ライフサイエンスコーパス: myogenesis

1 required for myoblast fusion (later stage of myogenesis).

2 efore termed Linc-RAM (Linc-RNA Activator of Myogenesis).

3 biologic and pathologic processes, including myogenesis.

4 uction and is essential for adipogenesis and myogenesis.

5 h receptor, which plays an essential role in myogenesis.

6 tellite cell homeostasis during regenerative myogenesis.

7 scle inflammation/injury and improving force/myogenesis.

8 le of Deltex in the epigenetic regulation of myogenesis.

9 genes, which are required for commitment to myogenesis.

10 ile ectopically increasing UPF1 levels slows myogenesis.

11 lls and its expression is upregulated during myogenesis.

12 K causes hyper-activation of p38 MAPK during myogenesis.

13 cific transcription factors that orchestrate myogenesis.

14 g the differentiation and miR-143 inhibiting myogenesis.

15 Mstn expression in C2C12 cells, and promoted myogenesis.

16 adipogenesis, but is indispensable for their myogenesis.

17 nd 3D organization of gene regulation during myogenesis.

18 orm cell-specific genome organization during myogenesis.

19 that is fundamentally important in skeletal myogenesis.

20 3) to (2/3) of a gene's normal repression in myogenesis.

21 yoblasts into multinucleated myotubes during myogenesis.

22 whether TBP2 deficiency can compromise adult myogenesis.

23 cells and their function during regenerative myogenesis.

24 hat direct their normal repositioning during myogenesis.

25 atase orphan 1 (Phospho1) as a new player in myogenesis.

26 fate, whereas higher levels of Pax3 lead to myogenesis.

27 lutionarily conserved role of MUNC lncRNA in myogenesis.

28 pression and mimics the effect of hypoxia on myogenesis.

29 while inhibiting endogenous miR-431 lowered myogenesis.

30 tors as suitable tools to promote functional myogenesis.

31 equire canonical Wnt signaling during tongue myogenesis.

32 ha is dispensable during embryonic and fetal myogenesis.

33 putative roles in myoblast proliferation and myogenesis.

34 of satellite stem cells and for regenerative myogenesis.

35 egative MLX reduce IGF2 expression and block myogenesis.

36 e gene expression during the early stages of myogenesis.

37 lates many developmental programs, including myogenesis.

38 MyoD-expressing subpopulations during tongue myogenesis.

39 eta-catenin signaling regulates each step of myogenesis.

40 tubule organising factor that is crucial for myogenesis.

41 subpopulations exist during embryonic tongue myogenesis.

42 to skeletal muscle contractility complex and myogenesis.

43 gulates several biological events, including myogenesis.

44 tune the requisite degradation of TBP during myogenesis.

45 n assays of chondrogenesis, osteogenesis and myogenesis.

46 promoting the commitment of muscle cells to myogenesis.

47 the M-ERRalpha(-/-) muscles at the onset of myogenesis.

48 nd reiterate their views on Myf5-independent myogenesis.

49 ciated ribonucleases, is required for proper myogenesis.

50 s in Wnt1-Cre; Alk5(fl/fl) mice during early myogenesis.

51 ctive oxygen species production during fetal myogenesis.

52 in BAF/Brg1 subunit composition and delayed myogenesis.

53 al slow precursors, thereby initiating trunk myogenesis.

54 ERK signaling suppressed both head and trunk myogenesis.

55 le of endogenous hyaluronan synthesis during myogenesis.

56 on defect was rescued, resulting in improved myogenesis.

57 ed in downregulation of myogenin and reduced myogenesis.

58 ntifying genes that play active roles during myogenesis.

59 esource for advancing our knowledge of human myogenesis.

60 mportance of methyltransferases in mammalian myogenesis.

61 Cu(+)-enhanced MTF1 expression and promoted myogenesis.

62 r 5 (Myf5)-in paraxial mesoderm and skeletal myogenesis.

63 n from centromeres to the nuclear rim during myogenesis.

64 te Ca(2+) levels that normally occurs during myogenesis.

65 differentiation into adipocytes and arrests myogenesis.

66 nduction of adipogenesis, chondrogenesis, or myogenesis.

67 last dynamics during embryonic and postnatal myogenesis.

