ライフサイエンスコーパス: native

1 uced CVD risk in American Indians and Alaska Natives.

2 e of death among American Indians and Alaska Natives.

3 Black, 12.7% were American Indian or Alaska Native, 12.7% were non-Hispanic White, and 3.7% were of

4 e for visualizing the large-scale tissue and native 3D organ structure due to its sampling limitation

5 ral TOP mRNAs identified recapping events at native 5' ends and downstream of the TOP sequence of EIF

6 aLISA-based method was implemented to detect native A(2A)R-D(2)R heteromers in mouse and human brain.

7 iAEC2 cells expressed native AEC2 markers (surfactant proteins and LPCAT-1) an

8 d on chromosome 5q35.1, indicating that each Native American ancestry allele was associated with a 0.

9 s the first study supporting the notion that Native American ancestry significantly contributes to NM

10 age, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%;

11 natal home-visiting intervention to pregnant Native American youth.

12 ces with an amino acid distribution near the native amino acid distribution in membrane proteins, ove

13 delivers precise results even with low, near-native amounts of receptors.

14 Alaska Native (AN) people have the world's highest recorded inc

15 tive S. epidermidis AIP signals and five non-native analogs with distinct activity profiles in the Ag

16 We evaluated biopsy samples of native and allograft kidneys from patients with COVID-19

17 also discuss the therapeutic applications of native and bioengineered EVs to cardiovascular diseases

18 For native and illuminated samples, the weight-average molec

19 uggest that differences in behaviour between native and introduced species are one mechanism through

20 ong life-history might affect the impacts of native and invasive predators on recipient communities.

21 he two experiments, showing (1) that in both native and non-native languages, while language producti

22 where peptide assemblies could complex with native and non-native systems to generate novel function

23 elated to more ordered physical structure in native and retrograded starches.

24 iomolecular mass spectrometry, in particular native and top-down protein analysis.

25 ivator, monoxime RS194B, reversibly bound to native and venomous agent X (VX)-inhibited human AChE, h

26 e straight graft most closely recapitulating native aortic root biomechanics.

27 and contemporaneous genetic structure in the native area of the gastropod Tritia neritea, using Bayes

28 ynamics and diversification of the Brazilian natives at a genomic level, which was made possible by r

29 ed successful RMCE reactions using a pair of native 'attB' sites that were inserted as a substrate in

30 ination and RMCE assays in human cells using native 'attB' sites.

31 correlations between sensory attributes and native beer compounds have not been evaluated within the

32 nt free energy barrier from the dimer with a native binding interface.

33 ons may occur as a result of interactions of native bioactives and carriers.

34 tive species had greater negative effects on native biodiversity where human population was high and

35 non-native species have pervasive impacts on native biodiversity, including population extirpations a

36 genic taccalonolide probes that maintain the native biological properties of the potent taccalonolide

37 ts have substantially lower crime rates than native-born citizens and legal immigrants across a range

38 Here, we studied the structure of native bovine IRBP in complex with a monoclonal antibody

39 Succeeding in the conservation of threatened native breeds will require going beyond merely genetic a

40 lowed by radical rebound, as observed in the native C-H hydroxylation mechanism of the P450 enzyme.

41 observe that the hC3Nb2 nanobody binds human native C3 and its degradation products with low nanomola

42 A native calcium ion channel has been identified in bacter

43 c 1,2-diarylation of an alkene directed by a native carboxylate group.

44 esigned prototype TPR ligands that mimic key native 'carboxylate clamp' interactions between Hsp90 an

45 ectors is poorly understood, particularly in native cell systems.

46 croscopy to study TNFR1 assembly directly in native cellular settings and at physiological cell surfa

47 re efficiently assembled via a semisynthetic native chemical ligation strategy.

48 (ultra-low-input micrococcal nuclease-based native ChIP-seq) shows that EZH1 could partially safegua

49 genous role of an enhancer in the context of native chromatin.

