ライフサイエンスコーパス: nascent

1 mechanisms controlling this diversity remain nascent.

2 seholds, the evidence base for SARS-CoV-2 is nascent.

3 nd even thrive, in urban landscapes is still nascent.

4 link between smoking and brain structure is nascent.

5 macromolecules, and design principles remain nascent.

6 ), HSCB and HSPA9 facilitate the transfer of nascent 2-iron, 2-sulfur clusters to recipient mitochond

7 1 (NCBP1) and 2 (NCBP2), associates with the nascent 5'cap of RNA polymerase II transcripts and impac

8 ogenously expressed R273H and R248W bound to nascent 5-ethynyl-2'-deoxyuridine-labeled replicating DN

9 onversely, poly(A) binding KPAF4 shields the nascent A-tail from uridylation and decay thereby protec

10 NMII, such as myosin filament formation and nascent adhesion assembly, but not those requiring stabl

11 butes to talin and vinculin recruitment into nascent adhesions.

12 sis for coordinate actin bundle formation at nascent adhesions.

13 Despite the field remaining nascent, AI-driven health interventions could lead to im

14 e of homologous chromosome pairing exists in nascent allopolyploids and serves as the first layer tha

15 omoeologous chromosomes was reported in many nascent allopolyploids.

16 sters the formation of a triplex between the nascent and fold-back template strands of the repeat.

17 phila wing imaginal disc in order to measure nascent and mature mRNA of genes downstream of the Wg an

18 genome wide by high-throughput sequencing of nascent and newly synthesized RNA.

19 ion of a new vascular connection between the nascent and parent root, which is crucial for establishi

20 of SNRNP70 reduces the localization of both nascent and polyadenylated lncRNA transcripts to chromat

21 iased methods to profile GxE genome-wide are nascent and, as we show, cannot accommodate general envi

22 s-parallel genetic architectures represent a nascent anti-repressor based transcriptional programming

23 e both clinically tested vaccines as well as nascent approaches and explore current challenges and po

24 acteristics of plant-based meat and pursuing nascent approaches through cellular agriculture methodol

25 be drugged, and lay the groundwork for this nascent area of research.

26 , while the use of inorganic hosts is a more nascent area of research.

27 A localization is mediated by ribosome-bound nascent ATI polypeptides that interact with ATI protein

28 p approach for the non-covalent synthesis of nascent axial organic heterostructures, which promises t

29 que opportunity to study the physiology of a nascent B(12) auxotroph.

30 r the proposed budding mechanism, where each nascent betaOMP forms a hybrid-barrel intermediate with

31 hrough the transcallosal pathway may prime a nascent binocular territory for subsequent experience-dr

32 antiangiogenic drugs targeting specifically nascent blood vessels with a mode-of-action complementar

33 rgo apoptosis, leading to massive pruning of nascent blood vessels.

34 tches near the bud neck and in the cortex of nascent buds.

35 The study recognizes that this is a nascent but very promising field; therefore, insights ar

36 Nascent C-terminal domain clusters at primed genomic loc

37 the catalytic activity of Integrator cleaves nascent capped piRNA precursors associated with promoter

38 aracterized by volatilization of over 60% of nascent carbon atoms and the oxidation of nitrogen atoms

39 one two years after CO(2) injection revealed nascent carbonate mineralization that was qualitatively

40 he major function of the Z-ring is to govern nascent cell pole morphogenesis by directing the spatiot

41 reatment, indicates they most likely reflect nascent cellulose microfibrils.

42 e segments, forms three channels occupied by nascent cellulose polymers.

43 oteins selectively involved in deposition of nascent CENP-A or in long-term transmission of chromatin

44 its translation termination by arresting the nascent chain (NC) in the ribosome exit tunnel.

45 binding protein C6orf203 (MTRES1) eject the nascent chain and peptidyl transfer RNA (tRNA), respecti

46 ctive electrostatic interactions between the nascent chain and the negatively charged ribosomal-RNA l

47 al sampling of translation-arrested ribosome nascent chain complexes is key to understand co-translat

48 Thus, nascent chain ejection times from the ribosome can vary

49 As nascent chain grows, emerging helical segments dock onto

50 he ribosome promotes RNH unfolding while the nascent chain is proximal to the ribosome, which may lim

51 served folding defect is highly dependent on nascent chain length as well as its attachment to the ri

52 rious large protein domains as a function of nascent chain length.

