ライフサイエンスコーパス: natural antibody

1 y nonspecific immunoglobulin, which may be a natural antibody.

2 in body cavities and an important source of natural antibody.

3 f complement is dependent in a large part on natural antibody.

4 rs that interact with the Fc portion of this natural antibody.

5 d that phagocyte function can be restored by natural antibody.

6 t drive the development of B cells producing natural antibodies.

7 DS2, which behaves in a manner comparable to natural antibodies.

8 immune system influencing the production of natural antibodies.

9 e, the major xenoantigen recognized by human natural antibodies.

10 pitope, is the target of a large fraction of natural antibodies.

11 in NOD-scid-beta2 m-, including xenoreactive natural antibodies.

12 sic pathway activation and bound IgG and IgM natural antibodies.

13 onsequently human sera contain anti-alphaGal natural antibodies.

14 izing an ELISA assay for rat anti-guinea pig natural antibodies.

15 O) exhibit markedly reduced binding of human natural antibodies.

16 O) exhibit markedly reduced binding of human natural antibodies.

17 e sequences with pairing properties found in natural antibodies.

18 2 (TI-2) antigens, and that they produce IgA natural antibodies.

19 nctions and pharmacokinetics comparable with natural antibodies.

20 oited the postischemia recognition system of natural antibodies.

21 eveloped for adenovirus quantification using natural antibodies.

22 id peroxidation and a major target of innate natural antibodies.

23 printed particles are comparable to those of natural antibodies.

24 ,3-galactose (alpha-gal) are highly abundant natural antibodies (Ab) in humans.

25 Human sera contain high levels of natural antibody (Ab) to Galalpha1-3Gal, a terminal glyc

26 Natural antibodies (Abs) can target host glycans on the

27 Here we show that natural antibodies, acting in concert with complement, a

28 B-1b cells produce IgM natural antibodies against alpha1-3Galbeta1-4GlcNAc (alp

29 e the characterization of xenoreactive human natural antibodies against antigens without the alphaGal

30 ate with peptide microarrays the presence of natural antibodies against known toxic Abeta and amyloid

31 apoA-I mimetic peptides increased titers of natural antibodies against oxidation-specific epitopes.

32 nfection and anti-inflammatory properties of natural antibodies against the small-molecule epitope ph

33 Whereas natural antibodies against these glycans can act as barr

34 ine organ xenograft, due to the existence of natural antibodies against this epitope in human serum.

35 Furthermore, haptens that inhibit natural antibodies also inhibit GS-1-B(4) from binding t

36 t this process is mediated by IgM anti-mouse natural antibodies and activation of the classical pathw

37 B1 B cells secrete most of the circulating natural antibodies and are considered key effector cells

38 aintaining homeostatic levels of circulating natural antibodies and being the first line of defense a

39 of the failure to fully deplete xenoreactive natural antibodies and block complement, or because of p

40 y with beta-glucans was limited by levels of natural antibodies and by tumor escape through eliminati

41 ediated lysis after the binding of preformed natural antibodies and cellular immunity involving both

42 s that were protected from neutralization by natural antibodies and complement although they were una

43 eceptors, including scavenger receptors, IgM natural antibodies and complement factor H, which bind,

44 Xenoreactive natural antibodies and complement were depleted by plasm

45 elds vector particles from neutralization by natural antibodies and complement.

46 ll compartmentalization in the production of natural antibodies and for body cavity immunity.

47 rinted polymers (MIPs) are the equivalent of natural antibodies and have been widely used as syntheti

48 for which B-1 cells, an important source of natural antibodies and host immune responses, have speci

49 ells contribute significantly to circulating natural antibodies and mucosal immunity as well as to im

50 ular degeneration, including the presence of natural antibodies and neoepitopes.

51 , as well as by innate proteins, such as IgM natural antibodies and soluble proteins, such as C-react

52 S107-mu transcripts, with a loss of certain natural antibodies and specific tolerance to phosphorylc

53 enza are discussed here, namely polyreactive natural antibodies and the role and function of germinal

54 ented by strategies directed at xenoreactive natural antibodies and/or complement activation.

