ライフサイエンスコーパス: necessary

1 al bias, as well as precursor chemicals, are necessary.

2 cular lens (IOL) implantation in infancy are necessary.

3 e to insect hosts in which this phenotype is necessary.

4 was later realized that rare disease was not necessary.

5 les and females to successfully reproduce is necessary.

6 l diagnostic work-up for these joints is not necessary.

7 better experimental design of future studies necessary.

8 standard synthetic approach, four stages are necessary.

9 ster features in a fast and reliable way are necessary.

10 , prevention, and treatment of diseases as a necessary and fundamental step towards precision medicin

11 BBzeta and 28zeta CARs, they demonstrate the necessary and nonredundant role of ncNF-kappaB signaling

12 erlin viral inhibitor of apoptosis pUL36 was necessary and sufficient both to degrade MLKL and to inh

13 hly useful data for current debates over the necessary and sufficient conditions for the emergence of

14 The MDMX acidic domain and zinc finger are necessary and sufficient for binding and inhibition of C

15 A covalent cleavage complex (TOP1cc) is both necessary and sufficient for cGAS-mediated cytoplasmic c

16 -1 functions as an intrinsic agonist that is necessary and sufficient for channel activation.

17 complex with neuropilin-1 and VEGFR2 that is necessary and sufficient for conferring mechanosensitivi

18 evealed that GPR139 signaling via G(q/11) is necessary and sufficient for counteracting MOR-mediated

19 uired for its nuclear translocation, is also necessary and sufficient for its targeting to the ciliar

20 +) cells are activated during mating and are necessary and sufficient for male sexual behaviors, whil

21 ap) from S. epidermidis has been shown to be necessary and sufficient for mature biofilm formation an

22 uct of apple RIN4 (MdRIN4) but not AtRIN4 is necessary and sufficient for MR5 activation.

23 essential mediator of HDAC6 function, and is necessary and sufficient for RMS cell migration and inva

24 ased studies revealed the GR domain as being necessary and sufficient for SRBP1 cell-to-cell movement

25 ed within the AON and that their activity is necessary and sufficient for the behavioural expression

26 trating that in vivo monomeric arrestin-1 is necessary and sufficient for this function.

27 the expression of the "master regulator" is necessary and sufficient to activate lineage-specific ge

28 s bind the BAM1 extracellular domain and are necessary and sufficient to activate SHR-mediated divisi

29 The N terminus of NOCT is necessary and sufficient to confer import and processing

30 Instead, dermal fibroblasts are both necessary and sufficient to induce the epithelial respon

31 escent is the unifying landmark that is both necessary and sufficient to orient both nuclear migratio

32 Thus, mTNF alone is necessary and sufficient to regulate lung inflammation b

33 ivity suppressed redundant responses and was necessary and sufficient to reproduce whitening in simul

34 te that domain 1 of LDLRAD3 (LDLRAD3(D1)) is necessary and sufficient to support infection by VEEV, a

35 tanin phosphorylation at a single residue is necessary and sufficient to target Katanin for proteasom

36 r melphalan irrigation, with retinectomy, if necessary, and silicone oil tamponade, allows anatomical

37 other forms of amyloidosis is difficult but necessary, and tissue typing with adequate technology av

38 nchmarks; identification of intervention, if necessary; and implementation of intervention and evalua

39 trasound dose delivered through the skull is necessary as the range of pressure for efficient and saf

40 rotein to the cellular processes where it is necessary at the myelin membrane for axon wrapping.

41 ppression is thus of great interest, but the necessary brain components remain incompletely identifie

42 ce diversity but targeted to individuals are necessary but insufficient for lasting change.

43 results establish that air temperature is a necessary but not sufficient variable for adequately cha

44 a moment-to-moment timescale, providing the necessary cognitive flexibility for sampling from highly

45 Biodegradation is one of the necessary conditions for the safe application of 2D mate

46 to further decrease exposures occurring in 'necessary' contexts.