53 the R16 domain exerts a maximal force on the nascent chain of ~15 pN during cotranslational folding.

54 dification chemistry occurs already prior to nascent chain release as the ribosome exit tunnel provid

55 ipeptide motifs, positively charged upstream nascent chain residues, and cognate tRNA concentration.

56 nitiation factor eIF4E and by ribosome-bound nascent chain ribopuromycylation.

57 ar their C-terminus eject the fastest, while nascent chains enriched in positively charged residues t

58 slational folding efficiency by giving these nascent chains more time to fold.

59 ssembled ribosomes associated with misfolded nascent chains move into cytoplasmic compartments enrich

60 ding and unfolding pathways of RNase H (RNH) nascent chains stalled on the prokaryotic ribosome in vi

61 Stalled protein synthesis produces defective nascent chains that can harm cells.

62 ascent chains, and deliver the ubiquitylated nascent chains to the proteasome.

63 In response, cells degrade these nascent chains via a process called ribosome-associated

64 alled ribosomes, ubiquitylate their tethered nascent chains, and deliver the ubiquitylated nascent ch

65 Two-step enrichment of these glycosylated nascent chains, combined with shotgun proteomics, allows

66 bosomal subunits obstructed with tRNA-linked nascent chains, which are substrates of ribosome-associa

67 re-emptive targeting of ribosomes with short nascent chains.

68 de novo acetyls on H4 in vivo Proteomics of nascent chromatin and proximity ligation assays with new

69 The association of HAT1 with nascent chromatin may be functionally relevant, as HAT1

70 ironment at the intersection of parental and nascent chromatin.

71 linking between PRDM9-bound hotspots and the nascent chromosome axis through its component cohesin pR

72 Here, we have characterized the nascent conformation and dynamics of the prion-like doma

73 s a linactant, stabilizes the open neck of a nascent COPII bud.

74 adation of damaged D1 and its replacement by nascent D1 are at the heart of a PSII repair cycle, with

75 x coordinates D1 synthesis with the need for nascent D1 during both PSII biogenesis and PSII repair i

76 regation of sister chromatids to each of the nascent daughter cells.

77 evelop by retrograde extension, in which the nascent dendrite endings anchor to the presumptive nose

78 illustrate the tremendous potential of this nascent discipline are presented, and ongoing technical

79 MRE11-independent nucleolytic degradation of nascent DNA at stalled replication forks.

80 on and the BRCA pathway results in increased nascent DNA degradation and PARP inhibitor sensitivity.

81 noprecipitation of bromodeoxyuridine labeled nascent DNA followed by bisulfite sequencing (Repli-BS)

82 to events such as processive degradation of nascent DNA or spontaneous partitioning of primer-end to

83 s mediating inheritance of methyl marks onto nascent DNA over cycles of replication.

84 s encounter G-quadruplexes, EXO1 resects the nascent DNA proximal to these structures to facilitate f

85 to stalled forks and that in their absence, nascent DNA strands at unprotected forks are degraded by

86 -C (scsHi-C), which is based on labelling of nascent DNA with 4-thio-thymidine and nucleoside convers

87 lication forks, in complex with PCNA and the nascent DNA, where it regulates DNA synthesis.

88 letion also reduced global RNA synthesis and nascent DNA-associated RNA.

89 ficant differences in labeling efficiency of nascent DNA.

90 oplasmic cohesin that is loaded de novo onto nascent DNAs associated with forks, a process that would

91 extensively tracked, it is unclear how these nascent economies developed within different environment

92 , and Septin7 are required for maturation of nascent endothelial podosomes into matrix-degrading orga

93 ings underscore the progress made in China's nascent environmental movement.

94 deregulated mechanical coupling between the nascent epithelium and three-dimensional yolk.

95 vent expression of the tic by inhibiting the nascent excitation released by the tic generator.

96 ate that hyaluronan preferentially surrounds nascent excitatory synapses.

97 in accessibility (ATAC-seq) and differential nascent expression (Bru-Seq) of neural-specific genes.