68 e first group of muscle fibers formed during myogenesis.

69 otein kinase in satellite cells committed to myogenesis.

70 or cell properties that suppresses postnatal myogenesis.

71 le of Plk1 in developmental and regenerative myogenesis.

72 tes confirmed CPNE1 and STC2 as modifiers of myogenesis.

73 ming the transcriptome through each stage of myogenesis.

74 emental and ambient magnetic fields modulate myogenesis.

75 ng for the transcriptional hierarchy driving myogenesis.

76 without suppressing p38alpha MAPK-dependent myogenesis.

77 paB, a key player in muscle inflammation and myogenesis.

78 ate, that like PABPN1, MATR3 is critical for myogenesis.

79 tocrine concentrations of IL-15 also support myogenesis.

80 the conclusion that an altered regulation of myogenesis and a downregulated mitochondrial biogenesis

81 bias toward adipogenesis at the detriment of myogenesis and an inhibitory activity on angiogenesis.

82 in kinase C beta (PKCbeta) as a repressor of myogenesis and as the enzyme that opposes calcineurin fu

83 that miRNAs regulate key interactions during myogenesis and can act by promoting the switch between q

84 e findings reveal a role for p110beta during myogenesis and demonstrate that long-term reduction of s

85 l activity, which plays a permissive role in myogenesis and depends on phosphatidylinositol 4,5-bisph

86 sion of muscle regulatory factors, embryonic myogenesis and formation of skeletal muscle occurred in

87 ursors to maintain COUP-TFII activity during myogenesis and found that elevated COUP-TFII activity re

88 MYF5 is the earliest to be expressed during myogenesis and functions as a transcription factor in mu

89 , restore mitochondrial function and promote myogenesis and hypertrophy.

90 hierarchy that uniquely regulates esophagus myogenesis and identify distinct genetic signatures that

91 previously unknown function of STIM2beta in myogenesis and improves the understanding of how cells e

92 protein levels are increased during in vitro myogenesis and in conditions that promote skeletal muscl

93 R-206 family is not absolutely essential for myogenesis and is instead a modulator of optimal differe

94 sporadic expression of DUX4, which inhibits myogenesis and is pro-apoptotic.

95 of the splicing transitions observed during myogenesis and is required for the specific step of myob

96 s conserved between human and mouse, delayed myogenesis and lowered the expression of myogenic marker

97 H2Bub levels are oppositely regulated during myogenesis and lung carcinogenesis.

98 in mouse models suggest that IL-15 promotes myogenesis and may protect against the inflammation-medi

99 Da PI3K catalytic subunit beta (p110beta) in myogenesis and metabolism.

100 was previously shown to accentuate in vitro myogenesis and mitochondriogenesis by activating a calci

101 ese findings support a role for nesprin-1 in myogenesis and muscle disease, and uncover a novel mecha

102 ulatory role of the VDR in the regulation of myogenesis and muscle mass, whereby it acts to maintain

103 ucose is a signaling molecule that regulates myogenesis and muscle regeneration via MLX/IGF2/Akt sign

104 uscle wasting in CKD, including proteolysis, myogenesis and muscle regeneration, and expression of pr

105 FGFR4 is involved in myogenesis and muscle regeneration.

106 essed on myocytes during embryonic and fetal myogenesis and on nascent myofibers during muscle regene

107 NF-kappaB and canonical Wnt signaling during myogenesis and promotes skeletal muscle growth and overl

108 ytes, where AUF1 levels rise at the onset of myogenesis and remain elevated throughout myocyte differ

109 re that Mettl21c expression is absent during myogenesis and restricted to mature type I (slow) myofib

110 g of MEF2C plays an important role in normal myogenesis and RMS development.

111 satellite cell niche and capacity for robust myogenesis and self-regeneration in vitro.

112 tor II (COUP-TFII) has been shown to inhibit myogenesis and skeletal muscle metabolism in vitro.

