ライフサイエンスコーパス: nail

1 ng to its designation as mK17n (n stands for nail).

2 rogressively undermined the integrity of the nail.

3 lipophilic 'active' in a microneedle-porated nail.

4 tation of solvent penetration into the human nail.

5 d as functions of time and of depth into the nail.

6 iosteum and stabilized via an intramedullary nail.

7 y is limited to the area associated with the nail.

8 dergo Wnt-dependent differentiation into the nail.

9 lial tissues such as: skin, cornea, hair and nail.

10 ation and later conversion to intermedullary nail.

11 on and later conversion to an intramedullary nail.

12 ast, mBMSCs and BCs formed abnormal bone and nail.

13 cessary for the full development of hair and nail.

14 t model compound from nanoparticles into the nail.

15 drug delivery into microneedle-treated human nail.

16 y, developmental delay, and brittle hair and nails.

17 elopmental anomalies of the hair, teeth, and nails.

18 ysis and is localized in the matrix of human nails.

19 and contraindication for the use of flexible nails.

20 otpads and presence of supernumerary ventral nails.

21 (n = 10); hair, 2.13 +/- 2.984 ng/g (n = 9); nails, 0.88 +/- 0.335 ng/g (n = 9); sweat, 1.90 +/- 1.69

22 periodontal disease (365, 11.3%), overgrown nails (234, 7.2%), and ocular discharge (188, 5.8%).

23 isorder diagnosed by the triad of dysplastic nails, abnormal skin pigmentation, and oral leukoplakia;

24 Hair and nail abnormalities are commonly associated with ibrutini

25 milies characterized by a split-foot defect, nail abnormalities of the hands, and hearing loss, due t

26 d Tgm 1 were already known to be involved in nail abnormalities when dysregulated.

27 earing loss (SNHL), amelogenesis imperfecta, nail abnormalities, and occasional or late-onset retinal

28 is of Lgr6-deficient mice, which have both a nail and bone regeneration defect.

29 r with later conversion to an intermedullary nail and documented the postoperative clinical condition

30 The primary outcome, nail and hair changes associated with ibrutinib therapy,

31 chia congenita (PC), a disorder in which the nail and other epithelial appendages are profoundly aber

32 Our results suggest that intramedullary nailing and plating provide equivalent long-term functio

33 Trochanteric entry-locked intramedullary nailing and submuscular bridge plating have also recentl

34 une-mediated disorder that affects the skin, nails and joints.

35 e 15 children (26.7%) including: hypoplastic nails and shortened fifth fingers (one), microtia with c

36 air follicles, sebaceous glands, taste buds, nails and sweat ducts.

37 hypertrichosis, and hypoplasia or aplasia of nails and terminal phalanges.

38 The molecular mechanism of nail (and claw) development is largely unknown, but we h

39 , enthesium, dactylitis, spine, and skin and nails), and coming to consensus on optimal treatment rec

40 lar rash, xerosis, pruritus as well as hair, nail, and mucosal changes.

41 palms, soles, body folds, genitals, face, or nails, and concomitant joint disease, are also important

42 characterized by dysplasia of the patellae, nails, and elbows and FSGS with specific ultrastructural

43 nduced redundant skin, papillomas, shortened nails, and hair loss.

44 common and debilitating disease of the skin, nails, and joints, with an acknowledged but complex gene

45 linical and dermoscopic examination of skin, nails, and mucous membranes was performed, and skin biop

46 u), and chromium (Cr) in hair, blood, urine, nails, and saliva from 635 Italian adolescents 10-14 yea

47 anomalies of the external ears, digits, and nails; and malformations of the breast.

48 tion of the HoxC cluster led to mice lacking nails (anonychia), a condition stronger than the previou

49 al SCs, located at the interface between the nail appendage organ and adjacent epidermis, which physi

50 other epidermal appendages: skin, teeth, and nails--as well as lacrimal, mammary, salivary, sebaceous

51 s that the level of amputation be within the nail bed and depends on expression of Msx1.

