ライフサイエンスコーパス: myristic acid

1 and high-yield modification of the ELP with myristic acid.

2 iolabeled with either [35S]methionine or [3H]myristic acid.

3 ular asses of 37, 35, and 25 kDa) label with myristic acid.

4 CD28 monoclonal antibodies (mAbs) or phorbol myristic acid.

5 labeled only with [35S]methionine, not with myristic acid.

6 nic and oleic acid and to a lesser extent by myristic acid.

7 rayed with a solution containing skatole and myristic acid.

8 over through the receptor's interaction with myristic acid.

9 ecrease in hSlo1 plasmalemma localization by myristic acid.

10 ), basic residues in NC, and the presence of myristic acid.

11 d in the X-ray structure of HSA complexed to myristic acid.

12 e 2 diabetes (HR [95% CI] per SD difference: myristic acid 1.15 [95% CI 1.09-1.22], palmitic acid 1.2

13 10:0) acid (HRSD: 0.93; 95% CI: 0.89, 0.99), myristic acid (14:0) (HRSD: 0.90; 95% CI: 0.83, 0.97), t

14 decreased, the binding affinity was reduced; myristic acid (14:0) bound with a K(d) of 1409 +/- 423 n

15 s with 4-10 carbons, lauric acid (12:0), and myristic acid (14:0) were associated with decreased risk

16 Myristic acid (14:0), 14:1n-9, and 14:2n-6 were all inco

17 Lauric acid (12:0), myristic acid (14:0), and palmitic acid (16:0) are appro

18 :0) and oleic acid (18:1), cholesterol ester myristic acid (14:0), and phospholipid palmitoleic acid

19 ly assessed other DNL fatty acid biomarkers [myristic acid (14:0), palmitoleic acid (16:1n-7), 7-hexa

20 Even-chain SFAs that were measured (14:0 [myristic acid], 16:0 [palmitic acid], and 18:0 [stearic

21 l-CoA, the other products were identified as myristic acid, 2-myristoylmyristic acid, and 14-heptacos

22 in palmitic acid (82.8 %), and C. crispus in myristic acid (48.7 %).

23 cid (10.07%), palmitelaidic acid (9.56%) and myristic acid (8.83%).

24 ion known as myristoylation, the transfer of myristic acid (a 14-carbon saturated fatty acid) to an N

25 Modification of HIV-1 Gag with myristic acid, a saturated 14-carbon fatty acid (14:0),

26 , with the IB isoform containing a potential myristic acid acceptor sequence.

27 NAE 14:0, but not myristic acid, activated phenylalanine ammonia lyase exp

28 le of ACBD6 on protein N-myristoylation with myristic acid alkyne (YnMyr) chemical proteomics in the

29 otein which prevented incorporation of [(3)H]myristic acid also altered the detergent solubility and

30 These compounds included a myristic acid analog known to interact with Src family k

31 With [3H]myristic acid and [3H]acetate, GPIX was found to be a ma

32 the simultaneous insertion of an N-terminal myristic acid and binding to a Golgi-associated binding

33 ically hydrolyzed by acetylcholinesterase to myristic acid and choline to prevent the color transitio

34 Phorbol myristic acid and dimethyloxalylglycine differentially s

35 virus expression system required addition of myristic acid and E9-14 acid precursors to demonstrate t

36 labeling of calcineurin B with radiolabeled myristic acid and electrospray mass spectral analysis co

37 pathways by treatment of cells with phorbol myristic acid and ionomycin rescued up-regulation of Btk

38 GPIb was acylated with about equal mounts of myristic acid and palmitic acids.

39 -translational modifications: acylation with myristic acid and phosphorylation at the C terminus.

40 Myristic acid and positively charged residues within the

41 ence (G2E), which eliminates the addition of myristic acid and the membrane-binding capacity of this

42 Based on evidence that myristic acid and TSP1 each modulate endothelial cell ni

43 nfidence interval: 1.06, 5.38) for saturated myristic acid, and 2.88 (95% confidence interval: 1.24,

44 ng studies using [3H]glycerol, [32P]Pi, [14C]myristic acid, and [14C]linoleic acid indicated that the

45 , the sum of pentadecylic and margaric acid, myristic acid, and SFAs from dairy sources.

46 Surprisingly, only myristic acid, and to a lesser extent palmitic acid, sti

47 udosubstrate-specific peptides with attached myristic acid are cell permeable and can be used to bloc

48 ptimized conditions (i.e., pH = 10, 23 nL of myristic acid as the extractant, and 20 min as the extra

49 ved using a long-chain organic acid, namely, myristic acid, as the extractant.

