ライフサイエンスコーパス: myeloid suppressor cell

1 Tumor growth promotes the expansion of myeloid suppressor cells.

2 s combined with a reduction in tumor-induced myeloid suppressor cells.

3 s the development, survival, and function of myeloid suppressor cells.

4 ating lymphocytes and reducing the number of myeloid suppressor cells.

5 vation of macrophages to function similar to myeloid suppressor cells.

6 ave M1 macrophages and retain high levels of myeloid suppressor cells after surgery; in addition, the

7 revealed CD11b(+)/Gr-1(+) as a heterogeneous myeloid suppressor cell also expressing low levels of MH

8 Tumor stroma is modified, myeloid suppressor cells are reduced, and M1 macrophage

9 phil-to-lymphocyte ratios and percentages of myeloid suppressor cells but increased numbers of cytoki

10 mation expands a heterogeneous population of myeloid suppressor cells capable of inhibiting T cell fu

11 environment may, thus, limit desmoplasia and myeloid suppressor cell differentiation.

12 We describe that myeloid suppressor cells expressing CD11b(+)/Gr-1(+) mar

13 differentiation and accumulation of immature myeloid suppressor cells (ImC) is one of the major mecha

14 hypothesized causal role for IL-4Ralpha and myeloid suppressor cells in glioma development.

15 eads to a rapid and significant expansion of myeloid suppressor cells in peripheral lymphoid tissues.

16 ffect, we found that a dramatic expansion of myeloid suppressor cells in SHIP(-/-) mice impairs primi

17 creased percentage of regulatory T cells and myeloid suppressor cells in the pancreatic tumor and tum

18 s in the immune microenvironment, decreasing myeloid suppressor cells, increasing CD8+ T cells, and s

19 Myeloid suppressor cell-induced immunosuppression is med

20 uitment of immunosuppressive CD11b(+)Gr-1(+) myeloid suppressor cells into the tumor microenvironment

21 ween natural killer (NK) cell activation and myeloid suppressor cell (MSC) expansion in tumor-bearing

22 These myeloid suppressor cells (MSC) are present in many patie

23 ed in regulatory T cells (T(reg)) as well as myeloid suppressor cells (MSC).

24 The accumulation of myeloid suppressor cells (MSCs) is associated with immun

25 Myeloid suppressor cells (MSCs) producing high levels of

26 population of immature myeloid cells, termed myeloid suppressor cells (MSCs), that have potent immuno

27 umors have elevated levels of Gr1(+)CD11b(+) myeloid suppressor cells (MSCs), which inhibit T cell ac

28 TGF-beta, explains previous observations on myeloid suppressor cells or TGF-beta and provides insigh

29 Vascularity and myeloid suppressor cell populations and their regulators

30 ion through effects on tumor vascularity and myeloid suppressor cell populations, in uveal melanoma t

31 goal of this study was to determine whether myeloid suppressor cells producing high arginase existed

32 Depletion of the CD11b+, CD14- myeloid suppressor cells reestablished T cell proliferat

33 Consistent with expansion of myeloid suppressor cells, splenocytes and lymph node cel

34 e this threshold, GM-CSF induced Gr1+/CD11b+ myeloid suppressor cells that substantially impaired ant

35 unosuppression by driving differentiation of myeloid suppressor cells together with TGF-beta.

36 ma microenvironment of arginase, a marker of myeloid suppressor cells, which is critical for their T-

37 eased infiltrating T lymphocytes and reduced myeloid suppressor cells, which were more apoptotic.

38 Myeloid suppressor cells with high arginase activity are

39 well as decreased levels of T regulatory and myeloid suppressor cells within the tumor microenvironme