ライフサイエンスコーパス: myelitis

1 (eg, meningitis, encephalitis, acute flaccid myelitis).

2 is), Guillain-Barre syndrome, and transverse myelitis).

3 omes, including encephalitis, meningitis and myelitis.

4 nd increased cases of nonpolio acute flaccid myelitis.

5 sporadically in patients with acute flaccid myelitis.

6 ren met our case definition of acute flaccid myelitis.

7 IFN signaling is protective during reovirus myelitis.

8 nalyzed a cohort of 22 patients with SLE and myelitis.

9 -IgG and its application to acute transverse myelitis.

10 e useful prognostic indicators in transverse myelitis.

11 n evolving understanding of acute transverse myelitis.

12 setting of a paraneoplastic acute transverse myelitis.

13 es in inflammatory non-infectious transverse myelitis.

14 rience with West Nile virus encephalitis and myelitis.

15 therapy of West Nile virus encephalitis and myelitis.

16 aracterized by attacks of optic neuritis and myelitis.

17 ad MOGAD, 21 had MS, and 46 had seronegative myelitis.

18 ing paralytic disease known as acute flaccid myelitis.

19 nd has recently been linked to Acute Flaccid Myelitis.

20 ere respiratory infections and acute flaccid myelitis.

21 the ventral posterior nucleus (VPN), due to myelitis.

22 apsing episodes of severe optic neuritis and myelitis.

23 tis, Guillain-Barre syndrome, and transverse myelitis.

24 tis, Guillain-Barre syndrome, and transverse myelitis.

25 n to MS in patients presenting with isolated myelitis.

26 eases such as poliomyelitis or acute flaccid myelitis.

27 ger Guillain-Barre syndrome, neuropathy, and myelitis.

28 me (GBS), meningoencephalitis, or transverse myelitis.

29 tacks of acute optic neuritis and transverse myelitis.

30 diagnosed as NMOSD or idiopathic transverse myelitis.

31 io-like neurological disorder, acute flaccid myelitis.

32 PE/IA may increase recovery in isolated myelitis.

33 ), and other sub-acute syndromes (transverse myelitis (1), opsoclonus myoclonus (1)).

34 paralysis syndrome (now termed acute flaccid myelitis)(1-3).

35 med encephalitis, 6 meningitis, 1 transverse myelitis, 1 nonhemorrhagic leukoencephalopathy), stroke

36 before we truly understand acute transverse myelitis: (1) What are the various triggers for the infl

37 tients seropositive for isolated MOG-IgA was myelitis (11/17 [65%]), followed by more frequent brains

38 1 with Zika infection; p=0.0008), especially myelitis (12 [22%] patients).

39 eminated encephalomyelitis (12%), transverse myelitis (12%), and cerebellar ataxia (10%).

40 ADEM (22 [19%]), optic neuritis (20 [17%]), myelitis (13 [11%]), neuromyelitis optica spectrum disor

41 ), less common among those with seronegative myelitis (20 of 46 children [43%]), and rare in children

42 d spinal cord lesions (46.3% long transverse myelitis, 36.1% short transverse myelitis), 37.1% satisf

43 emorrhage (34%, 20-50%), encephalitis and/or myelitis (37%, 17-60%) and myopathy (72%, 67-77%) were h

44 transverse myelitis, 36.1% short transverse myelitis), 37.1% satisfied 2010 McDonald criteria, and n

45 ations to be associated with ZIKV, including myelitis (4) , meningoencephalitis (5) and fatal encepha

46 h simultaneous/sequential optic neuritis and myelitis (44% vs 0%; P = .005).

47 lthough VPN was not smaller in patients with myelitis (674.3+/-67.5 mm(3)) than controls (679.7+/-68.

48 tcomes than typical patients with transverse myelitis/acute disseminated encephalomyelitis, and these

49 h concerns due to outbreaks of acute flaccid myelitis (AFM) and encephalomyelitis in North America an

50 de with a reported increase in acute flaccid myelitis (AFM) cases.

51 Since 2014, cases of acute flaccid myelitis (AFM) have been reported in the United States i

52 (EV-D68) in 2014 as a cause of acute flaccid myelitis (AFM) in children are unknown.

53 severe respiratory illness and acute flaccid myelitis (AFM) in children worldwide.

54 ciated with the development of acute flaccid myelitis (AFM) in children.

55 linked with the development of acute flaccid myelitis (AFM) in children.

