ライフサイエンスコーパス: myristoylate

1 N-terminal glycines of these 3A proteins are myristoylated.

2 hSlo1, is internally and posttranslationally myristoylated.

3 s reaction was most efficient when Vac8 is N-myristoylated.

4 hen expressed with a Gag mutant that was not myristoylated.

5 etroviruses, retroviral MAs are N-terminally myristoylated.

6 V Gag is unusual in that it is not naturally myristoylated.

7 Based on this interaction, we engineered a myristoylated 7 amino acid CCR10-binding domain (Myr-CBD

8 Transfection of myristoylated Akt (AktCA) in HK-11 cells induced Akt-Ser

9 Reconstitution of Rictor-null cells with myristoylated AKT (Myr-AKT) rescued vascular assembly in

10 a constitutively active form of the kinase, myristoylated Akt (Myr-Akt), demonstrates an ability to

11 d expression of constitutively active AKT by myristoylated AKT adenovirus results in increased phosph

12 Both constitutively active myristoylated Akt and hRheb(S16H) induce regrowth of axo

13 n-activated protein kinase kinase (MEK) 1 or myristoylated Akt blocked HDACI/perifosine-mediated cera

14 s, and expression of a constitutively active myristoylated Akt blocked the enhancement of ER stress-i

15 basal cells expressing the oncogenes Myc and myristoylated AKT can initiate heterogeneous tumors.

16 In contrast, Kras(G12D) mice transduced with myristoylated AKT developed GSI-sensitive T-ALLs that ac

17 ansgenic expression of constitutively active myristoylated Akt increased glucose uptake of resting T

18 -regulatable FL5.12 pre-B cell line in which myristoylated Akt is expressed under the control of doxy

19 Angiogenic HA fragments or overexpression of myristoylated Akt or HA receptors blunted these effects

20 iple cancer cell lines, forced expression of myristoylated Akt promoted resistance to ARC-induced apo

21 Expression of constitutively active myristoylated Akt reversed the siPDGFRbeta-mediated inhi

22 ort of this model, coexpression of Glut1 and myristoylated Akt transgenes resulted in a synergistic i

23 bitor and restored in cells transfected with myristoylated Akt yet perfused in stiff tubes.

24 ent mutant of PRAS40 inhibited the effect of myristoylated Akt, suggesting a definitive role of PRAS4

25 stably expressing gain-of-function H-Ras or myristoylated Akt.

26 drophobic motif site in Sin1(-/-) MEFs; both myristoylated-Akt and Akt lacking the PH domain are phos

27 We report that constitutively active, myristoylated-Akt increases FANCL protein level by reduc

28 Expression of myristoylated-Akt rescued 4-MU-induced apoptosis and inh

29 ne bone marrow transplantation model using a myristoylated AKT1 (myr-AKT), recipients develop myelopr

30 A myristoylated Akt1 (MyrAkt1) fusion protein expressed in

31 viruses expressing c-Myc and activated AKT1 (myristoylated AKT1 or myrAKT1) to mimic theMYCamplificat

32 Wild-type and myristoylated Akts (Akt(WT) and Akt(Myr)) suppress TGF-b

33 gene-array, including genes for profilin-1, myristoylated alanine rich protein kinase C substrate li

34 Here, we identify myristoylated alanine-rich C kinase substrate (MARCKS) a

35 analyzed mechanism of substrate-buffering by myristoylated alanine-rich C kinase substrate (MARCKS) a

36 ased phosphorylations of PKC at Thr(514) and myristoylated alanine-rich C kinase substrate (MARCKS) a

37 Ca(2+)-PKC) is hypothesized to phosphorylate myristoylated alanine-rich C kinase substrate (MARCKS) a

38 Myristoylated alanine-rich C kinase substrate (MARCKS) i

39 Myristoylated alanine-rich C kinase substrate (MARCKS) i

40 Myristoylated alanine-rich C kinase substrate (MARCKS) i

41 The present study reveals that myristoylated alanine-rich C kinase substrate (MARCKS) p

42 al studies by Gay et al. demonstrated that a myristoylated alanine-rich C kinase substrate (MARCKS) p