50 found to have undergone fusion with another native chromosome in some isolates and this fusion resto

51 ogues retained the low nanomolar activity of native CIA toward muscle-type nAChRs but showed greatly

52 ct to specific neuronal cells utilizing only native components of the neurotransmission machinery at

53 ies can modulate the biophysical features of native condensates, including their size, shape, viscosi

54 Under native condition, Blue Native-PAGE and Blue Native-PAGE/

55 tightly interacting intact antibodies under native conditions are lacking, we developed a straightfo

56 to solutions generated under native or near-native conditions has been demonstrated to be capable of

57 human recombinant beta(2)GPI purified under native conditions is oxidized.

58 v was continuously stabilized in its closed, native conformation.

59 and the kinetics of re-equilibration to the native conformational equilibrium can be determined by t

60 Such proteins adopt native conformations early on during the translation pro

61 be particularly favoured by formation of non-native contacts between the C-termini of the two helices

62 y translated residue establishing additional native contacts.

63 these secondary-structure elements in their native contexts are just partly understood.

64 ception, dimer/monomer cycling, abundance of native COP1 and RUP proteins, and interactions of the mo

65 were more phytochemically diverse than their native counterparts, and their metabolomic profiles were

66 y inspired design principles to recapitulate native crypt-villi topography and luminal flow, Nikolaev

67 lls, which possesses arrays with the highest native curvature investigated thus far.

68 re, we find that disulfide bonding between a native cysteine pair at the groove (C55) and C-terminal

69 ethod for the protection and deprotection of native cysteine with a succinimide group in a peptide fr

70 Disrupting each cluster selectively impairs native Ded1 association with eIF4A or eIF4E, and reduces

71 tios and mineral to matrix ratios to that of native dentine, both being significantly different from

72 hionylation and S-nitrosylation and form non-native disulfide bonds.

73 ine the structures of nucleosomes containing native DNA sequences.

74 he above problems is using readily available native DNA.

75 mprehensive analysis of a targeted region of native DNA.

76 t predetermined positions on the backbone of native double-stranded DNA.

77 mined whether TH-ir neurons colocalized with native EGFP(Vglut2) - or EGFP(Vgat) -fluorescence, respe

78 f the amyloid assembly process, we have used native electrospray ionization (ESI) together with ion m

79 Analysis of Pol I native elongating transcript sequencing data in Saccharo

80 am sequence elements influence Pol I in vivo Native elongating transcript sequencing studies reveal t

81 entials, and higher, but variable, levels of native embolism in the branches.

82 The gB in the native envelope of HSV-1 had reduced reactivity with ant

83 tion in a developing neuronal circuit in its native environment is unclear.

84 wheat (Triticum turgidum), thin sections of native epidermis cells from sorghum (Sorghum bicolor) co

85 Populations in the native European range had strong spatial genetic structu

86 between studied NE cats and the contemporary native European wildcats.

87 atures are a main driver of expansion of the native, evergreen shrub, Morella cerifera, in coastal la

88 llenge studies in immune-competent mice with native expression of mouse ACE2.

89 des a structural platform alternative to the native fold for RNase P to bind and mature SRP RNA co-tr

90 entify candidate structures that can lead to native folds or designable structures remains a challeng

91 d lysozyme, we showed that although compact "native" folds can be preserved, the collision cross sect

92 We present isotopic evidence for native forest being of higher quality than shade-coffee

93 native Pinus radiata plantations, and nearby native forests in a region of extensive plantation activ

94 hophytum mirabile, whose mtDNA has lost most native genes but contains intact foreign homologs acquir

95 ix effects and accounted for the presence of native glucose.

96 eurons to unveil the nanoscale topography of native GluN2A- and GluN2B-NMDA receptors (NMDARs)-which

97 ch revealed overall processing states of the native glycans highly similar to that of the recombinant

98 of the SARS-CoV-2 spike gene in place of the native glycoprotein gene (VSV-eGFP-SARS-CoV-2).

99 s similar, within a factor of 2, to those of native GM1.