52 highly restricted and most prevalent in the nail bed and matrix, leading to its designation as mK17n

53 d K17 exhibit severe lysis restricted to the nail bed epithelium, where all three genes are robustly

54 Because Msx1 is strongly expressed in the nail bed mesenchyme, it has been proposed that the Msx1-

55 been developed to deliver terbinafine to the nail bed to treat onychomycosis.

56 sal membranes, acral skin (soles, palms, and nail bed), and skin with chronic sun-induced damage have

57 a of the hair shaft, and in epithelia of the nail bed.

58 orm of melanoma occurring on palms, soles or nail beds, whole genome sequencing of 87 tumors with mat

59 Whether ibrutinib affects the hair and nails by binding and altering cysteine-rich proteins of

60 m (P < 0.05), suggesting that human hair and nails can be used as biomarkers to assess human exposure

61 Human hair and nails can provide integrated exposure measurements, and

62 The highly visible nail changes and painful plantar thickening exert a psyc

63 Alopecia and nail changes are not commonly reported side effects of v

64 Nail changes or loss occurred in 106 (70%) patients.

65 In addition, the severity of nail changes was determined from a 0 to 3 rating scale f

66 Alopecia and nail changes were common adverse effects associated with

67 presenting with FPPK alone, or with minimal nail changes, carry mutations in KRT16; however, most FP

68 to complete a survey regarding alopecia and nail changes.

69 nted with familial FPPK with minor or absent nail changes.

70 lates the overall differentiation process of nail/claw formation.

71 ed by LC/ESI-Orbitrap-MS in urine and finger nails collected from a Norwegian cohort.

72 Partial ablation of the nail created pores that extended to a range of depths; t

73 this mutant form of Krt75 developed hair and nail defects resembling PC.

74 nd our understanding of the role of RSPO4 in nail development and disease.

75 ecific beta-catenin-deficient mice, in which nail differentiation is abrogated.

76 bone morphogenetic protein signaling favors nail differentiation over epidermal fate.

77 ations for a better understanding of PsA and nail disease and for an improved understanding of the ps

78 c studies have suggested that both joint and nail disease do not share this association.

79 For patients with significant nail disease for whom topical therapy has failed, treatm

80 s of PsA, psoriasis and psoriatic-associated nail disease to show how the prevailing autoimmunity con

81 isease, psoriatic arthritis, and severity of nail disease with concomitant impairment of quality of l

82 For patients with significant skin and nail disease, adalimumab, etanercept, and ustekinumab ar

83 e physician's global assessment of psoriatic nail disease, and enthesitis (using the PsA-modified Maa

84 physician's global assessment of psoriatric nail disease, and the PsA-modified MASES index in each g

85 rthritis (PsA), and by implication psoriatic nail disease, have been considered as autoimmune disorde

86 with male gender, increased body mass index, nail disease, psoriatic arthritis, larger plaques, more

87 a history of atopy, autoimmune disease, and nail disease, thus deconstructing the clinical heterogen

88 ycosis because this may complicate psoriatic nail disease.

89 n of drug formulations to treat recalcitrant nail disease.

90 redrawn, especially in the case of joint and nail disease.

91 a (porcelain nails or white nails) is a rare nail disorder with an unknown genetic basis.

92 Clinically, many nail disorders accompany bone deformities, but whether t

93 neuropathy, peripheral edema, alopecia, and nail disorders were more frequent with D75.

94 prevalence of photosensitivity and hair and nail disorders.

95 t with T-/loB+NK+ SCID, with normal hair and nails, distinct from the classic nude/SCID phenotype in

96 Kamberov et al. nail down when it originated and, using transgenic mice,

97 that Lgr6-expressing cells give rise to the nail during homeostatic growth, demonstrating that Lgr6

98 ificant improvement in the mucocutaneous and nail dyspigmentation.

99 at is mutated in a human autosomal-recessive nail dysplasia.

100 Eight patients had nail dystrophies and 7 had hair anomalies.

101 (hazard ratio [HR] 3.89, 95% CI 2.18-6.94), nail dystrophy (HR 2.93, 95% CI 1.68-5.12), and interglu

102 oliative erythroderma, hypotrichosis, severe nail dystrophy and failure to thrive, two heterozygous m

103 oliative erythroderma, hypotrichosis, severe nail dystrophy and failure to thrive, two heterozygous m

104 later onset and less frequent occurrence of nail dystrophy and keratoderma in PC-K6b, PC-K6c, and PC

105 ed individuals is primarily characterized by nail dystrophy and late onset of mild skin fragility and

106 ongenita (PC), characterized by hypertrophic nail dystrophy and other ectodermal features.

