ライフサイエンスコーパス: myeloid progenitor cell

1 specific genes during the differentiation of myeloid progenitor cells.

2 orresponding to the two alternative fates of myeloid progenitor cells.

3 of gene expression in primary human CD15(+) myeloid progenitor cells.

4 nulocytic differentiation in these and other myeloid progenitor cells.

5 d1 is greater in mature granulocytes than in myeloid progenitor cells.

6 ll proliferation by overexpressing it in 32D myeloid progenitor cells.

7 expressed the c-Maf cDNA in 2 bipotent human myeloid progenitor cells.

8 -delta and -epsilon individually in the 32D myeloid progenitor cells.

9 g of diverse leukocytes and proliferation of myeloid progenitor cells.

10 ony growth of autologous CML blast cells and myeloid progenitor cells.

11 or to control leukemogenic transformation in myeloid progenitor cells.

12 optosis of interleukin 3 (IL-3)-deprived 32D myeloid progenitor cells.

13 ferentiation, survival, and proliferation of myeloid progenitor cells.

14 ibit the granulocytic differentiation of 32D myeloid progenitor cells.

15 of pre-B cells, but to have no influence on myeloid progenitor cells.

16 cDNAs were transfected and expressed in 32D myeloid progenitor cells.

17 ntiation of autonomously proliferating HL-60 myeloid progenitor cells.

18 by the proliferation of a malignant clone of myeloid progenitor cells.

19 ignancy characterized by clonal expansion of myeloid progenitor cells.

20 racterized by the (oligo)clonal expansion of myeloid progenitor cells.

21 ssion and Pol II promoter occupancy in human myeloid progenitor cells.

22 ved in IL-4/IL-13 signaling, mast cells, and myeloid progenitor cells.

23 ative cell surface marker of committed brain myeloid progenitor cells.

24 he gene encoding Fanconi C (Fancc) in murine myeloid progenitor cells.

25 and Ig synthesis, and enhances maturation of myeloid progenitor cells.

26 and short-term hematopoietic stem cells and myeloid progenitor cells.

27 d a growth advantage over wild-type HOXB4 in myeloid progenitor cells.

28 n of Fap1 with the Apc complex in Bcr-abl(+) myeloid progenitor cells.

29 genes that are activated by beta-catenin in myeloid progenitor cells.

30 gene expression in T cells, mast cells, and myeloid progenitor cells.

31 e properties of the Pu/Gata toggle switch in myeloid progenitor cells.

32 iption factor that is maximally expressed in myeloid progenitor cells.

33 ow previously to inhibit colony formation by myeloid progenitor cells.

34 ormal and transformed hematopoietic stem and myeloid progenitor cells.

35 that Tregs can affect the differentiation of myeloid progenitor cells.

36 ic and carcinogenic species in human CD34(+) myeloid progenitor cells.

37 ed fewer nucleated cells and was enriched in myeloid progenitor cells.

38 e GAS2 promoter and repress transcription in myeloid progenitor cells.

39 g to monocyte/DC lineage commitment of human myeloid progenitor cells.

40 ss of Notch-dependent signal transduction on myeloid progenitor cells.

41 tion factor HoxA10 is maximally expressed in myeloid progenitor cells.

42 ered in these leukemias compared with normal myeloid progenitor cells.

43 Further, CFU-ECs possess myeloid progenitor cell activity, differentiate into pha

44 marily attributable to autonomous defects in myeloid progenitor cells, although the hematopoietic mic

45 eletion of 2 alleles of p53 rescued both the myeloid progenitor cell and long-term hematopoietic stem

46 induces a select set of micro-RNAs (miR) in myeloid progenitor cells and AML patients with t(8;21).

47 (MDS) at 24 months of age, with dysplasia of myeloid progenitor cells and anemia with abnormal circul

48 ement of adhesion between BCR/ABL-expressing myeloid progenitor cells and bone marrow stroma may be o

49 ignaling pathway, we observed an increase in myeloid progenitor cells and CDllb(lo)Gr1(lo) promyelocy

50 expression of HoxA10 is maximal in committed myeloid progenitor cells and decreases as differentiatio

51 GF2 promoter that are activated by HoxA10 in myeloid progenitor cells and differentiating phagocytes.

52 AcmvIL-10 during latent infection of primary myeloid progenitor cells and found that LAcmvIL-10 is re

53 These studies demonstrate that both myeloid progenitor cells and HSCs resist TMTX by using n

54 The oncoprotein BCR-ABL transforms myeloid progenitor cells and is responsible for the deve

55 , a CC chemokine, is a specific inhibitor of myeloid progenitor cells and is the most potent activato

