

118 we identified region-specific differences in myelination between mice that displayed social avoidance

119 iator of oligodendrocyte differentiation and myelination, both during developmental myelination as we

120 dicate that calcineurin is not essential for myelination but has a novel role in myelin clearance aft

121 in oligodendrocyte differentiation and early myelination, but is not necessary for myelin maintenance

122 equired for mature SCs to restore peripheral myelination, but not to proliferate, after nerve injury.

123 d changes in neuronal activity can alter CNS myelination, but the signalling pathways responsible rem

124 type III (Nrg1TIII) drives peripheral nerve myelination by activating downstream signaling pathways

125 es that HIFalpha regulates CNS developmental myelination by activating the autocrine Wnt/beta-catenin

126 ting a direct induction of genes involved in myelination by anacardic acid.

127 patial memory in young mice, while enhancing myelination by deleting the muscarinic acetylcholine rec

128 Inhibiting myelination by deletion of Olig2 in oligodendrocyte prec

129 In addition, loss of Neurofascin reduces CNS myelination by impairing myelin sheath growth.

130 ependently regulates distinct aspects of CNS myelination by individual oligodendrocytes in vivo.

131 Understanding the regulation of myelination by oligodendrocytes is therefore critical fo

132 ired for oligodendrocyte differentiation and myelination by promoting assembly of an Olig2-dependent

133 that HIFalpha was required for developmental myelination by transiently controlling upstream OPC diff

134 The enhanced myelination capacity of the SMF stimulated oligodendrocy

135 During Schwann cell development and myelination chromatin is dramatically modified.

136 ration but fail to differentiate into mature myelination-competent oligodendrocytes, reminiscent of w

137 We suggest a model in which myelination contributes to sustained stimulus perception

138 oligodendroglial lineage contributes to the myelination control.

139 are regulated by NECL4 and affect peripheral myelination currently remain unclear.

140 ncreasing endothelin signalling rescues this myelination defect caused by social isolation.

141 The CNS myelination defect results from a cell-autonomous requir

142 Using a mouse model of CHN, we improved the myelination defects by early overexpression of NRG1 type

143 ignaling has beneficial effects and improves myelination defects during development in a model of CHN

144 eart development; and GPR126 mutations cause myelination defects in human.

145 tion of the nucleoporin Seh1 causes dramatic myelination defects in the CNS.

146 TMEM106B deficiency in mice results in myelination defects with a significant reduction of prot

147 Surprisingly, CnB(scko) mice have minimal myelination defects, no alteration of myelin thickness,

148 Tubb4a(D249N/D249N) mice have myelination deficits along with dramatic decrease in mat

149 provides molecular and cellular evidence for myelination deficits in WS linked to neuronal deletion o

150 Oligodendrocytes establish thick myelination demanded for a keen visual acuity.

151 Oligodendrocyte myelination depends on actin cytoskeleton rearrangement.

152 e model of neocortical GABAergic interneuron myelination determined by local axonal morphology.

153 We tested the hypothesis that myelination develops differentially across time and song

154 Early myelination did not substantially change these patterns

155 nuclei showed an increase in the density of myelination during development but at different rates an

156 e aGPCR Gpr126/Adgrg6 regulates Schwann cell myelination, ear canal formation, and heart development;

157 ual characteristics: it inhibits intraocular myelination, enables postnatal ON myelination of growing

158 of axonal morphology for guiding interneuron myelination, enlargement of SOM+ cell size dramatically

159 Myelination facilitates rapid axonal conduction, enablin

160 develop a quatitative marker of progressing myelination for assessment preterm neonatal brain matura

161 neocortex by quantifying interneuron axonal myelination from ex vivo surgical tissue.

162 stic understanding of HIFalpha-regulated CNS myelination from the previous Wnt-dependent view to a Wn

163 cell-autonomous reductions in OL numbers and myelination, functionally confirming OL transcriptional

164 rbed in multiple cell types, suggesting that myelination has a key role in Alzheimer's disease pathop

165 though nodal proteins cluster in response to myelination, how myelin-forming glia influence nodal ass

166 pathway has been implicated in promoting CNS myelination; however, there is a gap in our understandin

167 restored oligodendrocyte numbers, increased myelination, improved motor performance, normalized resp

168 ic resonance imaging marker of intracortical myelination in 68 brain regions in 248 healthy young peo

169 RG1 type III levels in neurons would restore myelination in a model of congenital hypomyelinating neu

170 During postnatal development, auditory fiber myelination in BACE1(-/-) mice lags behind dramatically

171 tudinal studies revealed that the pattern of myelination in cortex changed dramatically after regener

172 MRI can be used to visualize the process of myelination in detail, and MRI pattern recognition can p

173 , these data show differential maturation of myelination in different portions of the song system.

174 oral GlcNAc to lactating mice drives primary myelination in newborn pups via secretion in breast milk

175 f HRP3-I, increased Schwann cell numbers and myelination in PNS neuron-glia co-cultures.

176 ated signaling pathway to mitigate disturbed myelination in premature white matter injury.

