ライフサイエンスコーパス: naturally occurring

1 duction in soils based on the proportions of naturally occurring (15)N(15)N in N(2).

2 We then use the naturally occurring 3'-UTR approach to restore apoptosis

3 rich elements into the 3'-UTR or swapping in naturally occurring 3'-UTRs conferring different transcr

4 o and in vivo studies suggest that Lcn2 is a naturally occurring adipokine, and may serve as an anti-

5 persal by conducting a mark-capture study of naturally occurring Ae. aegypti from discarded container

6 in these circuits blocks aggression priming, naturally occurring aggression, and traumatic stress-ind

7 s been proven by the formal synthesis of the naturally occurring alkaloid (+)-(9S,13R)-13-hydroxyisoc

8 f chronic asthma induced by a panel of three naturally occurring allergens and novel delivery system

9 w known examples that are not derivatives of naturally occurring allosteric systems.

10 Naturally occurring alpha-thalassemia mutations that tri

11 We isolated H9 viruses that carried naturally occurring amino acids, variants found in other

12 C123 and AgA are naturally occurring amyloid-forming fragments of P1 and

13 DCT A, 10), and limonin (LMN, 11), and their naturally occurring analogues and synthetic derivatives.

14 GM is an additional mechanism for mobilizing naturally occurring and anthropogenic Hg from terrestria

15 e to normal levels and remarkably alleviated naturally occurring and colorectal distension-induced AD

16 were established to generate and purify both naturally occurring and in silico-designed DIs as fully

17 Affinity measurements and mapping of naturally occurring and in vitro-selected spike mutants

18 to highlight the current state of affairs on naturally occurring and rationally designed cyclic tetra

19 Naturally occurring and recombinant protein-based materi

20 This identification of naturally occurring and stress-induced hGR isoforms, as

21 Amino acids are naturally occurring and structurally diverse metabolites

22 useful chemical entities for medicine, with naturally occurring and synthetic macrocycles clinically

23 ved directional CSF flow can be explained by naturally occurring and/or experimenter-generated pressu

24 Primary amines are often cheap, naturally occurring, and chemically diverse starting mat

25 lfare issue for sheep farmers and a valuable naturally occurring animal model for human lung adenocar

26 nesis of OPA and strengthens the use of this naturally occurring animal model for human lung adenocar

27 atresone, responsible for biliary atresia in naturally-occurring animal models, that causes cholangio

28 showed that, compared to individuals who had naturally occurring anti-PfGARP antibodies, Tanzanian ch

29 tive to wild-type human MxA, the most potent naturally occurring anti-THOV restrictor identified.

30 nt derived anthraquinone and tetracycline (a naturally occurring antibiotic), are both absorbed into

31 selective total synthesis of mycothiazole, a naturally occurring anticancer agent through a sequence

32 nst the mimetic antigen indeed recognize the naturally occurring antigen in its physiological context

33 morphological insights into HDL comprising a naturally occurring apolipoprotein A-I mutant, which may

34 s is not essential for the viability of some naturally occurring Arabidopsis genotypes, at least over

35 Naturally occurring arsenic in groundwater affects milli

36 In naturally-occurring, as well as structured media, the in

37 Our findings reveal that naturally occurring AT1R variants alter the patterns of

38 and ERK1/2 signaling, we investigated three naturally occurring AT1R variants that show distinct rec

39 Naturally occurring autopolyploid species, such as the a

40 27me3) were observed at the Avr1b locus in a naturally occurring Avr1b-silenced strain but not in an

41 acterize associated deletions, and show that naturally occurring background DNA double-strand breaks

42 Bacteriophages, naturally occurring bacterial viruses, have long been ch

43 found that Drosophila larvae infected with a naturally occurring bacterium had smaller tumors compare

44 20-epoxydocosapentaenoic acid (19,20-EDP), a naturally occurring bioactive cytochrome P450 metabolite

45 Alternatively, single-stranded DNA, a naturally occurring biological polymer, has recently bee

46 Naturally occurring biological systems can utilize a var

47 bon isotope fractionation of CFC-11 suggests naturally occurring biotransformation by indigenous micr