56 support interleukin-3-independent growth of myeloid progenitor cells and long-term outgrowth of B-ly

57 survival of preleukemic short-term HSCs and myeloid progenitor cells and maintains the differentiati

58 lso typically TRAF-3 immunonegative, whereas myeloid progenitor cells and megakaryocytes were often T

59 is also expressed during latent infection of myeloid progenitor cells and monocytes and facilitates p

60 OPN (iOPN) diminished the population size of myeloid progenitor cells and myeloid cells, and secreted

61 letion analysis of TLS-ERG in both mouse L-G myeloid progenitor cells and NIH 3T3 fibroblasts reveale

62 taY187F cDNAs were transfected into both 32D myeloid progenitor cells and NIH 3T3 fibroblasts.

63 xpression of mouse Gr-1(+) and human CD15(+) myeloid progenitor cells and showed that the pattern of

64 romoted the outgrowth of Ly6C(+) and Ly6G(+) myeloid progenitor cells and their mobilization to tumor

65 fied LYL1 promoter showed strong activity in myeloid progenitor cells and was bound in vivo by Fli1,

66 pa was associated with a marked reduction in myeloid progenitor cells, and Gabpalpha null myeloid cel

67 and survival of hematopoietic stem cells and myeloid progenitor cells, and increased Fgf2-expression

68 s a role regulating programmed cell death in myeloid progenitor cells, and that its down-regulation i

69 ative capacity and self-renewal potential of myeloid progenitor cells; and support the hypothesis tha

70 that HoxA9 repressed ARIH2 transcription in myeloid progenitor cells, antagonizing the effect of Hox

71 all RNAs, termed microRNAs, encoded by human myeloid progenitor cells are capable of repressing a key

72 (-/-) and Glc-6-PT(-/-) mice, the numbers of myeloid progenitor cells are increased, while in the ser

73 ated by up to 4 h in AML-1B-expressing 32D.3 myeloid progenitor cells as compared with control cells

74 XC chemokine, were enhanced with bone marrow myeloid progenitor cells as well as macrophages, T cells

75 ted C57BL/6 mice, we observed a reduction in myeloid progenitor cells, as defined both phenotypically

76 ting proliferation and enhancing survival of myeloid progenitor cells at concentrations as low as 3 n

77 imulates the proliferation and maturation of myeloid progenitor cells both in vitro and in vivo.

78 g receptor family and is expressed highly on myeloid progenitor cells but at much lower levels in dif

79 tro phenotypes observed with loss of Gfi1 in myeloid progenitor cells but did not rescue Gfi1-/- bloc

80 air of our bones are formed from bone marrow myeloid progenitor cells by a complex differentiation pr

81 ICSBP inhibits growth of Bcr/Abl-transformed myeloid progenitor cells by activating several genes tha

82 interleukin-6 receptor (IL-6R) expression on myeloid progenitor cells by Delta-1 treatment combined w

83 and F1009/F1021 were overexpressed in FDC-P2 myeloid progenitor cells by retroviral-mediated gene tra

84 Moreover, murine myeloid progenitor cells carrying an Mll-CBP knock-in al

85 tological malignancy derived from neoplastic myeloid progenitor cells characterized by abnormal clona

86 nimals bear distorted hematopoietic stem and myeloid progenitor cell compartments compared with euplo

87 IRS-4, we expressed them individually in 32D myeloid progenitor cells containing the human insulin re

88 these findings reveal that Prom1-expressing myeloid progenitor cells contribute to the generation of

89 by colony-forming assays (for erythroid and myeloid progenitor cells), cytochemical staining, and mi

90 cell production or runting but corrected the myeloid progenitor cell deficiency seen in these mutants

91 s (AAV) vectors to transduce primitive human myeloid progenitor cells derived from marrow and cord bl

92 neovasculogenesis and that CD133(+)CXCR4(+) myeloid progenitor cells directly participate in new blo

93 vered that human embryonic stem cell-derived myeloid progenitor cells display a similar engraftment p

94 Apc heterozygous myeloid progenitor cells display an increased frequency

95 ly regulates the maturational advancement of myeloid progenitor cells during transitions between two

96 ll development, the gene was introduced into myeloid progenitor cells established from ICSBP-/- mice.

