ライフサイエンスコーパス: natural product

1 ect that 19-epi-arborisidine could also be a natural product.

2 emanding enol ester double bond found in the natural product.

3 of biological activity associated with this natural product.

4 e that specifies selective production of the natural product.

5 diently introduce all 19 carbon atoms of the natural product.

6 s a -CHMe-CH(2)- unit in the backbone of the natural product.

7 tep, 11-pot enantiospecific synthesis of the natural product.

8 sary, contributing to the production of more natural products.

9 tage functionalization of drug scaffolds and natural products.

10 y control the stereochemistry of hapalindole natural products.

11 cals and are common in medicinally important natural products.

12 the late-stage diversification of drugs and natural products.

13 c gene clusters (BGCs) that encode for novel natural products.

14 on scaffolds found in thousands of terpenoid natural products.

15 common structural motifs in various terpene natural products.

16 pplications spanning from pharmaceuticals to natural products.

17 n o-QM intermediate to biosynthesize complex natural products.

18 for the formation of a range of fascinating natural products.

19 erated discovery and characterization of new natural products.

20 ford the highest potential to discover novel natural products.

21 structural motifs, like precursors to lignan natural products.

22 reoselective synthesis of other epoxyquinone natural products.

23 es are common substructures in medicines and natural products.

24 esis of functionally optimised 'non-natural' natural products.

25 ng synthetic target among angular triquinane natural products.

26 portant substructures in pharmaceuticals and natural products.

27 no acids can be integrated into more complex natural products.

28 tically important scaffold but is rare among natural products.

29 atform for metabolic engineering of valuable natural products.

30 unusual enzymatic chemistries and bioactive natural products.

31 ining peptide) an unusual architecture among natural products.

32 known to be a prolific producer of cytotoxic natural products.

33 l efficacious anticancer agents derived from natural products.

34 t of future screening workflows of microbial natural products.

35 beo-framework of the swinhoeisterol class of natural products.

36 ng fusions is distinct from those of related natural products.

37 e of the most structurally varied classes of natural products.

38 croorganisms or semisynthetic derivatives of natural products.

39 ivated for characterization of their cognate natural products.

40 nes, two privileged scaffolds often found in natural products.

41 tic disconnections in the total synthesis of natural products.

42 the rapid identification of cryptic peptide natural products.

43 tion for the further elaborations of several natural products.

44 roisoquinoline (THIQ) or fully aromatized IQ natural products.

45 o improve the prospects of discovering novel natural products.

46 ral motifs found in many biologically active natural products.

47 series of N-terminal lipid analogues of the natural products.

48 r application in the biomimetic synthesis of natural products.

49 trahydronaphthalene cores presented in these natural products.

50 tantiated by applications to polyfunctional (natural) products.

51 t synthetic approach to the taxane family of natural products?

52 DHCR7 deficiency or treatment with the natural product 7-dehydrocholesterol (7-DHC) could speci

53 total synthesis of four to now six different natural product alkaloid classes by distinguishing late

54 nt mixture that had been used to analyze the natural product; all other isomers were prone to ring op

55 ng block, whose three-step conversion to the natural product allowed for an expeditious entry to this

56 However, current supply for this natural product analogue is limited because of the lengt

57 in the total synthesis of this scarce marine natural product and a number of its simpler analogues en

58 e analytical data with those of the reported natural product and by single X-ray crystal diffraction

59 ta confirm the assignment of this particular natural product and strongly suggest that xestocyclamine

60 decades, traditional drug discovery has used natural product and synthetic chemistry approaches to ge

61 ly 1500 bioactive small-molecules, including natural products and active pharmaceutical ingredients o

62 teinogenic amino acids as building blocks of natural products and are attractive biocatalysts.

63 portant building blocks for the synthesis of natural products and bioactive small molecules.

64 The wide abundance of gamma-lactones in natural products and bioactive targets calls for suitabl

65 s) and their derivatives are present in many natural products and biologically active small molecules

66 this approach could be generalized to other natural products and biopolymers containing Dha residues

67 rated of the late-stage functionalization of natural products and drug molecules, stereospecific synt

68 e prevalent substructures in a wide range of natural products and drugs.

69 he dankasterone and periconiastone family of natural products and features a beta scission of a 14-al

70 of key importance in the total synthesis of natural products and in medicinal chemistry.

71 ynthesis of complex organic small molecules, natural products and materials are shown.