48 W; (2) McMurray Formation groundwater (i.e., naturally occurring bitumen), and; (3) naturally occurri

49 This technique allows researchers to control naturally occurring brain rhythms and study their causal

50 In naturally occurring Ca(12)Al(14)O(33), the mineral mayen

51 enyl)prop-2-enoyl]amino]propanoic acid) is a naturally occurring caffeoyl conjugate and a potent anti

52 Herein, we demonstrate in the naturally occurring canine model of GLD that presymptoma

53 In this study, we evaluated the naturally occurring canine model of MPS IIIB for the ons

54 Naturally occurring carbon and nitrogen stable isotope r

55 enged by limited availability of donors with naturally occurring CCR5 mutations conferring resistance

56 These results establish a novel modality for naturally occurring cell death and demonstrate its impor

57 Naturally occurring cell death is a fundamental developm

58 hether this effect is due to DWV-A mimicking naturally occurring changes in brain gene expression tha

59 brane protein design(7,8) and in redesigning naturally occurring channel-containing proteins(9,10).

60 ching azobenzenes that model the function of naturally occurring chaperones.

61 ngle-unit recordings from aging monkeys with naturally occurring cholinergic depletion.

62 In tomato (Solanum lycopersicum), naturally occurring cis-regulatory mutations in the gene

63 To explore naturally occurring clusters of CM, we utilized data red

64 CM patients can be classified into three naturally-occurring clusters.

65 an genome contains vast genetic diversity as naturally occurring coding variants, yet the impact of t

66 BCR diversity is induced by naturally occurring combinatorial "V(D)J" rearrangement,

67 ng the mechanism of action (MOA) of novel or naturally occurring compounds mostly relies on assays ta

68 T-2 and its major metabolite HT-2 toxin are naturally occurring contaminants in cereals, with the hi

69 e the threat of increasing concentrations of naturally occurring contaminants in water sources and a

70 D240G combination has not been observed in a naturally occurring CTX-M variant.

71 impact of the ribonucleotide rATP and of its naturally occurring damaged analog 1,N (6)-ethenoadenosi

72 gus macaque (Macaca fascicularis) displaying naturally occurring depressive-like behaviors.

73 Electrostriction is a property of all naturally occurring dielectrics whereby they are mechani

74 t hearing and establishes species members as naturally occurring disease models to investigate human

75 antage of the C(2)-symmetry of the antitumor naturally occurring disorazole B(1) molecule, a symmetri

76 for coarse spatial scales, in line with the naturally occurring distributions of depths and disparit

77 The ent-kaurenes represent a class of naturally occurring diterpenes of biological importance.

78 ation and produces the most frequent type of naturally occurring DNA lesion.

79 al barriers in the DNA template that include naturally occurring DNA lesions and secondary structures

80 Functional characterization of naturally occurring DNA polymorphisms can provide useful

81 ow that it is possible to design fibers with naturally-occurring DNA linkers and NFRs that fold onto

82 -quadruplex and its flanking duplex DNA in a naturally occurring dsDNA-ssDNA telomere interface using

83 postnatal cerebellum-indicating that a high, naturally occurring EC proliferation provides a permissi

84 Mercury (Hg) is a naturally occurring element that bonds with organic matt

85 ugmentation is an effective alternative when naturally occurring enemies are not sufficiently abundan

86 erally limited by the reactions available to naturally occurring enzymes.

87 present the first evidence of aneuploidy in naturally occurring equine EPLs at a similar rate to hum

88 The naturally occurring estrogen estetrol and Selective Huma

89 lammation in patients with COPD experiencing naturally occurring exacerbations.

90 he case of viral infection, a common form of naturally occurring exogenous gene translation.

91 In this naturally occurring experiment in which drusen collapsed

92 ic-related threats, our understanding of how naturally occurring extreme events impact pollinators an

93 ights the potential for the amplification of naturally occurring extreme events like droughts by vege

94 verged Ficedula flycatcher species and their naturally occurring F(1) hybrids.

95 In contrast to naturally occurring F(2), O(2) and N(2), diatomic C(2) i

96 420 ka paleo-record of CO(2) leakage above a naturally occurring, faulted, CO(2) reservoir in Arizona

97 tion/lactonization sequence gave access to a naturally occurring gamma-butyrolactone in good yield, w

98 Carbon monoxide is a naturally occurring gasotransmitter combining inherent t

99 These findings show that naturally occurring genetic variants can profoundly alte

100 d mechanisms of Foxp3 function by leveraging naturally occurring genetic variation in wild-derived in

101 noticed the proximity between this locus and naturally occurring genetic variations highly significan

102 ed enzymes are over 10-fold more active than naturally occurring glucosaminide phosphorylases.