56 atory illness and is linked to acute flaccid myelitis (AFM) in infants and children.

57 ovirus D68 (EV-D68)-associated acute flaccid myelitis (AFM) is a devastating neurological disease for

58 Acute flaccid myelitis (AFM) is a disabling, polio-like illness mainly

59 /fall 2014, pediatric cases of acute flaccid myelitis (AFM) occurred in the United States, coincident

60 Acute flaccid myelitis (AFM) recently emerged in the United States as

61 al spikes in EV-D68-associated acute flaccid myelitis (AFM) that have left hundreds of children paral

62 a biennial spike in pediatric acute flaccid myelitis (AFM)(1-6).

63 a cause of recent outbreaks of acute flaccid myelitis (AFM), a poliomyelitis-like spinal cord syndrom

64 d spikes in pediatric cases of acute flaccid myelitis (AFM), which is a poliomyelitis-like paralytic

65 ological complications such as acute flaccid myelitis (AFM).

66 illness and is associated with acute flaccid myelitis (AFM).

67 severe respiratory disease and acute flaccid myelitis (AFM).

68 ratory and neurologic disease [acute flaccid myelitis (AFM)].

69 rategies for the optimal management of acute myelitis after CAR T-cell therapy and draw insights from

70 ent ON or recurrent longitudinally extensive myelitis alone are also often positive for AQP4-antibody

71 ome, neuralgic amyotrophy, encephalitis, and myelitis, although the mechanism remains unknown.

72 vs 10 of 38 children [26%] with seronegative myelitis and 1 of 15 children [7%] with MS).

73 4 of 9 (44%) developed recurrent transverse myelitis and 1 of 9 (11%) developed optic neuritis (p =

74 equency of longitudinal extensive transverse myelitis and a favourable clinical outcome in contrast t

75 One child with acute flaccid myelitis and a sibling with only upper respiratory illne

76 She then presented with recurrent transverse myelitis and a vesicobullous rash over her arms and feet

77 Classically, transverse myelitis and acute disseminated encephalomyelitis are co

78 ching how we classify subtypes of transverse myelitis and acute disseminated encephalomyelitis.

79 Particularly myelitis and bilateral optic neuritis have poor remissio

80 duced volumes in five patients with combined myelitis and brainstem attacks (B=-76.18, p=0.017).

81 MOSD) and related syndromes (optic neuritis, myelitis and brainstem encephalitis), but rarely in MS.

82 a is a member of the Apicomplexa that causes myelitis and encephalitis in horses but normally cycles

83 assessed for neurologic variables related to myelitis and for clinical and serologic features of SLE.

84 hysterical paraplegia, the second transverse myelitis and its consequences for bladder function.

85 ysis, and was diagnosed as having transverse myelitis and membranous glomerulonephritis secondary to

86 s had initial CNS manifestations: transverse myelitis and meningoencephalitis.

87 uromyelitis optica spectrum disorder (NMOSD) myelitis and myelitis of other cause.

88 ous system (CNS) characterized by transverse myelitis and optic neuritis.

89 r anaphylaxis and death; 0.04 for transverse myelitis and pancreatitis; and 0.009 for motor neuron di

90 unopathogenic mechanisms in acute transverse myelitis and related inflammatory disorders of the spina

91 ng poliomyelitis, myocarditis, acute flaccid myelitis and the common cold.

92 on between enterovirus D68 and acute flaccid myelitis and the contention that acute flaccid myelitis

93 by disabling relapses of optic neuritis and myelitis and the presence of aquaporin 4 antibodies (AQP

94 s, 36 women, 25 with prior ON, 36 with prior myelitis) and 37 healthy controls (age: 47.8 +/- 12.5 ye

95 %) with encephalitis, 3 (8%) with transverse myelitis, and 1 (3%) with newly diagnosed chronic inflam

96 ute neuromuscular disease), 2 had transverse myelitis, and 1 had chronic inflammatory demyelinating p

97 lpox, which include encephalitis, transverse myelitis, and acute disseminated encephalomyelitis among

98 e disseminated encephalomyelitis, transverse myelitis, and aseptic meningoencephalitis.

99 in 14 of 42 children (33%) with seronegative myelitis, and in none of those with MS.

100 phalomyelitis, optic neuritis, or transverse myelitis, and is less commonly associated with cerebral

101 ine coronavirus) causes meningoencephalitis, myelitis, and optic neuritis followed by axonal loss and

102 Dawson fingers, presence of long transverse myelitis, and presence of periependymal lesions along la

103 of encephalopathy, encephalitis, meningitis, myelitis, and seizures have also been reported.