43 utrophil elastase-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) p

44 ptide comprising the effector domain (ED) of myristoylated alanine-rich C kinase substrate (MARCKS) w

45 Myristoylated Alanine-Rich C Kinase Substrate (MARCKS),

46 We previously found the myristoylated alanine-rich C kinase substrate (MARCKS),

47 Phosphorylation of myristoylated alanine-rich C kinase substrate (phospho-M

48 pears to be the detachment of phosphorylated myristoylated alanine-rich C kinase substrate (pMARCKS)

49 The release of phosphorylated myristoylated alanine-rich C kinase substrate and its su

50 We show that phosphorylation of myristoylated alanine-rich C kinase substrate by membran

51 Strikingly, the lipid ligand MED (myristoylated alanine-rich C kinase substrate effector d

52 PKC-dependent myristoylated alanine-rich C kinase substrate phosphoryl

53 s determined by translocation of eGFP-tagged myristoylated alanine-rich C kinase substrate protein) r

54 Consequently, phosphorylation of myristoylated alanine-rich C kinase substrate was decrea

55 ral biologically important peripheral (e.g., myristoylated alanine-rich C kinase substrate) and integ

56 the major protein kinase C substrate MARCKS (myristoylated alanine-rich C kinase substrate) as a pote

57 The MARCKS protein (myristoylated alanine-rich C kinase substrate) is an act

58 porters, actin binding proteins (radixin and myristoylated alanine-rich C kinase substrate), and Rab

59 cific subunits of AMPA or NMDA receptors and myristoylated alanine-rich C kinase substrate).

60 We could demonstrate that Lck and myristoylated alanine-rich C kinase substrate, two main

61 Here, we identify the actin-binding protein myristoylated alanine-rich C-kinase substrate (MARCKS) a

62 next identified that the phosphorylation of Myristoylated alanine-rich C-kinase substrate (MARCKS) a

63 from the lipid binding domain of the protein myristoylated alanine-rich C-kinase substrate (MARCKS) b

64 ived from the phospholipid binding domain of Myristoylated alanine-rich C-kinase substrate (MARCKS) c

65 two actin-associated proteins, myosin II and myristoylated alanine-rich C-kinase substrate (MARCKS) i

66 Myristoylated alanine-rich C-kinase substrate (MARCKS) i

67 tol 4,5-bisphosphate (PIP2)-binding protein, myristoylated alanine-rich C-kinase substrate (MARCKS),

68 crease in a poorly-characterized MK protein, myristoylated alanine-rich C-kinase substrate (MARCKS),

69 The effector domain of myristoylated alanine-rich C-kinase substrate (MARCKS-ED

70 ine AD mouse models with an original marker, myristoylated alanine-rich C-kinase substrate phosphoryl

71 Here, we demonstrate in mice that the myristoylated alanine-rich C-kinase substrate protein (M

72 MARCKS (myristoylated alanine-rich C-kinase substrate) is a majo

73 C) activity and of phosphorylated (inactive) myristoylated alanine-rich C-kinase substrate, a PKC tar

74 hosphorylation of serines 713 and 726 in the myristoylated alanine-rich protein kinase (PK) C substra

75 ther (phosphatase and tensin homolog (PTEN), myristoylated alanine-rich protein kinase C substrate (M

76 The activity of myristoylated alanine-rich protein kinase C substrate (M

77 ular substrate for protein kinase C known as myristoylated alanine-rich protein kinase C substrate (M

78 eins we characterized two proteins, :MARCKS (Myristoylated Alanine-Rich protein Kinase C substrate) a

79 e ubiquitinated after rapid preconditioning: myristoylated, alanine-rich C-kinase substrate (MARCKS)

80 and that the major PKC epsilon target is the myristoylated, alanine-rich C-kinase substrate (MARCKS).