97 anced SCF, Flt3 ligand, and TPO expansion of myeloid progenitor cells ex vivo.

98 MBT-1(-/-) myeloid progenitor cells exhibit a maturational deficien

99 In contrast, HoxA10-overexpressing myeloid progenitor cells exhibited increased proliferati

100 y increases atherogenesis through regulating myeloid progenitor cell expansion and differentiation, f

101 d CD34(+)KIT(+) cells, which are enriched in myeloid progenitor cells, expressed and secreted the CCR

102 roarray gene expression analysis of Irf-8-/- myeloid progenitor cells expressing an IRF-8/estrogen re

103 Consequently, myeloid progenitor cells expressing oncogenic Kras and l

104 w here that hnRNP A1 levels are increased in myeloid progenitor cells expressing the p210(BCR/ABL) on

105 ew growth factors from IL-3-dependent murine myeloid progenitor cells (factor dependent cell progenit

106 cellularity of the bone marrow, elevation of myeloid progenitor cell frequencies in both organs and a

107 nalysis of gene expression (SAGE) on CD15(+) myeloid progenitor cells from 22 AML patients who had fo

108 okines in a manner similar to that of normal myeloid progenitor cells from bone marrow and cord blood

109 d expression of Fap1 and Gas2 in bone marrow myeloid progenitor cells from Icsbp(-/-) mice in compari

110 results document selective insensitivity of myeloid progenitor cells from mIL-8Rh(-/-) mice to inhib

111 We show here that in normal myeloid progenitor cells FUS, although not visibly ubiqu

112 n of haematopoietic stem cell/progenitor and myeloid progenitor cell genes.

113 During hematopoiesis, myeloid progenitor cells give rise to granulocytes and m

114 n of KLF7 results in a marked suppression of myeloid progenitor cell growth and a loss of short- and

115 ogenitor cells and may also be necessary for myeloid progenitor cell growth in a variety of hematopoi

116 In myeloid progenitor cells, HoxA10 represses transcription

117 and critical matrix-degrading activities of myeloid progenitor cells in an autocrine manner by augme

118 vival and abnormal cell cycle progression of myeloid progenitor cells in both cyclic and severe conge

119 due to accelerated apoptosis of bone marrow myeloid progenitor cells in CN.

120 rated an inhibitory effect on hemopoiesis of myeloid progenitor cells in colony formation assays.

121 peripheral blood, and the numbers of porcine myeloid progenitor cells in marrow, were increased in co

122 Myc preferentially stimulated the growth of myeloid progenitor cells in methylcellulose.

123 the phenomenon of microglial augmentation by myeloid progenitor cells in the adult brain.

124 LHRHa), increases the number of lymphoid and myeloid progenitor cells in the bone marrow and developi

125 for protein production with messenger RNA by myeloid progenitor cells in the bone marrow.

126 ncer, we have shown that bone marrow-derived myeloid progenitor cells in the premetastatic lung secre

127 itment of bone marrow-derived CD11b(+)Gr1(+) myeloid progenitor cells in the premetastatic lungs.

128 trafficking was linked to redistribution of myeloid progenitor cells in the spleen.

129 arrest in lymphopoiesis and the expansion of myeloid progenitor cells in TSLP transgenic mice suggest

130 (CXCL)12) enhances survival/antiapoptosis of myeloid progenitor cells in vitro.

131 lso determined that HoxA10 overexpression in myeloid progenitor cells increased Tgfbeta2 production b

132 on of the CML-related Bcr-abl oncoprotein in myeloid progenitor cells increases expression of Fas-ass

133 vere anemia and thrombocytopenia and expands myeloid-progenitor cells, indicating that FOG-1 is requi

134 sed Fgf2 production by HoxA10-overexpressing myeloid progenitor cells induced a phosphoinositol 3-kin

135 Enforced expression of Id1 in committed myeloid progenitor cells inhibits granulocyte but not ma

136 addition, the regeneration of erythroid and myeloid progenitor cells is delayed during stress hemato

137 3-mediated cleavage of cyclin A in dividing myeloid progenitor cells is important for the onset of d

138 viral infection using a clonal population of myeloid progenitor cells (Kasumi-3 cells).