107 skin disorder characterized predominantly by nail dystrophy and painful palmoplantar keratoderma.

108 IMPORTANCE Nail dystrophy in early childhood often suggests a diagn

109 The clinical features comprised nail dystrophy or nail loss, marginal palmoplantar kerat

110 Subsequently, 2 other family members who had nail dystrophy were also correctly diagnosed as having d

111 iency leads to thymic aplasia, alopecia, and nail dystrophy, accounting for the nude/severe combined

112 disorder, characterized by oral leukoplakia, nail dystrophy, and abnormal skin pigmentation, as well

113 e and a triad of abnormal skin pigmentation, nail dystrophy, and oral leukoplakia.

114 ers, epidermolytic palmoplantar keratoderma, nail dystrophy, enamel dysplasia, and sparse woolly hair

115 n abnormalities is typically associated with nail dystrophy, leucoplakia, bone marrow failure, cancer

116 bilitating plantar keratoderma, hypertrophic nail dystrophy, oral leukokeratosis, and a variety of ep

117 inant disorder characterized by hypertrophic nail dystrophy, oral leukokeratosis, and palmoplantar ke

118 ociated with a higher likelihood of PsA were nail dystrophy, scalp lesions, and intergluteal/perianal

119 racterized by athymia, alopecia totalis, and nail dystrophy.

120 n and that both mutants suffer from a severe nail dystrophy.

121 bone marrow failure, hyperpigmentation, and nail dystrophy.

122 us symptoms, including hyperpigmentation and nail dystrophy.

123 openia during infancy, often associated with nail dystrophy.

124 o human genetic disorders: monilethrix, hair-nail ectodermal dysplasia, pseudofolliculitis barbae and

125 egulate Hoxc gene expression in the hair and nail ectodermal organs.

126 ntribute to both the nail structure and peri-nail epidermis, and more toward the latter.

127 n, was lacking in the beta-catenin-deficient nail epithelium and that genetic deletion of Wntless (Wl

128 hat genetic deletion of Wntless (Wls) in the nail epithelium led to the lack of Wnt activation in ost

129 These results reveal a critical role for the nail epithelium on the digit bone during homeostatic reg

130 thin cells of the nail matrix portion of the nail epithelium, as well as in a subset of cells in the

131 nce in the DRI score at 3 months in favor of nail fixation (mean score, 44.2 in the nail group and 52

132 Intramedullary nail fixation (nail group; n = 161), a metal rod inserte

133 icular fracture of the distal tibia, neither nail fixation nor locking plate fixation resulted in sup

134 s of age and older undergoing intramedullary nail fixation of their femoral shaft fractures at a univ

135 tibial fracture treated with intramedullary nail fixation vs locking plate fixation.

136 e in mean OMAS at 3 and 6 months in favor of nail fixation.

137 its relation with the function of ocular and nail-fold blood vessels is unknown.

138 nuous retinal vessel diameter assessment and nail-fold capillaroscopy.

139 Peripheral nail-fold capillary (P = 0.009) and retinal vessel (aver

140 ocirculatory abnormalities of the retina and nail-fold vessels are present in CAD.

141 led telangiectasias on the labial mucosa and nail folds.

142 ORs were most commonly observed in the skin, nail, gastrointestinal tract, hepatic, eyes, and lungs.

143 -GFP is appropriately regulated within hair, nail, glands, and oral papilla.

144 and typified by dystrophic lesions affecting nails, glands, oral mucosa, and palmar-plantar epidermis

145 ut not at 12 months (mean score, 23.1 in the nail group and 24.0 in the plate group; adjusted differe

146 or of nail fixation (mean score, 44.2 in the nail group and 52.6 in the plate group; adjusted differe

147 ommon in the plate group at 12 months (8% in nail group vs 12% in plate group).

148 umber of postoperative infections (9% in the nail group vs 13% in the plate group).