81 We investigated the role of MARCKS (myristoylated, alanine-rich C-kinase substrate) in dendr

82 t fluorescence changes are consistent with a myristoylated amino terminus in the proximity of the mem

83 This work demonstrates that the myristoylated amino terminus of Galpha il proteins under

84 Overexpression of a myristoylated and active form of A. stephensi and Ae. ae

85 al proteomic tools for identification of the myristoylated and glycosylphosphatidylinositol-anchored

86 Myristoylated and guanosine 5'-3-O-(thio)triphosphate (G

87 The myristoylated and membrane-associated regulatory beta-su

88 L39, and the resulting new N termini were N-myristoylated and N-acetylated, respectively.

89 The L176F substitution improved affinity of myristoylated and non-acylated GCAP1 for the cyclase but

90 The difference in the binding affinity of myristoylated and non-myristoylated proteins to Ca(2+) a

91 he biochemical and biophysical properties of myristoylated and nonmyristoylated mouse methionine sulf

92 rein we demonstrate that HGAL protein can be myristoylated and palmitoylated and that these modificat

93 This study demonstrates that BBLF1 is a myristoylated and palmitoylated protein, as are UL11 and

94 no-acid (aa) tegument protein, pp28, that is myristoylated and phosphorylated.

95 matrix domain (MA) of HIV-1 Gag protein is N-myristoylated and plays an important role in virus buddi

96 We report the interaction of myristoylated and unmyristoylated HIV-1 Gag MA domains w

97 the similarity with Nef, we show that S2 is myristoylated, and, as is compatible with a crucial role

98 In addition, mutants that cannot be myristoylated are no longer mono-ubiquitinated but are s

99 Using myristoylated Arf1.GDP as a substrate, the k(cat) was 1.

100 interaction of uncomplexed Brag2 and of the myristoylated Arf1/Brag2 complex with a phosphatidylinos

101 The IA were myristoylated at a glycine penultimate to the N terminus

102 The N-terminus is myristoylated at Gly2 and palmitoylated at Cys3 and Cys2

103 Our results demonstrate that AtCPK5 is myristoylated at its amino terminus and that myristoylat

104 SSP spans the membrane twice and is myristoylated at its cytoplasmic N terminus.

105 We determined that cystin is myristoylated at its G2 residue and that N-myristoylated

106 We demonstrate that Neurl1 is myristoylated at its N terminus, and that myristoylation

107 proteins are permanently, cotranslationally myristoylated at the extreme amino terminus.

108 ChChd3 is myristoylated at the N terminus and has a CHCH domain wi

109 enger], catalase (an H2O2-degrading enzyme), myristoylated autocamtide-2 related inhibitory peptide (

110 ity and was blocked by the CaMKII inhibitor--myristoylated autocamtide-2-related inhibitory peptide (

111 II-alpha with the highly specific antagonist myristoylated autocamtide-2-related inhibitory peptide (

112 nels (CaCC) because simultaneous addition of myristoylated-autocamtide-2-related inhibitory peptide o

113 tion and, unexpectedly, that of numerous non-myristoylated BCR effectors including c-Myc, NFkappaB an

114 rotein subunit Gbeta and was mimicked by the myristoylated betagamma-binding/activating peptide mSIRK

115 The cytosolic form of the enzyme is myristoylated, but it is not known to translocate to mem

116 EGR2 is N-myristoylated by N-myristoyltransferase NMT1 at 22 degre

117 ristoylated c-Abl more potently than that of myristoylated c-Abl by binding to the myristate-binding

118 at GNF-2 inhibits the kinase activity of non-myristoylated c-Abl more potently than that of myristoyl

119 mmunofluorescence reveals a translocation of myristoylated c-Abl to the endoplasmic reticulum in GNF-

120 detectable effect on the localization of non-myristoylated c-Abl.

121 ivity but had enhanced stability compared to myristoylated c-Src.

122 dence that the membrane binding motif of the myristoylated C-subunit of PKA (PKA-C) steers the enzyme

123 ylyl cyclase-activating protein 1 (GCAP1), a myristoylated Ca(2+) sensor in vision, regulates retinal

124 The myristoylated calcium sensor SOS3 and its interacting pr

125 ansion results in the externalization of the myristoylated capsid protein VP4 and the N-terminal exte

126 The affinity between myristoylated cargo and carrier protein, Unc119, varies

127 a similar principle governs the transport of myristoylated cargo by the carrier proteins Unc119a and

128 ults establish the function of TbUnc119 as a myristoylated cargo carrier and support the presence of

129 d that binding of ARL3-GTP serves to release myristoylated cargo from UNC119.