177 igodendroglia is important for developmental myelination in rodents, while chemical inhibition or non

178 Myelination in the CNS requires oligodendrocytes to firs

179 During the process of myelination in the CNS, oligodendrocytes undergo extensi

180 on, linking microtubule cytoarchitecture and myelination in the CNS.

181 , increased mature OLs, and improved overall myelination in the corpus callosum and white matter trac

182 ning promotes oligodendrogenesis and de novo myelination in the cortex and associated white matter tr

183 Schwann cell (SC) myelination in the peripheral nervous system is essentia

184 Similarly, myelination in the spinal cord was disorganized after ex

185 specifically associated with lower levels of myelination in the ventral putamen.

186 ely involvement of neuronal NAA in postnatal myelination in these mice.

187 ndrocyte progenitor cell differentiation and myelination in vitro and ex vivo.

188 the wider scientific community that study 2D-myelination in vitro.

189 l for age-related SNHL by impairing cochlear myelination in WT aged mice.

190 we found that FASN is essential for accurate myelination, including myelin growth.

191 decreasing neuroinflammation and increasing myelination independently of motor symptoms.

192 pathology and characterized by regulators of myelination, inflammation, and neuron survival.

193 Myelination is a biosynthetically demanding process in w

194 STATEMENT Promoting disturbed developmental myelination is a promising option in treating diffuse wh

195 s the axonal nodes of Ranvier and appears as myelination is completed, acting as an ion-diffusion bar

196 Myelination is considered to be an important development

197 odendrocyte processes.SIGNIFICANCE STATEMENT Myelination is essential for normal CNS development and

198 We show that myelination is highly active in young mice and greatly i

199 Experience-dependent myelination is hypothesized to shape neural circuit func

200 oligodendrocyte iron-induced cell death and myelination is rescued by iron chelation in PMD pre-clin

201 However, how TMEM106B regulates myelination is still unclear.

202 Activity-dependent myelination is thought to contribute to adaptive neurolo

203 The molecular trigger of CNS myelination is unknown.

204 somatic growth, early lethality, effects on myelination, loss of oligodendrocyte precursor cells, in

205 Critically, our work suggests that adaptive myelination may be a mechanism that enables brain networ

206 age and degeneration, and activity-dependent myelination may represent an endogenous mechanism to imp

207 entify brain regions in which intra-cortical myelination (measured using Magnetisation Transfer, MT)

208 iated with lower levels of ventral putaminal myelination, measured using R1.

209 f ASO treatment after disease onset restored myelination, MNCV, and CMAP almost to levels seen in WT

210 Regarding postnatal myelination, myelin basic protein (MBP) and myelin-assoc

211 e current study suggests that changes in CNS myelination occur as a downstream mechanism following pe

212 In the PNS, myelination occurs postnatally when Schwann cells (SCs)

213 axon-myelin unit.SIGNIFICANCE STATEMENT The myelination of axons facilitates the fast propagation of

214 Myelination of axons facilitates the rapid propagation o

215 linating cells, nor did it affect the proper myelination of axons or lead to demyelination.

216 s in measures related to either thickness or myelination of cortex, respectively.

217 reduce SC proliferation, maturation, and the myelination of DRG axons.

218 ntraocular myelination, enables postnatal ON myelination of growing axons, modulates the fluid pressu

219 otection of axons in hippocampus region, and myelination of hippocampal area after cerebral ischemic

220 of showing robust neurite outgrowth (~5 mm), myelination of hNs by primary human Schwann cells (~5%),

221 Here, we studied the role of Golgi in myelination of peripheral nerves in mice through SC-spec

222 Better understanding myelination of peripheral nerves would benefit patients

223 mises the stability of muscle fibres and the myelination of peripheral nerves.

224 tion of GPR17 and microglia led to extensive myelination of regenerated axons.

225 han other nuclei, and HVC showed the slowest myelination of song nuclei.

226 We report that sPIF reduces paralysis and de-myelination of the brain in a clinically-relevant experi

227 During developmental myelination of the central nervous system (CNS), oligode

228 ndependent of disease severity and increased myelination of the facial nociceptive pathway.

229 Immunoelectron microscopy demonstrates myelination of the graft-derived axons in the corpus cal

230 in-coupled receptor with a conserved role in myelination of the peripheral nervous system.

231 2) is a crucial transcription factor for the myelination of the peripheral nervous system.

232 age, and, as a consequence, for an effective myelination of the PNS.

233 in SCs and, as a consequence, for the normal myelination of the PNS.SIGNIFICANCE STATEMENT To determi

234 of bioactive sphingolipid metabolites during myelination of the sciatic nerve.

235 ulation of a gene set enriched for decreased myelination, oligodendrocyte differentiation, and expres

236 enital nystagmus, motor delay, and deficient myelination on serial scans in infancy, prompting the di

237 lted in severely impaired axonal sorting and myelination onset.

238 r microscopic underpinnings such as aberrant myelination or fiber density (FD).