149 nths between groups (mean score, 29.8 in the nail group vs 33.8 in the plate group; adjusted differen

150 Intramedullary nail fixation (nail group; n = 161), a metal rod inserted into the holl

151 ling a gene involved in molecular control of nail growth.

152 r, the steroids could be further reduced and nails had regrown again.

153 pithelial lesions that differentially affect nail, hair, and glands in humans.

154 a pipet tip, and then sealing the hole with nail hardener.

155 f topically applied chemicals into the human nail has been visualized and characterized using stimula

156 ngal agent used to treat mycoses of skin and nails, has recently been demonstrated to be a potential

157 For disease limited to the nails, high-potency topical corticosteroids with or with

158 actures are plate fixation or intramedullary nailing; however, despite recent evidence, the optimal m

159 majority of individuals lack the fifth digit/nail hypoplasia phenotype, a hallmark of most SSRIDDs.

160 ity, coarse facial features, and fifth digit/nail hypoplasia that are caused by pathogenic variants i

161 chomycosis is the most common disease of the nail in adults.

162 d that each altered its own diffusion in the nail in an apparently concentration-dependent fashion.

163 ic epithelial lesions (excluding that of the nail in mice).

164 n in adult patients receiving intramedullary nailing in comparison to plating.

165 erline patients who underwent intramedullary nailing in comparison with those who underwent external

166 al activity against dermatophytes that cause nail infection than conventional terbinafine preparation

167 nt episodes of shingles, a widespread fungal nail infection, fungal dermatitis, oral herpetic lesions

168 layed by Krt75 in maintaining hair shaft and nail integrity.

169 In an effort to understand the lack of nail involvement in mK17 null mice, we discovered that t

170 terms of age of onset of symptoms, extent of nail involvement, and impact on daily quality of life.

171 entation of the skin did not have mucosal or nail involvement, suggesting 2 distinct mechanisms.

172 C) will continue because only one family has nail involvement.

173 Furthermore, the nail is functionally integrated with entheses associated

174 In stable patients, primary femoral nailing is associated with shorter ventilation time.

175 ditary leukonychia (porcelain nails or white nails) is a rare nail disorder with an unknown genetic b

176 y poor transport of active agents across the nail itself.

177 croscopy (AFM) and developed a novel "bed of nails"-like approach that uses quartz glass nanopillars

178 that needlelike pinnacles, as well as bed-of-nails-like arrays of pinnacles, emerge robustly from the

179 oped skin fragility, blisters, erosions, and nail loss on their paws - all features of EBA patients.

180 linical features comprised nail dystrophy or nail loss, marginal palmoplantar keratoderma, hypodontia

181 nt experiments established that transplanted nail LRCs can actively participate in functional nail re

182 These nail LRCs express the hair stem cell marker, keratin 15

183 Transcriptional profiling of isolated nail LRCs revealed bone morphogenetic protein signaling

184 typical phenotype, including severe hair and nail manifestations, we scrutinized the exome sequencing

185 ores that extended to a range of depths; the nail material adjacent to the ablated area was rendered

186 ese SCs dominantly delivering progeny to the nail matrix and differentiated nail plate, demonstrating

187 ail stem cells (NSCs) reside in the proximal nail matrix and that the mechanisms governing NSC differ

188 d that Lgr6 is expressed within cells of the nail matrix portion of the nail epithelium, as well as i

189 ves displayed patterning defects in bone and nail matrix.

190 then identified localization of PLCD1 in the nail matrix.

191 Foxn1 expression patterns in the HF and the nail matrix.

192 ery of the active agent into and through the nail may be envisaged.

193 Finger nails may be a useful noninvasive matrix for human biomo

194 have indicated that flexible intramedullary nails may lead to a shorter time to union and a decrease

195 s specifically localized to developing mouse nail mesenchyme at embryonic day 15.5, suggesting a cruc

196 yonic day 15.5, suggesting a crucial role in nail morphogenesis.

197 Group intramedullary nailing, n = 94; group external fixation, n = 71.

198 amino)-1-(3-pyridyl)-1-butanol, and hair and nail nicotine levels were measured in 60 subjects enroll

199 All 20 nails of each affected individual were chalky and white

200 , epilepsy, and hypoplasia or aplasia of the nails of the thumb and great toe.