130 analyzed the binding strength of N-terminal myristoylated cargo peptides (GNAT1, NPHP3, Cystin1, RP2

131 erature dependence in the cellular uptake of myristoylated cargo.

132 t as displacement factors for prenylated and myristoylated cargo.

133 also inhibited membrane translocation of the myristoylated CD36 signaling target Fyn and activation o

134 t not that of Arl2, regulates the release of myristoylated ciliary proteins from the GDI-like solubil

135 effector UNC119 as a binding partner of the myristoylated ciliopathy protein nephrocystin-3 (NPHP3).

136 virus 1 transduction with a gene encoding a myristoylated, constitutively active form of the oncopro

137 AECs with cortactin small interfering RNA or myristoylated cortactin Src homology domain 3 blocking p

138 s myristoylated at its G2 residue and that N-myristoylated cystin fractionates with membrane microdom

139 dinucleoside glutamate ester derivatives, N-myristoylated derivatives showed significantly higher an

140 otein 1 (CHP1) is a widely expressed, 22-kDa myristoylated EF-hand Ca(2+)-binding protein that shares

141 Yeast frequenin (Frq1), a small N-myristoylated EF-hand protein, activates phosphatidylino

142 alcineurin B homologous proteins (CHP) are N-myristoylated, EF-hand Ca(2+)-binding proteins that regu

143 Myristoylated ELPs provide a versatile platform for gene

144 L1 is a myristoylated envelope protein that is a potent target f

145 Vaccinia virus (VACV) L1 is a myristoylated envelope protein which is required for cel

146 Uptake of a myristoylated, fluorescent peptide was efficient in the

147 A constitutively active myristoylated form of Akt1 did not induce high-grade gli

148 hyperalgesic by SNL lost sensitivity to the myristoylated form of autocamtide-2-related inhibitory p

149 he later identification of a membrane bound, myristoylated form of OCA-B suggested additional, unique

150 or both forms of the enzyme, except that the myristoylated form reduced methionine sulfoxide in prote

151 roteasomal degradation in its membrane-bound myristoylated form.

152 GPAT4 activity requires CHP1 to be N-myristoylated, forming a key molecular interface between

153 d that whole virus particles, as well as the myristoylated fragment mu1N that is released from partic

154 Interference of Galpha13 expression or a myristoylated fragment of Galpha13 that inhibited intera

155 ificity, palmitoylating H- and N-Ras but not myristoylated G (alphai1) or GAP-43, proteins with N-ter

156 Activation of G betagamma subunits using myristoylated G betagamma-binding peptide (mSIRK) caused

157 on apparatus targets the fully mature, fully myristoylated G protein for mono-ubiquitination and deli

158 an in vitro binding assay using full-length myristoylated Gag and liposome-associated PI(4,5)P(2).

159 less-severe impacts on FRET between normally myristoylated Gag proteins than do CA-CTD mutations.

160 ly, disruption of PP1c-Gbeta1 complexes with myristoylated Gbeta1 peptides containing the PP1c bindin

161 (max) and K(m) values for both the peptide N-myristoylated-GCG and palmitoyl-coenzyme A.

162 s at the +2 and +3 positions relative to the myristoylated glycine for high and low affinities.

163 a flexneri protease IpaJ was found to cleave myristoylated glycine of eukaryotic proteins, yet the di

164 ion of CNB myristoylation by mutation of the myristoylated glycine triggered constitutive expression

165 that IpaJ cleaved the peptide bond between N-myristoylated glycine-2 and asparagine-3 of human ARF1,

166 In contrast, myristoylated GRASP promoted tethering and exhibited a u

167 s eliminates membrane association of the non-myristoylated gravin, the sensitivity to Ca2+/calmodulin

168 Binding of long-chain FFA and myristoylated H3 peptide is mutually exclusive.

169 particles modified with 0.25 mol% of a short myristoylated HBV derived peptide, that is Myr-HBVpreS2-

170 Using fluorescein isothiocyanate-labeled, myristoylated HBV preS1-peptides we demonstrate (1) the

171 y at the plasma membrane, is mediated by the myristoylated, highly basic matrix (MA) domain, which in

172 Extracellular myristoylated HIV Nef inhibited cholesterol efflux from

173 ally by determining the affinity of purified myristoylated HIV-1 MA for liposomes of defined composit

174 were qualitatively recapitulated by purified myristoylated HIV-1 MA.

