ライフサイエンスコーパス: nanogel

1 (Fc) embedded in crosslinked polymer network nanogel.

2 mprinting of this peptide epitope in the MIP nanogel.

3 f the mass of accessible thiol groups in the nanogel.

4 Electron microscopy confirmed a shell of nanogel.

5 fluorescence quenching of the coumarin-based nanogels.

6 used to verify iron chelating capability of nanogels.

7 colloidal solutions made by PNIPAm and PAAc nanogels.

8 able linkages into the network of micro- and nanogels.

9 gradable and biocompatible polypeptide-based nanogels.

10 es, to produce purely flow-induced permanent nanogels.

11 he synthesis of cross-linked (bio)degradable nanogels.

12 es may offer opportunities for designing new nanogels.

13 ctionalities at the core or the shell of the nanogels.

14 s to reversibly immobilize the corresponding nanogels.

15 ively, revealed high biocompatibility of the nanogels.

16 morphology, but it reduced surface charge of nanogels.

17 ticle size about 170nm for the double walled nanogels.

18 ty of guest molecules within these polymeric nanogels.

19 to improve the gastrointestinal stability of nanogels.

20 r assessing the penetration potential of the nanogels.

21 yptus oil coated PLGA-chitosan double walled nanogels.

22 ne demonstrated high cytocompatibilty of the nanogels.

23 rs with nanogel-modified fillers and/or free nanogel additives at 15 wt% in the resin phase.

24 Overall, modest amounts of free nanogel additives in the resin phase can be effectively

25 were significantly reduced for systems with nanogel additives into the resin.

26 Nanogel additives were chemically attached to the filler

27 c virus challenge after immunization with PC nanogel-adjuvanted pH1N1 vaccine.

28 ever, we observed a remarkable impact of the nanogel: After intravenous injection, a spatially contro

29 Nonetheless, the stability of nanogels against aggregation in gastrointestinal tract r

30 ies or domains have been incorporated in the nanogels, allowing them to spontaneously regulate their

31 moieties or domains were incorporated in the nanogels, allowing them to spontaneously regulate their

32 The nanogels also exhibited high thermal stability as analyz

33 notubes, liposomes, polymers, dendrimers and nanogels, among others, can be nanoengineeried for contr

34 Nanogels and nanogel networks were characterized by mult

35 the stability of encapsulation in polymeric nanogels and other related amphiphilic nanoassemblies.

36 Nanogels, approximately 70 nm in diameter and synthesize

37 These nanogels are based on biocompatible polyglycerols and fu

38 Concentrated solutions of nanogels are considered and we review the recent results

39 Specifically, smart nanogels are interesting because of their ability to res

40 Nanogels are nanosized crosslinked polymer networks capa

41 low density lipoprotein (LDL)/polysaccharide nanogels are newly explored as oral delivery systems wit

42 Additionally, these nanogels are nondenaturing and have been demonstrated to

43 Our findings suggest that multifunctional nanogels are promising drug delivery carriers for improv

44 Despite their obvious usefulness, nanogels are still not a commonplace occurrence in clini

45 We also observed that using PC nanogel as a vaccine adjuvant had a dose-sparing effect

46 cy of poly-gamma-glutamic acid/chitosan (PC) nanogel as an adjuvant for the influenza vaccine.

47 ential of squaric ester-based, pH-degradable nanogels as a promising platform to permit intravenous a

48 ight the distinct and unique capabilities of nanogels as carrier systems for the delivery of an array

49 for synthesizing and crosslinking micro- and nanogels, as well as their development for incorporation

50 The resulting single enzyme nanogel (ATRP-SEG) is uniform in size fairly.

51 In this work, a novel enzyme nanogel based on atom transfer radical polymerization (A

52 Our results demonstrate efficacy of nanogel-based lupus therapy and implicate a mechanism by

53 eristics were copolymerized into particulate nanogels bearing internal and external polymerizable fun

54 the release of encapsulated agents, and the nanogels biodegraded into water-soluble polymers in the

55 ng the phase behavior and flow properties of nanogels both in three and two dimensions, in the light

56 we designed a long-circulating bioscavenger nanogel by coating equine serum-derived BChE with a zwit

57 employed as particulate additives to prepare nanogel@calcite nanocomposite crystals.