113 e developmental trajectory of human skeletal myogenesis and the transition between progenitor and ste

114 is rapidly down-regulated upon induction of myogenesis and this is not due to changes in Cebpb mRNA

115 eveal their dynamic expression during embryo myogenesis and uncover the concerted negative regulation

116 A sequencing from various time points during myogenesis and uncovered many chimeric fusion RNAs.

117 r BET proteins in the regulation of skeletal myogenesis, and assign distinct functions to BRD3 and BR

118 dependent effects of Notch activation during myogenesis, and demonstrate that Notch1 activity improve

119 OIP5-AS1 levels increased robustly early in myogenesis, and its loss attenuated myogenic differentia

120 ive variants BAF60a and BAF60b during embryo myogenesis, and reveals that interactions between tissue

121 chanical cues are known to enhance stem cell myogenesis, and the paper focuses on the stem cell diffe

122 37% of all genes changing expression during myogenesis, and their combined knockdown almost complete

123 a characterize a regulatory role for UPF1 in myogenesis, and they demonstrate that UPF1 provides a me

124 s a platform to identify novel regulators of myogenesis, and uncovered surprising developmental funct

125 oD has been implicated as a key regulator of myogenesis, and yet there is little information regardin

126 ity to restore the contractile apparatus and myogenesis are important, and must be taken into conside

127 ations are established and maintained during myogenesis are not completely understood.

128 Different stages of myogenesis are orchestrated and regulated by myogenic re

129 has shown that the fundamental mechanisms of myogenesis are remarkably similar in vertebrates and inv

130 regions of genes expressed at late times of myogenesis, are in close physical proximity in different

131 Transcriptomic analysis revealed that myogenesis-associated genes were up-regulated in LSD2-KD

132 To investigate SPL's role in myogenesis at the cellular level, we generated and chara

133 endent RhoA-signalling, negatively regulates myogenesis at the level of Myogenin expression.

134 first model of miRNA:target interactions in myogenesis based on experimental evidence of individual

135 In addition, the myogenesis biomarker was a robust binary discriminator o

136 The myogenesis biomarker was also elevated in muscle biopsie

137 This myogenesis biomarker was elevated in FSHD and control he

138 GDF8 is a potent negative regulator of myogenesis both in vivo and in vitro.

139 We conclude that ALK4 inhibition increases myogenesis but also regulates the tight balance of prote

140 embryonic depletion of LAP1 does not impair myogenesis but that it is necessary for postnatal skelet

141 The function of Akt/PKB is critical for myogenesis, but less is clear as to the regulation of it

142 nd Ca(2+) channels have been shown to affect myogenesis, but little is known about roles of Cl(-) cha

143 Autophagy plays an important role in myogenesis, but the asynchronous and unique trajectory o

144 n fatty acids, and HACD1 has a role in early myogenesis, but the functions of this striated muscle-sp

145 tion of PUR proteins with circSamd4 enhances myogenesis by contributing to the derepression of MHC tr

146 hlight a mechanism whereby a lncRNA promotes myogenesis by enhancing the interaction of an RBP and a

147 The inhibition of myogenesis by H19 depletion during myoblast differentiat

148 tory cytokine, TNF-alpha, regulates skeletal myogenesis by inhibiting the interaction of SP1 with the

149 a critical upstream regulator of fast fiber myogenesis by modulating fgf8 signaling during zebrafish

150 This suggests that 4.1R may influence myogenesis by preventing VHL-mediated myogenin degradati

151 lizing activity, promotes the early steps of myogenesis by reducing the expression of the cell cycle

152 can control diverse biological processes of myogenesis by regulating step-specific molecules.

153 last differentiation and plays a key role in myogenesis by regulating the cytosolic activation of ERK

154 HuR promotes myogenesis by stabilizing the MyoD, myogenin and p21 mRN

155 magnetic fields (PEMFs) accentuated in vitro myogenesis by stimulating transient receptor potential (

156 Intriguingly, Deltex2 inhibits myogenesis by suppressing MyoD transcription, and the De

157 vide evidence that Mdm2 regulates entry into myogenesis by targeting C/EBPbeta for degradation by the

158 expression, suggesting that Ripply1 promotes myogenesis by terminating Tbx6-dependent inhibition of m

159 Robust myogenesis can be achieved in vitro within 1 month by pe

160 We show that primary and secondary skeletal myogenesis can be recapitulated in vitro from the PSM-li

161 ion and senescence of MPCs, and restored the myogenesis capacity while reducing inflammation and fibr

162 Finally, in vitro VDR-knockdown impaired myogenesis (cell cycling, differentiation and myotube fo

163 ocyte growth factor, known to be involved in myogenesis, cell migration, and immunoregulation.

