ライフサイエンスコーパス: myometrium

1 reduced in both rat and mouse late pregnant myometrium.

2 rs of key biological functions in the normal myometrium.

3 try and excitability with development of the myometrium.

4 sensitization was not apparent in adult rat myometrium.

5 els of expression in brown fat, neurons, and myometrium.

6 pro-inflammatory responses in human pregnant myometrium.

7 ion factor binding when compared with normal myometrium.

8 evidence of disturbed differentiation of the myometrium.

9 primarily by defects in the formation of the myometrium.

10 pattern of each fibroleiomyoma and adjacent myometrium.

11 id was undetectable in either leiomyomata or myometrium.

12 ion proximal to the internal os and into the myometrium.

13 e to enhance the contractile response of the myometrium.

14 lieu that impacts both normal and neoplastic myometrium.

15 ernal os and extension of the tumor into the myometrium.

16 p to the internal os but did not involve the myometrium.

17 ooth muscle quiescence in the pregnant human myometrium.

18 endothelium as far as the first third of the myometrium.

19 and preceded substantial enhancement of the myometrium.

20 s no staining in the myocytes of nonpregnant myometrium.

21 expressed in smooth muscle cells of pregnant myometrium.

22 enta could be readily distinguished from the myometrium.

23 of cells from rat circular and longitudinal myometrium.

24 major component of GJs) and GJ formation in myometrium.

25 the uterine mucosa into the underlying inner myometrium.

26 le and microvascular endothelium of pregnant myometrium.

27 double positive marks were identified in the myometrium.

28 stroma, vascularized mucosa and two-layered myometrium.

29 on involving the placenta in addition to the myometrium.

30 iated protein (CAP)/contractile genes in the myometrium.

31 sel coverage was only 12% that of the normal myometrium.

32 essure of 4mmHg compared to -1mmHg in normal myometrium.

33 , no studies of the effect of lactate on the myometrium.

34 licited dose-dependent contractions on human myometrium.

35 hanism to explain the ability of NO to relax myometrium.

36 losed by the two smooth muscle layers of the myometrium.

37 modulating contractile activity in the human myometrium.

38 , which are linked with more mature SMCs and myometrium.

39 n non-pregnant to 54 +/- 7% in late pregnant myometrium.

40 aving the same properties as in non-pregnant myometrium.

41 n 5-HT-induced contractions in late pregnant myometrium.

42 re similar in non-pregnant and late pregnant myometrium (0.11 +/- 0.03 microM and 0.17 +/- 0.02 micro

43 In myometrium, 5-HT2 receptors not only play a role in cont

44 s in biomechanical properties of the scarred myometrium after CD.

45 r, and no fetal macrophages are found in the myometrium after labor.

46 monstrated a functional ARF6 system in human myometrium and a correlation between ARF6 level and acti

47 o significant stimulatory effect on both the myometrium and amnion.

48 the maxi-K channel are present in the mouse myometrium and are regulated differentially during gesta

49 CTBs track along scars deep into the myometrium and beyond.

50 gen and progesterone-dependent tumors of the myometrium and cause irregular uterine bleeding, severe

51 Serum progesterone profiles, myometrium and cervix function, and mitochondrial electr

52 soforms have been examined in human pregnant myometrium and cultured human myometrial smooth muscle c

53 kine expression in the placenta, and uterine myometrium and decidua, was also attenuated.

54 identifying the effects of ER ligands in the myometrium and elucidating their mechanism of action.

55 ZEB1 protein is up-regulated in the myometrium and endometrial stroma after progesterone or

56 shly derived strains of fibroblasts from the myometrium and endometrium also demonstrated heterogeneo

57 In situ staining of human myometrium and endometrium showed heterogeneous staining

58 We cloned Kv4.3 channel from myometrium and found that its protein and transcript exp

59 Piezo1 is present in the myometrium and is dysregulated in women who experience p

60 We begin with the myometrium and its myocytes and describe how excitation

61 , CD73) was assessed in matched specimens of myometrium and leiomyoma by real-time qPCR, Western blot

62 ACi exert anti-inflammatory effects in human myometrium and may thus be useful in achieving a myometr

63 eam contractile and inflammatory pathways in myometrium and neonatal pup brain.

64 Fibroblast subsets were used from human myometrium and orbit to test this hypothesis.

65 ractile or lipid-like phenotype in the human myometrium and orbit.

66 on cell signalling and contractility in rat myometrium and other smooth muscles.

