ライフサイエンスコーパス: myoepithelial

1 tion of a cell subpopulation from luminal to myoepithelial.

2 original bilaterian mesodermal muscles were myoepithelial.

3 In contrast, Wnt pathway tumors exhibit myoepithelial, acinar, or glandular differentiation, and

4 In human tissue samples, increased myoepithelial alphavbeta6 expression correlated with inc

5 teins, which in turn stimulate AC present on myoepithelial and acinar cells.

6 derive from differentiated cells, including myoepithelial and ductal cells, that appear to dediffere

7 (EPM), a protein expressed on the surface of myoepithelial and fibroblast cells of the mammary gland,

8 intermediate" cells by lack of expression of myoepithelial and luminal apical membrane markers.

9 AKR1C3 and AKR1C1 were localized on the same myoepithelial and luminal epithelial cell layers.

10 zed EqMaOs based on expression of stem cell, myoepithelial and luminal markers, and found that EqMaOs

11 ormal mammary cell types, including luminal, myoepithelial and secretory.

12 from luminal epithelial cells but remain on myoepithelial and stromal cells.

13 HDAg was detected in MSG acinar, ductal, myoepithelial, and adipose cells and localized with the

14 gland-specific genes and proteins of acinar, myoepithelial, and duct cells, and exhibit gland functio

15 in concert with differentiation into acinar, myoepithelial, and ductal (basal and luminal) sub-lineag

16 T-cadherin delineates endothelial, myoepithelial, and ductal epithelial cells in the normal

17 opment, we find cilia on luminal epithelial, myoepithelial, and stromal cells during early branching

18 transcriptional network, including a set of myoepithelial- and luminal epithelial-specific intronic

19 of miR-145 and miR-205 was restricted to the myoepithelial/basal cell compartment of normal mammary d

20 rare boundary cells that sit at the critical myoepithelial border confining the spread of malignant c

21 Normal human luminal and myoepithelial breast cells separately purified from a se

22 Loss of myoepithelial calponin was specifically associated with

23 Myoepithelial carcinoma (MECA) is an aggressive salivary

24 X-6X) grow very slowly compared to their non-myoepithelial carcinomatous counterparts and accumulate

25 or receptor 2 (VEGFR2) signaling pathways in myoepithelial (CD10(+)) and endothelial (CD31(+), CD105(

26 in the breast: luminal (EpCAM(+)) and basal/myoepithelial (CD10(+)).

27 tively support the hypothesis that the human myoepithelial cell (even when transformed) is a natural

28 reas TrkA, TrkB, and TrkC, were localized in myoepithelial cell and ductal cell membranes.

29 Further, we demonstrate a specific defect in myoepithelial cell contractility in Acta2 null mammary g

30 We conclude that Acta2 specifically mediates myoepithelial cell contraction during lactation and that

31 s defects in vascular smooth muscle cell and myoepithelial cell differentiation and function.

32 fic and essential role for MRTF-A in mammary myoepithelial cell differentiation and points to commona

33 Progressive loss of the myoepithelial cell differentiation markers p63, calponin

34 a in situ (DCIS) and report that compromised myoepithelial cell differentiation occurs before transit

35 portance of Numb and Numbl in the control of myoepithelial cell fate determination, epithelial identi

36 Numb and Numbl act to determine mammary myoepithelial cell fate, maintain epithelial identity, a

37 lk protein synthesis, whereas others adopted myoepithelial cell fates.

38 basal epithelial cells or a single adlumenal myoepithelial cell in close proximity to the either the

39 ocal disruption of the integrity of both the myoepithelial cell layer and the basement membrane is an

40 l, Forster et al. (2014) show that the basal myoepithelial cell layer directs the final maturation of

41 Immunostaining for p63 demonstrated that the myoepithelial cell layer is disrupted in the p190A defic

42 ls that form ductile tubules surrounded by a myoepithelial cell layer that provides contractility req

43 It is not known how the myoepithelial cell lineage is specified, nor how signals

44 Myoepithelial cell lines (HMS-1-6), derived from diverse

45 These myoepithelial cell lines inhibit endothelial cell chemot

46 These myoepithelial cell lines sense hypoxia, respond to low O

47 By use of bovine mammary epithelial and myoepithelial cell lines, it was found that bovine S. au

48 diagnosed with pure DCIS, a similar loss in myoepithelial cell markers was observed.