47 ylogeny, researchers need to prepare all the necessary data and combine them by hand, which is time-c

48 stallographic defects, such as geometrically necessary dislocations, are reported to influence the re

49 Although inflammation is necessary during the early phases of tissue repair, pers

50 riable timing of drought stress, a risky but necessary endeavour.

51 ld be performed at referral centers with the necessary endoscopic expertise and interventional radiol

52 via food reserves in the seed, to supply the necessary energy for seed germination and early seedling

53 he germination of ingested spores is often a necessary first step required for enabling bacterial out

54 o four functional categories: those that are necessary for (1) glycosylase activity (C146 and C255),

55 Eradicating food insecurity is necessary for achieving global health goals.

56 RONMAN1 and IRONMAN2 In addition, bHLH121 is necessary for activating the expression of transcription

57 We show AnkR lacks the domain necessary for AIS localization.

58 helming inflammation on one hand but is also necessary for an effective control of infections on the

59 Furthermore, ovarian-derived hormones were necessary for and sufficient to restore (R,S)-ketamine-

60 We showed that Flvcr2 was necessary for angiogenic sprouting in the brain, but sur

61 ia through hepatic gluconeogenesis, which is necessary for anticipating and fueling "fight or flight"

62 support the conclusion that dissociation is necessary for antidepressant response to ketamine.

63 The beta(ps)-integrin Myospheroid, which is necessary for basal cell adhesion, is mislocalized in Sa

64 beta-cell failure acting as a growth factor necessary for beta-cell adaptation to higher metabolic l

65 ee of conformational dynamics of ECD that is necessary for binding GLP-1.

66 S29 TopoIIalpha phosphorylation, a response necessary for catenation resolution during mitosis.

67 ithout increasing biosynthetic intermediates necessary for cell proliferation.

68 o subunits of magnesium chelatase, an enzyme necessary for chlorophyll synthesis.

69 sting that cell-autonomous PTN signaling was necessary for CML disease evolution.

70 trix detachment, and both SIRT3 and SOD2 are necessary for colonization of the peritoneal cavity in v

71 However, virus community dynamics, necessary for conceptual and mechanistic model developme

72 As sarcomeres produce the force necessary for contraction, assessment of sarcomere order

73 coding an intermediate filament-like protein necessary for curvature formation in V. cholerae.

74 n which co-localizes with DA vesicles and is necessary for DA synthesis, was assessed across the samp

75 ecise assessment of the corneal condition is necessary for deciding which type of keratoplasty (i.e.,

76 transient transcriptional repression that is necessary for development.

77 whether local neuronal inhibition in NAc is necessary for DNQX microinjections to produce either des

78 Enteric bacteria and/or their products are necessary for doxorubicin (DXR)-induced small intestine

79 elatively stable HA protein (pH 5.5-5.6) was necessary for efficient replication and airborne transmi

80 The Human Silencing Hub (HUSH) complex is necessary for epigenetic repression of LINE-1 elements.

81 onclusive evidence that miR-31 expression is necessary for ESCC development.

82 dministration and/or liver biopsy are mostly necessary for establishing diagnosis, but they have seve

83 Subcellular compartmentalisation is necessary for eukaryotic cell function.

84 hancing robustness and create the conditions necessary for evolutionary success.

85 that the AHR-ARNT transcriptional complex is necessary for expression of MMP1 in OFs.

86 inhibition and quantify inhibitory potencies necessary for extrapolation of clinical drug-drug intera

87 sses in the developing human cerebral cortex necessary for generating expanded neuronal populations.

88 that the INR region of the GLI2 promoter is necessary for GLI2 repression.

89 ic oxide targets the same metabolic pathways necessary for glucose stimulated insulin secretion for p

90 cosa, moreover, we discovered that Ascl-1 is necessary for GnRH-1 ontogeny.

91 bution of IL-10 to the immunological balance necessary for granulomas to control bacterial burden and

92 to cartilage compression resistance and are necessary for healthy joint function.

93 ransition from latency to the lytic phase is necessary for herpesvirus-mediated pathology as well as

94 al for advancing the complex sample analysis necessary for high-throughput top-down proteomics.