98 ort of the ER required for the maturation of nascent FAs and protrusion orientation toward a chemoatt

99 It details the state of play of this nascent field and introduces three generalised hybridisa

100 The nascent field of bioelectronic medicine seeks to decode

101 ising areas for future investigations in the nascent field of circRNAs.

102 Initially, progress in the nascent field of synthetic biology was slow due to the a

103 laying an increasingly important role in the nascent field of three-dimensional (3D) bioprinting.

104 ll as highlighting future prospects for this nascent field.

105 omising findings and future horizons of this nascent field.

106 These findings demonstrate that nascent folding intermediates can play an important role

107 ing terminus of glycans in which a localized nascent free radical is generated upon collisional activ

108 tion is required for complete translation of nascent, functional receptor.

109 iplet-to-singlet intersystem crossing in the nascent geminate radical pair are crucial steps.

110 Nascent geographic atrophy (nGA) describes features on O

111 glycoforms representing those present in the nascent glycoproteins (prior to enzymatic modifications

112 We speculate that the nascent H2 helix may provide conformational flexibility

113 The sustained-release nascent-HBr enabled the chemoselective cleavages of acid

114 The generation of nascent-HBr from the slow hydrolysis of the dispersed ca

115 Apical protrusion formation of nascent HCs and planar polarity signaling are both impor

116 nd Roll by delaying apical protrusion of its nascent HCs but it does not determine HCs' ultimate posi

117 ase binding cassette protein ABCA1 initiates nascent high-density apolipoprotein (HDL) biogenesis by

118 223 is enriched in hemECs and in oligopotent nascent HSPCs.

119 The transport of nascent HSV particles from neuron cell bodies into axons

120 The present work exploits the nascent isocyclic ring as an anchor for directed assembl

121 targets MutSgamma only after it has bound to nascent joint molecules (JMs) in the context of synapsin

122 hurdle, result in repeat contractions in the nascent lagging strand.

123 icating that after bypass CMGs encounter the nascent lagging strands of the converging fork and then

124 ate (co-directional) resulted in gaps in the nascent leading strand, whereas lagging-strand template

125 NA helicase, and 2) on the damaged template, nascent leading-strand gaps were generated by replisome

126 hypothesized to arise due to the failure of nascent lineages to persist.

127 Yet, this nascent literature has shed light onto challenges and ga

128 k down as well as terminate transcription of nascent lncRNAs and mRNAs, Lee and Mendell (2020) and La

129 Measuring nascent macromolecular synthesis in vivo is key to under

130 Three-dimensional volumetric imaging of nascent macromolecule synthesis was performed in axolotl

131 Furthermore, nascent membrane protrusions selectively extended outwar

132 Here, this nascent method is applied to an archaeological site of p

133 ed in response to their interaction with the nascent mineral particles.

134 esults in smaller HLBs and the appearance of nascent, misprocessed histone mRNAs.

135 Intron splicing of a nascent mRNA transcript by spliceosome (SPL) is a hallma

136 tes XBP1s's ability to drive 12-h rhythms of nascent mRNA transcription at dawn and dusk, which are e

137 g of RNA polymerase and the lead ribosome on nascent mRNA, an interaction important for preventing pr

138 rowth is achieved by a mechanism integrating nascent mRNAs at the histone locus, which facilitates ph

139 f population doublings permitted analysis of nascent mutation accumulation.

140 its inhibition resulted in selective loss of nascent MYCN transcription.

141 during embryonic and fetal myogenesis and on nascent myofibers during muscle regeneration in vivo.

142 regulates the activity of Rho/Rac GTPases in nascent myotubes and effects changes in the actin cytosk

143 tor (FGF) signaling pathway were enriched in nascent myotubes in Drosophila embryos.

144 Nascent myotubes undergo a dramatic morphological transf

145 However, the nascent nature of the nutritional psychiatry field to da

146 elerated manifestation of atherosclerosis in nascent neointima after stenting, associated with advers

147 hich influences how activity develops within nascent neural networks.

148 rupting this process impacts the function of nascent neural networks.

149 cium alarm" signal rapidly propagates in the nascent neutrophil cluster in a contact-dependent manner

150 M2 to spindle microtubules that traverse the nascent nuclear envelope.

151 Here we report the discovery of a nascent obligate symbiosis in Howardula aoronymphium, a

152 By contrast, these activities are nascent or nonexistent for hHNPs.

153 ssively canalized from local interactions of nascent organs.

