ライフサイエンスコーパス: myofibroblastic

1 ng phenotypes described as proliferative and myofibroblastic.

2 -conditioned medium stimulated HSC to become myofibroblastic.

3 roblast transition (EMT), but did not affect myofibroblastic activation from interstitial fibroblasts

4 Hepatic stellate cells (HSCs) undergo myofibroblastic activation in liver fibrosis and regener

5 homolog 1 (known as Diaph1 or mDia1) for the myofibroblastic activation of HSCs.

6 le actin, fibronection, and CTGF, markers of myofibroblastic activation of HSCs.

7 The mechanisms governing myofibroblastic activation remain poorly understood, and

8 rgo phenotypic trans-differentiation called "myofibroblastic activation" in liver fibrogenesis.

9 ated VIC calcification through inhibition of myofibroblastic activation, osteogenic differentiation,

10 tained for markers of both contractility and myofibroblastic activation.

11 oenvironment alone is insufficient to induce myofibroblastic activation.

12 activated stroma are synonymous with higher myofibroblastic and immunogenic fibroblasts, and further

13 n degradation products and TGF-beta1 promote myofibroblastic and osteogenic differentiation in fibrob

14 sis using deconvoluted CAF subtypes revealed myofibroblastic CAF (myCAF) composition as a poor progno

15 essing proinflammatory and Lrrc15-expressing myofibroblastic CAF phenotypes while enriching for Ly6a/

16 ition to characterizing inflammatory CAF and myofibroblastic CAF subpopulations in detail, the analys

17 by a dense and hypoxic stroma that features myofibroblastic CAFs (myCAF) and inflammatory CAFs (iCAF

18 bladder cancer, including alphaSMA(+)IL-6(-) myofibroblastic CAFs (myCAFs), alphaSMA(-)IL-6(+) inflam

19 pulations into inflammatory CAFs (iCAFs) and myofibroblastic CAFs (myCAFs), respectively.

20 h factor beta (TGF-beta) as a main driver of myofibroblastic CAFs (myCAFs).

21 hermore, the mapCAF signature is enriched in myofibroblastic CAFs from various cancer conditions and

22 nd reveal a potential strategy for targeting myofibroblastic CAFs in vivo.

23 Endo180 (Mrc2) is predominantly expressed on myofibroblastic CAFs, and its genetic deletion depleted

24 Myofibroblastic cancer-associated fibroblast (myoCAF)-ri

25 They revealed that SPP1+ myofibroblastic cancer-associated fibroblasts (myCAF), i

26 ion between mesenchymal-like ccRCC cells and myofibroblastic cancer-associated fibroblasts (myCAF), w

27 as the spatial proximity of TGFB1-expressing myofibroblastic cancer-associated fibroblasts (myCAFs) t

28 the proximity of mesenchymal tumor cells to myofibroblastic cancer-associated fibroblasts and their

29 promotes morphologic transformation toward a myofibroblastic cell phenotype with increased expression

30 including numbers of hepatic progenitors and myofibroblastic cells (both P < 0.03).

31 myoblasts (CT cells) can differentiate into myofibroblastic cells after intramuscular transplantatio

32 tenin signaling occur distinctly in stellate/myofibroblastic cells and hepatoblasts, respectively.

33 ficant increases in both proliferative TDFSM myofibroblastic cells and TDECC cholangiocarcinoma cells

34 It has been recently recognized that myofibroblastic cells are the major contributors to the

35 Notably, our data also show that myofibroblastic cells can differentiate from nephron pro

36 onstrate heterogeneity of gene expression in myofibroblastic cells during active fibrogenesis.

37 -gamma but not in primary rat hepatocytes or myofibroblastic cells exposed to LPS or TNFalpha.

38 Although these myofibroblastic cells had high Yap and Taz accumulation

39 tion of myogenic cells to differentiate into myofibroblastic cells in injured muscle.

40 The myofibroblastic cells in some IMTs contain chromosomal r

41 se myogenic cells were gradually replaced by myofibroblastic cells in the injured muscle.

42 The 3G5 antigen was not present on myofibroblastic cells in the repairing area of a full-th

43 Embryonic stellate/myofibroblastic cells promote beta-catenin activation in

44 (activation) from lipid-storing pericytes to myofibroblastic cells to participate in liver fibrogenes

45 The SMA(+)NG2(+) myofibroblastic cells, F4/80(+) macrophages, and adjacen

46 lKO) and control skin had similar numbers of myofibroblastic cells, suggesting that myofibroblastic d

47 fferences between SSc myofibroblasts and non-myofibroblastic cells.