50 The presence of myristic acid at the N terminus of the Myr1E Gag protein

51 ele (nmt487D) produces temperature-sensitive myristic acid auxotrophy.

52 t of synthetically derived tagged analogs of myristic acid bearing a 'clickable' tag.

53 rs that target either the active site or the myristic acid binding pocket in the kinase domain C-lobe

54 losteric network linking the SH3 domain, the myristic acid binding pocket, and the active site of the

55 pported monohydroxylation of lauric acid and myristic acid, but secondary oxygenation of the primary

56 bolic labeling showed incorporation of [(3)H]myristic acid by wild-type Z protein but not by the G2A

57 fat pad showed a decrease in the content of myristic acid (C14), a principal substrate for protein m

58 ential enzyme that catalyzes the transfer of myristic acid (C14:0) from myristoylCoA to the N-terminu

59 tment of cells expressing hSlo1 with 100 muM myristic acid caused alteration of hSlo1 activation kine

60 se data demonstrate an unexpected link among myristic acid, CD36, AMP kinase, and eNOS activity.

61 ive constructs were used to demonstrate that myristic acid/CD36 stimulation of eNOS activity was depe

62 In vivo, treatment with a myristic acid conjugated trivalent histidine-histidine d

63 Of the fatty acids tested, only exogenous myristic acid contributed to increased intracellular myr

64 dynamics simulations show that luteolin and myristic acid cooperate to stabilize the Omega-loop amon

65 aplsX S. pneumoniae strain was refractory to myristic acid-dependent growth arrest, and unlike the wi

66 structure of beta-lactoglobulin complex with myristic acid determined at the highest accepted by the

67 ods, we report high-resolution structures of myristic acid-enriched HSA (HSA(MYR)) and its AA complex

68 The requirement of myristic acid for multimerization was reproduced using t

69 degrees C and in the presence of 1) phorbol myristic acid, forskolin and 3-isobutyl-1-methylxanthine

70 -myristoyltransferase (NMT), which transfers myristic acid from myristoyl coenzyme A to the amino gro

71 T41I/T78I mutant was defective in release of myristic acid from the more hydrophobic core.

72 in the sequence oleic acid > palmitic acid > myristic acid > linoleic acid > linolenic acid.

73 oleic acid, stearic acid, palmitic acid, and myristic acid had little effect.

74 Treatment of ER membranes with myristic acid in the presence of cytosol increases SVIP

75 tide was labeled with [35S]methionine or [3H]myristic acid in the translation reactions, while mutant

76 Mechanistically, metabolism of exogenous myristic acid increased the biosynthesis of myristoyl Co

77 d when feeders were sprayed with skatole and myristic acid individually.

78 ristoylation by nearly 90% and abolished the myristic acid-induced change in current density.

79 ates that ASFV effectively inhibited phorbol myristic acid-induced synthesis of antiviral, proinflamm

80 In human cells, phorbol myristic acid induces syndecan-1 shedding, resulting in

81 The Lineweaver-Burk plot showed that myristic acid inhibited firefly luciferase in competitio

82 Ueda and Suzuki reported that myristic acid inhibited firefly luciferase in microM ran

83 ndicated that caveolin-1 was not acylated by myristic acid; instead, it was acylated by palmitic acid

84 interleukin- (IL) 2 was measured in phorbol myristic acid-ionomycin-stimulated peripheral lymphocyte

85 These results establish that myristic acid is a primary determinant of the stability

86 Myristic acid is found here to bind Sig-1R as an agonist

87 molecules may adopt a conformation in which myristic acid is hidden and unavailable for membrane int

88 f glycosylphosphatidylinositol biosynthesis, myristic acid is incorporated into the anchor from the d

89 results strongly support the hypothesis that myristic acid is sequestered inside MA prior to capsid-m

90 of well-controlled studies, it appears that myristic acid is the most potent saturated fatty acid.

91 [3H]Myristic acid-labeled cells were lysed by nitrogen cavit

92 detergent-resistant fractions and that [(3)H]myristic acid-labeled HIV Gag showed a nine-to-one enric

93 c acid was confirmed by the detection of [3H]myristic acid labeling and the observation that labeling

94 A saturated fatty acid, myristic acid (MA), had no inhibitory effect on the isop

95 These results suggest that skatole and myristic acid might be acting as a multicomponent matern

96 reatment of Sig-1R-KO neurons with exogenous myristic acid mitigates p35 accumulation, diminishes tau

97 d from Gag proteins that lack the N-terminal myristic acid modification or the nucleocapsid (NC) prot

98 Both the myristic acid moiety and additional determinants within

99 coli lipopolysaccharide (LPS) that lacks the myristic acid moiety of lipid A.