49 cell were grown in neuronal, epithelial, and myoepithelial cell media, and examined by light morpholo

50 The protein p75 was expressed only on myoepithelial cell membranes.

51 phological differences of microenvironmental myoepithelial cell nuclei without any direct information

52 rther research is warranted into the role of myoepithelial cell p63 and calponin expression on DCIS p

53 ons were primarily enclosed by the adlumenal myoepithelial cell plasma membrane and interstitial proj

54 epigenomic reprogramming between luminal and myoepithelial cell types, with the genomes of luminal ce

55 structures were closely associated with the myoepithelial cell, as visualized by beta-tubulin antibo

56 que component of the microenvironment is the myoepithelial cell.

57 We show that FGF7, expressed by myoepithelial cells (MEC), activates the FGFR2-dependent

58 structures comprising an outer layer of cap/myoepithelial cells (MECs) and an inner layer of luminal

59 termine the pathogenic changes that occur in myoepithelial cells (MECs) from lacrimal glands of a mou

60 ), and Hs3st3a1 and Hs3st3b1 are enriched in myoepithelial cells (MECs) that produce basement membran

61 alpha-smooth muscle actin (SMA), which marks myoepithelial cells (MECs), by immunofluorescence micros

62 and epithelial cells (acinar and ductal), or myoepithelial cells (MECs).

63 Normal myoepithelial cells act as "natural tumor suppressors";

64 we found that ectopic expression of Cx26 in myoepithelial cells altered the expression of endogenous

65 ll lineages in ACC, cooperating with TP63 in myoepithelial cells and a Notch program in luminal epith

66 lls, aging is associated with a reduction of myoepithelial cells and an increase in luminal cells tha

67 terized by proliferation of both luminal and myoepithelial cells and are rare in human breast cancer,

68 niche triad with GM-CSF-producing ILC2s and myoepithelial cells and are required for efficient secre

69 ay, also contain a significant proportion of myoepithelial cells and cells expressing keratin 6.

70 A depletion of myoepithelial cells and ectopic intra-acinar ductular ce

71 els compared to non-malignant epithelial and myoepithelial cells and fibroblasts.

72 OLIN-1 is however highly expressed in breast myoepithelial cells and its expression is retained in tu

73 were strongly TRAF-4 immunopositive whereas myoepithelial cells and most of the mammary epithelial c

74 e varicosities, and leads the contraction of myoepithelial cells and/or of the acinar valve to contro

75 thelial cells advanced collectively, whereas myoepithelial cells appeared to restrain elongating duct

76 l cell type within the gland, that the basal/myoepithelial cells are key regulators of paracrine sign

77 nar ductular cells and the scattered loss of myoepithelial cells are other abnormalities in dacryoade

78 Myoepithelial cells bear a striking resemblance to smoot

79 nes induce the secreted protease Adamts18 in myoepithelial cells by controlling Wnt4 expression with

80 ell lineage is specified, nor how signals in myoepithelial cells contribute to lactogenesis.

81 t normally line parotid acini, newly induced myoepithelial cells densely populated recombined parotid

82 The presence of NET in myoepithelial cells did not require sympathetic innervat

83 While myoepithelial cells do not normally line parotid acini,

84 nance of the differentiated state of mammary myoepithelial cells during lactation, resulting in apopt

85 sitive Leydig, Sertoli, and some peritubular myoepithelial cells express SUMO-1, findings suggesting

86 ransient release of stored Ca(2+) in mammary myoepithelial cells followed by slow, irregular Ca(2+) o

87 d that in the normal breast of non-carriers, myoepithelial cells frequently co-express the p63 and TC

88 riptomes from primary luminal epithelial and myoepithelial cells from younger <30 (y)ears old and old

89 is repression of CDKN2A transcript p16 where myoepithelial cells harbour cancer-like gene expression

90 We have shown that myoepithelial cells in a subset of preinvasive ductal ca

91 tions suggested that the activity of typical myoepithelial cells in DCIS was lowered.

92 and both periductal fibroblasts and residual myoepithelial cells in DCIS.

93 ritical role in the maintenance of basal and myoepithelial cells in ectodermally derived tissues and

94 Here, we investigated myoepithelial cells in normal breast tissues of BRCA1 an

95 iated with a decrease in keratin 14-positive myoepithelial cells in PyMT(mgko) tumors following LOX i

96 ecules that define gland-specific acinar and myoepithelial cells in recombined salivary epithelium.

97 SED1 is expressed by both luminal and myoepithelial cells in the developing epithelial duct, a

98 estinal cells, their impact on human mammary myoepithelial cells in tissue culture was studied.

99 ype that is usually expressed exclusively in myoepithelial cells in women younger than 30 years.

