ライフサイエンスコーパス: natural history

1 agement is common, yet little is known about natural history.

2 l registry of patients with HFpEF to map its natural history.

3 or, there are large gaps in knowledge of its natural history.

4 is (AD) is a prevalent disease with variable natural history.

5 specimens relevant to cultural heritage and natural history.

6 ongitudinal data (1-2 years) to describe the natural history.

7 pathobiology, phenotypic heterogeneity, and natural history.

8 here was substantial individual variation in natural history.

9 al studies that provide understanding of the natural history and causality of diseases since early in

10 ults will allow greater understanding of the natural history and clinical and prognostic significance

11 We aim to assess the natural history and clinical relevance of TTNtv by analy

12 ches can provide important insights into the natural history and diversity of species, but the cogenc

13 xis outcomes limits our understanding of the natural history and epidemiology of anaphylaxis, hinderi

14 Given this complex natural history and immunology, the design of clinical t

15 The evidence on natural history and indications for liver transplantatio

16 s refine and extend our understanding of the natural history and individual spectrum/manifestations o

17 n the knowledge of its etiopathogenesis, its natural history and its findings in image.

18 t and is bringing new insights into both the natural history and management of this very prevalent di

19 of ISCMs to describe clinical presentation, natural history and outcomes of both surgical and conser

20 ission and suggest a key role for DCs in the natural history and pathogenesis of HTLV-1 infection.

21 spontaneously within 5 years in adults, the natural history and predictors of resolution in children

22 enosis (MS) increases with age; however, its natural history and relation to cardiac symptoms or como

23 H) is a heterogeneous condition with varying natural history and therapeutic response.

24 Our results improve our understanding of the natural history and transmission dynamics of SARS-CoV-2.

25 chastic compartmental model representing the natural history and transmission of cefixime-sensitive a

26 We compared the natural history and transmission potential of asymptomat

27 A and HBsAg concentrations occurs during the natural history and treatment of chronic hepatitis B.

28 gen (HBsAg) concentrations occurs during the natural history and treatment of chronic hepatitis B.

29 ibes the clinical features, pathophysiology, natural history and treatment of POLG-related disorders,

30 s mellitus (DM) effects on tuberculosis (TB) natural history and treatment outcomes, and to assess th

31 illomavirus genotyping is important to study natural history and vaccine efficacy.

32 involve therapeutic monitoring, follow-up of natural histories, and identification of allergenic reco

33 seeking to further define the risk factors, natural history, and clinical features of LATE, as well

34 ere are some strange tales in the history of Natural History, and few more so than the story of anima

35 r findings inform DICER1 syndrome phenotype, natural history, and genetic counseling.

36 olecular basis of SMA, disease pathogenesis, natural history, and recognition of the impact of standa

37 ard and to provide insights into the causes, natural history, and risk of DRT.

38 studies to better understand M. genitalium's natural history, and then examined the effects of implem

39 endpoints, increase the understanding of the natural history, and thus help to shape the design of fu

40 we summarise knowledge on the epidemiology, natural history, and treatment of chronic HBV infection

41 we summarise knowledge on the epidemiology, natural history, and treatment of chronic HCV infection

42 review, we highlight the complexities of the natural history, biology, and clinical management of thr

43 ith the goal to facilitate investigations of natural history, biology, and molecular pathogenetic mec

44 f predictability for diseases with different natural history, both empirically and in our simulations

45 evention or early intervention because their natural history cannot be reliably predicted.

46 mary cause of cancer-related deaths, but the natural history, clonal evolution and impact of treatmen

47 Two natural history cohorts were studied including 168 longi

48 al from the United States National Museum of Natural History collection.

49 Our study demonstrates how natural history collections can be used to broadly chara

50 Natural history collections can complement and enhance o

51 traspecific diversity is captured in immense natural history collections, giving us a window into tra

52 vement is available (a travel kernel), and a natural history consistent with pandemic influenza; we s

53 Epidemiologic and natural history data are limited.

54 We report natural history data in a large cohort of 199 patients w

55 atic review and meta-analysis of keratoconus natural history data including 11 529 eyes.

56 Here we analyze natural history data on a large sample of individuals wi

57 ion body myositis, and it provides important natural history data over 12 months.

