ライフサイエンスコーパス: naked mole rat

1 fish, insects), and in specialized habitats (naked mole rats).

2 V12 overriding anti-cancer mechanisms of the naked mole rat.

3 ancer resistance mechanism identified in the naked mole rat.

4 iking considering the small body mass of the naked mole rat.

5 es to the remarkable tumor resistance of the naked mole-rat.

6 e organization of somatosensory areas in the naked mole-rat.

7 monly mutated tumor suppressor, TP53, in the naked mole-rat.

8 , thrips, and beetles), snapping shrimp, and naked mole rats.

9 ns range from 4 years in mice to 32 years in naked mole rats.

10 to eusociality and the unusual physiology of naked mole-rats.

11 n function in outer hair cells isolated from naked mole-rats.

12 ythms differed in liver tissue from mice and naked mole-rats.

13 se is known to occur in species ranging from naked mole rats [1] to owls [2], chimpanzees are the mos

14 he longevity of the longest-lived rodent-the naked mole-rat(1,2).

15 We explore this in the naked mole-rat, a species with the most rigidly organize

16 nce the performance of a recently introduced naked mole-rat algorithm (NMRA), by local optima avoidan

17 Naked mole-rats also were completely lacking in cutaneou

18 Recent studies in naked mole rat and long-lived sea urchins showed that th

19 en cancer-prone mice and almost cancer-proof naked mole rats and blind mole rats.

20 adds to a growing list of adaptations in the naked mole-rat and provides a plausible proximate mechan

21 chronized, these were highly synchronized in naked mole-rats and likely linked to their use of feedin

22 oach and examined Nrf2-signaling activity in naked mole-rats and nine other rodent species with varyi

23 rs interested in the genome and genes of the naked mole rat, and also to facilitate further studies o

24 aps and genome assemblies of the guinea pig, naked mole-rat, and human.

25 into the neurobiology of social hierarchy in naked mole-rats, and add to a growing body of work that

26 ristic, but several mammals, such as whales, naked mole-rats, and humans, have notably less hair.

27 environments, such as those seen in turtles, naked mole-rats, and several other animals(1).

28 usion is consistent with the hypothesis that naked mole rats are neotenous, with retention of juvenil

29 Naked mole rats are the longest-living rodents, whose ne

30 Naked mole-rats are adapted to living in a low-oxygen an

31 Senescent cells in naked mole-rats are eliminated by apoptosis.

32 Naked mole-rats are eusocial rodents that live in large

33 Naked mole-rats are highly vocal, eusocial, subterranean

34 ual features of the cutaneous innervation in naked mole-rats are presumably adaptations to their subt

35 African naked mole-rats are subterranean rodents that have a rob

36 e of Gompertz's law 'uniquely identifies the naked mole-rat as a non-aging mammal'.

37 rences from the brain of the closely related naked mole-rat as well as from epigeic mammals (rat), wi

38 t acid pain, which would be advantageous for naked mole-rats as they normally live under chronically

39 uding mouse, guinea pig, blind mole-rat, and naked mole-rat, as well as humans.

40 Here we cloned naked mole-rat ASIC3 (nmrASIC3) and used a cell-surface

41 al tissues (blood, spleen) and thymus of the naked mole-rat at different ages by TCR repertoire profi

42 observed in long-lived species including the naked mole-rat, bats, and the bowhead whale, but these a

43 In sharp contrast, in the naked mole-rat both Per1 and Per2, as well as Bmal1, pea

44 hippocampal and olfactory structures of the naked mole rat brain.

45 We propose that excessive Ca(2+) influx into naked mole-rat brain is buffered by physical storage in

46 however, hypoxia-mediated Ca(2+) influx into naked mole-rat brain is markedly reduced relative to mic

47 This is important because naked mole-rat brain is robustly tolerant against in vit

48 Specifically, and relative to mouse brain, naked mole-rat brain mitochondria are larger and have hi

49 We report that naked mole-rat brain mitochondria buffer >2-fold more ex

50 We hypothesized that naked mole-rat brain mitochondria have an enhanced capac

51 The ability of naked mole-rat brain mitochondria to safely retain large

52 The unique ultrastructure of naked mole-rat brain mitochondria, as a large physical s

53 We show that in hypoxic naked mole-rat brain, oxidative capacity and mitochondri

54 olic Ca(2+) are retarded in hypoxia-tolerant naked mole-rat brain.