139 e myeloid-derived suppressor cells, immature myeloid progenitor cells known for immunosuppressive pro

140 e growth factor I receptor (IGF-IRWT) in 32D myeloid progenitor cells led to cell proliferation in re

141 To study these pathways, we have used a myeloid progenitor cell line (32D) which is dependent on

142 erence analysis (RDA) to compare a committed myeloid progenitor cell line (EPRO) with the multipotent

143 t proliferation of the IL-3-dependent murine myeloid progenitor cell line 32D is suppressed by human

144 ivation of STAT3-p27(Kip1) pathway in murine myeloid progenitor cell line 32D-G-CSFR cells was marked

145 esponse nor affects the proliferation of the myeloid progenitor cell line 32D-GR that is deficient in

146 on of cell surface adhesion molecules in the myeloid progenitor cell line 32D.

147 ar calcium and inhibits the proliferation of myeloid progenitor cell line 32D.

148 ide (DMSO) to induce apoptosis in the murine myeloid progenitor cell line 32Dcl3, we examined the eff

149 y we have sought to characterize a committed myeloid progenitor cell line in an attempt to isolate ge

150 in the human pre-B-cell line 697, the human myeloid progenitor cell line K562, and the murine fibrob

151 ion library derived from the B6SutA(1) mouse myeloid progenitor cell line to search for novel oncogen

152 phages, and ectopic expression of VentX in a myeloid progenitor cell line triggered its differentiati

153 over-expressed in the IL-3 dependent, murine myeloid progenitor cell line, 32D cl3 in order to test w

154 r interleukin-3 (IL-3) modulates MAPK in the myeloid progenitor cell line, 32D.

155 Expression of exogenous Fms in a murine myeloid progenitor cell line, FDC-P1 (FD-Fms), results i

156 A primitive human hematopoietic myeloid progenitor cell line, KG1a, characterized by hig

157 sitive increase in mTOR kinase activity in a myeloid progenitor cell line.

158 ed signal in an interleukin (IL)-3-dependent myeloid progenitor cell line.

159 fection on MHC class II in Kasumi-3 cells, a myeloid-progenitor cell line that endogenously expresses

160 We established conditionally immortalised myeloid progenitor cell lines co-expressing constitutive

161 ematopoietic growth factor-dependent, lympho-myeloid progenitor cell lines from the fetal livers of b

162 Thus, unlike platelets and myeloid progenitor cell lines, fully differentiated huma

163 the development of bipotent cells using two myeloid progenitor cell lines, KG-1 and KG-1a, as models

164 s and used to transduce precursor B-cell and myeloid progenitor cell lines.

165 In both cases, myeloid progenitor cells lose the ability to distinctly

166 When transformed with p210 Bcr/Abl, ICSBP-/- myeloid progenitor cells lost growth factor dependence a

167 onsils; (b) mature neutrophils (high) versus myeloid progenitor cells (low) in bone marrow; (c) corpu

168 CD33 (Siglec-3) is a marker of myeloid progenitor cells, mature myeloid cells, and most

169 strate that a population of adult BM-derived myeloid progenitor cells migrated to avascular regions o

170 Using Kasumi-3 cells as a myeloid progenitor cell model endogenously expressing MH

171 ly due in part to SDF-1 alpha enhancement of myeloid progenitor cell (MPC) survival.

172 t by influencing the proliferative status of myeloid progenitor cells (MPC).

173 ation of hematopoietic stem cells (HSCs) and myeloid progenitor cells (MPCs) has been shown to mediat

174 enhances proliferation of mature subsets of myeloid progenitor cells (MPCs), suppresses proliferatio

175 study, we examined the capacity of malignant myeloid progenitor cells of patients in the chronic phas

176 n to Ba/F3 murine pro-B cells but not to 32D myeloid progenitor cells or CTLL-2 murine helper T cells

177 In 32D myeloid progenitor cells, phosphorylation of Ser(307) in

178 Gene expression analyses of the myeloid progenitor cell population from obese mice demon

179 -cell transcriptomic analyses of bone marrow myeloid progenitor cell populations indicated a dramatic

180 Finally, overexpression of AML-1-ETO in myeloid progenitor cells prevented granulocyte colony-st

181 Romyelocel-L is a universal, allogeneic myeloid progenitor cell product being studied to reduce

182 o more pronounced suppression of bone marrow myeloid progenitor cell proliferation and monocytosis, a

183 leukemia is preceded by a period of extended myeloid progenitor cell proliferation and self-renewal.