58 etation, informs prognosis and also provides natural history data that will guide clinical trial desi

59 These SOD1-specific ALS natural history data will be important for the design an

60 Furthermore, natural-history data to test most predictions do not exi

61 e the behavior of a cavernous angioma in its natural history, documenting: a) its de novo appearance,

62 This effort must involve natural history, ecology, and evolutionary biology in ad

63 The disease natural history followed a "susceptible-exposed-infectio

64 5% CI 1.94 to 2.77), the Neuroprotection and Natural History in Parkinson Plus Syndromes Parkinson Pl

65 tive recommendations could be made about the natural history, indications, and outcome of liver trans

66 odeficiency syndrome have been reported, its natural history is not well understood.

67 t patients, the condition is chronic and the natural history is one of fluctuating symptoms.

68 common genetic variation to disease risk and natural history is poorly characterised.

69 autonomous cortisol excess (MACE), but their natural history is unclear.

70 They ignore the study system's natural history justifying our fitness measures, while f

71 To determine the cause and natural history, large prospective studies evaluating th

72 An HCV natural history Markov model was used to evaluate the co

73 recovered from sedimentary deposits, held in natural history museum collections, and cored into moder

74 highlight other ways in which herbarium and natural history museum records can be leveraged for futu

75 s, for example, the blue whale 'Hope' at the Natural History Museum, London.

76 re often featured as iconic open displays in Natural History Museums, for example, the blue whale 'Ho

77 the heterogeneous clinical presentations and natural histories of advSM.

78 We sought to compare natural histories of severity-matched patients with/with

79 The natural history of (sub)retinal oxalate deposits, the pa

80 series (UGI) to evaluate the development and natural history of a hiatal hernia.

81 The patient characteristics and natural history of a particular pattern of reticular bul

82 this study was to prospectively evaluate the natural history of a population with LAR, the potential

83 at ILT of AAAs releases mediators during the natural history of AAA growth.

84 INTRODUCTION: The characteristics and natural history of acute non-vitamin K antagonists oral

85 This study aims to clarify the natural history of adult patients with GM2 gangliosidosi

86 he past few years, dramatically changing the natural history of all SMA subtypes, including substanti

87 The allergic march refers to the natural history of allergic conditions during infancy an

88 mmunotherapy (AIT) is targeted to modify the natural history of allergic diseases.

89 tive studies are needed to better define the natural history of allograft steatosis.

90 geted therapies, will undoubtedly change the natural history of ALS.

91 ls has provided much needed insight into the natural history of amblyopia, its origins and sensitive

92 ffect of antiretroviral therapy (ART) on the natural history of anal high-risk HPV and anal lesion pr

93 effect of ART and HIV-related factors on the natural history of anal HPV-related disease in people li

94 Prospective data on the natural history of anal human papillomavirus (HPV) infec

95 There are limited data on the natural history of antenatal Zika virus (ZIKV) exposure

96 The natural history of anti-interferon-gamma (IFN-gamma) aut

97 tics and a variety of studies support a long natural history of associated resistance.

98 ions to prevent the development or alter the natural history of asthma-related diseases.

99 knowledge about the factors that impact the natural history of asthma.

100 The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regime

101 Little is known about the natural history of asymptomatic severe acute respiratory

102 rt was followed for 2 years to determine the natural history of asymptomatic thrombosis.

103 Natural history of AT differed among the most common for

104 describes this temporal relationship in the natural history of atopic diseases.

105 We sought to characterize the natural history of ATTR-CM and compare outcomes and qual

106 Systematic review and meta-analysis of the natural history of autosomal recessive Stargardt disease

107 icle summarizes our current knowledge of the natural history of baboons and highlights directions for

108 Purpose To better understand the natural history of BCVI and help define the most optimal

109 ailable clinical information to document the natural history of BHFS.

110 efore, we sought to define the incidence and natural history of biliary stricture caused by NP.

111 e in individuals with Down syndrome, but the natural history of biomarker changes in Down syndrome ha

112 ing to confusion in our understanding of the natural history of breast cancer and radiation effects.

113 The natural history of cancer-associated lymphoedema is defi

114 a competing risk framework to understand the natural history of candidates who declined and Cox regre

115 a competing risk framework to understand the natural history of candidates who declined, and Cox regr

116 need for more research to better clarify the natural history of cCMV in highly seropositive populatio

117 brated mathematical model that simulates the natural history of cervical cancer, we estimated the cum

118 l enable further discoveries that change the natural history of CF lung disease.