67 assium channel Kir7.1, which is expressed in myometrium and placental pericytes during late gestation

68 interaction between REST and PGR in healthy myometrium and present a putative mechanism for the dysr

69 ark contrast between fluorescence within the myometrium and relatively little within the fibroid tiss

70 man uterus, ZEB1 protein is increased in the myometrium and stroma during the secretory stage of the

71 ecular biological experiments on the uterine myometrium and telemetry-supported assessment of changes

72 * and LRP1 modulate the BKCachannel in human myometrium and that BKCaand its immunomodulatory interac

73 a to enhance the local metabolism of P(4) in myometrium and, thus, decrease PR function during the pr

74 y, branching to form varicose endings in the myometrium and/or vascular plexus.

75 tion of eosinophils, edema in the stroma and myometrium, and a decrease in the height of luminal epit

76 .5 revealed fibers within the vascular zone, myometrium, and endometrium, with greater density in the

77 e cells (SMC) of the vascular wall, bladder, myometrium, and gastrointestinal and respiratory tracts

78 and ability to evaluate the junctional zone, myometrium, and musculoskeletal structures for both sagi

79 soform PGR-B promotes a relaxed state of the myometrium, and PGR-A facilitates uterine contraction.

80 We conclude that increased CGRP-Rs in myometrium, and resulting enhanced myometrial sensitivit

81 bserved ZEB1 promoter activity in the virgin myometrium, and stroma and myometrium of the pregnant ut

82 sis showed that CGRP-Rs are present in human myometrium, and that the expression of these receptors i

83 nscriptionally represses GPR10 in the normal myometrium, and that the loss of REST in fibroids permit

84 lays little role in SR Ca2+ release from the myometrium, and that there are gestational-dependent alt

85 eased AMPK phosphorylation in pregnant mouse myometrium, and the direct AMPK activator A769662 also r

86 EK-1 is more highly expressed than TREK-2 in myometrium, and there was no detectable expression of TR

87 in the decidua; Il6, Il12b, and Il10 in the myometrium; and Il1b and Il6 in the placenta.

88 Voltage-gated K+ currents in human myometrium are not well characterized, and were therefor

89 ons of the smooth muscle of the uterus - the myometrium - are crucial to a successful pregnancy outco

90 regions of interest in the lesion and in the myometrium (as a reference).

91 regions of interest in the lesion and in the myometrium (as a reference).

92 ppaB activation normally occurs in the mouse myometrium at gestation day E18, prior to labor, whereas

93 ession of nitric oxide synthase within human myometrium at midgestation, a time when the uterus is no

94 urrents at the resting membrane potential of myometrium at term.

95 tudy gene regulatory mechanisms in the human myometrium at the term pregnancy stage for further advan

96 Both need to be defined in pregnant human myometrium before the therapeutic potential of cAMP-elev

97 cant differences in stiffness of the scarred myometrium between the two phenotypes.

98 al and structural changes in the decidua and myometrium but had no effect on their micro-mechanical p

99 a mRNA levels were lower in leiomyomata than myometrium, but only during the luteal phase of the cycl

100 estrogen remodels the expression of Kv4.3 in myometrium by directly diminishing its transcription and

101 main population cells isolated from adjacent myometrium carried a mediator complex subunit 12 mutatio

102 a hormonal imprint on the developing uterine myometrium, causing an increase in expression of estroge

103 Silencing of AP-1 subunits in primary myometrium cells leads to transcriptional dysregulation

104 Accuracy levels in detecting invasion of the myometrium, cervical stroma, parametria and/or adnexae,

105 channels play a critical role in regulating myometrium contractility.

106 roximately 1% of all leiomyoma and 2% of all myometrium-derived cells.

107 ntly, mice overexpressing human GPR10 in the myometrium develop myometrial hyperplasia with excessive

108 Macrophage density in mice myometrium did not change with advancing gestational age

109 cantly decreased in pregnant mouse and human myometrium during labor.

110 CREM gene to be "switched" within the human myometrium during pregnancy from the production of CREMt

111 splicing factor is tightly regulated in the myometrium during pregnancy.

112 sion of several IGFBPs also occur within the myometrium during pregnancy.

113 ary, in the decidual vasculature, and in the myometrium during pregnancy.

114 Myometrium enhanced briskly (ME(90) of 110%), with a red

115 ient-matched MED12 mutation-negative UFs and myometrium, exhibited defects in replication fork dynami

116 compared to MED12 mutation-negative UFs and myometrium, exhibited significantly higher levels of R-l

117 that nonpregnant or pregnant human and mouse myometrium express AdipoR1 and AdipoR2 mRNAs.