72 However, the key enzymes or the natural products and mechanisms involved are not well el

73 s been to adopt the concept of biomimicry of natural products and metabolites so as to improve multip

74 llustrated by the total syntheses of several natural products and other important molecules, further

75 are' sugars feature prominently in bioactive natural products and pharmaceuticals, including antivira

76 a privileged substructure of many bioactive natural products and semi-synthetic analogs.

77 riches the chemical space of actinobacterial natural products and shows the potential of Streptacidip

78 s in pharmaceutical and agrochemical agents, natural products and small-molecule biological probes(1,

79 ienes are a frequently occurring scaffold in natural products and specialty chemicals, and are used a

80 Unrelated small-molecule natural products and synthetic compounds inhibit Sec61 w

81 Recent work has identified natural products and synthetic small molecules capable o

82 nd guidance in the structure revision of old natural products and the anticipation of new ones.

83 Natural products and their derivatives represent over on

84 ht recent syntheses of hetidine and hetisine natural products and their derivatives.

85 This motif is central to many natural products and widely used as precursors to, or di

86 , ozone addition, and cleaning with terpene, natural product, and vinegar cleaners had a much smaller

87 ifs with increasing significance in ligands, natural products, and biologically active molecules.

88 e-gamma-lactones are present in ~3% of known natural products, and compounds comprising this motif di

89 ges associated with translating genomes into natural products, and examples of successful strain prio

90 fur compounds are omnipresent in many drugs, natural products, and functional materials; therefore, m

91 ed and post-translationally modified peptide natural product antibiotics that are effective against h

92 Among various natural products, anticancer potential of phenolics is w

93 Natural products are a major source of small-molecule th

94 Polyketide natural products are an important class of biologically

95 Finally, first pharmacokinetic data of these natural products are disclosed.

96 Plant halogenated natural products are rare and harbor various interesting

97 including drugs (for example, tedizolid) and natural products-are methylated site-selectively at the

98 They synthesize natural products as signaling molecules, antibiotics, or

99 tion of this enzyme can occur with drugs and natural products as well as environmental chemicals.

100 s catalyzes the release of resorufin and the natural product, as supported by molecular dynamics and

101 tegies and enabling technologies to discover natural products at scale and speed.

102 All four possible stereoisomers of the natural product (-)-avicennone C were synthesized using

103 a means of self-resistance to the genotoxic natural product azinomycin B.

104 g reactions are essential transformations in natural product biosynthesis.

105 An increasing number of natural product biosynthetic gene clusters, to which no

106 These data reveal a natural product biosynthetic workaround that evolved to

107 Th17-inducing vaccine adjuvants based on the natural product Brartemicin.

108 s exemplified by the synthesis of the marine natural product (+)-bretonin B.

109 tose core assembly of a thiosugar-containing natural product but also showcases the sophistication in

110 FL3 is a synthetic derivative of natural products called flavaglines, which exhibit anti-

111 Here, we describe how cores of macrocyclic natural products can serve as a high-quality in silico s

112 a novel paradigm for the accession of wider natural product chemical space, accelerating the discove

113 Natural product chemistry, microbiology, and food, human

114 This bioactive natural product class is reported for the first time in

115 olycyclic skeleton common to members of this natural product class.

116 divergent synthesis to access six different natural product classes from a single intermediate.

117 Natural product classes include polyketides (PKs), nonri

118 ch protein provides entry into diverse plant natural products classes, and our experiments suggest a

119 These novel 'pseudo-natural product' classes retain the biological relevance

120 Natural product clinical trials prioritized based on rig

121 tical, and actinomycetes, the main source of natural product compounds, have been overmined.

122 Microbial natural products constitute a wide variety of chemical c

123 Natural products containing Dha and/or Dhb residues are

124 antiomers, the absolute configuration of the natural product could be assigned using a bioassay on (+

125 e membrane permeable and orally bioavailable natural product cyclosporine A.

126 A large database, Universal Natural Products Database (UNPD) consisting of 213,210 c

127 initially dedicated to identifying bioactive natural products, dereplication aims at reducing the usu

128 es through late-stage functionalization of a natural product-derived FDA-approved therapeutic.

129 ds of docking of a carefully selected set of natural-product-derived cores led to the discovery of an

130 The natural product (+)-discodermolide (DDM) is a microtubul

131 s that have been used in the genomic era for natural product discovery from cultivatable bacteria.

132 tional classification of enzymes and advance natural product discovery.

133 estigated capacity-building in global marine natural product discovery.