119 The natural history of childhood rhinitis is not well descri

120 research to improve our understanding of the natural history of chlamydia and the pathways through wh

121 We prospectively investigated the natural history of CMR-based myocardial injury and chamb

122 However, the natural history of CMR-based tissue markers and their as

123 therapy allowing for characterization of the natural history of coccidioidomycosis.

124 prehensive batteries to better delineate the natural history of cognitive recovery across ICU patient

125 sheep tendon injury model characterised by a natural history of consistent failure of healing was cho

126 r fibrosis might be a relevant player in the natural history of COVID-19 is currently unknown.

127 The link between liver fibrosis and the natural history of COVID-19 should be evaluated in futur

128 Understanding the natural history of cryptosporidiosis and the correlates

129 This longitudinal study conveyed the natural history of CXLRS.

130 The natural history of cytomegalovirus (CMV) infection is co

131 spective cohort study helps characterize the natural history of DCM, provides insight into the host i

132 kostasis in diabetes and document within the natural history of diabetic retinopathy processes of pro

133 rthritis, improving our understanding of the natural history of disease and characterizing the immune

134 ponses can decrease over time because of the natural history of disease or the effects of therapy.

135 D, reducing health-care use and altering the natural history of disease.

136 and that its occurrence seems to change the natural history of disease.

137 We determined the natural history of dysfunction and degeneration of retai

138 the 3 most common blood-borne pathogens, the natural history of early HCV infection, and the scientif

139 activity are needed to fully understand the natural history of EoE.

140 entive antiepileptic treatment to modify the natural history of epilepsy has been proposed.

141 The natural history of FLT3-mutated AML is changing after th

142 es to better understand the pathogenesis and natural history of food allergy, as well as potential ap

143 of clinical trials and may shed light on the natural history of GA expansion.

144 Although the natural history of HCM-LVSD was variable, 75% of patient

145 sequential, evolving immunity as part of the natural history of HCs through gestation.

146 cardiac resynchronization therapy, given the natural history of heart failure, it is common practice

147 s of HemECs have, in part, recapitulated the natural history of hemangioma regression.

148 Their measurement during the natural history of hepatitis B, and on treatment with cu

149 Their measurement during the natural history of hepatitis B, and on treatment with cu

150 HER2-targeted therapy has changed the natural history of HER2-positive metastatic breast cance

151 paucity of clinical data with respect to the natural history of HFrecEF patients, there are no curren

152 etary intake has a discernable impact on the natural history of HIV/SIV infections and suggests that

153 Here, we review the natural history of house sparrows, highlight what the st

154 In 1984, a large prospective study of the natural history of human immunodeficiency virus (HIV) in

155 households (78 participants) delineating the natural history of human rhinovirus (HRV).

156 To identify differences in the natural history of IM after e-HRT exposure.

157 crease in tumor growth and thus altering the natural history of IMs.

158 is related to transmission patterns and the natural history of infection; its value also depends on

159 We developed a microsimulation model of the natural history of injection opioid use.

160 This national evaluation of the natural history of isolated splenic injuries from index

161 Detailed knowledge of the natural history of keratoconus is fundamental in making

162 sition microsimulation models to reflect the natural history of keratoconus progression and the impac

163 We set out to describe the natural history of keratoconus.

164 The knowledge about the natural history of local allergic rhinitis (LAR) is limi

165 We examined the incidence and natural history of macular retinochoroidal neovasculariz

166 ania in the context of bipolar disorder, the natural history of mania (with an emphasis on its recurr

167 s such as hepatitis B and C and studying the natural history of many forms of chronic liver disease.

168 e remaining gaps in our understanding of the natural history of medaka.

169 rt is currently focused on understanding the natural history of microbiome development in humans in t

170 The long-term natural history of microscopic colitis (MC) (collagenous

171 o advance understanding of the phenotype and natural history of multiple endocrine neoplasia type 2B,

172 Data are scarce on the natural history of multiple endocrine neoplasia type 2B.

173 tologists, due to their understanding of the natural history of NASH, are uniquely positioned to prov

174 (2) Is the natural history of NASH-related cirrhosis different from

175 The natural history of non-central nervous system (CNS) diss

176 To define the natural history of NSE in an Irish cohort.

177 would capitalize on the peculiarities of the natural history of OMOs and could feasibly be completed

178 we began a longitudinal study assessing the natural history of orthopoxviruses in Georgia.

179 tumor burden is important for following the natural history of orthotopic colon cancer and therapeut

180 The natural history of our moral stance told here in this co

181 stigations, advance our understanding of the natural history of pathogens and drivers of disease, and

182 myopathy Registry) were used to describe the natural history of patients with HCM-LVSD.