55 lts demonstrate a contrasting requirement of natural antibody and complement for opsonophagocytosis o

56 ecent studies indicate an important role for natural antibody and the classical pathway of complement

57 le PRRs, such as CD36, toll-like receptor-4, natural antibodies, and C-reactive protein recognize com

58 t (CD19(-/-)) mice lacked B-1a cells, lacked natural antibodies, and were more susceptible to infecti

59 existing approaches in predicting unobserved natural antibody-antigen affinity and maintains its effe

60 As such, they are analogues of the natural antibody-antigen systems.

61 Natural antibodies are an integral part of innate humora

62 Regulatory T cells and B1 cells secreting natural antibodies are atheroprotective.

63 Natural antibodies are autoreactive/polyreactive antibod

64 Natural antibodies are frequently elicited to recognize

65 B1 cell-derived natural antibodies are non-specific polyreactive antibod

66 Natural antibodies are those immunoglobulin molecules fo

67 We propose that complement and natural antibody are interdependent: clonal selection an

68 Natural antibodies as coatings were compared with biomim

69 These include a reduction in a natural antibody, B-1 responses to phosphocholine, and s

70 This suggests that once the natural antibody barrier is eliminated by the induction

71 ntained stabilizing interactions observed in natural antibodies between the framework and loops of co

72 Natural antibodies bind fungal organisms and enhance hos

73 Immunoglobulin M (IgM) natural antibodies bind oxidatively-modified low-density

74 orescent protein (GFP), we have mimicked the natural antibody binding footprint to create robust bind

75 rease in the mean channel shift (MCS) of IgM natural antibody binding from pooled human sera, and a 2

76 The MCS for human IgG natural antibody binding to the surface of pig cells dec

77 We hypothesized that IgM natural antibody binds to neoepitopes exposed in the glo

78 and control of functional responses in both natural antibody biology and their therapeutic applicati

79 Natural antibodies capable of cleaving nucleic acid, pro

80 Although preformed natural antibodies cause hyperacute rejection of primari

81 encoded for amino acids commonly observed in natural antibody CDRs.

82 Natural antibodies contribute to tissue homeostasis and

83 We propose that this function of natural antibodies could be exploited when developing ne

84 Furthermore, we observed that although the natural antibodies cross-reacted with all three variant

85 with complement inhibitors and xenoreactive natural antibody depletion leads to delayed xenograft re

86 idnanomolar affinities and were as stable as natural antibodies, despite having >30 mutations from ma

87 ce showed that B cell production of IL-17 or natural antibodies did not provide any defense against c

88 Natural antibodies directed against cell surface carbohy

89 any effect on the level of alphaGal-reactive natural antibodies, equal numbers (n=12) of A, B, AB, an

90 hiophenol (4-ATP) as Raman reporter and to a natural antibody for CEA as recognition element.

91 a molecularly-imprinted polymer (MIP) and a natural antibody for the accurate surface-enhanced Raman

92 ion of labor between the B-1 B cell subsets: natural antibodies from B-1a cells limit infection by St

93 eactivity of multiple different CLL rAbs and natural antibodies from CMV-seronegative adults with pUL

94 Finally, natural antibodies from human serum also reacted with ME

95 at the high abundance of Tyr, Ser and Gly in natural antibody germ line sequences reflects the intrin

96 architectures, and specific modification of natural antibodies has proven quite challenging.

97 The target of this natural antibody, however, was unknown.

98 rf5(-/-) mice have decreased serum levels of natural antibodies; however, the antigen-specific IgG1 p

99 gh pretreatment and post-treatment levels of natural antibody IgG1-4, complement C3, and/or C1q were

100 d its receptors mediating the interaction of natural antibodies (IgM) with pathogens to effect protec

101 ions of complement inhibitors, adsorption of natural antibodies, immunosuppressive therapy, and splen

102 y be used to expand the epitope repertory of natural antibodies, improving their functionality for di

103 at least in part, to the very low titers of natural antibodies in newborn recipients.

104 demonstrated very low levels of xenoreactive natural antibodies in newborns, suggesting the possibili

105 ell populations producing anti-Gal and other natural antibodies in primates are unknown.