55 te to the hypoxia and ischaemia-tolerance of naked mole-rat brain.

56 idative phosphorylation is >2-fold higher in naked mole-rat brain.

57 is and neuronal migration are not unusual in naked mole rat brains.

58 the longevity mechanism that evolved in the naked mole-rat can be exported to other species, and ope

59 -2/Vdelta1-4 NK-like effector T cells in the naked mole-rat can contribute to tumor immunosurveillanc

60 HMW-HA triggers hypersensitivity of naked mole rat cells to contact inhibition, which is ass

61 Furthermore, the naked mole-rat cells are more sensitive to HA signalling

62 erexpressing the HA-degrading enzyme, HYAL2, naked mole-rat cells become susceptible to malignant tra

63 In summary, our results show that naked mole-rat cells produce fewer aberrant proteins, su

64 nduce robust anchorage-independent growth in naked mole-rat cells, while it readily transforms mouse

65 tion of mouse fibroblasts fails to transform naked mole-rat cells.

66 d historical lifespan data on more than 3200 naked mole-rats, collected over a total observation peri

67 Multi-year observations of large naked mole-rat colonies did not detect a single incidenc

68 The discovery of a disperser morph in naked mole-rat colonies has revealed the first possible

69 ochlear innervation in mature and developing naked mole rats compared to mice (Mus musculus), gerbils

70 othesis that the more stable proteome of the naked mole-rat contributes to its longevity.

71 t, pALT(INK4a/b) of the INK4a/b locus in the naked mole rat, contributes to the increased resistance

72 enous Ca(2+) and examined Ca(2+) handling in naked mole-rat cortical tissue.

73 with the diminished function of KCC2, adult naked mole-rats demonstrate a reduced efficacy of inhibi

74 Naked mole-rats, despite having functional ASICs, are in

75 Behaviorally, naked mole-rats did not avoid fumes from moderately high

76 x2 reversibly inhibits ASIC-like currents in naked mole-rat dorsal root ganglia neurons.

77 We found that the p53 protein in naked mole-rat embryonic fibroblasts (NEFs) exhibits a h

78 Finally, somatosensory cortex in naked mole-rats encompasses virtually all of the neocort

79 sites at which the level of CRF1 binding in naked mole-rats exceeds that in Cape mole-rats include t

80 thout pharmacological intervention, in adult naked mole-rats exposed to a simulated hyperthermic surf

81 In cell culture, naked mole-rat fibroblasts arrest at a much lower densit

82 Here we show that naked mole-rat fibroblasts display hypersensitivity to c

83 We report that naked mole-rat fibroblasts have significantly increased

84 We found that naked mole-rat fibroblasts secrete extremely high-molecu

85 component of extracellular matrix, protects naked mole rats from cancer and reduces cancer incidence

86 developed a freely available web portal, the Naked Mole Rat Genome Resource, featuring the data and r

87 Analysis of the naked mole-rat genome revealed, uniquely among mammals,

88 Using our own TCR annotation in the naked mole-rat genome, we report that the gammadelta TCR

89 r transcriptomes of the eusocial mammal, the naked mole-rat H. glaber, with orthologous A. cephalotes

90 ly cutaneous saphenous and sural nerves, the naked mole-rat had the lowest C:A-fiber ratio ( approxim

91 In contrast to the furred species, naked mole-rats had a paucity of Abeta-fiber Merkel endi

92 In contrast, the hairless skin of the naked mole-rats had an exceptional abundance of presumpt

93 However, naked mole-rats had very few VP-ir cells in the bed nucl

94 We speculate that naked mole rats have evolved a higher concentration of H

95 In addition to its longevity, naked mole-rats have an extraordinary resistance to canc

96 Although naked mole-rats have been reported to lack natural kille

97 Naked mole-rat hearts show reduced succinate levels duri

98 The naked mole-rat Heterocephalus glaber is a eusocial mamma

99 The naked mole rat (Heterocephalus glaber) displays exceptio

100 The naked mole rat (Heterocephalus glaber) is a long-lived a

101 The naked mole rat (Heterocephalus glaber) is an exceptional

102 Compared to many other rodent species, naked mole rats (Heterocephalus glaber) have elevated au

103 system of two African mole-rat species, the naked mole-rat (Heterocephalus glaber) and the Ansell's