58 Importantly, the nanogel can effectively reduce cellular ferritin express

59 The MNPs within the nanogel can elevate H(2) O(2) levels in cancer cells und

60 strep-tag, and the resulting functionalized nanogels can be delivered into living cells after comple

61 We show that the nanogels can be loaded with proteins bearing either biot

62 e studies demonstrate that polypeptide-based nanogels can serve as novel nanocarriers for encapsulati

63 The biodegradation of nanogels can trigger the release of encapsulated molecul

64 An automated nanogel capillary electrophoresis system is developed th

65 trations of GCE (1% and 2%) onto carrageenan nanogels (CAR NGs) to compare their antibacterial and an

66 pplying a pH-degradable, squaric ester-based nanogel carrier system.

67 lizable platform constituting of DNA-protein nanogel carriers cross-linked through streptavidin-bioti

68 ells were engineered with surface-conjugated nanogels carrying an IL-15 superagonist, but it was ulti

69 y using poly(N-isopropylacrylamide) (PNIPAM) nanogel colloidal particles that self-assemble into crys

70 Metal nanogels combine a large surface area, a high structural

71 In this context, a hybrid refers to nanogels combined with different polymers and/or with na

72 Nanogels composed of dimyristoyl-sn-glycero-2-phosphocho

73 Nanogels composed of dimyristoyl-sn-glycero-2-phosphocho

74 nthesized and evaluated oral applications of nanogel conjugates of a protected Gemcitabine, the drug

75 have demonstrated a potential of therapeutic nanogel conjugates with the activated and stabilized Gem

76 hiphilic polyvinyl alcohol and dextrin-based nanogel conjugates with the phosphorylated 5-FU nucleosi

77 h orally treated Gemcitabine- or Floxuridine-nanogel conjugates.

78 dulus in the dry state for networks based on nanogels containing a hydrophobic dimethacrylate and hyd

79 Furthermore, nanogels containing both 17-AAG and doxorubicin exhibite

80 e can be effectively combined with a limited nanogel content filler-resin interphase to lower volumet

81 A significantly greater nanogel content was required to generate the same magnit

82 HEMA) homopolymer or in networks formed from nanogels copolymerized with HEMA.

83 The optimized MIP nanogel could bind the epitope and cognate protein with

84 These nanogels could be used for targeted drug delivery scaffo

85 pared to free antibiotics and non-responsive nanogel counterparts.

86 Stable biodegradable nanogels cross-linked with disulfide linkages were prepa

87 Compared to original uncrosslinked nanogels, crosslinking did not change particle size, pol

88 f two carbonyl fragments and concomitant NIR-nanogel degradation to facilitate cargo release.

89 The mobilities in buffer and nanogel demonstrated that 20-30% nanogel supports sievin

90 The nanogels demonstrated extended stability in aqueous medi

91 A new class of nanogel demonstrates modular biodistribution and affinit

92 The nanogel disperses in both aqueous and hydrocarbon phases

93 n addition, we evaluated the effects of free nanogel dispersion into the resin matrix, combined or no

94 Nanogel dispersions were stable at high concentrations i

95 Dual drug-loaded nanogels displayed potent cytotoxicity in a breast cance

96 viability, uptake, and physical stability of nanogel-DNA complexes were evaluated under physiological

97 This nanogel does not recognize target cells or disrupt endos

98 Here, we designed and tested a novel nanogel drug delivery vehicle for the immunosuppressant

99 Surprisingly, these nanogel-drug conjugates were relatively stable in gastri

100 We demonstrated that the RBC-nanogels effectively neutralized MRSA-associated toxins

101 The nanogel electrophoresis generates separation efficiencie

102 Nanogel electrophoresis is an inexpensive, rapid, and si

103 ose residues were transferred, the capillary nanogel electrophoresis system was used to determine the

104 Additionally, capillary nanogel electrophoresis was adapted to transfer galactos

105 As a result, the delivery efficiency of the nanogel-encapsulated nanoprobes to tumors was dramatical

106 We developed an injectable elastin nanogels (ENG) for efficient drug delivery system to ove

107 incorporation of Decursin (DEC) into elastin nanogels (ENG) for prostate cancer therapy.