95 Here, we show that NP-Ct is necessary for IB formation when NP is expressed alone.

96 CD8+ T cell responses are necessary for immune control of simian immunodeficiency

97 d carbon-11 radioisotopologues are generally necessary for in vitro and in vivo characterization of r

98 difications of the FOXP3 gene enhancer CNS2, necessary for indelible expression of this critical tran

99 e also show that infection of the GIT is not necessary for induction of protective immunity in the FR

100 providing nutritional and bioactive factors necessary for infant development, human breast milk cont

101 In muscle, LRP2 is necessary for insulin-dependent IR internalization, an i

102 ults suggest five areas of understanding are necessary for interpreting spectra, and progress in unde

103 otein, and nuclear localization of AFFL-2 is necessary for its role in heat shock response.

104 Yet we find that it is necessary for larval development in D. melanogaster.

105 cate that cross-area population dynamics are necessary for learned motor skills.

106 (CPG) circuitry produces the rhythmic output necessary for limb coordination during locomotion.

107 n after diagnosis of MBC will continue to be necessary for many patients.

108 Our findings demonstrate that SETD6 is necessary for memory-related nuclear factor-kappaB RELA

109 These signal transducing systems are necessary for metabolic regulation, resistance to antibi

110 ess E-cadherin, and a full EMT is not always necessary for metastasis; also, positive roles for E-cad

111 aintaining the context-dependent information necessary for mice to solve a delayed match to sample ta

112 hway and MRPS7 and IDH2 that encode proteins necessary for mitochondrial function.

113 lation of gene expression affecting pathways necessary for neurogenesis and upregulation of gliogenic

114 monstrate that orbitofrontal cortex (OFC) is necessary for normal behavior in this task, but a causal

115 Several of the 11 classical HDAC enzymes are necessary for optimal Treg function while others are dis

116 Phospholipase Cbeta is necessary for OXTR-mediated excitation of CeL neurons an

117 ng necks to perform membrane-modeling events necessary for particle abscission.

118 d motor task information and are selectively necessary for performance.

119 tal stresses and modulating the gas exchange necessary for photosynthesis.

120 s that a pigment called beta-carotene is not necessary for photosynthesis.

121 of SARS-CoV-2 and add to the knowledge pool necessary for postpandemic preparedness for SARS-CoV-2.

122 n developed that possess the characteristics necessary for potential prophylactic or therapeutic appr

123 nd III-B), only the I-B system and Cas3 were necessary for priming.

124 thermore, a rise in the MC ATP level was not necessary for Pro-sigma(K) cleavage by SpoIVFB, based on

125 intrinsic lymphatic contractile activity is necessary for proper lymph transport.

126 FGF21 signaling in glutamatergic neurons is necessary for protection against body weight gain and in

127 showed that the autophagy protein ATG16L1 is necessary for protection against MRSA strains encoding a

128 Although high antibody levels are necessary for protection, our study suggests that on the

129 her, we demonstrate that Sox2 3'UTR AREs are necessary for RBM24-based elevation of Sox2 mRNA half-li

130 liana) cyclin-dependent kinase G1 (CDKG1) is necessary for recombination and synapsis during male mei

131 retinal pigment epithelium (RPE)65 isomerase necessary for recycling 11-cis-retinal, the light-sensit

132 otein-coding genes (Hnrnph1, Rufy1) that was necessary for reduced methamphetamine-induced locomotor

133 RePRP is sufficient and necessary for repression of root development by water de

134 ic strategies in consumer-resource models is necessary for reproducing experimental growth curves of

135 environmental exposure and perform the tasks necessary for respiration.

136 mporal and spatial changes of sampled genets necessary for restoration planning and can be applied to

137 and the substantial time and human resources necessary for sample preparation.

138 Prescreening of CP may be necessary for selecting donors with high titers of neutr

139 the relative value of the options, a process necessary for species survival.

140 trate that another sperm protein, TMEM95, is necessary for sperm-egg interaction.

141 50 reductase (POR), to provide the electrons necessary for substrate metabolism.