118 ve constructed a cellular atlas of the aging myometrium from 186,120 cells across twenty perimenopaus

119 38 uterine leiomyomas and the corresponding myometrium from 30 women.

120 nexin-43 mRNA expression were reduced in the myometrium from 8-month-old vs. 3-month-old mice (P < 0.

121 tional profiling of leiomyoma and unaffected myometrium from humans and Eker rats, the best character

122 any effect on the inherent contractility in myometrium from late pregnant (19 days gestation) animal

123 sion and activity of 20alpha-HSD in laboring myometrium from mouse and human.

124 dent relaxation in spontaneously contracting myometrium from pregnant women.

125 as they progressed to labor and in laboring myometrium from pregnant women.

126 of proinflammatory cytokines from samples of myometrium from pregnant women.

127 tion events were differentially expressed in myometrium from women with failed IOL compared with myom

128 ium from women with failed IOL compared with myometrium from women with previous vaginal birth.

129 -6 expression, barely detectable in the d7.0 myometrium, gradually increases until it is very strongl

130 to lowest LNPEP U/mg protein by tissue were: myometrium > follicle wall > endometrium > kidney > CL >

131 changes in CGRP receptors (CGRP-Rs) in human myometrium have not been described.

132 Ovarian stroma enhanced less than myometrium in 30 of 43 cases.

133 n of Piezo1 by the agonist Yoda1 relaxes the myometrium in a dose-dependent fashion, indicating that

134 o CGRP, may play a role in maintaining human myometrium in a quiescent state during pregnancy, and th

135 bal comparison of mRNA from leiomyoma versus myometrium in human and rat identified a highly signific

136 esponses at the maternal-fetal interface and myometrium in the absence of an increased influx of neut

137 Finally, we discuss the myometrium in the periconceptional space and review its

138 analyses of calcium dynamics in contracting myometrium in unprecedented spatiotemporal detail.

139 y have antiestrogenic effects in the uterine myometrium, in contrast to apparently estrogenic effects

140 lity of the uterine smooth muscle layer, the myometrium, increase drastically.

141 induced contractility.Tonic stretch of human myometrium increases contractility and stimulates the ex

142 the expression of ARF6 and its GEF in human myometrium indicate a potential involvement of this sign

143 ial glands were observed embedded in uterine myometrium, indicating adenomyosis-like phenotypes.

144 at autocrine prostaglandin signalling in the myometrium, initiated by elevated intrauterine cytokine

145 ) invasion of decidua and inner third of the myometrium is critical for a successful pregnancy.

146 tion of cathelicidin expressing cells in the myometrium is higher in samples obtained from women in l

147 ry, iNOS expression in the myocytes of human myometrium is increased greatly during pregnancy, and de

148 During normal gestation, the myometrium is maintained in a quiescent state by progest

149 The uterine myometrium is the tissue of origin of an extremely commo

150 e, volumes, and differentiation into layers (myometrium, junctional zone, and endometrium) of uterine

151 then review each of the ion channels in the myometrium: L- and T-type Ca(2+) channels, K(ATP) (Kir6)

152 Compared with normal human myometrium, leiomyomata had 3- to 5-fold higher levels o

153 pressed in malignant tumors derived from the myometrium (leiomyosarcomas), (b) is overexpressed in tu

154 ophysiological origins of human labor at the myometrium level.

155 high intensity vessel-like structures in the myometrium, low-intensity vessel structures within the p

156 ry epithelial cells, uterine endometrium and myometrium, mammary ductal epithelial cells, and the gas

157 ors containing histone acetylase activity in myometrium may contribute to the onset of labor by impai

158 In intact rat myometrium, MCD treatment increased Ca(2+) signalling an

159 that mediate the effect of stretch on human myometrium.Myometrial explants, prepared from biopsies o

160 Interestingly, myometrium not only clustered away from the tumors, but

161 iously had a vaginal birth and compared with myometrium obtained at the time of emergency caesarean f

162 d global phosphoproteomics analysis of human myometrium obtained at the time of term elective caesare

163 levels (using immunoblotting) in samples of myometrium obtained from non-pregnant women, and women w

164 This relaxation effect is diminished in myometrium obtained from patients during labor and in th

165 uterine cells from both the endometrium and myometrium of five healthy premenopausal individuals, an

166 and total protein are greatly diminished in myometrium of late pregnant rats versus nonpregnant anim

167 STAT5b expression coordinately decreased in myometrium of mice as they progressed to labor and in la

168 Expression of iNOS was highest in myometrium of preterm not-in-labor patients.

169 agonist effects, respectively, in the intact myometrium of sexually mature rats.