164 tion but disappear as cells progress through myogenesis, concomitant with the destruction of proteins

165 er expression of genes in energy metabolism, myogenesis, contractile properties and oxidative stress

166 or the first time that dyW-/- mice exhibit a myogenesis defect already in utero.

167 nt with a non-phosphorylatable mutant allows myogenesis despite inhibition of calcineurin signalling,

168 e points during which human healthy and FSHD myogenesis differ.

169 During myogenesis, downregulation of PTB and miR-221 robustly i

170 tial for adipogenesis and less potential for myogenesis, driven by differences in beta-catenin, a reg

171 e family participate in cardiac and skeletal myogenesis during development in zebrafish, Drosophila a

172 signalling is essential for skeletal muscle myogenesis during development, but its role in adult hum

173 T signaling plays multiple roles in skeletal myogenesis during gestation and postnatal stages.

174 iR-1, a microRNA specifically induced during myogenesis, efficiently enters the mitochondria where it

175 by actin overexpression, was beneficial for myogenesis, expression of sarcomeric proteins and proper

176 (2015) identified key regulators of skeletal myogenesis from mouse and human pluripotent stem cells.

177 Upon initiation of myogenesis from primary myoblasts, both MTF1 expression

178 provide a comprehensive overview of skeletal myogenesis from the earliest premyogenic progenitor stag

179 Transition steps in myogenesis, from stem cell proliferation to differentiat

180 ression of brown adipogenesis genes, whereas myogenesis genes were not affected.

181 ; however, the role of beta-catenin in adult myogenesis has been contentious, and its mechanism(s) un

182 Although myogenesis has been studied in mouse and chicken embryos

183 dorsal mesoderm formation, but their role in myogenesis has been unclear.

184 While many of the molecular details of myogenesis have been investigated extensively, the funct

185 , the expression and function of 4.1R during myogenesis have not been characterized.

186 otemporal expression and play vital roles in myogenesis; however, it is still largely unknown how WNT

187 BAF60c is essential for myogenesis; however, the mechanisms regulating the subun

188 ellite cells, but its function in late-stage myogenesis, i.e. post-differentiation myocytes and post-

189 3 in the cross-talk between angiogenesis and myogenesis in adults.

190 We found that compound 53 improves delayed myogenesis in CDM1 myoblasts, while compounds 1 and 53 h

191 tudies indicate that Smyhc1 is essential for myogenesis in embryonic slow muscles, and loss of Smyhc1

192 molecular mechanisms driving such disrupted myogenesis in FSHD are poorly understood.

193 changes in high resolution that occur during myogenesis in FSHD ex vivo, identifying suppression of t

194 As a result, both inhibitors rescued myogenesis in myoblasts treated with GDF8.

195 key regulator of stem cell self-renewal and myogenesis in normal skeletal muscle; however, little is

196 We propose that MYF5 enhances early myogenesis in part by coordinately elevating Ccnd1 trans

197 cting Hdac3 to the nuclear periphery rescues myogenesis in progenitors otherwise lacking Hdac3.

198 l-sensing transcription factor MTF1 promotes myogenesis in response to copper.

199 h the Myf5 and MyoD genes drives the de novo myogenesis in satellite cells even in aged muscle.

200 crest cells that trigger NOTCH signaling and myogenesis in selected epithelial somite progenitor cell

201 echanisms activate Ci-Mrf Here, we show that myogenesis in the atrial siphon muscles (ASMs) and oral

202 osteoblast differentiation RUNX2 to promote myogenesis in the C2C12 model system.

203 regulatory network (GRN) model that promotes myogenesis in the sea urchin embryo, an early branching

204 Myogenesis in the tail of the simple chordate Ciona exhi

205 rovide a roadmap for recapitulating skeletal myogenesis in vitro from pluripotent stem cells (PSCs).

206 ility (hypoxia) impedes progenitor-dependent myogenesis in vitro through multiple mechanisms, includi

207 rentiation of skeletal myoblasts and promote myogenesis in vitro.