106 ollectively underlie the rapid production of natural antibodies in response to in vivo LPS stimulatio

107 uccessful is rejection mediated by preformed natural antibodies in the host, directed toward a single

108 ce binding to H. influenzae, suggesting that natural antibody, induced through prior exposure to the

109 In this study, we investigated whether natural antibodies influenced the number and/or phenotyp

110 The diversity of natural antibodies is limited by the genetic mechanisms

111 The major source of natural antibody is CD5+ B-1 cells which differ from con

112 coronavirus-2 (SARS-CoV-2) evolves to escape natural antibodies, it also loses sensitivity to therape

113 presence of anti-Gal(alpha)1-3Gal (alphaGal) natural antibodies leads to the hyperacute rejection of

114 The eventual return of Gal natural antibodies led to the destruction of graft epith

115 We investigated the relationship between natural antibody levels and treatment outcomes of 126 tr

116 restingly, lck-null mice exhibited increased natural antibody levels characteristic of B-1 cells.

117 3-5 d of FtL priming and fade within 1 wk to natural antibody levels that persist indefinitely in the

118 d constitutive immunity testing lysozyme and natural antibody levels, and blood bactericidal and phag

119 Pb exposure in spring reduced natural antibody levels, whereas in autumn, it reduced l

120 production of serum IgM and IgG anti-FtL at natural antibody levels; and (iii) elicits FtL-specific

121 gether, these results show that ingestion of natural antibodies limits the spirochete burden within f

122 re antibody sequence was returned, mimicking natural antibody maturation in silico.

123 f an allograft or xenograft, suggesting that natural antibodies may not be entirely T-cell independen

124 Natural antibodies may therefore have an impact on patho

125 e only significant predictor of both innate (natural antibody-mediated complement activation) and ada

126 Natural antibody-mediated cytotoxicity to pig endothelia

127 The kinetics of anti-Gal natural antibodies (NAb) and total immunoglobulin levels

128 racute and delayed vascular rejection due to natural antibodies (NAb) present major obstacles in pig-

129 the B-cell subsets that produce xenoreactive natural antibodies (NAb).

130 nized by more than 80% of human anti-porcine natural antibodies (NAb).

131 ous studies have implicated xenoreactive IgM natural antibody (nAb) as the predominant immunoglobulin

132 ding a disproportionate induction of the IgM natural antibody (NAb) E06/T15 to oxidized phospholipids

133 Natural antibodies (NAbs) against a terminal alpha1-3 ga

134 However, natural antibodies (NAbs) against Galalpha1,3Gal (Gal) p

135 vide evidence that B cells and their innate, natural antibodies (NAbs) are critical for the detection

136 n and physiological production of protective natural antibodies (NAbs) have been associated with expo

137 Glycan-reactive natural antibodies (NAbs) have been reported to play pro

138 to the presence of anti-Galalpha1-3Gal (Gal) natural antibodies (NAbs) in their sera.

139 As natural antibodies (nAbs) to cardiolipin and phosphatidy

140 determine which levels of preformed antipig natural antibodies (Nabs) will be safe for clinical xeno

141 Natural antibodies (Nabs) with polyreactive and autoreac

142 ent (Rag2-/-) mice, the protective effect of natural antibodies (NAbs), and the expression of complem

143 will establish the fundamental importance of natural antibodies not only in defense, but in regulatio

144 ed throughout evolution, we propose that the natural antibodies of sharks, the most anciently emerged

145 but may be due to low-affinity, polyreactive natural antibodies of the IgG subclass.

146 nal and cardiac xenografts is initiated when natural antibodies of the recipient bind to donor endoth

147 is initiated by the binding of xenoreactive natural antibodies of the recipient to blood vessels in

148 Interestingly, natural antibody of the adaptive immune system provides

149 ere utilized for creating positive images of natural antibodies on polymer layers.

150 rneal xenograft rejection is mediated not by natural antibodies or CD8+ T cells directly, but by CD4+

151 ance from the circulation was independent of natural antibodies or complement factor C3, and instead

152 Strategies that reduce IgM natural antibody or that prevent complement activation m

153 Here we show that natural antibodies play a critical role in C3 opsonizati

154 d rabbits and by their immunoreactivity with natural antibodies present in ApoE null mice.