170 ity in the virgin myometrium, and stroma and myometrium of the pregnant uterus.

171 mbryogenesis, and is also upregulated in the myometrium of the uterus during pregnancy.

172 involved in PR gene activation in stroma and myometrium of the uterus in response to estrogen and pro

173 ndometrial glands and stroma deep within the myometrium of the uterus.

174 cs were assessed in comparison with those of myometrium on T1-weighted and gadolinium-enhanced images

175 ntified whose expression can distinguish the myometrium origin.

176 PrP-C than did intercaruncular endometrium, myometrium, oviduct, ovary, fetal bladder, or fetal kidn

177 ammatory cytokines IL-6 and IL-8 in cultured myometrium (P<0.05), compared to vehicle-treated control

178 performed for LNPEP and OXT on endometrium, myometrium, pituitary and corpus luteum (CL).

179 The myometrium plays a critical role during pregnancy as it

180 etrial cells produces profound relaxation of myometrium precontracted by a broad spectrum of contract

181 Bitter tastants can completely relax myometrium precontracted by different uterotonics.

182 ant implications regarding activation of the myometrium prior to the onset of labor.

183 urce of IL-18 production was found to be the myometrium rather than macrophages.

184 al and functional properties with native rat myometrium receptors, certain native P2Z purinoceptors a

185 nd biochemical studies provide evidence that myometrium remodelling during pregnancy is in part assoc

186 During each ovulatory cycle, the myometrium responds to the ovarian steroids, estradiol,

187 oM nickel to spontaneously contracting human myometrium reversibly slows contraction frequency.

188 identify proteins that interact with BKCain myometrium samples from term pregnant (>/=37 wk gestatio

189 presentative sections of fibroids and normal myometrium showed a smaller number of vessels with decre

190 sion of ERG1-3 (KCNH1-3) genes in the murine myometrium (smooth muscle layer of the uterus) and deter

191 presence of functional CRH receptors in the myometrium suggests that CRH may modulate myometrial con

192 (T1, 1,597 msec +/- 42; T2, 74 msec +/- 9), myometrium (T1, 1,514 msec +/- 156; T2, 79 msec +/- 10),

193 is study was to identify cell types in human myometrium that contain inducible nitric oxide synthase

194 alpha subunit splice variant (SV1) from rat myometrium that is also present in brain.

195 r fibroids, are benign tumors of the uterine myometrium that significantly affect up to 30% of reprod

196 In isometric tension studies of non-pregnant myometrium, the ERG channel blockers dofetilide (1 micro

197 From our analyses we suggest that in human myometrium there is no fixed pacemaking site, but rather

198 ating differentiation and development of the myometrium, these data suggest that adenomyosis may be c

199 n extracts from uterine leiomyoma and normal myometrium tissues.

200 osure or dilation and even broke through the myometrium to develop extrusion outside the uterine horn

201 h gene expression data from term and preterm myometrium to identify subnetworks of PTB-SNP associated

202 hen compared to matched specimens of healthy myometrium, uterine leiomyomas were characterized by red

203 Solid tissue enhancement relative to outer myometrium was assessed visually and with TIC.

204 The myometrium was cut into strips and placed in an organ ba

205 s greater in the cervical lesion than in the myometrium was defined as time-signal intensity curve ty

206 acentas and spiral arteries from nonpregnant myometrium were cultured with angiogenic growth factors

207 The T2* values in the myometrium were however not correlated to gestational ag

208 (defined as earlier enhancement than in the myometrium) were highly specific for malignancy for both

209 This contrasts with rat myometrium, where there is a reduction of channel transc

210 human maternal-fetal interface including the myometrium, which enables us to resolve the full traject

211 re grossly deficient in smooth muscle of the myometrium, which has been replaced by adipose, a phenot

212 cular layer of the uterine wall known as the myometrium, which is composed mainly of smooth muscle ce

213 erstanding these mechanistic distinctions in myometrium will reveal molecular targets that are unique

214 rise from smooth muscle cells of the uterine myometrium with an incidence rate as high as 70% in wome

215 ence of endometrial glands and stroma in the myometrium with EMT and ultimate fibrosis.

216 Incubation of myometrium with GRP receptor antagonists attenuates the

217 ignalling and contractility occurring in the myometrium with MCD.

218 dipoR2 protein expression in human and mouse myometrium, with increased abundance in late mouse pregn

219 ng evidence from studies of animal and human myometrium, with particular emphasis on what may occur i