100 : maize stover >> miscanthus ~ switchgrass ~ native grasses ~ poplar > early successional >= restored

101 We quantified this interaction in native grassland by experimentally eliminating temporal

102 on response element (TAR) RNA, such that the native GS conformation becomes a low-abundance ES.

103 enotyping in a large number of self-reported Native Hawaiians (N = 3693) a functionally important, Po

104 ican Americans, Japanese Americans, Latinos, native Hawaiians, and whites in the Multiethnic Cohort (

105 yl lysines recognized by a mAb that binds to native HBHA ~100-fold better than to rHBHA-Ms This pepti

106 period and decrease to levels typical of the native heart by 90 d.

107 tallization of both chimeric and full-length native heavy chain-containing Abs provided structural in

108 ctor VIII (hFVIII) protein activity mirrored native hFVIII in hemostatic ability.

109 ificantly worse in the KCE cohort with their native HOA's, relative to controls and in the ectatic ey

110 by more than 10-fold relative to that of the native hormone.

111 generation of three BCR KI lines expressing native human precursors, instead of computationally infe

112 Here, IL-22 SyCyRs phenocopied native IL-22 signal transduction, indicated by induction

113 trated a better glucose-lowering effect than native insulin, even with a much lower dose and less fre

114 Here, we identified a non-native interaction interface on the three-dimensional di

115 a (CIC) demonstrates the importance of ATXN1 native interactions for correct B cell functioning.

116 ntramolecular electron transfer (IET) to the native intermediate (NI), which only slowly decays to th

117 ssociation results in the formation of a non-native intermediate, separated by a significant free ene

118 n in vitro share the highest similarity with native intestinal ECs relative to kidney and lung.

119 Determining how native island populations respond demographically to inv

120 Native joint septic arthritis (NJSA) is poorly studied.

121 The discovery of non-native kelp washed up on Antarctic beaches led us to que

122 teristics of autoantibody: concentration and native kinetic parameters that reflect autoantibody aggr

123 The proposed biosensor and method of native kinetic registration can be used to develop new c

124 ndividuals; and (2) that with increasing non-native language proficiency, reading and speech comprehe

125 , type of interview (interpreter-assisted or native language), and diagnostic measure.

126 nts, showing (1) that in both native and non-native languages, while language production was left lat

127 Native LGR4 and LGR5 existed as dimers on the cell surfa

128 couple for signal transduction and whether a native ligand or other activating input is required.

129 We show that (1) tandem-TIMS/MS retains native-like avidin tetramers with deeply buried solvent

130 ss, the mechanism by which PRC2 engages with native-like chromatin remains incompletely understood.

131 All three could be overexpressed and had native-like circular dichroism spectra and 1D-NMR spectr

132 tly produce the large scale of proteins with native-like fold and hence can act as an efficient vacci

133 xamine the effect of E2 mutations under more native-like infection conditions, a neomycin-selectable

134 ia monocytogenes strain EGD-e while bound to native-like lipid membranes.

135 ective for future structural studies of some native-like nucleosomes that play critical roles in chro

136 res and review the few structural studies on native-like nucleosomes.

137 nt exists in a major native state, two minor native-like states, and two locally unfolded states in a

138 ing noncovalent interactions and maintaining native-like structures.

139 w second step occurring over many days where native lipid membranes assemble into well-defined multil

140 Native livestock breeds, i.e. those autochthonous to a s

141 Recombinant human lubricin (rhPRG4) and native lubricin purified from the SF of patients were in

142 y, increases the respiratory quotient of the native lung and could reduce both the occurrence of alve

143 As a result, the risk of harmful non-native marine species being introduced into this critica

144 ography with multiangle light scattering and native mass spectrometry (MS) for the biophysical charac

145 Native mass spectrometry (MS) has long been a tool of ch

146 Native mass spectrometry (MS) is a powerful means for st

147 Native mass spectrometry (MS) provides the capacity to m

148 Native mass spectrometry (MS) reveals that the modular O

149 peration in Science and Technology Action on Native Mass Spectrometry and Related Methods for Structu

150 Analysis of intact proteins by native mass spectrometry has emerged as a powerful tool

151 tein mass analysis, top-down proteomics, and native mass spectrometry have created a need for improve

152 del to explain the results of several recent native mass spectrometry studies of protein-lipid comple

153 This work uses native mass spectrometry to investigate PF4 interactions

154 Therefore, native mass spectrometry would greatly benefit from high

155 ding interaction cooperativity, confirmed by native mass spectrometry, makes the gates largely insens

156 cases exhibit symmetries not present in the native material(3-5).