104 The naked mole-rat (Heterocephalus glaber) contains abundant

105 ently showed that the saphenous nerve of the naked mole-rat (Heterocephalus glaber) has a C-fiber def

106 s natural habitat, the strictly subterranean naked mole-rat (Heterocephalus glaber) has lived in a li

107 The strictly subterranean naked mole-rat (Heterocephalus glaber) has markedly redu

108 The naked mole-rat (Heterocephalus glaber) is a long-lived r

109 The naked mole-rat (Heterocephalus glaber) is a subterranean

110 The naked mole-rat (Heterocephalus glaber) is unusual in num

111 parison of the guinea pig (Cavia porcellus), naked mole-rat (Heterocephalus glaber), and human.

112 ar, a brain atlas was available only for the naked mole-rat (Heterocephalus glaber).

113 erformed a Kaplan-Meier survival analysis of naked mole-rats (Heterocephalus glaber) and concluded th

114 Naked mole-rats (Heterocephalus glaber) have a large cor

115 Naked mole-rats (Heterocephalus glaber) have numerous an

116 Naked mole-rats (Heterocephalus glaber) live in groups t

117 some studies of social mole rats (including naked mole rats, Heterocephalus glaber, and Damaraland m

118 generated a transgenic mouse overexpressing naked mole-rat hyaluronic acid synthase 2 gene (nmrHas2)

119 African mole rat, Heterocephalus glaber, the naked mole rat in which cells display hypersensitivity t

120 2 binding, the sites with a greater level in naked mole-rats include the basolateral amygdaloid nucle

121 metabolic and genetic adaptations unique to naked mole-rats including elevated glycogen, thus enabli

122 Tumor resistance in the naked mole rat is mediated by the extracellular matrix c

123 as fish and amphibians, suggesting that the naked mole-rat is a powerful model for exploring the mec

124 The naked mole-rat is a subterranean rodent, approximately t

125 In contrast, early contact inhibition in naked mole-rat is associated with the induction of p16(I

126 hat the retinogeniculocortical system in the naked mole-rat is considerably smaller than that of rode

127 ontribution of the LG to brain volume in the naked mole-rat is less than a third of that of the rat.

128 report that 28S ribosomal RNA (rRNA) of the naked mole-rat is processed into two smaller fragments o

129 The naked mole-rat is the longest living rodent with a maxim

130 s C-fiber deficit in the cutaneous nerves of naked mole-rats is unlikely to be due primarily to lack

131 The preternaturally long-lived naked mole-rat, like other long-lived species and experi

132 Naked mole-rats live in large eusocial colonies that are

133 Naked mole-rats live in large, subterranean colonies whe

134 as lower, while that of mTORC2 was higher in naked mole-rat livers compared to mice, unlike that of m

135 ppress neuronal activity, we studied whether naked mole-rats might demonstrate energy savings in GABA

136 Naked mole rat (MR) Heterocephalus glaber is a rodent mo

137 , data from the longest-living rodent known, naked mole-rats [MRs; mass 35 g; maximum lifespan (MLSP)

138 The subterranean-dwelling naked mole-rat (NM-R; Heterocephalus glaber) exhibits pr

139 In contrast, the highly abundant PPGs of the naked mole rat (NMR) exhibited substantial deviation fro

140 The naked mole rat (NMR), a long-lived and cancer-resistant

141 The naked mole rat (NMR), Heterocephalus glaber, is known as

142 The Naked Mole Rat (NMR), Heterocephalus glaber, provides an

143 The naked mole rat (NMR), Heterocephalus glaber, the longest

144 tly demonstrated by us and Liang et al. that naked mole-rat (NMR) cells are more resistant to SV40LT

145 In naked mole-rat (NMR) colonies, breeding is monopolized b

146 The naked mole-rat (NMR) is an exceptionally long-lived rode

147 In the long-lived naked mole-rat (NMR), the entire process of oogenesis oc

148 Naked mole-rat (NMR), the longest-living rodent, produce

149 l role of HA in the cancer resistance of the naked mole-rat (NMR), we undertook to explore the struct

150 Naked mole rats (NMRs) are currently one of the most pop

151 Naked mole rats (NMRs) are the longest-lived rodents yet

152 Naked mole rats (NMRs) live in sizable colonies where br

153 e mitochondria of various tissues from mice, naked mole rats (NMRs), and bats possess two mechanistic