100 t tumor microenvironment, IL-6 secreted from myoepithelial cells influences DNMT1 stability, induces

101 bed that fibroblasts promote, whereas normal myoepithelial cells inhibit, the progression of ductal c

102 The fraction of p63(+)TCF7(+) myoepithelial cells is also significantly decreased in D

103 The absence of mammary myoepithelial cells is associated with invasive mammary

104 and adaptation to matrix rigidity in breast myoepithelial cells is determined by the bond dynamics o

105 tion carriers the frequency of p63(+)TCF7(+) myoepithelial cells is significantly decreased and p63 a

106 and binds to alpha(v) integrin receptors on myoepithelial cells leading to MAPK activation and cell

107 lomerular (JG) cells, a specialized group of myoepithelial cells located near the entrance to the kid

108 rogenitors to mammary luminal epithelial and myoepithelial cells may be the targets for oncogenesis b

109 The expression of MEPI in myoepithelial cells may prevent breast cancer malignant

110 ations may represent a conserved language in myoepithelial cells of other secretory epithelia, such a

111 ssion signature similar to that of the basal/myoepithelial cells of the breast and is reported to hav

112 We use the myoepithelial cells of the Caenorhabditis elegans sperma

113 e outer root sheath of the hair follicle, in myoepithelial cells of the eccrine gland, and in the bas

114 (c) basal cells of the prostate glands; (d) myoepithelial cells of the mammary glands; (e) distal co

115 norhabditis elegans, specialized contractile myoepithelial cells of the somatic gonad, the gonadal sh

116 has detected this serpin exclusively in the myoepithelial cells on the normal and noninvasive mammar

117 rise), while such shortening was not seen in myoepithelial cells or normal large lactiferous ducts of

118 Myoepithelial cells participated in the hyperplasias but

119 Myoepithelial cells play key roles in normal mammary gla

120 Contractile myoepithelial cells surround the secretory complex to fa

121 P-cadherin expression is localized to the myoepithelial cells surrounding the lumenal epithelial c

122 many more DMRs with adult breast luminal and myoepithelial cells than with melanocytes and fibroblast

123 hat it provided a communication conduit from myoepithelial cells that drove directional change in lum

124 eas myosin IIB expression is up-regulated in myoepithelial cells that have more mesenchymal character

125 legans spermatheca is a bag-like organ of 24 myoepithelial cells that houses the sperm and is the sit

126 intercellular signaling between luminal and myoepithelial cells that is required for branching morph

127 The metaplasia of myoepithelial cells to chondrocytes appears to require t

128 thelial component, whereas the proliferating myoepithelial cells undergo metaplasia to form chondrocy

129 sue had a distinctive pattern of expression: myoepithelial cells uniformly showed strong PTEN express

130 SMA-positive myoepithelial cells were found in the acini but not in t

131 Human myoepithelial cells which surround ducts and acini of ce

132 lial cells and an outer layer of contractile myoepithelial cells with mesenchymal properties.

133 cts, blood vessels, acini, nerve fibers, and myoepithelial cells within the gland.

134 demonstrate that Cav-3 is also expressed in myoepithelial cells within the mammary gland.

135 nge ATP signal stimulates the contraction of myoepithelial cells wrapped tightly around the submucosa

136 ) and alpha-smooth muscle actin (a marker of myoepithelial cells).

137 cluding keratinocytes and breast luminal and myoepithelial cells, against neural crest-derived melano

138 le (SM22) alpha protein were detected in the myoepithelial cells, and a large number of cytokeratin s

139 , Gli2 and Gli3 are expressed in stromal and myoepithelial cells, and Gli3 is also found within the l

140 roliferation, cancer-associated fibroblasts, myoepithelial cells, and immune cells are all implicated

141 differentiated luminal epithelial and basal myoepithelial cells, as well as undifferentiated stem ce

142 hey proliferated to produce both luminal and myoepithelial cells, comprised both lobule-limited and d

143 eal mesothelial cells, osteocytes, glandular myoepithelial cells, ependymal cells, and by stromal ret

144 trans-dominant negative for Cx43 function in myoepithelial cells, highlighting the importance of cell

145 Progenitor cell markers and myoepithelial cells, however, are lacking in mammary tum

146 rogenitors and their differentiated progeny, myoepithelial cells, in epithelial basal and suprabasal

147 A whole transcriptome analysis of basal/myoepithelial cells, luminal estrogen receptor negative

148 populations including mammary epithelial and myoepithelial cells, progenitors, and multi-lineage stem