184 G-CSF signaling in the regulation of marrow myeloid progenitor cell proliferation in mice with Strep

185 This impairment of myeloid progenitor cell proliferation was not attenuated

186 ly test whether G-CSF can compensate for the myeloid progenitor cell reduction in the T(-) model of h

187 ia with a significant expansion of committed myeloid progenitor cells, resembling human myelodysplast

188 We determined that expression of Mll-Ell in myeloid progenitor cells resulted in autocrine productio

189 get binding to normal hematopoietic stem and myeloid progenitor cells, resulting in adverse hemato-to

190 s, we demonstrated that AML EVs are taken-up myeloid progenitor cells, resulting in the selective pro

191 wth factor 2 (Fgf2) by HoxA10-overexpressing myeloid progenitor cells results in activation of beta-c

192 NF1 deficiency in myeloid progenitor cells results in cytokine hypersensit

193 ed and sufficient for the immortalization of myeloid progenitor cells, shares strong similarities to

194 lin-stimulated processes in 32D(IR) cells, a myeloid progenitor cell stably overexpressing the insuli

195 induced IL-2Ralpha mRNA expression using 32D myeloid progenitor cells stably transfected with either

196 of p53 in limiting aberrant self-renewal of myeloid progenitor cells, such that loss of p53 counters

197 d the apoptotic and growth properties of 32D myeloid progenitor cells, suggesting DeltaTrkA may have

198 llular effects were consistent with enhanced myeloid progenitor cell survival by SDF-1 alpha after de

199 Human myeloid progenitor cells temporarily express HLA class I

200 oxidase (MPO), an enzyme found in developing myeloid progenitor cells, the likely origin for myeloid

201 Nf1) increases the proliferative response of myeloid progenitor cell to hematopoietic cytokines.

202 es have relied on ex vivo differentiation of myeloid progenitor cells to DCs in culture.

203 ed that differentiation of latently infected myeloid progenitor cells to dendritic or macrophage-like

204 Mcl1 facilitates AML development by allowing myeloid progenitor cells to evade Myc-induced cell death

205 hich is characterized by hypersensitivity of myeloid progenitor cells to granulocyte macrophage colon

206 JMML is acquired hypersensitivity by clonal myeloid progenitor cells to granulocyte macrophage-colon

207 pression enhanced the sensitivity of primary myeloid progenitor cells to granulocyte-macrophage colon

208 nal activators involved in the commitment of myeloid progenitor cells to the DC lineage and predicted

209 that traumatic injury induced recruitment of myeloid progenitor cells to the sprouting axons of senso

210 mitogenic response of M07e cells and murine myeloid progenitor cells to these cytokines and particul

211 mirrored by impairment of the ability of 32D myeloid progenitor cells to undergo proper terminal diff

212 tion-induced adaptation of hematopoietic and myeloid progenitor cells toward enhanced myelopoiesis mi

213 Inactivation of Mtg16 skewed early myeloid progenitor cells toward the granulocytic/macroph

214 We therefore investigated whether myeloid progenitor cells transformed by Hoxa9 and Meis1

215 and colleagues examine deletion of Dicer1 in myeloid progenitor cells using a conditional Cebpa-Cre a

216 the enhanced self-renewal of early postnatal myeloid progenitor cells was limited and did not result

217 tand the pattern of gene expression in mouse myeloid progenitor cells, we carried out a genome-wide a

218 and induced trafficking and proliferation of myeloid progenitor cells were disordered in -/- mice.

219 marrow was protected and enhanced numbers of myeloid progenitor cells were found in S and G2/M.

220 Under the condition used, both erythroid and myeloid progenitor cells were generated.

221 Normal numbers of myeloid progenitor cells were present in Nr4a1-/- mice,

222 To approach these aims, FDC-P1 murine myeloid progenitor cells were transfected with vectors d

223 ucing transcription factors IRF8 and PU.1 in myeloid progenitor cells, whereas it reduces G-CSF-drive

224 Transplantation of myeloid progenitor cells, which are the cells of origin

225 leen and liver, and the presence of immature myeloid progenitor cells with high nucleus-to-cytoplasm

226 lso compared the expression of mouse Gr-1(+) myeloid progenitor cells with that of mouse brain tissue

227 ated in interleukin 3 (IL-3)-dependent 32D.3 myeloid progenitor cells, yet this induces apoptosis whe