154 Naked mole-rats (NMRs) (Heterocephalus glaber) are long-

155 Naked mole-rats (NMRs) are best known for their extreme

156 mined the brains of breeding and subordinate naked mole-rats of both sexes, including several regions

157 VP in the brains of subordinate and breeding naked mole-rats of both sexes.

158 When overexpressed in naked mole rat or human cells, pALT(INK4a/b) has stronge

159 mouse and human p53, a larger proportion of naked mole-rat p53 protein is constitutively localized i

160 We determined that the long half-life of the naked mole-rat p53 protein reflects protein-extrinsic re

161 d basal nuclear localization of p53 in NEFs, naked mole-rat p53 retains its canonical tumor suppressi

162 at major cortical remodeling has occurred in naked mole-rats, paralleling the anatomical and behavior

163 ithms: Prairie Dog, INFO, Fission Fusion and Naked mole-rat (PIFN) algorithm.

164 For subterranean rodents such as the naked mole-rat, proposed phenotypic adaptations include

165 diverse mammalian species (including mouse, naked mole rat, rabbit, marmoset, cat, sheep, horse, and

166 The excised fragment is unique to the naked mole-rat rRNA and does not show homology to other

167 we identify a mechanism responsible for the naked mole rat's cancer resistance.

168 may have contributed to the evolution of the naked mole rat's extraordinary traits, including in regi

169 The African naked mole-rat's (Heterocephalus glaber) social and subt

170 ion of the p53 protein may contribute to the naked mole-rat's remarkable resistance to cancer.

171 Overall, we conclude that naked mole rats show an extremely protracted period of b

172 In addition to their longevity, naked mole rats show an unusual resistance to cancer.

173 Developmentally, naked mole rats showed reduced and prolonged postnatal r

174 ery high concentration of acetic acid (50%), naked mole-rats showed significant avoidance behavior an

175 ies had low iodide levels in the thyroid and naked mole-rats showed signs of thyroid gland hyperplasi

176 We investigated naked mole-rat somatosensory cortex to determine how bra

177 During anoxia, the naked mole-rat switches to anaerobic metabolism fueled b

178 ) decreases Deltapsi(m) is ~4-fold higher in naked mole-rat than mouse brain.

179 Here, we show that, in the naked mole rat, the INK4a/b locus encodes an additional

180 it crabs, the subterranean tunnel systems of naked mole rats, the intricately decorated bowers of bow

181 traits, and whether these are unique to the naked mole-rat, the mole-rat clade, or are also present

182 The exception is the naked mole-rat, the only known vertebrate to show physio

183 dy, we performed optic nerve injury in adult naked mole-rats, the longest living rodent, with a maxim

184 K4a/b) is present in both cultured cells and naked mole rat tissues but is absent in human and mouse

185 is consistent with exceptional endurance of naked mole rat tissues to various genotoxic stresses.

186 Fructose-driven glycolytic respiration in naked mole-rat tissues avoids feedback inhibition of gly

187 -molecular-mass HA accumulates abundantly in naked mole-rat tissues owing to the decreased activity o

188 mers may reflect a further adaptation of the naked mole-rat to living in an environment with high-car

189 Under experimental conditions, naked mole-rats tolerate hours of extreme hypoxia and su

190 both the thoracic and cervical thymus of the naked mole-rat until adult life.

191 eceptor binding densities in female and male naked mole-rats varying in breeding status.

192 tabolomics and RNAseq of cardiac tissue from naked mole-rats was compared to other African mole-rat g

193 body hair follicles, and intervening skin in naked mole-rats was compared with that in rats and a fur

194 rences in other species, its distribution in naked mole-rats was of interest.

195 subordinates from reproducing (for example, naked mole-rats, wasps and ants).

196 isms underlying the cancer resistance of the naked mole-rat, we investigated the regulation and funct

197 hole-colony behavioral monitoring of captive naked mole-rats, we found a durable nest, characterized

198 ses revealed that the body hair follicles in naked mole-rats were exceptionally large and well innerv

199 African naked mole-rats were likely the first mammals to evolve

200 sms responsible for the cancer resistance of naked mole-rats were unknown.

201 eight African rodent species related to the naked mole-rat with the painful substances capsaicin, ac