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1 e transcriptional activity of ANF induced by myotrophin.
2  neonatal or adult myocyte growth induced by myotrophin.
3  as the [3H]leucine incorporation induced by myotrophin.
4 ted the [3H]leucine incorporation induced by myotrophin.
5 ically and immunologically active as natural myotrophin.
6 I kappa B alpha proteins, were identified in myotrophin.
7 nuclear extract proteins and the recombinant myotrophin.
8 n two direct regulators of CP-CARMIL and V-1/Myotrophin.
9 transgenic (Tg) mouse model that overexpress myotrophin (a 12-kDa protein that stimulates myocyte gro
10  mouse models with cardiac overexpression of myotrophin (a prohypertrophic molecule) or TNFalpha show
11                                              Myotrophin, a 12-kDa ankyrin repeat protein, stimulates
12                     We identified and cloned myotrophin, a 12-kDa protein from hypertrophied human an
13 mong others, we have isolated and identified myotrophin, a factor that stimulates myocytes growth, fr
14 lved in the hypertrophic response induced by myotrophin, a hypertrophic activator identified from spo
15                                              Myotrophin, a novel protein that has been shown to stimu
16  We have recently cloned the gene coding for myotrophin and expressed it in Escherichia coli.
17 phin to determine the effect of the loops on myotrophin and p65 localization, induction of protein sy
18 phy thus require nuclear co-translocation of myotrophin and p65, in a manner that depends crucially o
19         Proteomics demonstrated increases in myotrophin and spectrin that could promote hypertrophy a
20 bcellular events whose occurrence was due to myotrophin and translocation of PKC, we studied the effe
21 eonatal and adult myocytes were treated with myotrophin, and Western blot analyses were performed by
22               Our data strongly suggest that myotrophin appears to be a candidate gene for cardiac hy
23 w that the minor kinetic phases observed for myotrophin arise from heterogeneity of the ground states
24                              Here we propose myotrophin as a model system to study the folding of ank
25  take place as a result of overexpression of myotrophin at both the cellular and molecular levels wil
26 ng-Protein-Interacting (CPI) motifs, and V-1/myotrophin, based on biochemical functional studies and
27             The highly conserved protein V-1/Myotrophin binds CP tightly in vitro to render it incapa
28                              The protein V-1/myotrophin binds to the F-actin-binding site on CP and s
29        We isolated and characterized various myotrophin cDNA clones corresponding to the multiple tra
30 acetylglucosaminyltransferase, spectrin, and myotrophin, contribute to hypertrophy and functional spa
31 d that, after internalization into myocytes, myotrophin cotranslocates into the nucleus with p65 to s
32                                              Myotrophin does not change PKC isoform expression (both
33                                              Myotrophin-E33A internalized into myocytes but did not t
34                        Our data suggest that myotrophin exerts its action on protein synthesis, possi
35                                    Recently, myotrophin gene has been mapped and shown to be a novel
36      In the present study, the expression of myotrophin gene was analyzed, and at least seven transcr
37 5, in a manner that depends crucially on the myotrophin hairpin loops.
38                            The gene encoding myotrophin has been cloned and expressed in E. coli.
39 f these assays indicate that the recombinant myotrophin has the ability to interact with NF-kappa B/r
40           Recently, the cDNA clones encoding myotrophin have been isolated and expressed in Escherich
41 cal significance, we examined transcripts of myotrophin in SHR heart during progression of hypertroph
42 ophy and HF as a result of overexpression of myotrophin in the heart associated with an elevated leve
43 effects of overexpression of cardio-specific myotrophin in transgenic mice in which cardiac hypertrop
44 ta on the pathophysiological significance of myotrophin in vivo, showing the effects of overexpressio
45  only the PKCepsilon isoform was involved in myotrophin-induced adult myocyte hypertrophy.