201 T-B+NK+ SCID phenotype, whereas the hair and nails of these mice were normal.

202 with specialized pedal grasping (including a nail on the hallux) and a petrosal bulla likely evolved

203 on of the femur shaft with an intramedullary nail or an external fixateur with later conversion to an

204 Local penetration tests (nail or conical punch) often produce presumably sporadic

205 genitors result in failure to regenerate the nail or digit.

206 r initial (<24 hours) intramedullary femoral nailing or external fixation and later conversion to an

207 ure patterns may be best treated with locked nailing or plating.

208 altering cysteine-rich proteins of hair and nails or by means of another mechanism remains unknown.

209 y produce various keratinized organs such as nails or claws.

210 Hereditary leukonychia (porcelain nails or white nails) is a rare nail disorder with an un

211 volving the ankle joint, contraindication to nailing, or inability to complete questionnaires.

212 urrent or persistent infections of the skin, nail, oral, and genital mucosae with Candida species, ma

213 is reliant on the presence of the overlaying nail organ and is mediated by a proliferative blastema.

214 phalangeal bone that is associated with the nail organ.

215 nservative treatment and the presence of the nail organ.

216 n be released and diffuse laterally into the nail over an extended period of time.

217 nita (PC), a disorder typified by dystrophic nails, painful hyperkeratotic calluses in glabrous skin,

218 us loss-of-function mutations in LMX1B cause nail patella syndrome (NPS).

219 tra-renal manifestations, otherwise known as nail patella-like renal disease (NPLRD).

220 f genetically distinct conditions, including nail-patella syndrome and collagen type III glomerulopat

221 Mutations of the LMX1B gene cause nail-patella syndrome, a rare autosomal-dominant disorde

222 Mutations in LMX1B cause nail-patella syndrome, characterized by dysplasia of the

223 tural abnormalities of the GBM suggestive of nail-patella-like renal disease.

224 ription factor 1-beta (LMX1B) are a cause of nail patellar syndrome, a condition characterized by ske

225 and abuse tests such as bending, cutting and nail penetration.

226 r, an array of 100 pores in 0.2cm(2) area of nail permitting a 10(3)-fold increase in initial drug up

227 unique in presenting with a brittle-hair-and-nail phenotype, which most likely reflects the high cyst

228 ts that are consistent with abnormal toe and nail phenotypes in individuals with Van der Woude and po

229 ntal skin features included [corrected] hair/nail phenotypes, while [corrected] the most common syste

230 on the face and lips and was associated with nail pigmentation, blue pigmentation on the hard palate,

231 These mice showed regression of not only the nail plate but also of the underlying digit bone.

232 shown that PLCD1 is a component of the human nail plate by proteomic analysis and is localized in the

233 or abnormalities in skin appendages, such as nail plate dystrophy and structural defects in hair.

234 rogeny to the nail matrix and differentiated nail plate, demonstrating their plasticity to adapt to w

235 alized epithelia surrounding the keratinized nail plate.

236 rug access to targets within and beneath the nail plate.

237 Upon nail plucking injury, the homeostasis is tilted with the

238 The frequent use of nail polish slightly increased the risk of having PBC.

239 alate [DBP]), skin toners (90% for DEP), and nail polishes (90% for DBP).

240 Amputations proximal to the Wnt-active nail progenitors result in failure to regenerate the nai

241 Early nail progenitors undergo Wnt-dependent differentiation i

242 Nails protect the soft tissue of the tips of digits.

243 uiescent cells within the basal layer of the nail proximal fold, organized in a ring-like configurati

244 eatures that differentiated PsA, followed by nail psoriasis and current or previous dactylitis.

245 Nail psoriasis can be difficult to treat and has a signi

246 controlled trials evaluating treatments for nail psoriasis have been published.

247 Treatment of nail psoriasis poses a clinical challenge.

248 Treatment recommendations for 4 clinical nail psoriasis scenarios were developed based on the evi

249 e Health Assessment Questionnaire (HAQ), the Nail Psoriasis Severity Index (NAPSI), the physician's g

250 Treatment of nail psoriasis should balance consideration of the exten

251 improved active PsA and associated skin and nail psoriasis through week 24.