108 Phospholipid nanogels enhance the stability and performance of the ex

109 of double walled PLGA-chitosan biodegradable nanogel entrapped with 5-fluororuacil (5-FU) coated with

110 e of applications, well beyond the polymeric nanogel examples studied here.

111 Both nanogels exhibited K(d) <10 pM for their respective targ

112 lamino) ethyl methacrylate based copolymeric nanogels exhibited pH responsive behavior that was optim

113 NIR-nanogels feature a photolabile cyanine cross-linker (Cy7

114 Importantly, imidazoquinoline-ligated nanogels focused the in vivo immune activation on the dr

115 We used a cationic nanogel for the nasal vaccine delivery system and target

116 such patients, oxidation-induced degradable nanogels for iron chelation were rationally designed by

117 loited this undesirable trait to develop NIR-nanogels for NIR light-mediated cargo delivery.

118 Several fluorescent molecularly imprinted nanogels for the detection of the anticancer drug suniti

119 tential for the utility of the biodegradable nanogels for treating skin cancers.

120 Cationic nanogels formed monodisperse complexes with oligonucleot

121 the precise and efficient therapeutic use of nanogel formulations.

122 r the precise and efficacious therapeutic of nanogel formulations.

123 d on the target loading of 10mug/mg for both nanogels found to be 84% and 86% for the nHG-SW and nHP-

124 allenges that need to be overcome to advance nanogels further in the field of biomedical applications

125 The nanogel had high affinity to native mercury species pres

126 The nanogels had a uniformly cross-linked network, which can

127 Nanogels had enhanced biodistribution to organs and asso

128 The nano spray dried LDL/CMC/EDC nanogels had relatively poor surface structure with aggl

129 This thiolated amphiphilic polymeric nanogel has significant potential to remove environmenta

130 Typical nanogels have an average radius of approximately 230 nm,

131 Biodegradable polypeptide-based nanogels have been developed from amphiphilic block copo

132 Nanogels have been identified as outstanding nanocarrier

133 Nanogels have been identified as outstanding nanocarrier

134 The resulting functionalized nanogels have dimensions on the order of 100 nm, contain

135 Nanogels have emerged as a versatile hydrophilic platfor

136 DCs that internalized nanogels helped mediate immunosuppression, as they had r

137 e review the recent literature on micro- and nanogels, i.e. cross-linked polymer networks swollen in

138 ning 100 mM NaCl with a thermally reversible nanogel in a 10 mum inner diameter fused silica capillar

139 view is to look at the results on micro- and nanogels in a more quantitative way that allow us to exp

140 rategy to enhance the stability of LDL-based nanogels in digestive conditions.

141 sed nowadays on using multifunctional hybrid nanogels in nanomedicine, not only as drug carriers but

142 d sustained release profile from crosslinked nanogels in simulated gastrointestinal fluids.

143 cessful applications of innovative polymeric nanogels in the form of conjugates with activated nucleo

144 Treatment with MPA-loaded nanogels increased the median survival time (MST) of lup

145 ble TLR7/8 agonist, imidazoquinoline-ligated nanogels induce superior antibody and T-cell responses a

146 d to improve the penetration efficacy of the nanogel into stratum corneum.

147 r-based photosensitizer (TIr3)-encapsulating nanogels (IrNG) through the hyperoxidation of resulting

148 Together, these results suggest that PC nanogel is a promising vaccine adjuvant that could broad

149 A supramolecular nanogel is now used as an artificial neutrophil by enzym

150 The NCPD nanogel is stable in physiological environments while in

151 In this report, a phospholipid nanogel is used for the first time for capillary gel ele

152 A thermally reversible nanogel is used in capillary electrophoresis to create d

153 ifferent synthetic routes on the softness of nanogels is discussed.