134 a could provide a comprehensive strategy for natural product discovery.

135 , six-, and seven-membered heterocycles, and natural product diversification.

136 aches to overcome longstanding challenges in natural products drug discovery.

137 -AT type systems represent a new paradigm in natural product enzymology.

138 Many lariat peptide natural products exhibit interesting biological activiti

139 bstrate scope, scalability, and synthesis of natural products exhibited the vitality of this protocol

140 This family of natural product exhibits promising antioxidant activitie

141 esponsible for the enormously diverse fungal natural products exist almost exclusively in fungi.

142 High-throughput screening of natural product extract and fraction libraries for inhib

143 oducts from reaction mixtures, fractionating natural product extracts, and isolating compounds.

144 mproved synthetic route to a highly valuable natural product, facilitating further investigation of h

145 aken together, our work highlights how novel natural product families can be discovered by methods go

146 yed with EPL solution, making it a promising natural product for the control of plant diseases caused

147 led the unambiguous characterization of this natural product for the first time and helped establish

148 n able to design plausible routes to complex natural products, for which much more far-sighted, multi

149 -octahydronaphthalene-1-carboxylic acid is a natural product found in Dodonaea viscosa that constitut

150 Serrulatane diterpenoids are natural products found in plants from a subset of genera

151 which can be selectively reduced to give the natural product framework without recourse to stepwise U

152 total synthesis of the vasicinone family of natural products from bulk chemicals was developed.

153 Despite this success, interest in natural products from major pharmaceutical companies has

154 on (SFE) is widely used for the isolation of natural products from plants, but its application in eff

155 he prevalence of aryl thioether in bioactive natural products, functional materials, agrochemicals, a

156 y of alcohol nucleophiles, including complex natural products, glycosides, and amino acids were beta-

157 d aza-tetracycline derivatives including the natural products griffithazanone A and marcanine A.

158 The pentasubstituted pyridine natural products harzianopyridone and atpenins are poten

159 It is therefore surprising that virtually no natural products have been described for its sister genu

160 Bacterial natural products have inspired the development of numero

161 hadow the existence of other exotine-derived natural products having isomeric frameworks.

162 Thousands of halogenated natural products (HNPs) pervade the terrestrial and mari

163 The flavagline class of natural products (i.e., rocaglamide A) has been shown to

164 nd carbohydrate research, organic synthesis, natural-product identification and analysis, as well as

165 B and C has been developed, affording these natural products in 29% and 27% overall yield, respectiv

166 otential, a general strategy to access these natural products in a concise and divergent fashion is h

167 ise synthetic approach enables access to the natural products in a sequence of 8-12 steps from readil

168 accelerate the implementation of hydrophobic natural products in clinical applications.

169 Additionally, several known natural products including griseofulvin, dechlorogriseof

170 Some natural products, including ginsenoside Rg3 (Rg3), exhib

171 thesis of several important classes of plant natural products, including indole alkaloids, benzylisoq

172 er to distinguish between structurally close natural products, including stereoisomers.

173 ine bioactivity and bioavailability of plant natural products, including that of terpenoids and stevi

174 the biosynthesis of the presilphiperfolanol natural products, including the first experimental evide

175 The resulting natural product is the novel fungal metabolite fumigermi

176 structural assignment of small molecules and natural products is critical for drug discovery and orga

177 , and its utility as a tool for synthesizing natural products is demonstrated through the total synth

178 physicochemically often dissimilar microbial natural products is limited to date.

179 he products, as well as the syntheses of the natural product iso-moracin and the drug (E)-metanicotin

180 -nonribosomal peptide (PK-NRP) hybrid marine natural product isolated from Streptomyces sp. RKND-216.

181 Chrysophaentin A is an antimicrobial natural product isolated from the marine alga C. taylori

182 Teixobactin, a macrocyclic depsipeptide natural product, isolated from uncultured bacteria (Elef

183 tic and semisynthetic methodology as well as natural product isolation to tackle these problems and w

184 and identify the oligocyclopropyl-containing natural product jawsamycin (FR-900848) as a potent hit.

185 alog, or hydroxalog, of the cytotoxic marine natural product kalkitoxin in which the -NMe-O- moiety r

186 Myo-inositol hexakisphosphate (IP6) is a natural product known to inhibit vascular calcification

187 The natural product koningic acid (KA) is a selective covale

188 lied as the key step in the synthesis of the natural product lamellarin R.

189 action may differ from that of the original natural product lead.