103 ds is challenging due to the large number of naturally occurring glycan structures, the limited avail

104 om, have been used as stable bioisosteres of naturally occurring glycans because the thiosugar glycos

105 e further examined the binding affinity of a naturally occurring GQ stabilizing compound, berberine,

106 Fougerite is a naturally occurring green rust, that is, a layered doubl

107 Lipids are a naturally occurring group of molecules that not only con

108 range of azulenes, including derivatives of naturally occurring guaiazulene, were investigated in re

109 ity with some features recently inferred for naturally occurring hammerhead and pistol ribozymes.

110 nthetic peptides derived from indolicidin, a naturally occurring HDP, and tested their efficacy again

111 of wild tobacco (Nicotiana attenuata) with a naturally occurring hemibiotrophic pathogen, Fusarium br

112 ineer high HbF include de novo generation of naturally occurring hereditary persistence of fetal hemo

113 Here, we provide empirical evidence of naturally occurring heritable variation in loner behavio

114 rious aromatic and heterocyclic analogues of naturally occurring homoisoflavonoids.

115 Thus, naturally occurring homologous recombination events betw

116 show increased thermodynamic stability over naturally occurring homologs.

117 indings on Galpha(13) mutants establish that naturally occurring hotspot mutations in Galpha subunits

118 Here, we describe the discovery of a naturally occurring human antibody (Ab), FluA-20, that r

119 Raj and colleagues recently described a naturally occurring human antibody response to a parasit

120 provides an opportunity to better understand naturally occurring human autoimmune and inflammatory di

121 Here, we survey naturally occurring human deletion variants and identify

122 In contexts of siRNA knockdown and naturally occurring human genetic mutation, cellular BOL

123 Naturally occurring human genetic variants that are pred

124 Here, we report the first naturally occurring human monoclonal antibodies (mAbs) a

125 of hydroxyl fatty acids (FAHFAs), which are naturally occurring hybrid peptides that modulate inflam

126 ing incident to study migratory behaviour in naturally occurring hybrids as well as in their parental

127 or safely extracting natural gases stored in naturally occurring hydrates within the Earth, and for d

128 idermal hyperplasia in adult mice as well as naturally occurring hyperproliferation in neonatal mouse

129 ion of membrane proteins to cause binding of naturally occurring IgG.

130 IL-18 binding protein (IL-18BP) acts as a naturally occurring IL-18 decoy receptor.

131 Naturally-occurring IL-1 receptor antagonist (IL-1Ra) bi

132 tial ability of Nef to counteract SERINC5 by naturally occurring immune-associated mutations was asso

133 A similar physical setting may be naturally occurring in [Formula: see text], [Formula: se

134 an herbaceous aromatic and edible halophyte, naturally occurring in coastal areas of the Mediterranea

135 Naphthenic acids (NAs) are carboxylic acids naturally occurring in crude oils and bitumen and are su

136 hat bind phycocyanobilin (PCB), a phycobilin naturally occurring in cyanobacteria and only a few euka

137 +), SO(4)(2-)) and trace (e.g., Cu(2+)) ions naturally occurring in seawater.

138 oli, Salmonella spp., and Enterococcus spp.) naturally occurring in UWW and 74 organic microcontamina

139 Most IV analyses use naturally occurring instruments, such as distance to a h

140 presents the second independent discovery of naturally occurring intermetallic Al-Cu-Fe alloys and is

141 Our data suggest that naturally occurring introgression between wild and domes

142 Mobility separations of ions from the naturally occurring ion isotopic envelopes (e.g., [M], [

143 Naturally occurring iridescent systems produce brilliant

144 Photorelease of the naturally occurring isomer 1,5-(PP)(2)-InsP(4) led to an

145 Because naturally occurring isotopes and isotopic impurity also

146 LA-ICP-TOF-MS is employed to detect naturally occurring isotopes in the whole mass range as

147 he major body fluid in humans, has four main naturally occurring isotopologues, H(2)(16)O, H(2)(17)O,