100 A single myristic acid molecule simultaneously binds the LBP, sug

101 The docking of ajwain nsLTP1 with ligands; myristic acid (MYR), and oleic acid (OLE) was performed,

102 catalyzes the cotranslational acylation with myristic acid of the NH2-terminal glycines of a number o

103 tic studies demonstrated that the effects of myristic acid on eNOS function were not dependent on PI

104 ng antibody demonstrated that the effects of myristic acid on eNOS required association with CD36.

105 293 cells, when stimulated with oleic acid, myristic acid, or the agonist 4-[[(3-phenoxyphenyl)methy

106 correlation was significant specifically for myristic acid (P < 0.001).

107 te (GLCA), petroselinic acid, linoleic acid, myristic acid, palmitic acid, palmitoleic acid and the d

108 r exposure to dexamethasone (DEX) or phorbol myristic acid (PMA), PMA had no effect on expression of

109 Phorbol myristic acid (PMA)-treated U937 cells and elutriated mo

110 s claudin-1 were treated with 200 nM phorbol myristic acid (PMA).

111 On Postnatal Day 2, polyethylenimine-(5) myristic acid/polyethylene glycol-oleic acid/cholesterol

112 C (PKC) by the diacylglycerol mimic phorbol-myristic acid resulted in specific and dose-responsive i

113 ourse labeling of VV-infected cells with [3H]myristic acid reveals at least three additional putative

114 Metabolic labeling with [3H]myristic acid showed that both the 120- and 160-kDa kine

115 hobically modified silica nanoparticles with myristic acid (SNPs-C14) or tocopherol succinate (SNPs-T

116 s in IL-8 and MCP-1 resulted from CM phorbol myristic acid-stimulated T-lymphocytes.

117 the molecular basis of how the metabolism of myristic acid stimulates high-fat diet-mediated prostate

118 Phorbol myristic acid stimulation significantly decreases DiD (1

119 ent acyltransferase which is responsible for myristic acid substitutions at the hydroxy moiety of lip

120 This indicates that myristic acid targets MARCKS to the membrane, where it i

121 ine, threonine, and/or tyrosine residues and myristic acid; this type of esterification was further c

122 lation by potentially carrying and providing myristic acid to p35 for enhanced p35 degradation to cir

123 The application of skatole and myristic acid to the feeders of weaned pigs significantl

124 s) cotranslationally transfer the fatty acid myristic acid to the N terminus of newly synthesized pro

125 myristoylation is the covalent attachment of myristic acid to the N terminus of proteins in eukaryoti

126 N-myristoylation refers to the attachment of myristic acid to the N-terminal glycine of proteins and

127 reversible attachment of a C(14) fatty acid, myristic acid, to the N-terminal glycine of a protein vi

128 Furthermore, we show that myristic acid treatment of hepatocytes increases both VT

129 xpressed in HEK293T cells incorporated [(3)H]myristic acid via a posttranslational mechanism, which i

130 % (IC50) at 13.6 microM, whereas the IC50 of myristic acid was 0.68 microM.

131 Modification of ArgIB by myristic acid was confirmed by the detection of [3H]myri

132 ospray mass spectral analysis confirmed that myristic acid was covalently and stoichiometrically link

133 Myristic acid was detected on cysteine residue(s) (i.e.

134 Myristic acid was linked to GPIX by an amide bond, and t

135 Myristic acid was the only nutrient that appeared to med

136 However, the concentration of skatole and myristic acid were 2.68 and 1.13 times higher after farr

137 Trace amounts of myristic acid were also detected in transgenic plants co

138 The K(d) values for palmitic and myristic acid were in the nanomolar range.

139 oleic acid, stearic acid, palmitic acid and myristic acid, were the primary chemicals identified usi

140 lated almost exclusively with straight-chain myristic acid, whereas lysine was acylated preferentiall

141 ith pure alpha-LNA showed a decrease in free myristic acid, while pure LA led to an increase in free

142 d, and the highest activity was observed for myristic acid with a Km of 1.7 mol % and a Vmax of 0.63