183 ternational Study of Efficacy trial, and the natural history of PBC was informed by published clinica

184 The natural history of PDGFRA- and PDGFRB-rearranged neoplas

185 ated immune dysregulation contributes to the natural history of PEL will improve outcomes.

186 that IL-6 and IL-10 levels contribute to the natural history of PEL.

187 Unique to the natural history of perinatal HCMV infections is the occu

188 The Vascular Leaders Forum reviewed the natural history of peripheral arterial disease, the use

189 ity has made little progress in changing the natural history of peripheral T-cell lymphomas.

190 of this study was to describe phenotype and natural history of PRKAG2 variants in a large multicente

191 Rationale: The preclinical natural history of progressive lung fibrosis is poorly u

192 y have fundamental pathogenic effects on the natural history of psychosis, suggest a biological mecha

193 inflammation and lung disease throughout the natural history of RA.

194 mong children, accounting for aspects of the natural history of rotavirus and differences in transmis

195 However, little is known about the natural history of SaAAAs and the threshold for interven

196 nt with vigabatrin was safe and modified the natural history of seizures in TSC, reducing the risk an

197 Little is known about the natural history of serrated polyps (SPs), partly due to

198 Hiatal hernias are common but the natural history of sliding and paraesophageal type herni

199 dings contribute to the understanding of the natural history of SMA type III and will be helpful in t

200 Background The effect of bracing over natural history of stable dysplastic hips is not well kn

201 The natural history of stage B aortic regurgitation (AR) is

202 This study sought to characterize the natural history of subclinical AF in at-risk patients fr

203 reconstruct the timing, likely origins, and natural history of superinfecting strains.

204 mation is central to the pathophysiology and natural history of takotsubo cardiomyopathy.

205 We used the model to infer differences in natural history of TB and in future projections of TB.

206 Our work provides insights into the natural history of terrestrial ecosystems.

207 Conclusions The natural history of the analyzed TTNtv shows a relatively

208 small molecules could profoundly change the natural history of the disease and decrease complication

209 ve implications for our understanding of the natural history of the disease and for the clinical asse

210 e approach allows further elucidation of the natural history of the disease and may better guide clin

211 The findings suggest the natural history of the disease from a radiological point

212 recent decades, and the ability to alter the natural history of the disease has never been better.

213 Starting from the natural history of the disease in humans, there is accum

214 investigated the impact of iNKT cells in the natural history of the disease in the Emu-Tcl1 (Tcl1) CL

215 ld as Roman, although accurate diagnosis and natural history of the disease is lacking.

216 of cases have been reported to date, and the natural history of the disease is poorly understood.

217 inform on the activity of T cells during the natural history of the disease or in response to treatme

218 hly efficacious and has markedly altered the natural history of the disease(6,7).

219 rage of treatment and prevention programmes, natural history of the disease, HCV prevalence, and HCV-

220 ucibly is essential to understand better the natural history of the disease, to identify high-risk si

221 h has led to abundant evidence regarding the natural history of the disease.

222 UC and highlight their roles in shaping the natural history of the disease.

223 who debate that this could still reflect the natural history of the disease.

224 ome, influences the host immune response and natural history of the disease.

225 lities have allowed a direct window into the natural history of the disease.

226 nt in an effort to investigate the cause and natural history of the disease.

227 in patient four, compared with -37.7 in the natural history of the disease.

228 onclusion that both entities merge along the natural history of the disease.

229 eta-cell function that is a component of the natural history of the disease.

230 ndergo preventive interventions early in the natural history of the disease; 2) discover as yet unkno

231 Additionally, little is known about the natural history of the disorder, genotype-phenotype corr

232 ing and quarantine depends critically on the natural history of the infectious disease, its inherent

233 Data are limited on the natural history of the precursor to this carcinoma, anal

234 Data on the natural history of the precursor, anal squamous intraepi

235 The natural history of the pro-inflammatory immune response

236 eter as part of the multicenter, prospective Natural History of the Progression of Atrophy Secondary

237 However, the long-term natural history of the residual retinal pigment epitheli

238 We also examined how the natural history of the RPD (whether the dilatation persi

239 ng, are common in preterm-born subjects, the natural history of the wheezing phenotypes and the influ

240 The true cause and natural history of these complications are unclear and r

241 linical recognition and understanding of the natural history of these conditions.

242 ent of interventions that interfere with the natural history of these diseases is a priority.