148 c osteoarthritis (PTOA) animal models and in naturally occurring joint injuries in humans and animals

149 er aviary were used to score the severity of naturally-occurring KBFs between the ages of 21-62 weeks

150 Monazite is a naturally occurring lanthanide (Ln) phosphate mineral [L

151 Perhaps in no other biomedical field have naturally occurring large animal (canine, feline, ovine,

152 ith canine degenerative myelopathy: the only naturally occurring large animal model of amyotrophic la

153 To date, only a few naturally occurring layered 2D ternary materials have be

154 activity of targeted V4 neural sites beyond naturally occurring levels.

155 Here, we show that in cancellous bone, a naturally occurring lightweight microarchitectured mater

156 some spacing; second, we design systems with naturally-occurring linker lengths that fold onto specif

157 are reported to activate TLR2, which include naturally occurring lipoproteins, synthetic lipopeptides

158 d not follow the herds but instead preyed on naturally occurring local wildlife prey in the CHs.

159 ANGPT2(443) is a naturally occurring, lower oligomeric protein isoform wh

160 te assay in real bacteria culture containing naturally occurring LPS, with similar recoveries in both

161 may also differ in palatability compared to naturally-occurring macroalgae, influencing herbivory.

162 zole are particularly common constituents of naturally occurring macrocyclic peptide molecules.

163 ral biomarkers along a transect taken from a naturally occurring marine CO(2) seep in Levante Bay of

164 s and, furthermore, are distinguishable from naturally occurring materials such as seaweed.

165 -matter coupling of electronic resonances of naturally occurring materials.

166 One rationalization is that many naturally occurring metabolites detected by LC/MS are tr

167 [FeFe] hydrogenases are the best known naturally occurring metalloenzymes for hydrogen generati

168 ated the metabolic activity and diversity of naturally occurring microorganisms as well as their time

169 ic energy and electron transfer processes of naturally occurring microorganisms.

170 Ettringite is a naturally occurring mineral found in cementitious matric

171 venging rate constant (k(=S)) for alumina, a naturally occurring mineral in soil and aquifer material

172 Ultimately, we describe a naturally occurring mineral/protein crystalline assembly

173 Both naturally occurring minerals (crocoite, tellurite, and c

174 n, phosphorus (P(4)), and sulfur (S(8)) from naturally occurring minerals (e.g., silicate, phosphate,

175 ersion of metabolism, initially catalyzed by naturally occurring minerals and metal ions.

176 Naturally occurring minerals, such as the iron sulfide m

177 al dichotomy, the intracellular fates of two naturally occurring misfolded N-glycosylated variants of

178 Here, we explore the impact of naturally occurring missense variants in the human popul

179 ciency virus-2 infection represents a unique naturally occurring model for investigating Tfh role in

180 re potent antitumor agents than their parent naturally occurring molecules.

181 k substantially expands the landscape of the naturally occurring mutational signatures in cancer geno

182 Retrospective lineage tracing harnesses naturally occurring mutations in cells to elucidate sing

183 There are no reports of naturally occurring mutations in LGICs associated with t

184 However, naturally occurring mutations that increase tolerance vi

185 ns, has evolved in intimate association with naturally occurring nanomaterials.

186 haracterizing the behavior of the labile and naturally occurring Ni fraction by implementing a new si

187 We found that other naturally occurring NifD proteins containing alternate a

188 i.e., naturally occurring bitumen), and; (3) naturally occurring non-bitumen.

189 ression of full-length protein by preventing naturally occurring non-productive alternative splicing

190 ncestral reconstruction and demonstrates how naturally occurring non-synonymous variants in RGS alter

191 entry and intracellular replication using a naturally occurring, nontoxic sugar.IMPORTANCE Induction

192 essible by repurposing the limited number of naturally occurring NTF2-like proteins.

193 tures and exhibit more pocket diversity than naturally occurring NTF2-like proteins.