142 havior; however, collecting the sample sizes necessary for successful genetic studies has remained a

143 e-free electrodeposition of lithium metal is necessary for the adoption of high energy-density rechar

144 the integrity of CA activity in the brain is necessary for the consolidation of fear extinction memor

145 ription of genes in the autophagic machinery necessary for the degradation of primary cilia.

146 ples, the projected titer of virus particles necessary for the detection of SARS-CoV-2 spike and nucl

147 hile early experience with moving stimuli is necessary for the development of direction selectivity i

148 d in development and DNA damage 1 (REDD1) is necessary for the development of oxidative stress in the

149 ypothalamic paraventricular nucleus (PVN) is necessary for the expression of binge-eating behavior in

150 ing and shortly after the critical period is necessary for the expression of LTP at PV-IN output syna

151 ator, and it is well-described that KIF11 is necessary for the formation and maintenance of the bipol

152 ons posited to occur during neurogenesis are necessary for the formation of the characteristic lamina

153 ategy is to help to sustain the interactions necessary for the functioning of essential goods and ser

154 to identify cell envelope proteins that are necessary for the import of PyoG and its killing activit

155 ory neurons in the centrolateral amygdala is necessary for the inhibition of a conditioned response t

156 matrix metalloproteinases (MMPs), which are necessary for the invasive and metastatic phenotype.

157 ory neurons in the centrolateral amygdala is necessary for the long-term storage of conditioned-threa

158 ith a mutation in MSK1, we show that MSK1 is necessary for the majority of gene expression changes as

159 which interact in the late endosome(9), are necessary for the membrane fusion and delivery of RNA fr

160 hat unexpectedly, the autophagy machinery is necessary for the normal formation and compartmentalizat

161 dult mouse brain, we show that microglia are necessary for the normal functional development of adult

162 importin proteins IMPalpha-1, -2 and -3 are necessary for the nuclear import of LHP1.

163 perimental features or model assumptions are necessary for the observed continual evolution to emerge

164 nced activation of remote neural populations necessary for the performance of motivated actions.

165 igh quantum yield measured for triclosan and necessary for the photodegradation mechanism that forms

166 tibody response, we will have the foundation necessary for the rational development of an HIV-1 vacci

167 a crucial function as a scaffold for ATG16L1 necessary for the suppression of BAX activation and indu

168 gets because a three-dimensional assembly is necessary for their formation.

169 demonstrate that a Thi5-dependent pathway is necessary for thiamine biosynthesis in Legionella pneumo

170 and confirm that core promoter sequences are necessary for this activity.

171 in of p150(Glued), thus explaining why H2 is necessary for tight binding.

172 In an hns deletion strain, LuxR is no longer necessary for transcription activation of the biolumines

173 Both complexes are necessary for transcriptional regulation but through dif

174 Complete live viruses are necessary for transmission, not the fragments identified

175 However, beta-HPVs are not necessary for tumor maintenance in the general populatio

176 ication of differentially expressed genes is necessary for unraveling disease pathogenesis.

177 transmodulation across the striatum that is necessary for updating previous goal-directed learning.

178 for the first time that VEGF-C signaling is necessary for valve morphogenesis.

179 genome packing and in host-protein co-opting necessary for viral replication and infectivity.

180 s, becoming internalized with CD63, which is necessary for virus production.

181 Importantly, we find that TRIM27 alone is necessary for ZNF165 transcriptional activity and is req

182 sigma factors initiate the transcription of necessary genes responsible for maintaining a life-susta

183 This system contains all the necessary hardware and software interfaces for end-to-en

184 at lower DNA and protein concentrations than necessary in equilibrium, suggesting rate enhancement by

185 A mini-laparotomy is, therefore, necessary in order to ensure safe implantation and posit

186 While RAD51 has been shown to be necessary in the early steps of ICL repair to prevent ab

187 as payers, that we believe will provide the necessary incentives for pharmaceutical and device compa

188 However, the necessary inclusion of lead, a toxic element, raises a c

189 ependence of invertebrate production and the necessary inclusion of resources in metabolic scaling ef

190 ssment of transplant program performance and necessary information for patient decision-making.