154 e transient zones prior to converging at the nascent outer adult niche in a dynamic settling process,

155 orporates dGTP opposite oxoA, suggesting the nascent oxoA:dGTP overcomes the geometric discrimination

156 equired for efficient Env incorporation into nascent particles and viral transmission in primary CD4(

157 Maintaining the fidelity of nascent peptide chain (NP) synthesis is essential for pr

158 inhibits protein synthesis by binding in the nascent peptide exit tunnel and trapping the release fac

159 towards synergistic binders that occupy the nascent peptide exit tunnel.

160 cis), or does it methylate this residue on a nascent peptide tethered to a T domain on another module

161 ide or in the proximity of the ribosome, the nascent peptide undergoes structural fluctuations on the

162 Nascent peptide-mediated anchoring of ribosome-mRNA tran

163 rovide evidence that ATI mRNA is anchored by nascent peptides and translated at the inclusion sites r

164 Some of these uORF-encoded nascent peptides enable responses to specific metabolite

165 alternative rescue factor B (ArfB) releases nascent peptides from ribosomes stalled on mRNAs truncat

166 dly inhibit the release of puromycin-labeled nascent peptides from ribosomes.

167 highlight several examples of conserved uORF nascent peptides that stall ribosomes to regulate gene e

168 odulate the ribosomal response to regulatory nascent peptides, determines the slow dissociation rate

169 Notably, class A PBPs could process this nascent peptidoglycan from a CbpD-sensitive to a CbpD-re

170 The complex cleaves nascent peptidoglycan internally to produce free oligome

171 ity imposed by this design also enhances the nascent peroxidase activity of the protein-heme complex.

172 Motile endolysosomes contact nascent phagosomes to promote phagocytosis, whereas endo

173 The dominant model holds that nascent plasma cells adapt to increased antibody synthes

174 ytoskeleton forms a diffusive barrier around nascent podosomes to promote their maturation.

175 Cps1B suggested processive elongation of the nascent polymer, whereas Cps1B-DeltaTPR appeared to work

176 As lipid II is polymerized, nascent polymers remain membrane-anchored at one end, an

177 ple in which the conformational state of the nascent polypeptide chain has been linked to PRF.

178 ribosomal slip site generates a force on the nascent polypeptide chain that scales with observed fram

179 the intrinsic dynamic properties of emerging nascent polypeptide chains and guides them toward their

180 ay be confounded by release of puromycylated nascent polypeptide chains prior to fixation.

181 ce puromycin is covalently incorporated into nascent polypeptide chains, anti-puromycin immunofluores

182 ocess prevents premature degradation of such nascent polypeptide chains.

183 essential in all cells and initiates when a nascent polypeptide emerges from the ribosome exit tunne

184 The nascent polypeptide exit tunnel (NPET) is a major functi

185 he peptidyl transferase center (PTC) and the nascent polypeptide exit tunnel (NPET), and export of as

186 ing the role of a cotranslational chaperone, nascent polypeptide-associated complex (NAC), in regulat

187 nt conformational changes in MRP mL45 at the nascent polypeptide-exit site within the large mitoribos

188 Nascent polypeptides begin to fold in the constrained sp

189 provide a specialized scaffold against which nascent polypeptides can begin to form structure in a hi

190 the anti-puromycin staining of puromycylated nascent polypeptides in fixed cells accurately reports o

191 biochemical assays and live cell imaging of nascent polypeptides in mammalian cells, that puromycyla

192 that sequestration of misfolded proteins and nascent polypeptides into two distinct compartments, str

193 tides in mammalian cells, that puromycylated nascent polypeptides rapidly dissociate from ribosomes e

194 control (RQC) pathway for the degradation of nascent polypeptides that are encoded by defective messe

195 by a specificity factor that recognizes the nascent polypeptides they encode.

196 ce regulator (CFTR) have distinct effects on nascent polypeptides.

197 ifferentiation, the migrating SG contact the nascent PR axon, which in turn release FGF to induce SGs

198 ocused on the Sec translocon and its role in nascent protein biosynthesis, including the correct fold

199 (PDIA6), an oxidoreductase that functions in nascent protein folding in the endoplasmic reticulum.