243 rtunity to target abnormalities early in the natural history of these disorders in a sex-dependent wa

244 population at multiple time points over the natural history of these models.

245 models continue to provide insight into the natural history of these potentially lethal conditions.

246 s of swine IAVs are key to understanding the natural history of these viruses in swine and to selecti

247 etic therapies would dramatically change the natural history of this disease.

248 The natural history of this disorder suggests that untreated

249 ration mandated CT studies to understand the natural history of this finding, differences between tra

250 erm follow-up is necessary to understand the natural history of this rare anomaly.

251 e aware of the extra-endocrine signs and the natural history of this rare syndrome.

252 While there is knowledge about the natural history of this species, what is currently lacki

253 an essential component to understanding the natural history of this virus and its transmission to hu

254 The natural history of TTR-CM is poorly characterized, which

255 And yet the natural history of tuberculosis in children, as a contin

256 However, HIV has a profound effect on the natural history of tuberculosis, manifesting in an incre

257 Determining the natural history of unifocal versus multifocal geographic

258 To describe the anatomic changes and natural history of vitelliform lesions in Best vitellifo

259 Our aim was to describe the natural history of XLA.

260 analyze the adjustable gastric banding (AGB) natural history on a national basis.

261 s note insufficient evidence to quantify its natural history or risk associated with specific exposur

262 oderate, and severe TR were derived based on natural history outcome data.

263 Data on natural history, outcomes and therapeutic strategies are

264 pidemiology and cause to clinical diagnosis, natural history, patient stratification and clinical man

265 s more than that observed in our prior acute natural history patients (0.17 logMAR; P < 0.001).

266 reater than that observed in our prior acute natural history patients of 0.21 logMAR (P = 0.053).

267 5 years from symptom onset, enrolled in the Natural History Project of the Dystonia Coalition, were

268 oor, but because of its relative rarity, the natural history remains incompletely characterized.

269 rment is common among ICU survivors, but its natural history remains unclear.

270 without HIV infection participating in HSV-2 natural history studies (University of Washington Virolo

271 mendations on the use of these modalities in natural history studies and interventional clinical tria

272 isease, and paves the way toward large-scale natural history studies and treatment trials in COQ8A-at

273 rrelation that is relevant for the design of natural history studies and upcoming interventional tria

274 ic spectrum of the disease, but longitudinal natural history studies are lacking.

275 wer in actively treated patients compared to natural history studies from the pretreatment era.

276 his study replicates the results of previous natural history studies of eyes with DPED including the

277 ase is rare, limiting the ability to perform natural history studies or to perform clinical trials.

278 tants, and trainees work together to perform natural history studies that promote clinical trial read

279 dations are based on the literature, ongoing natural history studies, and extensive clinical experien

280 p-matched participants in the CINRG Duchenne Natural History Study (corticosteroid-naive, n = 19; cor

281 We used data from the US Military HIV Natural History Study (NHS), to examine the association

282 EXPLORE is a prospective, multinational, natural history study characterizing disease activity an

283 cal syndrome were recruited through the Rett Natural History study from 2006 to 2015.

284 terized.METHODSWe performed an observational natural history study of 50 patients with CTLA4h who wer

285 ss were collected as part of a screening and natural history study of alcohol use disorders in 454 in

286 ate of disease progression in a longitudinal natural history study of children with Charcot-Marie-Too

287 aim of this research is to initiate a 5-year natural history study of dry eye disease (DED) using obj

288 ested within a multinational prospective HPV natural history study of men aged 18-70 years in the Uni

289 We performed a 12-month natural history study to characterise the phenotype of H

290 ned immunodeficiency (SCID) to a prospective natural history study.

291 olled in the Rett and Rett-Related Disorders Natural History Study.

292 ysis of a generalized model of breast cancer natural history that allows for a mixture of progressive

293 Its natural history, the development of nonalcoholic steatoh

294 inical trials and literature on tuberculosis natural history to model outcomes, assuming different pr

295 ous forms of G1D, associated manifestations, natural history, treatment efficacy, and diagnostic proc

296 The eliciting factors, natural history, underlying molecular biology, and clini

297 This should be considered in the disease natural history when attempts for treatments are propose

298 vidence is available about its prognosis and natural history, which are crucial to inform clinical pr

299 Our elucidation of the natural history will provide clinicians and patients wit

300 Luminal breast cancer has a long natural history, with recurrences continuing beyond 10 y