191 eting transmission is widely recognized as a necessary intervention toward that goal.

192 ged or intermittent social distancing may be necessary into 2022.

193 cations: People prefer to allocate strictly "necessary" items to lower-income recipients (study 8), e

194 pproach increased throughput by reducing the necessary machine time.

195 enomic events are important in providing the necessary metabolic network activity.

196 On the other hand, although necessary, NPF neurons were not able to induce a PER.

197 Future research is necessary on understanding the timing of associated risk

198 Accordingly, ACC is necessary only for updating model-based strategies, not

199 r not) to the extent that it is perceived as necessary (or not).

200 mechanisms must be explored to minimize the necessary period of proteasome inhibition and reduce the

201 ture of potential complications, to take the necessary precautions to prevent their occurrence and fa

202 ficient autotransporter protein secretion, a necessary prerequisite for virulence.

203 ions they need calculated from it, while all necessary procedures and optimal settings are completed

204 used, 11 systematic reviews would have been necessary rather than 31, with minimal impact on the rec

205 e compared to glucose and thereby yields the necessary redox cofactors.

206 a key driver of inflammation, a critical yet necessary response involving several mediators that is a

207 ts activity, and therefore, did not have the necessary sensitivity to serve as a proxy for examining

208 wth in competitive market economies inhibits necessary societal change.

209 st genome and it appears to have created the necessary space in the capsid by evolving the shortest R

210 chieve large reductions in disease burden, a necessary step in the pathway towards elimination.

211 oods and domains), which can perform all the necessary steps in automated fashion and put the derived

212 ine whether conservation initiatives receive necessary support and lead to adequate policy change.

213 ensable test in some eye examinations, being necessary the evaluation of the precision of instruments

214 er, in cases where prophylaxis is considered necessary, the periods of hydration are shorter than in

215 roaches, roughly 100 mg of material would be necessary, the robot-based platform can screen 2000 comb

216 tes, and that including the 2ph processes is necessary to accurately predict the electron mobility in

217 ent and future wind turbine (WT) deployments necessary to achieve 20% electricity from wind are analy

218 efferential center, use of carbapenems seems necessary to achieve a high antibiotic coverage.

219 ng on-scalp systems is: how many sensors are necessary to achieve adequate performance/spatial discri

220 ical research goals providing critical tools necessary to achieve an end to the global STIs epidemic.

221 orizontally acquired regulatory gene ssrB is necessary to activate the ancestral regulatory system Ph

222 e spectroscopy (SMFS) reveals that the force necessary to activate the CB molecular gate on the time

223 Epidemic" initiative; and (3) policy changes necessary to affect the trajectory of the opioid epidemi

224 s include a paucity of longitudinal studies (necessary to assess causality), non-random sampling of p

225 unmask the strong oxidizing power of sMMO-Q necessary to attack the highly inert C-H bonds of methan

226 and fever-recovery-related QT lengthening is necessary to avoid misattributing malaria-disease-relate

227 s via a metabolic engineering approach it is necessary to better characterize both the primary metabo

228 he atmosphere and terrestrial biosphere, are necessary to better understand the role of the terrestri

229 a new MRI device is approved for use, it is necessary to calibrate it properly and to check its tech

230 ides guidance with regard to volume of urine necessary to carry out multi-omic studies and reveals no

231 and the function of cortical circuits, it is necessary to catalog their cellular diversity.

232 ur results suggest that the complex dynamics necessary to cause regime shifts and other transitions m

233 vigilance and anti-poaching efforts will be necessary to combat poaching and to conserve African ele

234 In intractable bronchial asthma cases, it is necessary to consider the complications of other disease

235 nstrate that HIF1alpha activation in cDCs is necessary to control vessel wall inflammation.