48 nd promotes accumulation of inflammatory and myofibroblastic cells.

49 sing LIM homeobox 2 (LHX2), which suppresses myofibroblastic changes in HSCs in mice.

50 creased extracellular matrix deposition, and myofibroblastic changes.

51 ar matrix production, and (3) having reduced myofibroblastic conversion in response to cytokine chall

52 The CG treatment also induced myofibroblastic conversion of MCs in the liver.

53 A typically thin mural myofibroblastic cuff was smooth muscle actin positive, w

54 d immunocytochemical changes associated with myofibroblastic dedifferentiation were complete.

55 d incubation in serum-free medium and during myofibroblastic dedifferentiation.

56 erum-free environment and is enhanced during myofibroblastic dedifferentiation.

57 Our results demonstrate myofibroblastic differentiation and a lack of epithelial

58 of circulating fibrocytes that show enhanced myofibroblastic differentiation and that are less respon

59 r necrosis factor-alpha (TNF-alpha) modulate myofibroblastic differentiation and the production of EC

60 RX1 inhibition also impacted TGF-beta driven myofibroblastic differentiation by inhibiting SMAD2/3 ph

61 Portal fibroblast myofibroblastic differentiation can be modeled in cultur

62 ake by lung fibroblasts and their effects on myofibroblastic differentiation have not been establishe

63 I-mediated signaling in pericytes to prevent myofibroblastic differentiation in the tumor microenviro

64 eration, proangiogenic factor secretion, and myofibroblastic differentiation of ASCs.

65 w that epithelial MAPK activity promotes the myofibroblastic differentiation of CAFs by sustaining th

66 moothened was required for TGF-beta1-induced myofibroblastic differentiation of control fibroblasts,

67 Furthermore, SAB suppressed TGF-beta-induced myofibroblastic differentiation of MRC-5 fibroblasts and

68 oblast EVs (fEVs), suppress TGFbeta1-induced myofibroblastic differentiation of normal and idiopathic

69 factor A (MRTF-A) plays an important role in myofibroblastic differentiation of primary human MSC in

70 bers of circulating fibrocytes, with greater myofibroblastic differentiation potential, were observed

71 t suppresses TbetaRII and TGF-beta dependent myofibroblastic differentiation to constrain tumor growt

72 rs of myofibroblastic cells, suggesting that myofibroblastic differentiation was not responsible for

73 ere also dependent on mechanical tension for myofibroblastic differentiation, and cells cultured on p

74 mEV uptake by lung fibroblasts, which blocks myofibroblastic differentiation, and that mEVs are enric

75 (MSC) are a possible source of CAF following myofibroblastic differentiation, and we have previously

76 st, platelet-derived growth factor inhibited myofibroblastic differentiation.

77 ficient to initiate high-grade sarcomas with myofibroblastic differentiation.

78 ed in vitro, and little is known about their myofibroblastic differentiation.

79 ased mEV uptake and prevented suppression of myofibroblastic differentiation.

80 opulations that remained discriminant across myofibroblastic differentiation.

81 yet attenuated SMAD-dependent signalling and myofibroblastic differentiation.

82 effects on normal and IPF fibroblasts during myofibroblastic differentiation.

83 localization of lipid-raft components during myofibroblastic differentiation.

84 or endogenous hyaluronan in the mediation of myofibroblastic differentiation.

85 treated primary bovine keratocytes developed myofibroblastic features, including actin stress fibers

86 We suggest a role for stellate/myofibroblastic FGF10 within the liver stem cell niche i

87 cell phenotype with increased expression of myofibroblastic genes Collagen-1alpha1, Fibronectin, and

88 In cirrhotic livers, cholangiocytes, and myofibroblastic hepatic stellate cells (MF-HSC) produce

89 Hepatic accumulation of myofibroblastic hepatic stellate cells (MF-HSCs) is pivo

90 In mouse cholangiocytes, coculture with myofibroblastic hepatic stellate cells, a source of solu

91 bit epithelial and adipocytic features, into myofibroblastic-HSC (MF-HSCs) is a key event in liver fi

92 After transdifferentiation, the myofibroblastic HSCs are incapable of expressing many MM

93 mbalance between cytokine-producing HSCs and myofibroblastic HSCs during liver disease progression wa

94 rast, type I collagen, enriched in activated myofibroblastic HSCs, promoted proliferation and tumour

95 nt and human liver fibrosis, specifically in myofibroblastic HSCs.