200 L924P showed more nascent protein retention in ER than D923N; more ER-asso

201 Mechanical forces can be generated when nascent protein segments are integrated into a membrane.

202 observed a coordinate dramatic reduction in nascent protein synthesis in neuronal cell bodies and de

203 immunofluorescence enables visualization of nascent protein synthesis.

204 hese forces are then transmitted through the nascent protein to the ribosome's catalytic core, but on

205 ds on the folding speed and stability of the nascent protein.

206 translating ribosome in interaction with the nascent protein.

207 hat is involved in both the translocation of nascent proteins across cell membranes and the integrati

208 Nascent proteins enriched in negatively charged residues

209 r cell-type-specific labeling and imaging of nascent proteins in the entire animal.

210 During microbial infection, unfolded nascent proteins may exceed the folding capacity of the

211 The ejection of nascent proteins out of the ribosome exit tunnel, after

212 ted protein biogenesis factors (RPBs) direct nascent proteins to distinct fates.

213 n leads to a co-translational association of nascent RAB13 with the exchange factor RABIF.

214 tes crossing over by binding and stabilizing nascent recombination intermediates.

215 hile the other initiates the assembly of the nascent replication product into a viral ribonucleoprote

216 From nascent reports describing SARS-CoV-2, we make inference

217 w separating widely admixing lineages versus nascent reproductively isolated species.

218 viruses adapt and become enzootic in swine, nascent reverse zoonoses may result in virus detections

219 Previous studies based on nascent RNA approaches concluded that Arabidopsis (Arabi

220 ombines a nuclear run-on assay for capturing nascent RNA before post-transcriptional modifications, a

221 nsible for bringing new N protomers onto the nascent RNA during genome replication.

222 RNAPI elongation confirmed the importance of nascent RNA folding in transcription.

223 ion roadblocking approach enables display of nascent RNA molecules from RNAP in a minimal in vitro tr

224 ular-sequencing step that sequences the same nascent RNA molecules multiple times to improve accuracy

225 Using nascent RNA sequencing, we show that an AS15 analogue tr

226 al RNA template (deletion DI species) or the nascent RNA strand (copyback DI species).

227 ough the stage of loading soluble N onto the nascent RNA strand as it exits the polymerase during RNA

228 Periods of active nascent RNA synthesis known as bursts represent individu

229 Sequencing of nascent RNA to explore DMD transcription dynamics reveal

230 he DNA template is repetitively added to the nascent RNA transcript.

231 We demonstrate here that MeCP2 represses nascent RNA transcription of highly methylated long gene

232 p, we uncovered evidence for abasic sites in nascent RNA, messenger RNA, and ribosomal RNA from yeast

233 ally, due to its location in the path of the nascent RNA, the C-tail of Mtf1 serves as a sensor of th

234 polyubiquitylated Pol II and its associated nascent RNA.

235 ion upon invasion of the DNA template by the nascent RNA.

236 We use capped-nascent-RNA sequencing to efficiently capture bidirectio

237 nscriptional processing (nano-COP), in which nascent RNAs are directly sequenced through nanopores, e

238 lymerases and exonucleases act on 3' ends of nascent RNAs to promote their maturation or degradation

239 ross metazoans and controls the fate of many nascent RNAs transcribed by RNA polymerase II (RNAPII).

240 C-NHEJ) proteins, including PNKP, along with nascent RNAs under physiological conditions.

241 emonstrated effective enrichment of PFAAs in nascent sea spray aerosols (SSA), suggesting that SSA ar

242 ion inside yield-stress fluids and develop a nascent set of archetypal operations that can be perform

243 g selective sweeps that have occurred within nascent species after speciation.

244 rapid postzygotic reproductive isolation of nascent species that are initially sympatric with one or

245 val from chromatin because in the absence of nascent strand synthesis, converging CMGs are still unlo

246 ular assemblies that drive DNA unwinding and nascent strand synthesis.

247 CST is required for blocking MRE11-mediated nascent-strand degradation.

248 reversed forks, thus antagonizing excessive nascent-strand degradation.