104 ding meningitis, encephalitis, acute flaccid myelitis, and seizures) and enterovirus detected from an

105 re presentations of encephalitis, transverse myelitis, and seizures.

106 l retrograde to produce meningoencephalitis, myelitis, and stroke.

107 oses included multiple sclerosis, transverse myelitis, and unspecified neurodegenerative myelopathy.

108 lammatory syndrome, Bell's palsy, transverse myelitis, appendicitis, pulmonary embolism, and encephal

109 who had relapsing optic neuritis, transverse myelitis, AQP4-IgG seropositivity, and recurrent myalgia

110 Prognostic factors in pediatric transverse myelitis are reviewed.

111 euritis, longitudinally extensive transverse myelitis, area postrema attacks and less common brainste

112 ders associated with inflammatory transverse myelitis, as well as a greater appreciation of its diver

113 at presentation who are more likely to have myelitis associated with MOGAD.

114 For example, in acute transverse myelitis associated with systemic disease (i.e. systemic

115 To establish if myelitis-associated chronic pain in NMOSD is related to

116 sed risk of relapse compared with transverse myelitis at onset (hazard ratio [HR], 2.66; 95% CI, 1.01

117 ovirus D68 (EV-D68)-associated acute flaccid myelitis at the same hospital between 2013 and 2018.

118 Patients with isolated thoracic cord myelitis at the time of pain onset were significantly mo

119 as follows: (1) AQP4-IgG seropositivity, (2) myelitis attack and (3) MRI spinal cord demonstrating ri

120 with rLETM-onset NMO followed a median of 3 myelitis attacks (range, 2-19).

121 differences in the frequencies of transverse myelitis, brainstem involvement, cerebellar signs and se

122 nterovirus D68 with those with acute flaccid myelitis but negative for enterovirus D68 using the two-

123 D68 and the recent increase in acute flaccid myelitis cases in the United States.

124 Myelitis causes pain, weakness, and sphincteric deficits

125 hildren with EV-D68-associated acute flaccid myelitis, children with EV-A71-associated acute flaccid

126 ally and geographically linked acute flaccid myelitis clusters at the height of the 2014 outbreak, an

127 ncluding longitudinally extensive transverse myelitis), contributes to an evolving understanding of a

128 initial longitudinally extensive transverse myelitis, delay to diagnosis/treatment was greater when

129 Optic neuritis or transverse myelitis developed after vomiting onset in 11 patients (

130 al fluid from 14 patients with acute flaccid myelitis did not reveal evidence of an alternative infec

131 Short transverse myelitis does not exclude consideration of AQP4-IgG test

132 enterovirus D68 infection and acute flaccid myelitis during the 2014 enterovirus D68 respiratory out

133 hildren with EV-A71-associated acute flaccid myelitis during the study period with these findings in

134 Using experimental allergic encephalo myelitis (EAE), an animal model of multiple sclerosis, w

135 Our findings indicate that SLE myelitis encapsulates 2 distinct and previously unrecogn

136 1996 and 2015 with SCS or NMOSD whose first myelitis episode was accompanied by a spinal cord lesion

137 th an initial STM represented 14% of initial myelitis episodes among patients with NMOSD.

138 g-enhancement accompanies one-third of NMOSD myelitis episodes and distinguishes NMOSD from other cau

139 xial images in 36 of 43 (84%) ring enhancing myelitis episodes and extended a median of two vertebral

140 e clinical characteristics of ring-enhancing myelitis episodes did not differ from non-ring-enhancing

141 -enhancement was detected in 50 of 156 (32%) myelitis episodes in 41 patients (83% single; 17% multip

142 In AQP4-IgG-positive STM cases, subsequent myelitis episodes were longitudinally extensive in 92%.

143 nge, 1-12); in 21 of 48 (44%) ring enhancing myelitis episodes, the ring extended greater than or equ

144 erintensity in 44 of 50 (88%) ring enhancing myelitis episodes.

145 e neurological disease such as acute flaccid myelitis (EV-D68) and viral encephalitis (EV-A71).

146 ntly observed up to 20 days after a clinical myelitis event.