157 rification and to preserve interactions with native membrane lipids during purification.

158 charge-reducing agents when dissociated from native membrane protein-lipid complexes in the gas phase

159 icial and crystalized conformation to a more native, membrane-bound conformation in silico.

160 when subjected to chemically similar but non-native metal substitutions is a long-standing puzzle.

161 xture, whereas there is no insertion for the native mixture.

162 ms and their complexes in both denatured and native modes of operation, revealing information not obt

163 ranscripts can later lead to IgE against the native molecule and also explain how anaphylaxis may occ

164 Here, using a native mouse model of glioblastoma, we develop a high-th

165 ng immunoprecipitation of size-fractionated, native, mouse and human brain-derived Abeta assemblies.

166 an be aberrantly counted along with a cell's native mRNA and result in cross-contamination of transcr

167 separation methods that are compatible with native MS and improve tandem MS (MS/MS) approaches with

168 y demonstrates the yet untapped potential of native MS coupled to gas-phase ion chemistry as a means

169 cluster synthesis and highlight the power of native MS in defining protein-associated intermediates a

170 The charge states produced by native MS of membrane proteins often result in gas-phase

171 By native MS, the binding affinities for five ligand-DNA an

172 Here, we employed a native MS-based approach to directly detect oligomeric f

173 sylated, making them challenging targets for native MS.

174 cardiac muscle is biomechanically similar to native myocardium remains unknown.

175 Using native nano-electrospray ionisation ion mobility-mass sp

176 channel YnaI was extracted and delivered in native nanodiscs in closed-like and open-like conformati

177 d Zn impurities beneficially reduce the high native net dopant concentration in the space charge regi

178 given that the visualization of HSCs in the native niche in live animals has not, to our knowledge,

179 The native NMR structure revealed a novel fold comprising a

180 a greater effect on survival of offspring of native O. hecate compared to introduced O. taurus.

181 d small colonies of introduced O. taurus and native O. hecate to three temperature treatments, includ

182 Postsynthetic ligand exchange of native oleate capping ligands for NHCs results in a bath

183 trophotometric assay for transpeptidation of native or near native peptidoglycan precursors and fragm

184 ization applied to solutions generated under native or near-native conditions has been demonstrated t

185 Direct competition of hosts containing native or recombined symbionts against isogenic symbiont

186 lack some cellular populations found in the native organ, including vasculature.

187 amined catch abundance of two exotic and six native Osmia species over the span of fifteen years (200

188 Under native condition, Blue Native-PAGE and Blue Native-PAGE/SDS-PAGE 2D analyses de

189 native condition, Blue Native-PAGE and Blue Native-PAGE/SDS-PAGE 2D analyses demonstrated co-existen

190 oride, phosphate [P], or sulfate) to convert native Pb species to PLJ and used a mouse assay to asses

191 mbine the advantages and benefits of various native peptides.

192 assay for transpeptidation of native or near native peptidoglycan precursors and fragments by Escheri

193 As a natural next step, we show that native phospho-proteoforms of proteins display a distinc

194 nuanced approaches that are synergistic with native physiological processes.

195 soil physico-chemical properties between non-native Pinus radiata plantations, and nearby native fore

196 diseases of agriculture, forestry, and even native plant populations.

197 community, as well as data of a Guarani Mbya native population from Southern Brazil and of three othe

198 tion from Southern Brazil and of three other native populations from the Amazonian region.