175 We have examined the binding of naturally myristoylated HIV-1 matrix (MyrMA) and matrix plus capsi

176 ize just such a conformational change in the myristoylated HIV-1 Nef protein (myrNef): at high lipid

177 increased statin sensitivity, expression of myristoylated HRAS did not rescue this effect.

178 Abnormal processing or production of this myristoylated HTT fragment might be involved in the path

179 Myristoylated HTT553-585-EGFP, but not its non-myristoyl

180 Our results suggest that accumulation of myristoylated HTT553-586 in cells may alter the rate of

181 A replication in G144 cells is stimulated by myristoylated (i.e., constitutively active) Akt and redu

182 blished that 0.43-0.46% of the proteome is N-myristoylated in T. cruzi approaching that of other euka

183 Furthermore, Pto was myristoylated in vivo dependent on the presence of Gly-2

184 Protein-tyrosine kinase 6 (PTK6) is a non-myristoylated intracellular tyrosine kinase evolutionari

185 A myristoylated isoform is activated by Ca(2+) to initiate

186 Finally, a non-myristoylated isoform is essential to complete cytokines

187 ed alanine-rich C kinase substrate, two main myristoylated kinases in T cells, were mislocalized in t

188 long-chain fatty acyl modifications such as myristoylated lysine compared with acetylated counterpar

189 e main structural protein Gag depends on its myristoylated MA domain and PM PI(4,5)P2.

190 ontains three major domains: the N-terminal, myristoylated MA domain that targets the protein to the

191 anchoring of human immunodeficiency virus-1 myristoylated MA protein using a coarse-grained represen

192 Myristoylated MA strongly preferred binding to clustered

193 specific interactions between the N-terminal myristoylated matrix (MA) domain and phosphatidylinosito

194 ne targeting is mediated by the N-terminally myristoylated matrix (MA) domain of Gag and is dependent

195 n is mediated by binding of Gag's N-terminal myristoylated matrix (MA) domain to phosphatidylinositol

196 osphate (PI(4,5)P(2)) and Gag's N-terminally myristoylated matrix (MA) domain.

197 on calcium and is mediated by the N-terminal-myristoylated matrix (myr(+)MA) domain.

198 calcium and is mediated by the N-terminally myristoylated matrix (myr(+)MA) domain.

199 ediated by specific interactions between the myristoylated matrix [myr(+)MA] domain of Gag and phosph

200 ed a novel mechanism for the function of the myristoylated, membrane-bound form of OCA-B/p35 as a sig

201 Synthetic myristoylated micro1N peptide forms size-selective pores

202 on lateral association was abolished if the myristoylated moiety at the C-terminus was replaced by a

203 We further show that a conserved N-terminal myristoylated motif of both invertebrate and vertebrate

204 ation releases two virally encoded peptides, myristoylated mu1N (myr-mu1N) and Phi.

205 A non-myristoylated mutant of cGKII did not support cGMP inhib

206 n oncogene in a T-ALL mouse model expressing myristoylated (Myr) Akt2.

207 highly-basic-region (HBR), located near the myristoylated (Myr) N-terminus of the protein.

208 iac-specific expression of either activated (myristoylated [myr]) or dominant-negative (dn) Akt and a

209 Further, constitutively activated Akt (myristoylated [myr]Akt) or human NgBR can rescue the NgB

210 cludes membrane interactions mediated by the myristoylated N terminus of Gag, protein-protein interac

211 ficity of UNC119 is unique: UNC119 bound the myristoylated N terminus of Galpha(t1) with much higher

212 Recoverin has two functional EF hands and a myristoylated N terminus.

213 tic removal of sigma3 lead to release of the myristoylated N-terminal cleavage fragment micro1N and u

214 The exceptionally small, myristoylated N-terminal ectodomain of p15 lacks any of

215 Both myristoylated N-terminal fragment mu1N and C-terminal fr

216 The myristoylated N-terminal preS1 domain of the L protein s

217 is mediated through specific binding of the myristoylated N-terminal preS1-domain of the HBV L-prote

218 Two major conformations of the myristoylated N-terminus are the most populated: a long

219 athway in an unconventional fashion with the myristoylated N-terminus facing the lumen of the microne

220 e data indicate an important role(s) for the myristoylated N-terminus in Pto signalling.