149 s are distinct from the K14-expressing basal/myoepithelial cells, proliferate at a significantly high

150 ne interacting factors showed that the basal/myoepithelial cells, remarkably, expressed over twice as

151 eolar pneumocytes, kidney glomeruli, mammary myoepithelial cells, Schwann cells, and most types of br

152 l population located between the luminal and myoepithelial cells, similar to the unpolarized body cel

153 aryotyping, and applied it to epithelial and myoepithelial cells, stromal fibroblasts from normal bre

154 tissue, both TrkC and Bcl2 were expressed in myoepithelial cells, suggesting a principal role for thi

155 stem/progenitor cells or are associated with myoepithelial cells, suggestive of an epithelial-mesench

156 ted cell types, including acinar, ductal and myoepithelial cells, that are maintained in a lineage-re

157 ex carcinomas offer an ideal system to study myoepithelial cells, the second major cell lineage of th

158 , which in normal breast is localized to the myoepithelial cells, tracks with malignant phenotype in

159 Epithelial cells, especially myoepithelial cells, were determined to be a rich source

160 nd activin type II receptor are expressed by myoepithelial cells, whereas no expression was detected

161 ession of Srf-dependent genes in the mammary myoepithelial cells, which control milk ejection followi

162 that Numb and Numbl are enriched in mammary myoepithelial cells, with their expression peaking durin

163 ations are observed in the tumor-stromal and myoepithelial cells.

164 from the active motility of both luminal and myoepithelial cells.

165 control differentiation of smooth muscle and myoepithelial cells.

166 ression of markers expressed in normal basal/myoepithelial cells.

167 ithelial cells but absent from either cap or myoepithelial cells.

168 , NET simultaneously appeared in sweat gland myoepithelial cells.

169 Tag-induced proliferation of epithelial and myoepithelial cells.

170 -positive axons in both basal epithelial and myoepithelial cells.

171 membranes of acinar and ductal cells and on myoepithelial cells.

172 cription factor expression within acinar and myoepithelial cells.

173 the biphasic proliferation of epithelial and myoepithelial cells.

174 stinct cell lineages: luminal epithelial and myoepithelial cells.

175 nriched in luminal cells but absent in basal myoepithelial cells.

176 terminally differentiated acinar, ductal and myoepithelial cells.

177 contractile cells, such as smooth muscle and myoepithelial cells.

178 , while HGF is produced by stromal and basal myoepithelial cells.

179 pomethylated enhancer elements compared with myoepithelial cells.

180 l epithelial cells or the basally positioned myoepithelial cells.

181 organized as a bilayer of luminal and basal/myoepithelial cells.

182 ithelial cells and Cx43 is expressed only in myoepithelial cells.

183 nohistochemical evidence for the presence of myoepithelial cells.

184 se to incompletely differentiated luminal or myoepithelial cells.

185 The AC II was found exclusively on myoepithelial cells; AC IV was located intracellularly i

186 e composed of luminal (secretory) and basal (myoepithelial) cells, which are descendants of a common

187 ing of the ductal tree, lumen formation, and myoepithelial compartmentalization in the postnatal MG.

188 e resistant to viral transduction than their myoepithelial counterparts.

189 gesterone or MPA increased expression of the myoepithelial cytokeratins (CK) 5 and 6 in a subpopulati

190 sis in the mammary gland is likely driven by myoepithelial-derived VEGF-C and/or VEGF-D.

191 e observed expression of genes indicative of myoepithelial differentiation, as expected, including th

192 d cystic carcinoma (ACC), is notable for its myoepithelial differentiation, proclivity for hematogeno

193 Surprisingly, myoepithelial disruption was more advanced in DCIS patie

194 on occurs, resulting in separate lineages of myoepithelial, ductal, and acinar cells in postnatal gla

195 anism for the underlying phenotype is due to myoepithelial dysfunction postpartum resulting in precoc

196 se to elevated IL-6 levels secreted by tumor myoepithelial (Epi-T) cells.

197 , EHF and ELF5 (LASP), TP63 and KRT14 (basal-myoepithelial), epithelial subtypes displayed several un

198 RK1/2) effector RSK prevents the EGF-induced myoepithelial expansion.

199 is ovulated by increasing contraction of the myoepithelial gonadal sheath and relaxation of the dista

200 pressing markers associated with luminal and myoepithelial HMEC lineages in vivo in contrast to the b

201 ed with the same genes: basal-like BPLER and myoepithelial HMLER.