208 t evidence that HIF1alpha regulates skeletal myogenesis in vivo and establish a novel link between HI

209 owever, whether HIF1alpha regulates skeletal myogenesis in vivo is not known.

210 uggesting a detrimental role for elastase on myogenesis in vivo.

211 spatial and temporal regulation to skeletal myogenesis in zebrafish.

212 dramatic morphological transformation during myogenesis, in which the myotubes elongate over several

213 Myogenesis includes sequential stages of progenitor cell

214 nin signaling can regulate multiple steps of myogenesis, including cell proliferation, myoblast fusio

215 s as a transcriptional co-factor to activate myogenesis, independently of WNT ligand.

216 s 50-5000-fold higher than Pck1 during C2C12 myogenesis, indicating Pck2 is the predominant PEPCK iso

217 d in high C/EBPbeta levels and a blockade of myogenesis, indicating that Mdm2 is necessary for myogen

218 Upregulation of Huwe1 expression during myogenesis induces TBP degradation and myotube different

219 Skeletal myogenesis involves sequential activation, proliferation

220 Myogenesis involves the stable commitment of progenitor

221 Myogenesis is a tightly regulated differentiation proces

222 Myogenesis is an evolutionarily conserved process.

223 Here we report that activation of embryonic myogenesis is associated with establishment of long-rang

224 tochondrial biogenesis normally accompanying myogenesis is associated with nuclear translocation of n

225 we show that TrxR1 decrease occurring during myogenesis is functionally involved in the coordination

226 Myogenesis is recapitulated in the tissue culture of myo

227 Skeletal myogenesis is regulated by signal transduction, but the

228 tems, a general mechanistic understanding of myogenesis is still lacking.

229 he fundamental Ca(2+) signaling mechanism in myogenesis, is mediated by stromal interaction molecule

230 In contrast, neurons appeared 2 days after myogenesis, just before the hatching of fully formed cyd

231 hat ZBED6 affects mitochondrial activity and myogenesis largely through its regulation of IGF2 expres

232 Deletion of Myh3 during embryonic myogenesis leads to the depletion of the myogenic progen

233 c level, we used the 200 human gene Hallmark Myogenesis list.

234 dramatically reduced levels of PAX7 and late myogenesis markers.

235 During myogenesis, muscle genes are activated, lose MLL3 occupa

236 variation in meat tenderness participate in myogenesis, neurogenesis, lipid and fatty acid metabolis

237 MLX promotes myogenesis not via an adjustment of glucose metabolism b

238 BMPs can induce osteogenesis and inhibit myogenesis of mesenchymal stem cells.

239 strate a central role of Ptpn11 in postnatal myogenesis of mice.

240 nisolone treatment was unable to improve the myogenesis of stem cells and reduce fibrosis in dKO musc

241 osin therefore dictates fundamental steps of myogenesis prior to regulating contraction in the sarcom

242 We find that myotomal and primary myogenesis proceed normally in homozygous dyW-/- embryos

243 TOR functions during different stages of the myogenesis program driven by two different substrates.

244 propose that MEF2C is a key effector of the myogenesis program promoted by AUF1.

245 exit from self-renewal, and induction of the myogenesis program.

246 -ratio (1:1 and 10:1) yeast and mouse embryo myogenesis proteomes.

247 myoblasts of ambient magnetic fields slowed myogenesis, reduced TRPC1 expression, and silenced NFAT-

248 ent miRNAs with important roles in adulthood myogenesis (regeneration) and myofibre hypertrophy and a

249 and polytropic retrovirus receptor 1 (XPR1), myogenesis regulating glycosidase (MYORG), platelet-deri

250 d, cultured, and evaluated for expression of myogenesis regulator PAX7.

251 educes myoblasts growth by inducing an early myogenesis -related gene expression pattern which includ

252 oles of LncRNAs in stem cell maintenance and myogenesis remain largely unexamined.

253 pathways underlying its positive effects on myogenesis remain unclear.

254 hanism and detailed function of STIM2beta in myogenesis remain unclear.

255 on during development, but its role in adult myogenesis remains unclear.