194 arly genome editing strategies involved many naturally occurring nucleases, including meganucleases,

195 because it is the target of five classes of naturally occurring nucleoside inhibitors with potent an

196 because it is the target of five classes of naturally occurring nucleoside inhibitors with potent in

197 iral compounds, nucleoside analogues, mimics naturally occurring nucleosides to inhibit viral replica

198 The naturally occurring nucleotide 2-deoxy-ATP (dATP) is a m

199 airborne particles caused by the presence of naturally occurring or anthropogenic radionuclides.

200 ngs or raw materials, distillers could allow naturally occurring or commercially available microflora

201 Naturally occurring or drug-induced DNA-protein crosslin

202 Taken together, these data establish that naturally occurring OsSGR promoter and related lifespan

203 s platform is a two-dimensional crystal with naturally occurring out-of-plane luminescent dipole orie

204 n of the receiving mEC network by evoked and naturally occurring output patterns in mouse hippocampal

205 we uncover two distinct mechanisms by which naturally occurring oxidized dNTPs and therapeutic dNTPs

206 ll was a compound heterozygote, carrying one naturally occurring P(C) Celtic POLLED allele and an all

207 The exon 6 deletion, G insertion, and naturally occurring P260S mutation all confer loss of en

208 In this study, we identified a naturally occurring pDC subset expressing high levels of

209 A closer look at the naturally occurring peptide repertoires of our fermentat

210 We previously reported that naturally occurring peptides of collagen type I are elev

211 ), also known as antimicrobial peptides, are naturally occurring peptides that can combat infections

212 nts on phenotypes, using genetic variants as naturally occurring perturbation of a biological system.

213 findings demonstrate fusion transcripts are naturally occurring phenomenon spanning across the healt

214 y to innate sensing of viral DNA and reveals naturally occurring phenotypic variation in HIV-1 capsid

215 Natural hazards are naturally occurring physical events that can impact huma

216 Our study describes a naturally occurring picornavirus that elicits strong ant

217 sitive and GFP-negative zebrafish revealed a naturally occurring picornavirus that induced a canonica

218 Phytoestrogens, naturally occurring plant chemicals, have long been thou

219 ted from 31 systemically healthy adults with naturally occurring plaque-induced gingivitis.

220 m has been attempted with both synthetic and naturally occurring polymers with mixed results.

221 of mononuclear phagocytes to beta-glucan, a naturally occurring polysaccharide, contributes to the i

222 Sulphating naturally occurring polysaccharides and their synthetic

223 Here, we take advantage of naturally occurring post-translational modifications for

224 reign sequences to the p53 gene and maintain naturally occurring post-translational modifications.

225 hrough an external stimulus meant to mimic a naturally occurring process.

226 e total probability of human extinction from naturally occurring processes.

227 The stereocontrolled synthesis of naturally occurring products containing a 5,5-spiroketal

228 These naturally occurring products induce beneficial consequen

229 the first structure of an Arg-AA9, LsAA9B, a naturally occurring protein from Lentinus similis The Ls

230 The plasticity of naturally occurring protein structures, which can change

231 ther known nucleophilic functional groups of naturally occurring proteinogenic amino acids.

232 The ability of naturally occurring proteins to change conformation in r

233 Naturally occurring proteins vary the precise geometries

234 t player designs with sequences unrelated to naturally occurring proteins were encoded in synthetic g

235 Inspection of naturally occurring proteomes and in-cell NMR data show

236 y low extracellular pH, high temperature, or naturally occurring pungent molecules such as allicin, c

237 Furthermore, naturally occurring quinones can also be cytotoxins with

238 utilized in flow battery technology, though naturally occurring quinones have not yet been investiga

239 distribution of reduction potentials of the naturally occurring quinones varying from - 1.4 V to 1.5

240 identify weapons-grade plutonium, masked by naturally-occurring radioactive material (NORM), in a me

241 aimed to measure the recombinase activity of naturally occurring RAG2 mutant proteins and to correlat

242 retroviruses encoding either wild-type or 41 naturally occurring RAG2 variants.

243 nts closely mimicked the interaction mode of naturally occurring Ras effectors and acted as dominant-

244 evolves rapidly, and mechanistic studies of naturally occurring Rev and RRE sequences are essential

245 osides excellent stabilized analogues of the naturally occurring ribo-furanose sugars.