154 nges that hinder the clinical translation of nanogels is the low efficiency of drug delivery to the t

155 nges that hinder the clinical translation of nanogels is the low efficiency of drug transmitting to t

156 rm (narrow size distribution), and exhibited nanogels-like behavior.

157 ion enhancers coated biodegradable polymeric nanogels loaded with cytotoxic drugs applied via the top

158 d and drug-free controls, treatment with NIR-nanogels loaded with paclitaxel (a potent cytotoxic agen

159 obtained under standard conditions with the nanogel matrix at a 98.5% accuracy of base-calling (for

160 iminary DNA sequencing results show that the nanogel matrixes are capable of delivering significantly

161 The properties and performance of nanogel matrixes are compared here to those of a linear

162 We further investigated the use of the nanogel matrixes in a high-throughput microfabricated DN

163 Moreover, nanogel matrixes require 30% less polymer per unit volum

164 eaction zone maintained at 37 degrees C, the nanogel medium resolves the substrate from contaminants

165 ing polymer NPs, small-molecule organic NPs, nanogels, micelles, vesicles, and biomaterial-based NPs)

166 gels, broadly classified by particle size as nanogels, microgels, aerogels, and macrogels.

167 in the form of molecularly imprinted polymer nanogels (MIP-NGs).

168 Nanogels modified with a colon cancer-targeting oligopep

169 Nanogels modified with an endosome disrupting peptide fa

170 When the nanogel-modified filler surface treatment and resin-disp

171 /TEGDMA resin blend with 60 wt% fillers with nanogel-modified fillers and/or free nanogel additives a

172 Nanogel-modified fillers significantly reduced the polym

173 into the resin matrix, combined or not with nanogel-modified fillers.

174 ion in flexural strength associated with the nanogel-modified interphase was observed.

175 approach allowed the detection of changes in nanogel molar mass and topology as a function of both te

176 Soft molecularly imprinted nanogels (nanoMIPs), selective for human transferrin (HT

177 These nanogel nanosecond phenomena may be useful in the design

178 Nanogels and nanogel networks were characterized by multiangle laser

179 Both nanogel networks were characterized in terms of particle

180 rwise rapidly released from common PEG-based nanogel networks.

181 using nanocapsules (NC), liposomes (LP), and nanogels (NG).

182 Nanogels (NGs) based on polyethylene glycol (PEG) macrom

183 Peptide-based nanogels (NGs) represent a cutting-edge class of nanosca

184 p to monitor the complexation of aqueous MIP nanogels (NGs) with model cancer-related antigens.

185 ional multimodal polypeptide-based polymeric nanogels (NGs).

186 terial and antibiofilm effects with unloaded nanogels (NGs).

187 Nanogels offer hope for precise drug delivery, while add

188 In the last few decades, hybrid nanogels or composites have been developed to overcome t

189 s self-cross-link at low concentrations into nanogels or form macroscopic hydrogel networks at higher

190 A novel stabilized aggregated nanogel particle (SANP) drug delivery system was prepare

191 T-jump from 30 to 35 degrees C actuates the nanogel particle shrinkage; the resulting increased diff

192 Aggregated nanogel particles (ANPs) were generated by aggregating G

193 In this review, we will describe nanogels, particularly in the form of composites or hybr

194 A universal nanogel patterning scheme is developed that does not req

195 ons are loaded into the capillary during the nanogel patterning step to surround the enzyme zone.