96 Navitoclax induced apoptosis in CAF and in myofibroblastic human hepatic stellate cells but lacked

97 Coculturing CCA cells with myofibroblastic human primary hepatic stellate cells or

98 s well as human primary hepatic stellate and myofibroblastic LX-2 cells, for these studies.

99 ation of pro-metastatic and immunoregulatory myofibroblastic-MAFs (myMAFs) critically depends on macr

100 expressed E-cadherin as well as vimentin, a myofibroblastic marker not usually detected after mesenc

101 ing the expression of the well-characterized myofibroblastic marker S100A4, are functionally relevant

102 gen deposition and ectopic expression of the myofibroblastic markers vimentin and alpha-smooth-muscle

103 p < 0.05), and mitigated gene expression of myofibroblastic markers.

104 culture, the ALCAM(+) cells rapidly acquired myofibroblastic morphology and alpha-SMA expression.

105 thelial marker E-cadherin, transformation of myofibroblastic morphology, and production of interstiti

106 ransforming growth factor beta1 (TGF-beta1), myofibroblastic MSC differentiation is associated with t

107 Stimulation of myofibroblastic Muller cells by IGF-I and -II, but not P

108 rom normal retina and from proliferative and myofibroblastic Muller cells did not detect message for

109 ed in all samples, but was least abundant in myofibroblastic Muller cells.

110 matory and growth factor-enriched (iCAF) and myofibroblastic (myCAF) subpopulations, displaying disti

111 Here, we have uncovered a red-pulp-specific, myofibroblastic niche that supports murine splenic HSCs

112 samples, where a novel combined inflammatory myofibroblastic-osteogenic VIC (IMO-VIC) phenotype was d

113 interleukin 7 (IL-7) and were identified as myofibroblastic pericytes that expressed integrin alpha(

114 into proliferative and fibrogenic activated myofibroblastic phenotype (activated hepatic stellate ce

115 pecific markers and acquire a mesenchymal or myofibroblastic phenotype and express mesenchymal cell p

116 a fundamental role in the acquisition of the myofibroblastic phenotype and liver fibrosis.

117 bstructive intimal lesions, showing mainly a myofibroblastic phenotype and variable endothelial/vascu

118 smooth muscle actin, the most used marker of myofibroblastic phenotype and, more important, involved

119 iable stiffness demonstrated an increasingly myofibroblastic phenotype as stiffness increased.

120 efore, attempts to prevent and/or revert the myofibroblastic phenotype could result in novel therapeu

121 ealing corneal wounds, keratocytes exhibit a myofibroblastic phenotype in response to transforming gr

122 of endogenous fibroblast S100A4 rescues the myofibroblastic phenotype in S100A4 KO fibroblasts.

123 In addition, GANT61 treatment reduced the myofibroblastic phenotype of human MSCs isolated from pa

124 oA pathway was essential for the contractile myofibroblastic phenotype present in early cushion forma

125 te that TMAO activates aortic VICs towards a myofibroblastic phenotype through the induction of endop

126 tor beta(1)-dependent differentiation to the myofibroblastic phenotype was antagonized by the inhibit

127 n I, and fibronectin EDA(+) (markers for the myofibroblastic phenotype) were increased, whereas those

128 n of the organized tubular epithelium to the myofibroblastic phenotype, a process potently driven bot

129 h transdifferentiation of keratocytes to the myofibroblastic phenotype, implicating these cells as th

130 he mutant stromal cells have acquired a more myofibroblastic phenotype, which have been described as

131 a prolonged period of time assume a CAF-like myofibroblastic phenotype.

132 Those with myofibroblastic phenotypes produce more type I collagen

133 tates including quiescent, inflammatory, and myofibroblastic phenotypes; however, the mechanisms by w

134 ls, Hh-pathway activation, EMT, expansion of myofibroblastic populations, and liver fibrosis occurred

135 acute/chronic (SA/C) vasculitis, and luminal myofibroblastic proliferation (LMP).

136 If left untreated, myofibroblastic proliferation can lead to pulmonary vein

137 Evaluation of myofibroblastic proliferation should provide indirect ev

138 g hydroxyproline accumulation and inhibiting myofibroblastic proliferation.