249 at arrested forks to safeguard integrity of nascent strands and generates poly-SUMOylation which pro

250 A strands guides symmetric CG methylation on nascent strands, but non-CG methylation requires modifie

251 e motion of the reacting oxygen atom and the nascent substrate radical, whereas reactions following t

252 lyses to demonstrate that the ability of the nascent subunit to adopt the scanning complex is tested

253 step that ensures scanning competence of the nascent subunit.

254 RAC chaperones by ensuring proper folding of nascent Sup35p, thus preventing its joining amyloid fibe

255 h visible to near-infrared light will enable nascent technologies in the emerging fields of bio- and

256 provide much needed causal evidence for the nascent theory of interoceptive inference.

257 completed, RHD3 is degraded by LNPs so that nascent three-way junctions can be stabilized and a tubu

258 The PAT complex engages nascent TMDs that contain unshielded hydrophilic side ch

259 d together, with higher error frequencies at nascent transcript 3' ends.

260 x from chromatin without global reduction of nascent transcript 5' cap stability.

261 d with analysis of transcriptional output by nascent transcript analysis and genome-wide AML1-ETO bin

262 Two features of the nascent transcript correlated with RNAPI distribution: f

263 Nascent transcript level fold-increases for speckle-asso

264 Initial investigation reveals that increased nascent transcript levels accompanying speckle associati

265 Severalfold higher nascent transcript levels for several Hsp70 flanking gen

266 Live-cell imaging reveals that HSPA1B nascent transcript levels increase/decrease with speckle

267 Nascent transcript measurements derived from run-on sequ

268 -based methodology that reduces the bias for nascent transcription, while increasing genomic coverage

269 tion factor binding and they are enriched in nascent transcription.

270 Using nascent-transcription reporter knock-ins of YAP target g

271 y, our results indicate that the Arabidopsis nascent transcriptome contains unstable RNAs and RNA pro

272 By examining the nascent transcriptome following exposure to a lytic trig

273 and MATLAB to visualize and quantify nuclear nascent transcripts and cytoplasmic mRNAs as a function

274 Here, we show that ASOs act upon nascent transcripts and, consequently, induce premature

275 Analysis of nascent transcripts delineated putative direct targets o

276 rovides a platform for the biogenesis of the nascent transcripts emanating from these genes.

277 transcripts, the extent to which RsmA binds nascent transcripts has not been addressed.

278 To generate only partial nascent transcripts in iATS, progression must be slowed,

279 imentally monitor the expression dynamics of nascent transcripts in resting and activated CD4+ T cell

280 dinucleoside polyphosphates at the 5' end of nascent transcripts in vitro and the percentage of trans

281 binding of posttranscriptional regulators to nascent transcripts may be commonplace in bacteria where

282 imaging of more than 1,000 genomic loci and nascent transcripts of more than 1,000 genes together wi

283 RNA chaperone Hfq targets a subset of those nascent transcripts that RsmA associates with and that t

284 nhibitor rifampicin, we identify hundreds of nascent transcripts that RsmA associates with in P. aeru

285 required for the dissociation of Pol II and nascent transcripts, and failure of this process dramati

286 tion termination is triggered by cleavage of nascent transcripts, generally during polyadenylation, r

287 iptionally active TE loci by base pairing to nascent transcripts, however the downstream mechanisms a

288 on of chromatin-associated, 3' UTR-extended, nascent transcripts, through inhibition of proximal poly

289 ass, for "complete" ATS, harbors full-length nascent transcripts.

290 in the recruitment of mRNA export factors to nascent transcripts.

291 , for "incomplete" ATS, harbors only partial nascent transcripts; the cATS class, for "complete" ATS,

292 membrane cargo prior to its packaging into a nascent transport carrier.

293 pose a model whereby tethering of MIWI2 to a nascent transposable element transcript recruits repress

294 ew trimeric architecture, (TriCyt1)(3.) This nascent trimer was redesigned into second and third-gene

295 TTC5 mutants incapable of ribosome or nascent tubulin interaction abolished tubulin autoregula

296 Nascent tumors must subvert these mechanisms to achieve

297 During herpesvirus infection, egress of nascent viral capsids from the nucleus is mediated by th

298 We used EdC labeling of nascent viral DNA to image aberrant viral replication co

299 eins orchestrate the assembly and release of nascent virus particles from the plasma membranes of inf

300 irus ecology and molecular biology are still nascent, with many questions largely unexplored, thus hi