196 tegrating the synthesis of protein-imprinted nanogels ("plastic antibodies") with a highly sensitive

197 drogel which permits the individual embedded nanogel PNIPAM particles to coherently and synchronously

198 ovalently immobilized in a thermally tunable nanogel positioned in the thermally controlled region of

199 Here, we developed a phosphate polymer nanogel (PPN) to selectively recover REEs from low REE c

200 controlled degradability indicated that the nanogels prepared by ATRP were superior to their corresp

201 inities reported for solid-phase-synthesized nanogels prepared using low-surface-area glass-bead supp

202 The nanogels prepared with the one-pot method showed favorab

203 We reported an erythrocyte membrane-coated nanogel (RBC-nanogel) system with combinatorial antiviru

204 , the alendronate-loaded squaric ester-based nanogels represent an attractive approach for nanotherap

205 of layer-by-layer nanoparticles, dendrimers, nanogels, self-assembled nanoparticles, nanocomplexes, a

206 or ultrahigh molar mass LPA to the optimized nanogel sequencing matrix further improves read length a

207 signed and robustly fabricated pH-responsive nanogels serving as versatile immunodrug nanocarriers fo

208 probes are delivered into target cells, the nanogel shells are degraded in acidic endosomes, where a

209 intracellular reducing environment, the RBC-nanogels showed an accelerated drug release profile, whi

210 PC nanogel significantly enhanced antigen-specific cross-pr

211 ed with intracellular MRSA bacteria, the RBC-nanogels significantly inhibited bacterial growth compar

212 FA-decorated nanogels significantly suppressed the growth of intraper

213 ditionally, we confirmed the conservation of nanogel stimuli-responsivity through turbidity measureme

214 filler surface treatment and resin-dispersed nanogel strategies were combined, there was a stress red

215 We have developed sparsely cross-linked "nanogels", subcolloidal polymer structures composed of c

216 the internally cross-linked structure of the nanogels, substantially longer average read lengths are

217 buffer and nanogel demonstrated that 20-30% nanogel supports sieving of proteins ranging from 20 to

218 erosion was evident from both an increase in nanogel swelling and a decrease in scattering intensity

219 The nanogels synthesized in this study demonstrate potential

220 report the synthesis of a heteromultivalent nanogel system against Pseudomonas aeruginosa (P. aerugi

221 ults indicate the great potential of the RBC-nanogel system as a new and effective antimicrobial agen

222 an erythrocyte membrane-coated nanogel (RBC-nanogel) system with combinatorial antivirulence and res

223 iol-abundant (11.8 wt % S, as thiol) polymer nanogel that can remove environmentally relevant mercury

224 Herein, we report a multifunctional nanogel that can shield a single gold nanoparticle (AuNP

225 , we design a two-component photo-switchable nanogel that exhibits variable fluorescence lifetime upo

226 eparation is facilitated with self-assembled nanogels that also contain a single stationary zone of l

227 ed an approach to network formation based on nanogels that are dispersed in inert solvent and directl

228 erein we design a series of soft, deformable nanogels that are employed as particulate additives to p

229 the host-guest characteristics of polymeric nanogels that contains these acetal or ketal moieties as

230 synthesis and characterization of degradable nanogels that display bulk erosion under physiologic con

231 ave demonstrated the synthesis of degradable nanogels that erode under conditions and on time scales

232 Therefore, soft molecularly imprinted nanogels that obey to analyte-induced deformation stand

233 method for the preparation of biocompatible nanogels that provides the ability to encapsulate hydrop

234 veloped poly(acrylamide-co-methacrylic acid) nanogels that were modified in a modular manner with bio

235 esponse at the site of action, which imparts nanogels the ability to participate actively in the inte

236 agonist to 50-nm-sized degradable polymeric nanogels the potency of the agonist to activate TLR7/8 i

237 With nanogels, there is no need to covalently immobilize the

238 and polymers, redox-responsive micelles and nanogels, thermo- or magnetic-responsive nanoparticles (

239 re biocompatible MIPs in the form of soluble nanogels, these synthetic antibodies have found favor in

240 s to control the pH and thermal responses of nanogels, this work illustrates a new way to design soft

241 positively charged acid-degradable polymeric nanogel to facilitate decoration of DNase I into the NCl

242 perties of colloidal systems, from synthetic nanogels to biological macromolecules, from viruses to s

243 rational design and structural modulation of nanogels to overcome the barriers and challenges on the

244 rational design and structure modulation of nanogels to overcome the barriers and challenges on the

245 evealed a prevalent passive diffusion of the nanogels to the draining lymph node.