46 that activation of NF-kappaB was required in myotrophin-induced cardiac hypertrophy, in spontaneously
47                                 Importantly, myotrophin-induced expression of two hypertrophic genes
48 ay may play a critical role in mediating the myotrophin-induced hypertrophic response in cardiomyocyt
49 the involvement of protein kinase C (PKC) in myotrophin-induced hypertrophy, PKC activity and its dis
50 myocytes with staurosporine also reduced the myotrophin-induced mRNA levels of c-fos and beta-myosin
51                                              Myotrophin-induced myocyte growth and initiation of hype
52  and PKCepsilon isoforms participated in the myotrophin-induced neonatal myocyte growth, whereas only
53 f genistein, a tyrosine kinase inhibitor, on myotrophin-induced neonatal myocyte growth.
54                                Consistently, myotrophin-induced NF-kappaB activation was enhanced by
55                                 Furthermore, myotrophin-induced PKC activity was primarily located in
56                                              Myotrophin is a soluble-12 kilodalton protein isolated f
57                      The 118 residue protein myotrophin is composed of four ankyrin repeats that stac
58                                              Myotrophin is folded over a large pH range and is solubl
59  revealed that one of the ankyrin repeats of myotrophin is highly homologous specifically to those of
60 s highly homologous specifically to those of myotrophin is highly homologous specifically to those of
61                                              Myotrophin is the first example of a naturally occurring
62  the MPD6-IRES-mediated translation, but not myotrophin-MPD6 transcription, was significantly up-regu
63                            The expression of myotrophin-MPD6 transcripts was up-regulated in some tum
64                    Northern blot analysis of myotrophin mRNA showed multiple transcripts.
65 ame located in the 3'-untranslated region of myotrophin mRNA.
66                                              Myotrophin (Mtpn) was predicted to be and validated as a
67                                The effect of myotrophin on the stimulation of PKC activity and [3H]le
68         Moreover, our recent study using the myotrophin-overexpressed transgenic mouse (Myo-Tg) model
69 ve further analyzed the primary structure of myotrophin protein and identified significant new struct
70 hus, these results clearly indicate that the myotrophin protein to be a unique rel/NF-kappa B interac
71         Our data show that overexpression of myotrophin results in initiation of cardiac hypertrophy
72 CP-capped filaments, whereas the protein V-1/myotrophin sequesters CP in an inactive complex.
73                                              Myotrophin significantly stimulated PKC activity in neon
74                                        While myotrophin-specific antibodies inhibited the formation o
75 n vitro transcripts generated from all these myotrophin-specific cDNA clones translate in vitro to a
76 pecificity of the PKC isoform(s) involved in myotrophin-stimulated myocyte growth, both neonatal and
77                       The mechanism by which myotrophin stimulates protein synthesis and initiates my
78 ture-based mutations on the hairpin loops of myotrophin to determine the effect of the loops on myotr
79                                              Myotrophin treatment stimulated NF-kappaB nuclear transl
80                                              Myotrophin (V-1) is a 13-kDa ankyrin repeat-containing p
81                     Here we demonstrate that myotrophin/V-1 binds directly to CP in a 1:1 molar ratio
82               In vitro studies indicate that myotrophin/V-1 can promote the formation of p50-p50 homo
83                      Thus, overexpression of myotrophin/V-1 during NFkappaB activation resulted in a
84   Co-immunoprecipitation studies reveal that myotrophin/V-1 interacts with NFkappaB proteins in vitro
85                                              Myotrophin/V-1 is a cytosolic protein found at elevated
86 earts, this study cumulatively suggests that myotrophin/V-1 is a regulatory protein for modulating th
87                                      Because myotrophin/V-1 is found at elevated levels during NFkapp
88 y, we demonstrated that in HeLa cells native myotrophin/V-1 is predominantly present in the cytoplasm
89 -dimensional alignment studies indicate that myotrophin/V-1 resembles a truncated IkappaBalpha withou
90 rmore, adenovirus-mediated overexpression of myotrophin/V-1 resulted in elevated levels of both p50-p
91           Correspondingly, overexpression of myotrophin/V-1 resulted in significantly reduced kappaB-
92 sed in Escherichia coli, and the recombinant myotrophin was found to be as biologically and immunolog
93                                              Myotrophin (whose gene is localized on human chromosome