155 xenotransplantation is the reaction between natural antibodies present in humans and Old World monke

156 Natural antibodies, present in the tear film before immu

157 a large proportion of CLL clones emerge from natural antibody-producing cells expressing immunoglobul

158 B-1a cells are primarily thought of as natural antibody-producing cells.

159 d regulatory pathways that enable continuous natural antibody production by B-1 cells, the main cellu

160 xposure per se is not sufficient to increase natural antibody production.

161 order to fully recapitulate the features of natural antibody production.

162 to initiate the complement cascade following natural antibody recognition of neoepitopes, which is th

163 Here, we show that characteristic monoclonal natural antibodies recognize common chemical moieties or

164 raft rejection mediated by complement-fixing natural antibodies recognizing alpha(1,3)-galactosyl epi

165 ive baboon sera, which has preformed antipig natural antibodies, reduced SMPDL-3b expression, disrupt

166 tive antibodies are a major component of the natural antibody repertoire and bind to a variety of str

167 g the effects of childhood infections on the natural antibody repertoire and the mechanisms of antibo

168 and phospholipids permanently reprograms the natural antibody repertoire directed toward these antige

169 mbranes, represent a large proportion of the natural antibody repertoire in mice.

170 that the broad antibacterial activity of the natural antibody repertoire is largely due to polyreacti

171 sequence-wise featureless epitopes and how a natural antibody repertoire with limited variants can re

172 The origin of U-CLL lies among the natural antibody repertoire, and dominance of IGHV1-69 r

173 eactive antibodies, a major component of the natural antibody repertoire, bind with low affinity to a

174 ion model in which recipients contain a full natural antibody repertoire, both constructs blocked gra

175 The similarities between mouse and human natural antibody repertoires suggest that reduced microb

176 ositional amino acid frequencies observed in natural antibody repertoires.

177 We therefore show that natural antibodies represent a link between biomolecule

178 This study assessed the natural antibody response profile of seven novel Plasmod

179 The absence of a natural antibody response will allow investigation of th

180 d by polyclonal sera through the course of a natural antibody response.

181 antigens is typically guided by studying the natural antibody responses to a pathogen.

182 cine xenoantigens whose recognition by human natural antibodies results in hyperacute rejection would

183 Thus, the pool of natural antibody-secreting B-1 cells is heterogeneous an

184 these findings show that memory B cells and natural antibody-secreting cells are BLyS-independent an

185 ed by anti-BLyS treatment, yet the number of natural antibody-secreting cells remained constant.

186 rained language model trained on 558 million natural antibody sequences followed by graph networks th

187 ficant portion of the variable domain of all natural antibody sequences remains germline.

188 roach could be used to prevent production of natural antibodies specific for alphaGal, the ability to

189 to atherosclerosis is the prominent role of natural antibodies, specifically those binding to the ox

190 well as supplemental Hg reduced the level of natural antibodies, suggesting impaired humoral immunity

191 riants, viral interference, cross-protective natural antibodies, T cell immunity, and highly effectiv

192 nse that in turn increases the titers of the natural antibody T15/EO6, which recognizes the oxidized

193 Healthy individuals also possessed natural antibodies targeting M3AR, Dsg1 and Dsg3 epitope

194 d by genome editing to produce custom or non-natural antibodies that are not induced by immunization.

195 n in vitro, which is similar to findings for natural antibodies that are subjected to somatic hypermu

196 Natural antibodies that bind the carbohydrate antigen Ga

197 Since human natural antibodies that bind to porcine cells are polyre

198 formed antibodies that may be related to the natural antibodies that formulate a first line of defens

199 s, as they minimize inherent complexities of natural antibodies that have hindered the establishment

200 B-1 B cells produce circulating natural antibodies that provide "innate-like" protection

201 sing CD19 (hCD19Tg) generated B-1a cells and natural antibodies that provided protection during infec

202 Natural antibodies that react with galactose-alpha(1,3)g

203 s is caused by the deposition of preexisting natural antibodies that recognize Galalpha1-3Gal (alphaG

204 1 cells are known to contribute most of the "natural antibodies" that are secreted in the steady stat

205 ion of one of these monoclonal, polyreactive natural antibodies, the IgM clone 9H4, revealed its abil

206 Inspired by natural antibodies, the use of epitopes as imprinting te

207 reactive B-1 cells generate steady levels of natural antibodies throughout life.