221 (3) N-Terminally myristoylated NCS-1 dimerizes in a calcium-dependent man

222 Determination of the x-ray structure of myristoylated NPHP3 peptide in complex with Unc119a reve

223 Nef is myristoylated on the N-terminus, associates with membran

224 Vac8p is the first N-myristoylated, palmitoylated protein identified as a sub

225 A myristoylated peptide based on the autoinhibitory pseudo

226 understanding the intracellular delivery of myristoylated peptide cargoes for cell-based biochemical

227 uin 2 (SmSirt2) and kinetic experiments on a myristoylated peptide demonstrated lysine long-chain dea

228 The myristoylated peptide did not adversely affect cell viab

229 e effectively reversed by 50 nm H89 or 50 nm myristoylated peptide inhibitor (MPI), specific inhibito

230 A myristoylated peptide that blocks importin 7-mediated ER

231 n mu1 allows the release of its N-terminally myristoylated peptide, mu1N (4 kDa), which probably then

232 protein PrBP/delta did not interact with the myristoylated peptide.

233 yrate did not enhance cellular uptake of the myristoylated peptide.

234 Previous findings showed that N-terminally myristoylated peptides constituting a receptor binding d

235 Recombinant HEAT and ARM repeats bind to myristoylated peptides independent of the peptide sequen

236 Myristoylated peptides with either positive or negative

237 pathic helices or sheets, hydrophobic loops, myristoylated peptides, and proteins with phospholipase

238 arboring HEAT and ARM repeats bind to lysine myristoylated peptides.

239 of resolving hydrophobic and acylated (e.g., myristoylated) peptides by optimizing the steps in a mas

240 upled receptor kinase 2 or membrane-targeted myristoylated-phosducin-attenuated or abolished Cav2.3 m

241 e human cytomegalovirus UL99-coded pp28 is a myristoylated phosphoprotein located in the virion tegum

242 amma kinase-dead mutants, and potentiated by myristoylated PI3Kgamma.

243 maleimide I, Go-7874 or Go-6976, or with the myristoylated PKA inhibitor, PKI-(14-22)-amide failed to

244 inase A (PKA) inhibitors (H-89, KT-5720, and myristoylated PKA inhibitory peptide 14-22) failed to pr

245 myocytes, adenovirus-mediated expression of myristoylated PKBalpha (myr-PKBalpha) increased cellular

246 of HPAECs with dnPKC-zeta, or treatment with myristoylated PKC-zeta peptide inhibitor abrogated S1P-i

247 Expression of myristoylated-PKCalpha in S4(-/-) cells restores rictor,

248 allel, inhibition of the atypical PKCzeta by myristoylated PKCzeta pseudosubstrate inhibitor signific

249 uppressed by a PKCzeta specific inhibitor (a myristoylated PKCzeta pseudosubstrate peptide).

250 ein kinase inhibitor (PKI) (6-22) amide, and myristoylated PKI (14-22), applied alone or in combinati

251 100 microm m-iodobenzylguanidine or 5 microm myristoylated PKI amide did not alter the activation of

252 emonstrated using the PKA inhibitors H89 and myristoylated PKI(6-22) amide.

253 ted by the protein kinase A (PKA) inhibitor, myristoylated PKI, but was not dependent on PI3K-Akt sig

254 gene expression in deletion mutants of two N-myristoylated PPs.

255 ral Gag proteins are synthesized as soluble, myristoylated precursors that traffic to the plasma memb

256 iral drug evaluation, the GMP version of the myristoylated preS-peptide (Myrcludex-B), a lipopeptide

257 We determined the solution structure of the myristoylated protein and found that the myristoyl group

258 e observed with the peptide melittin and the myristoylated protein Arf-1.