147 Among patients with short-segment myelitis, factors identified as highly predictive of con

148 nts had a relapsing course and more frequent myelitis, findings compatible with neuromyelitis optica

149 D68 sequences associated with acute flaccid myelitis grouped into a clade B1 strain that emerged in

150 biomarkers associated with acute transverse myelitis has led to a better understanding of the spectr

151 Radiation myelitis has long been recognised as a sinister conseque

152 For the last century, descriptions of SLE myelitis have been primarily limited to case reports.

153 features associated with distinct causes of myelitis in children is essential to guide investigation

154 Acute transverse myelitis in children, in contrast to adults, is more lik

155 n linked to the development of acute flaccid myelitis in children.

156 neurologic toxicity consisting of transverse myelitis in five patients, CNS toxicity in three, and se

157 and a paralytic disease called acute flaccid myelitis in infants.

158 river of epidemic outbreaks of acute flaccid myelitis in recent years(4), yet not much is known about

159 he central nervous system; necrotizing focal myelitis in the cervical spinal cord; radiculitis; neuri

160 ive myelopathy of other cause (n=66) and (2) myelitis in the context of a concurrent or subsequent di

161 his work contributes to our understanding of myelitis in these conditions and highlights the clinical

162 th haemorrhage in five, necrosis in one, and myelitis in two, and isolated myelitis (n = 1).

163 stigate innate immune responses during viral myelitis, including the activation of glia (microglia an

164 Acute transverse myelitis is a group of disorders characterized by focal

165 Acute transverse myelitis is a pathogenetically heterogeneous inflammator

166 elitis and the contention that acute flaccid myelitis is a rare yet severe clinical manifestation of

167 Short transverse myelitis is not uncommon in NMOSD and, when it is presen

168 owever, nonlongitudinal extensive transverse myelitis lesions were also observed frequently (105 of 2

169 es were more common (27% vs 4%; p=0.021) and myelitis less common (21% vs 50%; p=0.012) in Japanese t

170 nts with longitudinally extensive transverse myelitis (LETM) behave differently from those with AQP4-

171 Longitudinally extensive transverse myelitis (LETM) is a frequently devastating clinical syn

172 ation of longitudinally extensive transverse myelitis (LETM) predicts relapse of myelitis or developm

173 a (NMO), longitudinally extensive transverse myelitis (LETM), multiple sclerosis with a history of op

174 n 25 of 77 patients (32%) with short-segment myelitis (longest lesion spanning <3 vertebral segments

175 Acute transverse myelitis may be an isolated entity or may occur in the c

176 uding microcephaly, Guillain-Barre syndrome, myelitis, meningoencephalitis, and fatal encephalitis.

177 ay be complicated by postherpetic neuralgia, myelitis, meningoencephalitis, and VZV vasculopathy.

178 uded radiation recall (n = 2) and transverse myelitis (n = 1).

179 is in one, and myelitis in two, and isolated myelitis (n = 1).

180 (NMOSD, n=10), idiopathic AQP4-IgG-negative myelitis (n=4), idiopathic AQP4-IgG-negative optic neuri

181 4), and other subacute syndromes (transverse myelitis [n = 1], opsoclonus myoclonus [n = 1]).

182 In many recurrent cases who also have myelitis (neuromyelitis optica) a serum antibody to aqua

183 nded fever, seizure, meningitis/encephalitis/myelitis, nonanaphylactic serious allergic reaction, ana

184 e flaccid paralysis associated with anterior myelitis noted in the United States from 2012 to 2015.

185 rger-scale cohort studies have revealed that myelitis occurring in the idiopathic demyelinating disea

186 ptica spectrum disorder (NMOSD) myelitis and myelitis of other cause.

187 o MS occurred at a median of 2.8 years after myelitis onset.

188 ansverse myelitis (LETM) predicts relapse of myelitis or development of optic neuritis.

189 No transverse myelitis or late toxicities of grade 4 or greater have b

190 lomyelitis (ADEM), one episode of transverse myelitis or optic neuritis, multiple sclerosis (MS), ant

191 weakness and sensory loss due to transverse myelitis or peripheral nerve disease.

192 s ratio [OR] = 0.97, p = 0.011), presence of myelitis (OR = 0.38, p = 0.002), CR from previous attack

193 event (optic neuritis, incomplete transverse myelitis, or brain-stem or cerebellar syndrome) and evid

194 ation (optic neuritis, incomplete transverse myelitis, or brain-stem/cerebellar syndrome) and at leas

195 in the diagnosis of any acute encephalitis, myelitis, or encephalomyelitis.