246 rm models for the origins and replication of naturally occurring RNA genetic elements and suggest a m

247 onal structures have been solved for several naturally occurring RNA triple helices, although all are

248 This is reminiscent of naturally occurring RNA-dependent DNA polymerases, inclu

249 synthesize DNA, despite the presence of many naturally occurring roadblocks.

250 up at the reducing end fucoside to mimic the naturally occurring saponin adjuvant QS-7.

251 Previous examples have primarily examined naturally occurring self-assembling proteins, such as si

252 and their host Dicranum scoparium across its naturally occurring senescence gradient using a metatran

253 ication, but its activity was compromised by naturally occurring sequence polymorphisms within Gag.

254 A naturally occurring sequence variant (P310L, rs2227376)

255 We propose that such naturally occurring SHFAs may play a role in the promoti

256 This report describes a small family of naturally occurring small molecules with chimeric struct

257 Selective breeding for the naturally occurring social immune trait "hygienic behavi

258 ased on generating amino acids labelled with naturally occurring stable (that is, nonradioactive) iso

259 thesis of numerous secondary metabolites, no naturally occurring stand-alone Diels-Alderase has been

260 Naturally occurring stem cells isolated from humans have

261 A naturally occurring strain of Wolbachia, wAnga, infects

262 it has yet to replicate any of these complex naturally occurring structures.

263 ch regions on Earth and identify clades with naturally occurring substances potentially suitable for

264 , to explore the functional effects of these naturally occurring substitutions in a simplified AgRP s

265 Our data demonstrate that the naturally occurring sugar trehalose at doses safely achi

266 Bournonite CuPbSbS(3) is a naturally occurring sulfosalt mineral that crystallizes

267 Naturally occurring Synpo isoforms are known (Synpo-shor

268 ionships are a fundamental principle of many naturally occurring systems.

269 Here, we took advantage of naturally occurring tail regeneration-competent and -inc

270 Naturally occurring terpenoid lactones and their synthet

271 Naturally-occurring thermal materials usually possess sp

272 nductance values of ~1 nS, commensurate with naturally occurring toxin channels such as alpha-hemolys

273 Naturally occurring trans-species small RNAs are used by

274 enetic circuits have almost exclusively used naturally occurring transcriptional repressors.

275 We found that a naturally occurring transmitted founder (T/F) variant sh

276 t both the full-length protein, Ma1, and its naturally occurring truncated protein, ma1, localize to

277 fy the power of covalent tethering using the naturally occurring truncated variant (DeltaN6) of the h

278 y, and discuss empirical evidence related to naturally occurring tumor dormancy and treatment-induced

279 ortantly, this approach could be extended to naturally occurring tumor peptides (both tumor-associate

280 ine model, the frequent presence of multiple naturally occurring tumors at diagnosis, thus providing

281 We also discovered that the naturally occurring UL138 protein isoforms, the full-len

282 Here, we show that naturally-occurring v-SNARE TMD variants differentially

283 carp oil has been found to contain plenty of naturally occurring valuable phytonutrients.

284 s study, we explored the potential for these naturally occurring variant capsids to impact recognitio

285 Our results identify a naturally occurring variant of ATP5G1 from a mammalian h

286 est 35,212 truncated human 5' UTRs and 3,577 naturally occurring variants and show that the model pre

287 Naturally occurring variants of HPV have been classified

288 lated with a cloned master sequence revealed naturally occurring variants, and showed that G/U pairs

289 ring mutations are frequently observed among naturally occurring variants, suggesting that the enzyme

290 against at least one MAb, demonstrating that naturally occurring variation can affect one or more fun

291 review advances in the understanding of how naturally occurring variation in clinical isolates affec

292 lenge in modern biology is to understand how naturally occurring variation in DNA sequences affects c

293 a improve our understanding of the impact of naturally occurring variation on the antigenicity of the

294 These data highlight the impact of naturally occurring variation on the structure of the HP

295 We found that naturally occurring variations at within-membrane residu

296 Targeting naturally occurring vasomotion in patients with CAA or A

297 flammation triggered a profound depletion of naturally occurring Vgamma4(+)/Vdelta1(+) intraepithelia

298 Through analysis of point mutants and naturally occurring Vif variants, we further show that d

299 ructures, population biology, and ecology of naturally occurring viruses and viral parasites.

300 Naturally occurring zinc nanoparticles were detected in