199 Genetic diversity within and among 42 native populations of Bromus tectorum (cheatgrass) was c

200 fits of stocking-or removing established non-native populations-under a rapidly changing climate.

201 with distance restraints, we found the near-native poses were ranked 1st, 1st and 10th among 54 000

202 uggesting stingrays may be forced to rely on native prey items to supplement the decreased amount of

203 P(bb0648) and P(bosR), and we focused on the native promoter.

204 hereas it had no effect on three of the four native promoters that contained -7T.

205 The non-native protein functions also raise the prospect of futu

206 classification scheme for identification of native protein quaternary assemblies (binders/nonbinders

207 ls who lacked specific IgE when tested using native protein reagents.

208 Relief from excess levels of non-native proteins by increasing the levels of folding fact

209 romatographic quantification of the residual native proteins.

210 all, CarD increased the activity of 15 of 16 native R. sphaeroides promoters tested in vitro that lac

211 bidopsis thaliana accessions from across its native range and applied spatially varying coefficient m

212 s was smaller relative to bullfrogs in their native range as well as in populations across their inva

213 results of Tritia neritea populations on its native range highlight a mixture of ancient and recent p

214 secondary colonisation, rather than from the native range of the species.

215 gher latitudes in the introduced but not the native range.

216 rom leaf material from across the BI and the native range.

217 ures of long-term balancing selection in the native ranges, with 15-47% of loci exhibiting significan

218 ad to standardised grade extracts, both from native raw materials and by-products.

219 t binds to the transferrin receptor (TfR), a native receptor and BBB transporter for the iron chapero

220 The native receptor was purified from Torpedo electric tissu

221 ere statistically distinguishable from their native relatives.

222 yzed 34,630 hospitalized patients undergoing native renal biopsy between January 1, 2009 and December

223 Concordantly, rs679482-A impairs native repressor activity and increases basal and DMRT2-

224 r a significantly longer period of time than native rhDNase (12 days vs 5 days).

225 cusp closing forces approaching that of the native root, whereas relative forces were >5-fold higher

226 Cusp closing velocities were similar between native roots and the SG group, and were significantly lo

227 n of GCaMP3 and imaged zG cells within their native rosette structure.

228 to characterize the structures of the three native S. epidermidis AIP signals and five non-native an

229 e rats which disrupt nutrient subsidies from native seabirds.

230 ta-derived peptides that contain more of the native sequence and thus better mimic the oligomers form

231 ations, native structure discrimination, and native sequence recovery.

232 The devices native setup shows limited ability to perform a true scr

233 ssay in which the enzyme is removed from its native site on the bacterial surface and truncated to im

234 We focused on two questions: 1) What is the native size and what are the dynamic features of membran

235 In contrast, native South American mammals show higher extinction.

236 physiological environment, particularly the native spatial context of proteins inside a cell.

237 EEG was recorded while 29 adult native speakers (22 women, 7 men) listened to naturally

238 We found that non-native species had greater negative effects on native bi

239 Invasive non-native species have pervasive impacts on native biodiver

240 he mechanisms involved in the extirpation of native species in the post-invasion period.

241 eater plasticity of invader populations than native species may underlie invader dominance.

242 This is the first evidence of non-native species reaching the Antarctic continent alive on

243 ve sources to better estimate the success of native species' reintroductions.

244 lications for managing lionfish and impacted native species, and improve our understanding of biologi

245 e change differentially affects invasive and native species.

246 and displacement of saguaro cacti and other native species.

247 ive target species) and non-sown (mostly non-native) species.

248 e (UCR) by using telomeric repetitive DNA as native spike-in control.

249 ompositions of the N-linked glycans from the native spikes were analyzed by mass spectrometry, which

250 formed in 6 pigs; 5 studies were done in the native state and 4 after infarction of the left anterior

251 operative two-state transition involving the native state and unstructured denatured species.

252 view, using diffusion-precipitation assays, native state MS, isothermal titration calorimetry, singl

253 al data, after correcting for differences in native state stability.