190 During an unbiased screening of natural product libraries, this novel compound was found

191 s a result of a functional transformation of natural product ligustrazine, (Z)-N-tert-butyl-1-(3,5,6-

192 f C-H bonds in complex molecules, especially natural products like terpenoids, is a highly efficient

193 s do not always work as well as desired on a natural product-like scaffold.

194 etrical and synthetically challenging marine natural products lomaiviticins A and B present alluring

195 the collective and concise syntheses of the natural products (-)-microthecaline A, (-)-leubehanol, (

196 ent of the alpha-glucopyranosyl motif in the natural product mimic adenophostin 2 by d-chiro-inositol

197 confirmed the absolute configuration of the natural products mucorisocoumarins A and B as (-)-(10R,1

198 The antitumor natural product nataxazole is a model for a large class

199 to link the gene cluster to the beta-lactone natural product, nocardiolactone.

200 The diversity of natural products not only fascinates us intellectually,

201 PPs) are a particularly interesting class of natural products noted for their unique mode of biosynth

202 While great interest in health effects of natural product (NP) including dietary supplements and f

203 it from other scaffolds and may characterize natural product (NP) space more generally.

204 mimicking modality, termed PepNats, in which natural product (NP)-inspired structures are incorporate

205 Natural products (NP) are a valuable drug resource.

206 Bacterial natural products (NPs) and their analogs constitute more

207 Natural products (NPs) are a significant source of inspi

208 Plant natural products (NPs) represent a promising source of a

209 ine (DKPs) alkaloids are a diverse family of natural products (NPs) whose unique structural architect

210 Rhizolutin (1) was discovered as a natural product of ginseng-rhizospheric Streptomyces sp.

211 Triptolide is a trace natural product of Tripterygium wilfordii.

212 Meroterpenoids are natural products of hybrid biosynthetic origins-derived

213 Natural products of mixed polyketide/terpenoid origins (

214 lmonella enterica showed that such sRNAs are natural products of RNase E-mediated mRNA decay and asso

215 achieving total syntheses of two oxygenated natural products, one of which was prone to over-oxidati

216 lation are pivotal for accessing a myriad of natural products, pharmaceuticals, and drug candidates.

217 Aliphatic primary amines are prevalent in natural products, pharmaceuticals, and functional materi

218 These types of compounds are ubiquitous in natural products, pharmaceuticals, as well as in functio

219 bioactivity types and potencies of peptidic natural products (PNPs) are of high interest for the dev

220 Narciclasine, a natural product present in Amaryllidaceae family of flow

221 a human invention as most of them are either natural products produced by soil microorganisms or semi

222 of structurally complex and highly strained natural products provides unique challenges and unexpect

223 ries of derivatives of the antimycobacterial natural product pyridomycin have been prepared with the

224 With this method, the natural product pyrolaside B was synthesized for the fir

225 d with the regioselective acetylation of the natural product quercetin.

226 Microbial natural products represent a rich resource of evolved ch

227 sters (BGCs) and represent a new frontier in natural product research.

228 discovered that the plecomacrolide family of natural products restored MHC-I to the surface of Nef-ex

229 ants and regarding the discovery of a marine natural product, revealing biological insights at the co

230 The natural product-ribosome structure enabled the synthesis

231 tides (RiPPs), also called ribosomal peptide natural products (RPNPs), form a growing superfamily of

232 l for the biosynthesis of two very different natural product scaffolds: the (dihydro)pyrazine-N-oxide

233 Natural products serve as chemical blueprints for most a

234 wo libraries screened, 17 compounds from the natural product set III library and 7 compounds from the

235 r networking of GC-MS data within the Global Natural Product Social (GNPS) Molecular Networking analy

236 Global Natural Product Social Molecular Networking (GNPS) is an

237 g (FBMN) as an analysis method in the Global Natural Products Social Molecular Networking (GNPS) infr

238 that they come from few chemical classes or natural product sources.

239 by the late-stage amination-aromatization of natural products, steroids and terpene feedstocks.

240 uaternary carbon is a predominant feature of natural product structures and has been associated with

241 also severely limits our ability to predict natural product structures from biosynthetic gene cluste

242 ows the synthesis of the core ring system of natural products such as cordigol and lophirone H.

243 atoms within the core ring, include diverse natural products such as macrolides with potent bioactiv

244 Existing biosynthetic pathways for natural products, such as vitamins, organic acids, amino

245 through the preparation of the cores of the natural products sulcatine G and perforatol.