246 s, which significantly improved stability of nanogels under simulated gastrointestinal conditions.

247 Remarkably, such nanogels undergo a significant morphological change-from

248 lon cancer cells in vitro, while influencing nanogel uptake by fibroblasts and macrophages to a lesse

249 Here, we synthesized Pd nanogels using a conventional wet chemistry route, and a

250 ynthetic method for highly stable, polymeric nanogels using a simple intra/interchain cross-linking r

251 Intranasal immunization with the nanogel vaccine induced E7-specific CD4(+) and CD8(+) T

252 l immunization of nonhuman primates with the nanogel vaccine using a spray device that is also applic

253 e BALB/c and C57BL/6 mice, these 5-component nanogel vaccines demonstrated enhanced humoral and cell-

254 Polymeric nanogel vectors were developed for cellular gene and ant

255 RBC membrane was coated onto the nanogel via a membrane vesicle templated in situ gelatio

256 nd further reacted with thiol-functionalized nanogels via a free radical thiol-ene reaction.

257 surface modified biodegradable double walled nanogel was characterized for particle size, charge and

258 The number of biotin molecules in each nanogel was determined to be 142,000, and the formation

259 The nanogel was used for the analysis of proteins in human s

260 imidazoquinolines alone or conjugated to the nanogels was demonstrated by macrophages in vitro.

261 f fully hydrated networks formed solely from nanogels was shown to equal or exceed the modulus in the

262 ar microenvironment for curcumin embedded in nanogels was strengthened, which therefore enhanced enca

263 Then, the cationic nanogels were assessed for their ability to load and rel

264 The nanogels were characterised by a novel competitive fluor

265 the same magnitude stress reduction when the nanogels were dispersed only in the resin phase.

266 ity, stability, and swelling behavior of the nanogels were investigated by NMR, light scattering, tra

267 Nanogels were modified with up to 15 wt% peptide without

268 Further, OH-functionalized nanogels were prepared to demonstrate facile applicabili

269 Monodisperse nonionic and cationic nanogels were produced with controllable sizes ranging f

270 osslinked fluorescently doped polyacrylamide nanogels were subsequently produced by high-dilution pol

271 Drug-loaded nanogels were surface-functionalized with folic acid (FA

272 Erodible poly(N-isopropylmethacrylamide) nanogels were synthesized by copolymerization with N,O-(

273 Biodegradable, cationic nanogels were synthesized via a UV-initiated free radica

274 Nanogels were synthesized via inverse emulsion (water-in

275 ts either adsorbed to or encapsulated within nanogels, which were capable of noncovalent anchoring to

276 Smaller nanogels will show even faster volume phase transitions.

277 r a proof-of-concept for modifying synthetic nanogels with a combination of peptides that address bar

278 Cross-linked nanogels with a uniformly cross-linked network were prep

279 tion confirmed efficient 17-AAG release from nanogels with activity comparable to free 17-AAG.

280 2,000, and the formation of bioconjugates of nanogels with avidin was confirmed using optical fluores

281 With a further modification of these nanogels with BMAP-18 short chain peptides (GRFKRFRKKFKK

282 ion was utilized to synthesize biocompatible nanogels with controlled size, morphology, and compositi

283 Loading efficiency for both of the nanogels with NR was determined by spectrophotometry to

284 re hydrophilized affording fully hydrophilic nanogels with profound stability in human plasma but sti

285 ed through comparative analysis of polymeric nanogels with variable accessibility to disulfide bonds

286 Nanogels with varied characteristics were synthesized (i

287 1) vaccine was substantially increased by PC nanogel, with increased hemagglutination-inhibition tite

288 CD4-targeted nanogels yielded similar therapeutic results compared wi