196 syndromes such as optic neuritis, transverse myelitis, or isolated brainstem syndromes in whom multif

197 m 12 (48%) of 25 patients with acute flaccid myelitis overall.

198 for isolated optic neuritis versus isolated myelitis (p < 0.001), and for unilateral versus bilatera

199 patients (0%) with longitudinally extensive myelitis (p=0.002).

200 sed by a longitudinally extensive transverse myelitis (p=0.003), more often a complete resolution of

201 NMOSD myelitis patients were more commonly women, had concurre

202 cephalopathy, optic papillitis, inflammatory myelitis, postural tremor, and cerebellar ataxia.

203 ratory illness in children and acute flaccid myelitis, raising concerns about its potential impact on

204 Acute flaccid myelitis refers to acute flaccid limb weakness with spin

205 total lesion burden and number of transverse myelitis relapses did not correlate with pain.

206 ronic pain scores, irrespective of number of myelitis relapses, lesion length and lesion burden.

207 1.4 per month, and admissions for transverse myelitis remained constant at 0.6 per month.

208 itis and longitudinally extensive transverse myelitis [reported on at least 1 magnetic resonance imag

209 Isolated myelitis responded better to PE/IA than to HD-S as first

210 f a spinal cord biopsy during ring-enhancing myelitis revealed tissue vacuolation and loss of AQP4 im

211 ecurrent longitudinally extensive transverse myelitis (rLETM) are lacking.

212 ially presented with 2 attacks of transverse myelitis (rLETM-onset NMO).

213 ears with unilateral optic neuritis, partial myelitis, sensory disturbances, or brainstem syndromes s

214 f serious illnesses, including acute flaccid myelitis, severe respiratory complications, and hand-foo

215 alized with meningitis, encephalitis, and/or myelitis showed 92% sensitivity and 96% specificity rela

216 tudy was undertaken to determine whether SLE myelitis similarly encapsulates distinct syndromes.

217 Short transverse myelitis (STM; <3 vertebral segments) is considered nonc

218 cidated about the causes of acute transverse myelitis, tantalizing clues as to the potential immunopa

219 rteriovenous fistula is a very rare cause of myelitis that can only be treated interventionally or su

220 recognized cause of longitudinally extensive myelitis that commonly mimics NMOSD.

221 In idiopathic acute transverse myelitis, there is an intraparenchymal or perivascular c

222 tis (ADEM), two with ON, one with transverse myelitis (TM) and two with clinically isolated syndrome

223 sent with optic neuritis (ON) and transverse myelitis (TM) are diagnosed with NMO and those who show

224 Transverse myelitis (TM) is an immune-mediated spinal cord disorder

225 ggested that vaccines may trigger transverse myelitis (TM) or acute disseminated encephalomyelitis (A

226 syndromes (CIS), 27 patients with transverse myelitis (TM), 50 patients with human immunodeficiency v

227 by severe optic neuritis (ON) and transverse myelitis (TM).

228 ritis (ON); 20% bilateral ON; 15% transverse myelitis (TM); 15% simultaneous TM&ON; 10% Acute dissemi

229 atients were included: 25 with acute flaccid myelitis, two with enterovirus-associated encephalitis,

230 Myelitis usually is known to respond well to immunosuppr

231 Reovirus myelitis was associated with the pronounced activation o

232 Transverse myelitis was rare (<5 events in all vaccinated cohorts)

233 Transverse myelitis was the initial diagnosis.

234 Longitudinally extensive transverse myelitis was the predominant SC lesion pattern (upper co

235 es in clinical presentation of acute flaccid myelitis, we also used a subgroup analysis to compare cl

236 initial longitudinally extensive transverse myelitis were excluded (n = 151).

237 ibody positivity, and relapsing seronegative myelitis were excluded.

238 hildren with EV-A71-associated acute flaccid myelitis were younger, showed neurological onset earlier

239 entral grey matter component to MOG-antibody myelitis, which we hypothesize could be partially respon

240 Patients with acute flaccid myelitis who presented to two hospitals in Colorado and

241 rt study, we included patients with isolated myelitis who were followed clinically and radiologically

242 We compared patients with acute flaccid myelitis who were positive for enterovirus D68 with thos

243 on-multiple sclerosis optic neuritis without myelitis will be shown to be associated with this autoan

244 uromyelitis optica spectrum disorder (NMOSD) myelitis, with no satisfactory treatment; few studies ha