208 Natural antibody titers against M2FA are elevated in ath

209 reduced as a consequence of the increase in natural antibody titers, and IL-5 is identified as the l

210 d detection were conducted using plastic and natural antibodies to compare three different strategies

211 resulted in reduced binding of xenoreactive natural antibodies to endothelial cells of transgenic mi

212 sured in 114 MM patients and 31 HDs, because natural antibodies to MUC1 have been detected in patient

213 ibody responses to TNP-Ficoll, production of natural antibodies to phosphocholine, and survival after

214 Human natural antibodies to pig endothelial cell antigens appe

215 Non-opsonic natural antibodies to PNAG found in NHS interfered with

216 h immunization-induced animal antibodies and natural antibodies to PNAG in NHS interfere with the pro

217 cells into the circulation after removal of natural antibodies to the antigen.

218 cies is a result of the binding of preformed natural antibodies to the endothelium of the donor organ

219 Since normal nonalloimmunized males have natural antibodies to the heavy chains (HCs) of HLA anti

220 Levels of natural antibodies to the pneumococcal polysaccharide co

221 ted by the binding of preformed xenoreactive natural antibodies to the vascular endothelium of the gr

222 Leishmania co-option of a host natural antibody to facilitate mating in the insect vect

223 Here we evaluated whether natural antibody to PNAG in normal human serum (NHS) had

224 Natural antibody to PNAG is common in humans and animals

225 nd in serum samples of healthy subjects with natural antibody to PNAG, to which immunization-induced

226 women is associated with decreased levels of natural antibody to selected pneumococcal capsular serot

227 This phenomenon depends on the binding of natural antibody to the vascular endothelium, fixation o

228 n Africa exist concerning the development of natural antibody to these antigens, however.

229 ation because many humans have minimal or no natural antibody to TKO pig cells.

230 t mice, which, like humans, produce anti-Gal natural antibodies, to investigate the ability of mixed

231 Estimates of the mean time to loss of natural antibodies varied by model, ranging from 49 to 1

232 ion scheme for the target protein, while the natural antibody was responsible to signal the presence

233 Studies in the 1980s first showed that some natural antibodies were "catalytic" and able to hydrolyz

234 alphaGal-specific natural antibodies were detectable by enzyme-linked immu

235 ntrast, only low titers of alphaGal-specific natural antibodies were detectable only in the serum of

236 Monkey anti-pig natural antibodies were immunoadsorbed by extracorporeal

237 inity and selectivity comparable to those of natural antibodies, were prepared by combining a functio

238 ochete Borrelia burgdorferi first encounters natural antibodies when its arthropod vector, Ixodes sca

239 ucidate a novel homeostatic pathway by which natural antibodies, which are products of the adaptive i

240 ently limitless range of foreign proteins by natural antibodies, which has been exploited to develop

241 Again, this is consistent with studies of natural antibodies, which have shown that nonspecific, s

242 Natural antibody, which represents a collection of germl

243 the infarct identified a novel population of natural antibodies with few somatic mutations in complem

244 y diverse strains was limited by preexisting natural antibody with a lesser contribution of complemen

245 area of cell-based xenotransplant therapies, natural antibodies (XNA) and complement have also been c

246 human, is rejection mediated by xenoreactive natural antibodies (XNA) that bind the carbohydrate epit

247 y protein-G chromatography, and xenoreactive natural antibodies (XNA) were depleted by passing the Ig

248 In additional groups, xenoreactive natural antibodies (XNA) were depleted by pig lung perfu

249 Human xenoreactive natural antibodies (XNA), both IgM and IgG subtypes, whi

250 Human xenoreactive natural antibodies (XNA), of IgM and IgG subtypes, capab

251 ute rejection (HAR) mediated by xenoreactive natural antibodies (XNA), which are thought to develop i

252 nized on porcine cells by human xenoreactive natural antibodies (XNA).

253 nt inhibitors without eliminating xenogeneic natural antibody (XNA) reactivity may provide insufficie

254 Xenoreactive natural antibodies (XNAs) and complement mediate hyperac