202 Keratin K17, the myoepithelial keratin, is expressed in psoriasis but is

203 ration of the existence of a layer of normal myoepithelial KRT14 expressing cells that separate HER2+

204 rate that loss of Numb/Numbl compromised the myoepithelial layer and expanded the luminal layer, led

205 was further associated with retention of the myoepithelial layer reminiscent of ductal carcinoma in s

206 cells, which are normally restricted to the myoepithelial layer, are found within the luminal compar

207 g1 expression is primarily restricted to the myoepithelial layer.

208 ation of lung stem cells along the basal and myoepithelial-like lineages allowing them to invade and

209 61 and HMS-1, an immortalized 'benign' human myoepithelial line which produced an abundant extracellu

210 ates, one restricted to the Krt14+ basal and myoepithelial lineage and the other to the Krt8+ acinar

211 Little is known about the myoepithelial lineage or about growth factor effects on

212 ctor (EGF) causes a massive expansion of the myoepithelial lineage.

213 ts in both a shift in the balance of luminal/myoepithelial lineages and to changes in the functional

214 tablish long-term clones of both luminal and myoepithelial lineages in adult animals, and via lineage

215 genitor cell expansion along the luminal and myoepithelial lineages.

216 gel which included cells of both luminal and myoepithelial lineages.

217 sed of three cell lineages, namely the basal/myoepithelial, luminal epithelial estrogen receptor posi

218 Stem cell markers ESRRB and CK5, myoepithelial marker CK14, and lactocyte marker alpha-la

219 CF10A cells and a variant that expresses the myoepithelial marker p63 stably overexpressing the const

220 However, mucous acinar and myoepithelial markers continued to be expressed in subma

221 This suggests that the stromal and myoepithelial microenvironment of preinvasive breast can

222 (BK5) promoter and is directed to either the myoepithelial or basal cells in a variety of organs, inc

223 have an effect on the cell cycle of primary myoepithelial or luminal cells.

224 hway tumors also have scanty stroma and lack myoepithelial or squamous differentiation.

225 was prominent in the parotid, which was not myoepithelial or vascular smooth muscle.

226 These myoepithelial perturbations in normal breast tissues of

227 orphogenesis relies on the preservation of a myoepithelial phenotype.

228 y epithelial stem cell (MaSC) enriched basal/myoepithelial population and an increase in in vitro ste

229 ng cell (BCIC) population, and a decrease in myoepithelial progenitor cells in the DCIS lesions in vi

230 2 and HER3 signaling pathways and fewer DCIS myoepithelial progenitor cells in vivo.

231 ast in part, originates from region-specific myoepithelial progenitors.

232 the gonad arm by contraction of the proximal myoepithelial sheath and dilation of the distal spermath

233 Myoepithelial sheath cells of the proximal ovary are smo

234 pled via gap junctions to smooth muscle-like myoepithelial sheath cells.

235 Here we report that the myoepithelial sheath has a distinct myosin population co

236 Therefore, although the myoepithelial sheath has smooth muscle-like contractile

237 The myoepithelial sheath in the somatic gonad of the nematod

238 ecting the contractile actin networks in the myoepithelial sheath of the somatic gonad.

239 PL-1 and Ce-CPZ-1 enzymes are present in the myoepithelial sheath surrounding germ cells, oocytes, an

240 tive for function of the nonstriated oviduct myoepithelial sheath, and defective for epidermal morpho

241 were associated with actin filaments in the myoepithelial sheath, and the association of troponin C

242 Two myosin heavy chains are expressed in the myoepithelial sheath, which are also expressed in the bo

243 nately regulate ovulatory contraction of the myoepithelial sheath.

244 Myoepithelial sialadenitis (MESA) is the reactive saliva

245 rated that many lesions formerly regarded as myoepithelial sialadentis or benign lymphoepithelial les

246 and remain unipotent when healing epidermal, myoepithelial-specific, and lumenal-specific injuries.

247 In contrast, both luminal and myoepithelial subpopulations of normal breast tissues ex

248 e markers and contain luminal epithelial and myoepithelial tumor cells that share a secondary mutatio

249 lines (HMS-1-6), derived from diverse benign myoepithelial tumors, all constitutively express high le

250 daptive secretory precursor (LASP) and basal-myoepithelial), two endothelial and adipocyte subtypes,

251 s of epithelial cell states, including basal/myoepithelial, which are diminished in DCIS.

252 xtensive necrosis in comparison to their non-myoepithelial xenograft counterparts.

253 These myoepithelial xenografts exhibit only minimal hypoxia bu