259 oxygenase-2 that acts as a trap to inhibit N-myristoylated protein function.

260 or that of Meh1, another palmitoylated and N-myristoylated protein in yeast.

261 d consequently, binding of Ca(2+) to the non-myristoylated protein is not cooperative.

262 endent (insensitive to 30 muM H-89 or 100 nM myristoylated protein kinase A inhibitor).

263 in [Tor] complex 2)-mediated activation of a myristoylated protein kinase B (PKB; PKBR1) and the phos

264 ciliary localization, we identified CIL-7, a myristoylated protein that regulates EV biogenesis.

265 ith a lipid probe for affinity enrichment of myristoylated proteins and direct detection of lipid-mod

266 Membrane binding of viral and cellular N-myristoylated proteins can be regulated by selectively s

267 istic acid and click chemistry to identify N-myristoylated proteins in different life cycle stages of

268 otease is highly promiscuous among diverse N-myristoylated proteins in vitro but is remarkably specif

269 demonstrate that IpaJ cleaves an array of N-myristoylated proteins involved in cellular growth, sign

270 the ciliary membrane and suggest that other myristoylated proteins may be similarly targeted to spec

271 he binding affinity of myristoylated and non-myristoylated proteins to Ca(2+) also was reflected by T

272 embrane targeting GTPase cycle that delivers myristoylated proteins to the ciliary membrane and sugge

273 optosis allowed the identification of >100 N-myristoylated proteins, >95% of which are identified for

274 d to participate in the quality control of N-myristoylated proteins, in which N-terminal glycine degr

275 ontrast to all known examples of CaM-binding myristoylated proteins, our data show that the myr group

276 Here, we report the global N-myristoylated proteome in human cells determined using q

277 Here we describe the myristoylated proteome of Toxoplasma gondii using chemop

278 nables high-confidence identification of the myristoylated proteome on an unprecedented scale in cell

279 te a bulky hydrophobic moiety at C-terminus, myristoylated PrP can still incorporate into fibrillar s

280 reformed PrP fibrils were provided as seeds, myristoylated PrP supported fibril elongation and format

281 us been proposed for the membrane binding of myristoylated recoverin in the presence of calcium.

282 owed confirmation of the specific binding of myristoylated recoverin to phosphatidylserine, whereas t

283 t cooperativity for binding of Ca(2+) to non-myristoylated recoverin.

284 y, cells rescued with the Noonan-associated, myristoylated-Shoc2 mutant (Myr-Shoc2) displayed a gain-

285 yltransferases (NMT) 1 and 2 can efficiently myristoylate specific lysine residues.

286 Finally, a myristoylated SR2 peptide shows demonstrable decrease in

287 reased the biosynthesis of myristoyl CoA and myristoylated Src and promoted Src kinase-mediated oncog

288 ontributions governing the interactions of a myristoylated Src peptide with zwitterionic and anionic

289 viral envelope glycoproteins, GPC contains a myristoylated stable signal peptide (SSP) as an essentia

290 However, a mutant PKGII (G2A) that was not myristoylated substituted for functional PKGI, suggestin

291 Although this cytosolic protein is clearly myristoylated, the protein does not have the N-terminal

292 ristoylated HTT553-585-EGFP, but not its non-myristoylated variant, initially localized to the ER, in

293 F3) = 0.1 muM and K(EF2) = 1-4 muM), whereas myristoylated VILIP-1 binds two Ca(2+) with lower affini

294 MA is myristoylated, which enhances membrane binding, and spec

295 tured myoblasts (in which AChRs are absent), myristoylated WT rapsyn mostly localizes to lysosomes an

296 rmacological PKM-zeta inhibitors such as the myristoylated zeta inhibitory peptide (ZIP) or cheleryth

297 The myristoylated zeta inhibitory peptide (ZIP), which was o

298 Myristoylated zeta inhibitory peptide had no effect on s

299 Furthermore, intracranial infusion of myristoylated zeta inhibitory peptide in the VTA disrupt

300 PKMzeta inhibition by chelerythrine or myristoylated zeta inhibitory peptide significantly atte