239 hwann cells were arrested immediately before myelination or generated abnormally thin, unstable myeli

240 the CNS, CCN3 is not required for efficient myelination or remyelination in the murine CNS in vivo.

241 wn whether regeneration restores the complex myelination patterns in cortical circuits.

242 Myelination plays an important role in cognitive develop

243 x 10(-8)), viability (P = 8.9 x 10(-7)), and myelination potential (P = 0.038).

244 To identify the core components of the myelination process, here we adopted a microarray analys

245 of neurons individualize remodeling of their myelination profiles to diversify circuit tuning in resp

246 n by their different axonal arborization and myelination profiles.

247 whereas overexpression of CTCF promotes the myelination program.

248 Restoring myelination properties with clemastine or increasing axo

249 , with an enrichment for genes implicated in myelination-related cellular processes including axon en

250 godendrocyte cell numbers and mRNA levels of myelination-related genes.

251 Overall, myelination-related processes were recurrently perturbed

252 d group of correlated genes was enriched for myelination-related processes.

253 , our study revealed increased expression of myelination-related proteins and elevated proliferation

254 rning the topography of cortical interneuron myelination remain incompletely understood.

255 ular mechanisms of HIFalpha in developmental myelination remain incompletely understood.

256 signals that emanate from axons and regulate myelination remain largely unknown.

257 along the myelin unit, yet their role during myelination remains unclear.

258 ls, but its role in oligodendrocytes and CNS myelination remains unknown.

259 Plasticity of myelination represents a mechanism to tune the flow of i

260 Myelination requires extensive plasma membrane rearrange

261 LPP1, which are involved in neurogenesis and myelination, respectively.

262 ulation of actin dynamics during CNS and PNS myelination.SIGNIFICANCE STATEMENT Myelin is critical fo

263 decreasing neuroinflammation and increasing myelination.SIGNIFICANCE STATEMENT Pain is a highly prev

264 e differentiation, providing new targets for myelination.SIGNIFICANCE STATEMENT This study identifies

265 Quantitative assessment of the myelination status requires dedicated imaging, but the c

266 regulate proliferation, differentiation, and myelination, suggesting that OS of SCs may offer a new a

267 es were already observed during the onset of myelination, suggesting that they are formed by aberrant

268 anasal administration of CTZ enhanced axonal myelination, synaptic transmission, improved thalamocort

269 curve fits revealed that DLM showed earlier myelination than other nuclei, and HVC showed the slowes

270 a molecular mechanism required for adaptive myelination that is aberrant in CRCI due to microglial a

271 For % myelination the myelin sheaths are selected using the Fr

272 Improved understanding of the process of myelination, the metabolic axonal support functions of m

273 ulating SC process formation, migration, and myelination, therefore uncovering a novel role for these

274 by PI4KB are critically important for proper myelination through control of lipid metabolism, protein

275 ffectors TAZ and YAP in SC proliferation and myelination through modulating G-protein expression and

276 Our results support that TMEM106B regulates myelination through modulation of lysosome function in o

277 vidence that mTOR promotes the initiation of myelination through regulating specific cytoskeletal tar

278 hanisms by which mTOR promotes developmental myelination through regulating specific downstream targe

279 n ligase Nedd4 is required for developmental myelination through stabilization of VHL via K63-linked

280 injury may recapitulate normal developmental myelination through targeting cholesterol homeostasis in

281 tral transcriptional regulator of peripheral myelination, to its target genes.

282 These results suggest that de novo myelination tunes activated circuits, promoting coordina

283 Tamoxifen-induced deletion of Fbxo7, after myelination using the Plp1-CreERT2 line, led to a small

284 omoting oligodendroglial differentiation and myelination via clemastine treatment, rescues spatial me

285 chwann cells that regulates peripheral nerve myelination via its cognate receptor ADAM22 expressed by

286 CMT1B and also suggest that PERK may hamper myelination via mechanisms outside its role in the unfol

287 tion of HPR3 between axons and nuclei during myelination was consistent with its axonal localization

288 (CNS) histology was grossly intact, but CNS myelination was delayed and overall myelin volume was de

289 The association with myelination was specific to waiting impulsivity: R1 was

290 vy chain in Schwann cell (SC) maturation and myelination, we created 3 conditional KO mice in which t

291 ocampal axonal guidance and peripheral nerve myelination were not affected.

292 polymerization is required for initiation of myelination whereas actin depolymerization promotes myel

293 al analysis revealed regional differences in myelination, which coincide with these activity patterns

294 nd mechanism of HIFalpha in oligodendroglial myelination, which is severely disturbed in preterm infa

295 olipid levels and is important for full axon myelination, which requires elevated levels of membrane

296 ere consistent with tissue growth related to myelination, which we verified with adult histological m

297 rgement of PV+ interneurons increased axonal myelination, while reduced cell size led to decreased my

298 ganization (brain morphometry, intracortical myelination, white matter integrity, and resting-state f

299 sed numbers of regenerating axons, increased myelination with about 40% of axons myelinated, and an e

300 reveal an important function for TMEM106B in myelination with possible consequences for therapeutic s