246 ted resource using a synthetic-bioinformatic natural product (syn-BNP) approach, which relies on bioi

247 ights in cascade polycyclizations applied to natural product syntheses over the last five years are d

248 cturally interesting cores with potential in natural product synthesis and drug discovery.

249 . cerevisiae, highlighting the potential for natural product synthesis and large-scale fermentation i

250 rumental, which had not found application in natural product synthesis before.

251 Application in natural product synthesis enables gram-scale access to t

252 the first application of this technology in natural product synthesis is demonstrated here.

253 agetitoxin (1), a long-standing challenge in natural product synthesis, has been the subject of multi

254 ld, frequently applied in drug discovery and natural product synthesis, most research endeavours focu

255 ication in the context of drug discovery and natural product synthesis.

256 importance to drug discovery programmes and natural product synthesis.

257 , an antipode of the cephalosol intermediate natural product that contains a tricyclic isocoumarin fr

258 Our findings report on a natural product that inhibits PIEZO2 function and counte

259 ying, to perform a behavior-based screen for natural products that affect serotonin signaling.

260 Nonribosomal peptides (NRPs) are natural products that are biosynthesized by large multi-

261 ducts (RPNPs), form a growing superfamily of natural products that are produced by many different org

262 ass of macrocyclic, heavily modified peptide natural products that are unified by the presence of a s

263 cyclines are structurally diverse anticancer natural products that bind to DNA and poison the topoiso

264 ORPphilins are bioactive natural products that strongly and selectively inhibit t

265 Within this large and diverse family of natural products, the insecticidal metabolite (+)-brevia

266 ile receptors (CRs) to detect poorly soluble natural products, thereby defining a form of contact-dep

267 Also referred to as natural products, they have been widely applied in medic

268 t synthetic strategy provides access to both natural products through a pivotal spirolactam intermedi

269 at truncating the C28 oligosaccharide of the natural product to the tetrasaccharide (as in 5d (beta))

270 ity studies imputed the bioactivity of these natural products to a DNA cross-linking mechanism, but t

271 lowed the proposed structure of these marine natural products to be confirmed.

272 our of these scaffolds have been observed in natural products to date.

273 ivatized a broad range of approved drugs and natural products to generate valuable trifluoromethylate

274 ously reported derivatization of resorcylate natural products to produce fungal-selective compounds,

275 ribed demonstrate the value that programs in natural product total synthesis have in advancing organi

276 Bryostatin 1 is a marine natural product under investigation for HIV/AIDS eradica

277 ctive intermediate for coupling with diverse natural products under very mild conditions.

278 es and the synthesis of several protobruceol natural products using singlet oxygen ene reactions.

279 r the biosynthesis of quinolone-gamma-lactam natural products via Dieckmann condensation.

280 tural diversification of aromatic polyketide natural products via unusual redox tailoring reactions t

281 Yet, the target natural product was obtained isomerically pure in an ove

282 thetic approach to various polyquinane-based natural products was accomplished efficiently by employi

283 s in the chemical space exemplified by these natural products, we generated a library of scaffolds us

284 erivatives, and those derived from bioactive natural products were successfully implemented to direct

285 llows access to unnatural derivatives of the natural product, which would not be accessible through t

286 nt of turmeric and also one of the important natural products, which has been investigated extensivel

287 Since 25HC is a natural product with no known toxicity at effective conc

288 Hemiasterlin is an antimitotic marine natural product with reported sub-nanomolar potency agai

289 eover, we synthesized alchornedine, the only natural product with the AOXD scaffold.

290 ryostatins are a family of 21 complex marine natural products with a wide range of potent biological

291 e alkaloids represent an important family of natural products with a wide-spectrum of biological acti

292 enes from farnesyl diphosphate as high-value natural products with applications in medicine, agricult

293 The paraherquamides are potent anthelmintic natural products with complex heptacyclic scaffolds.

294 meroterpenoids are a diverse group of hybrid natural products with impressive structural complexity a

295 a role in the formation of novel yet unknown natural products with incorporated l-proline-like precur

296 ) are a structurally complex class of fungal natural products with potent anticancer activity.

297 ivileged structural motif found in over 1000 natural products with relevance to neurodegenerative dis

298 We synthesized a total of nine complex natural products with rich oxygenation patterns and skel

299 hongoquercins are tetracyclic meroterpenoid natural products with the trans-transoid decalin-dihydro

300 kaloids represent a fascinating new class of natural products with unprecedented chemical structures,