139 nd that TMAO induces the upregulation of the myofibroblastic proteins alpha-smooth muscle actin and t

140 Myofibroblastic RPE (35 days in culture) express cytoker

141 the predominant binding protein produced by myofibroblastic RPE cells.

142 Early reactive and myofibroblastic RPE have detectable levels of message fo

143 on is limited to the area demarcated by this myofibroblastic scaffold and occurs independently of epi

144 ng experiments suggest that the SMA(+)NG2(+) myofibroblastic scaffold originates from choroidal peric

145 with subsequent formation of a SMA(+)NG2(+) myofibroblastic scaffold, into which endothelial cells t

146 nt number of genes, including S100A4, in the myofibroblastic signature; however, DNA copy number vari

147 mechanically quiescent state to an activated myofibroblastic state.

148 Snail1-depleted CAF failed to acquire myofibroblastic traits in response to TGFbeta, including

149 Hepatic stellate cells (HSCs) undergo myofibroblastic trans-differentiation in liver fibrogene

150 , vitamin A-storing liver pericytes, undergo myofibroblastic trans-differentiation or "activation" to

151 Hepatic stellate cells (HSCs) undergo myofibroblastic transdifferentiation (activation) to par

152 vated receptor gamma (PPARgamma) accompanies myofibroblastic transdifferentiation of hepatic stellate

153 antibodies against glycoprotein M6a, undergo myofibroblastic transdifferentiation.

154 st activation, increased ECM deposition, and myofibroblastic transformation of dermal fibroblasts.

155 paB activity selectively in REPs resulted in myofibroblastic transformation, indicating that NFkappaB

156 s pericyte recruitment to tumor vasculature, myofibroblastic transformation, tumor angiogenesis, and

157 pathway-dependent mechanisms that stimulated myofibroblastic transition of HSCs and enhanced MF-HSC v

158 ix persistence in aHSCs, and augmentation of myofibroblastic transition.

159 PM3-ALK in a clinical biopsy of inflammatory myofibroblastic tumor (IMT) carrying the t(1;2)(q21;p23)

160 resistance in a patient with an inflammatory myofibroblastic tumor (IMT) harboring a RANBP2-ALK trans

161 Inflammatory myofibroblastic tumor (IMT) is a distinctive mesenchymal

162 Inflammatory myofibroblastic tumor (IMT) is a rare, but distinctive m

163 Inflammatory myofibroblastic tumor (IMT) is a relatively rare soft ti

164 Inflammatory myofibroblastic tumor (IMT), also known as inflammatory

165 n the nonhematopoietic neoplasm inflammatory myofibroblastic tumor (IMT), and some are present in bot

166 large-cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT).

167 MR) imaging features of hepatic inflammatory myofibroblastic tumor (IMT).

168 ymphoma kinase (ALK)-rearranged inflammatory myofibroblastic tumor, cedarinib for alveolar soft part

169 gastrointestinal stromal tumor, inflammatory myofibroblastic tumor, congenital fibrosarcoma and mesob

170 trointestinal stromal tumor and inflammatory myofibroblastic tumor.

171 gies were osteosarcoma (n = 6), inflammatory myofibroblastic tumors (IMT; n = 6), and pleuropulmonary

172 Inflammatory myofibroblastic tumors (IMTs) are characterized by myofi

173 PURPOSE OF REVIEW: Inflammatory myofibroblastic tumors (IMTs) are indolent mesenchymal n

174 Inflammatory myofibroblastic tumors (IMTs) are neoplastic mesenchymal

175 large cell lymphomas (ALCL) and inflammatory myofibroblastic tumors (IMTs).

176 shown good results in pediatric inflammatory myofibroblastic tumors and anaplastic large cell lymphom

177 id cancers, spitzoid neoplasms, inflammatory myofibroblastic tumors, and acute leukemias.

178 plastic large-cell lymphoma and inflammatory myofibroblastic tumors.

179 tic large cell lymphoma (ALCL), inflammatory myofibroblastic tumour (IMT), neuroblastoma, and rhabdom

180 roblastoma, three of seven with inflammatory myofibroblastic tumour, and one of two with NSCLC).

181 plastic large-cell lymphoma and inflammatory myofibroblastic tumours, and that further investigation

182 anaplastic large-cell lymphoma, inflammatory myofibroblastic tumours, non-small-cell lung cancer (NSC

183 ity lipoprotein (oxLDL), in turn, stimulated myofibroblastic VIC differentiation and secretion of num