256 of circRNAs differentially expressed during myogenesis revealed that circSamd4 expression increased

257 logical analysis describing FSHD and control myogenesis, revealing altered myogenic differentiation r

258 nalysis of alternative splicing during human myogenesis reveals that CDM-relevant exons undergo prena

259 In this process, termed myogenesis, satellite cells get activated, proliferate,

260 abundance partially rescued the decrease in myogenesis seen after MYF5 silencing.

261 n levels partially rescued the impairment of myogenesis seen after reducing AUF1 levels.

262 molecular pathways that orchestrate skeletal myogenesis should enhance our understanding of, and abil

263 increase in the myoblast pool, whereas fetal myogenesis-specific deletion of Myh3 causes the depletio

264 hagy flux (i.e., autophagy rate) at separate myogenesis stages.

265 Unlike the well-studied events of myogenesis, such as myoblast specification and myoblast

266 ciated with PURA and PURB, two repressors of myogenesis that inhibit transcription of the myosin heav

267 We discuss the upstream regulators of myogenesis that lead to the activation of myogenic deter

268 regulation of skeletal muscle structure and myogenesis that may contribute to unexplained disorders

269 PAX7 is a master regulator of myogenesis that rescues DUX4-mediated apoptosis.

270 precursor is the nascent myotube, and during myogenesis the myotube completes guided elongation to re

271 scribe a key function for lncRNA OIP5-AS1 in myogenesis, the process whereby myoblasts differentiate

272 f tissue degradation and subsequent enhanced myogenesis, thereby accelerating muscle repair and funct

273 Beyond the study of myogenesis, this differentiation method offers an attrac

274 Given the conserved features of IFM myogenesis, this sequence of cell interactions and membr

275 ors further suggest that HIF1alpha represses myogenesis through inhibition of canonical Wnt signaling

276 Subsequently, muscle-CB1R ablation increased myogenesis through its action on MAPK-mediated myogenic

277 gase subunit FBXL2 is essential for skeletal myogenesis through its important effects on cell cycle p

278 keletal muscle at steady state that supports myogenesis through suppression of metabolic endotoxemia

279 strate that Kbtbd5 regulates skeletal muscle myogenesis through the regulation of E2F1-DP1 activity.

280 0, an ARMS cell line, is most similar to the myogenesis time point when PAX3-FOXO1 is expressed.

281 sults intimately associate the initiation of myogenesis to a change in cell adhesion and may reveal a

282 rogenitor cells, but is required during late myogenesis to directly control the expression of a set o

283 They can either undergo myogenesis to promote muscle regeneration or differentia

284 The process of stem cell myogenesis (transformation into skeletal muscle cells) i

285 we investigated the function of STIM2beta in myogenesis using the C2C12 cell line with RNA interferen

286 unced dysregulation of molecules involved in myogenesis, vascularization, hypertension, hypertrophy (

287 ent and supplemental magnetic fields promote myogenesis via a TRPC1-mitochondrial axis: evidence of a

288 ers, suggesting the involvement of miR-23 in myogenesis via TrxR1 repression.

289 n for genes required for myoblast fusion and myogenesis, we discovered an 84-amino acid muscle-specif

290 positive committed myoblasts (early stage of myogenesis), whereas mTORC1-S6K signaling is required fo

291 mimetic mutant in primary myoblasts inhibits myogenesis, whereas replacement with a non-phosphorylata

292 ling is less effective at initiating adaxial myogenesis, which is instead initiated by Hedgehog signa

293 ng promotes proliferation of FAPs to support myogenesis while inhibiting their differentiation into a

294 Suppressing UPF1 accelerates myogenesis, while ectopically increasing UPF1 levels slo

295 Moreover, MYF5 silencing reduced myogenesis, while ectopically restoring CCND1 abundance

296 Importantly, lowering AUF1 delayed myogenesis, while ectopically restoring MEF2C expression

297 A, increases NPM protein levels and inhibits myogenesis, while its overexpression elicits the opposit

298 ription factor that is a master regulator of myogenesis, while leaving MYOD mRNA stability unaffected

299 c injury, implying that it coordinates adult myogenesis with nutrient availability in vivo.

300 Numerous muscle lineages are formed during myogenesis within both slow- and fast-specific cell grou