254 By comparing the stability of the native state with reference to the knotted and unknotted

255 ging of biological materials, preserved in a native state, by using an OrbiSIMS instrument equipped w

256 Here, we describe the native state, observable intermediate state, and unfolde

257 ents show that the variant exists in a major native state, two minor native-like states, and two loca

258 is a useful tool to study proteins in their native state.

259 alternative approach to protein folding and native-state dynamics presents a generally applicable st

260 ng simulations that rely on knowledge of the native structure can provide critical, detailed informat

261 ns in the bilayer, DeltaDeltaG calculations, native structure discrimination, and native sequence rec

262 o which noncovalent protein complexes retain native structure in the gas phase is highly dependent on

263 ergy model yield significant improvements in native structure recovery of protein-protein and protein

264 r and submicrometer sized capillaries on the native structures of the protein complexes streptavidin,

265 ctions pairing wildtype PKS modules with non-native substrates primarily resulted in poor conversions

266 The resolution of PfCRT's native substrates will aid the development of drugs that

267 elative designs, including data on 2,229,880 native Swedes born between 1950 and 1970 and observed fr

268 assemblies could complex with native and non-native systems to generate novel functional materials.

269 Regions with high native T(1) corresponded to regions dense in proliferati

270 Reductions in tumor-native T(1) represented a sensitive biomarker of respons

271 .88, respectively; P = .046), and similar to native T1 (AUC, 0.97 vs 0.93, respectively; P = .63) and

272 Normative data are presented for myocardial native T1 and ECV using the MOLLI T1 mapping sequence at

273 l [CI]: 0.91, 1.00) for EP-3533, followed by native T1, Gd-Hyd, and MR elastography with AUCs of 0.90

274 6) for EP-3533, Gd-Hyd, MR elastography, and native T1, respectively.

275 affected the relative dominance of the sown (native target species) and non-sown (mostly non-native)

276 gate formation, by folding reliably into its native, thermodynamically stabilized structure.

277 anical properties comparable to those of the native tissue, (2) thermodynamically-stable extra-cellul

278 epth-dependent cellularity mirroring that of native tissue.

279 rt, and biointegration that is possible with native tissue.

280 ll analyses of matched organoid cultures and native tissues by mass cytometry for 38 markers provide

281 g enzymes were up-regulated, either in their native tissues or in an ectopic manner, whereas genes en

282 Mosses native to and transplanted into spruce stands supported

283 Native to southern Africa, this species has been extensi

284 ndom combinations of monomer glycoforms; (4) native top-down sequence analysis of the avidin tetramer

285 Further improvements for such native top-down sequencing experiments were possible by

286 We suggest that the native topology of DPO4 leads to a trade-off between fas

287 opism, tier 2 neutralization resistance, and native trimer conformation.

288 roplastics and other anthropogenic fibres in native UK shark species and highlights the pervasive nat

289 nd biological properties similar to those of native urethra is a challenge for which the field of tis

290 ge, sex, >=3 positive blood culture bottles, native valve disease, prosthetic valve, previous IE, and

291 g use of 18F-FDG-PET/CT for the diagnosis of native valve endocarditis (NVE).

292 however, sensitivity was markedly lower for native valve IE than prosthetic valve IE and cardiac imp

293 87 [81%] men, median age 62 years, 153 [66%] native valves) comprised 58 (25%) PVC results and 173 (7

294 SIC storage, respectively, compared to their native vegetation (grassland or woodland) pairs, and irr

295 ation policies on biodiversity (indicated by native vegetation) and two ecosystem services (carbon st

296 stability through a conformational shift of native Watson-Crick pair to a wobble-like pattern with t

297 n have both positive and negative impacts on native wildlife populations at different scales of space

298 compared the electrophysiological effects of native (WT) and p.P888L SAP97, a common polymorphism.

299 dvanced tools for real-time visualization of native YAP and target gene transcription dynamics, we sh

300 Native yeast and yeast cell wall particles (YCWPs) were