252 A PubMed search for publications on nail psoriasis treatments was performed from January 1,

253 or clinicians who are treating patients with nail psoriasis.

254 s had detection frequencies (% DF) in finger nails ranging from 46 to 95%.

255 utation, this Wnt activation is required for nail regeneration and also for attracting nerves that pr

256 LRCs can actively participate in functional nail regeneration.

257 Drug treatment of diseases of the human nail remains a difficult challenge; topical therapy, in

258 The effective treatment of diseases of the nail remains an important unmet medical need, primarily

259 nt population exists in continuously growing nails remains unknown.

260 le, 10%, saved $272 and $406 per patient per nail, respectively.

261 exemplars that metallic pipe leaks caused by nails, rocks, and erosion corrosion autogenously repaire

262 ized in a ring-like configuration around the nail root.

263 ential occupational exposures to SVOCs among nail salon workers.

264 to semivolatile organic compounds (SVOCs) in nail salons.

265 between quintile selenium levels measured in nail samples and cognitive test scores, with adjustment

266 Nail samples were collected and analyzed for selenium co

267 Lower selenium levels measured in nail samples were significantly associated with lower co

268 PBDE levels in the hair and nail samples were significantly correlated with their le

269 rther identified in vivo in urine and finger nail samples, this suggests that in vitro assays can rel

270 partial and complete laser poration of human nail samples, with the energy per pore and the exposure

271 ately applied to the dorsal surface of human nail samples.

272 tration of a model drug across laser-treated nails showed that complete poration resulted in essentia

273 Finally, for a patient with significant nail, skin, and joint disease, adalimumab, etanercept, u

274 , scrotal erythema/ulceration (6 [15%]), and nail splinter hemorrhages (5 [12%]).

275 ies describe successful results with elastic nail stabilization of pediatric femur fractures.

276 Here we show that nail stem cells (NSCs) reside in the proximal nail matri

277 owth, demonstrating that Lgr6 is a marker of nail stem cells.

278 Also note the nail striations in the second digit of the left hand (*)

279 K15-derived cells can contribute to both the nail structure and peri-nail epidermis, and more toward

280 bly due to local thermal perturbation of the nail structure.

281 was identified for the first time in finger nails, suggesting that this matrix may also indicate pas

282 n as immobile reservoirs, sequestered on the nail surface and in the microneedle-generated pores, fro

283 ded the following: whole blood, urine, hair, nails, sweat, brain tissue, breast milk, and explants.

284 Our results suggest that nail technicians are occupationally exposed to certain p

285 Bs) worn on lapels and wrists from 10 female nail technicians in the Boston area in 2016-17.

286 tively little is known about the exposure of nail technicians to semivolatile organic compounds (SVOC

287 ovative, magnesium-containing intramedullary nail that facilitates femur fracture repair in rats with

288 tabolites was higher in urine than in finger nails; the opposite was observed for the primary metabol

289 ith a detectable mutation, PC manifests with nail thickening and plantar keratoderma before school ag

290 as used to image D2O, PG-d8/DMSO-d6, and the nail through the O-D, -CD2, and -CH2 bond stretching Ram

291 rsion of epithelial cells in skin, hair, and nails to keratin.

292 emia (65%), asthenia (55%), dry mouth (45%), nail toxicity (35%), constipation (34%), decreased appet

293 Total excision of the nail unit followed by a full-thickness skin graft is a s

294 ion treated by wide surgical excision of the nail unit followed by full-thickness skin graft reconstr

295 ding strong evidence that this region of the nail unit is initially targeted in PC.

296 has shown that wide surgical excision of the nail unit was associated with a low rate of recurrence.

297 efficiency of wide surgical excision of the nail unit with full-thickness skin graft reconstruction

298 coated wires were selectively insulated with nail varnish, electrophoretic paint, or fast-setting epo

299 d in urine (97% DF) and identified in finger nails, while no DPHP metabolites were detected in vivo.

300 richophyton rubrum infection of the skin and nails without significant visceral involvement.