236 Adaptive behaviour is necessary to cope with the complexity of practice.

237 While further studies of SARS-CoV-2 are necessary to determine immune responses, evidence from o

238 l tools, co-polymers theoretical methods are necessary to determine the ensemble of three-dimensional

239 To further confirm this speculation, it is necessary to develop a systematic knowledge beyond merel

240 on social and environmental determinants is necessary to develop effective outbreak response interve

241 Thus, it will be necessary to develop robust, reliable, and model-based e

242 multiple histological samples per patient is necessary to effectively capture these progression-relat

243 emature children in developing countries are necessary to elaborate evidenced-based preventive interv

244 tions of comorbidity and periodic audits are necessary to ensure data accuracy and minimize bias.

245 normal growth, suggesting that KBTBD2 may be necessary to ensure IGF1 signaling in other tissues, not

246 balance of accessibility to reductive agents necessary to ensure stability in transit, but rapid mice

247 for providing the brain with the resilience necessary to ensure the consolidation of extinction of e

248 To this end, it is necessary to enumerate all potential off-target sites wi

249 h MD remains difficult due to the timescales necessary to equilibrate pLGICs from their artificial an

250 Furthermore, future studies are necessary to establish the role of the apparently avian-

251 fection and furthermore in depth research is necessary to evaluate its potential use for Lyme disease

252 Longer and larger trials are necessary to evaluate the efficacy and safety of sodium

253 ials for biomedical applications, it will be necessary to evaluate their biodistribution for health a

254 Future clinical trials are necessary to evaluate whether supplementation with BCAAs

255 This makes it necessary to examine in detail the morphology and synapt

256 Therefore, it is necessary to find an adapted pollen season definition as

257 diffusing on the DNA backbone achieve speeds necessary to form the large loops seen in experiments?

258 iversity effects over longer time periods is necessary to fully understand the effects of tree divers

259 ive information on somatic mutations in vivo necessary to gain insight into their possible causal rol

260 timmunization did not trigger the mechanisms necessary to generate immunological memory able to induc

261 Renewable energy production is necessary to halt climate change and reverse associated

262 Thus, it is necessary to identify all the factors affecting the fina

263 is transformed into human behaviours, it is necessary to identify task-specific networks and analyse

264 In particular, it will be necessary to identify the most suitable biomarkers to fa

265 ala neurons are involved in the computations necessary to implement learning through observation.

266 However, it would be necessary to improve consumer acceptance through technol

267 h the addition of quinoa so that it would be necessary to incorporate less nitrites, or it might even

268 It is necessary to increase our understanding of the cellular

269 , SYK lowered the threshold for SFK activity necessary to initiate antigen receptor signaling in both

270 The use of systems approaches will become necessary to integrate data from more than one omic tech

271 ll respond in an untested environment, it is necessary to integrate mathematical models across biolog

272 Further studies are necessary to investigate genetic and phenotypic changes

273 on-sense morality, and new paradigms will be necessary to investigate other key aspects of utilitaria

274 onally, structural lipid characterization is necessary to link the lipid structure to lipid function.

275 results indicate that hippocampal inputs are necessary to maintain a precise cortical representation

276 rgreen trees had the deepest roots, which is necessary to maintain canopy during simulated dry season

277 asis mechanisms, requiring ATP7 and COG, are necessary to maintain mitochondria functional integrity

278 ergoes constant replacement, which is likely necessary to maintain network plasticity to accommodate

279 that endothelial cell-initiated signaling is necessary to maintain self-renewal of dental pulp stem c

280 ther than B. henselae Additional research is necessary to more fully define the utility of WB for the

281 l cortex may handle the abundance of schemas necessary to navigate the real world.

282 e detection in complex biological samples is necessary to obtain a complete evaluation with greater s

283 he hypothesis that the energy sensor AMPK is necessary to offset the metabolic burden of overnutritio

284 y these types of strategies will probably be necessary to optimize SCI treatment.

285 interventions to prevent nonadherence may be necessary to optimize stroke prevention.

286 d appropriately regulate expression of genes necessary to persist within these distinct environments.

287 at critical phases of palate development is necessary to pioneer novel prenatal interventions.

288 at this sample would display the variability necessary to probe whether temporal psychological distan

289 Long-term clinical studies are necessary to reach final conclusions.

290 slet viability, metabolic activity, and dose necessary to reverse diabetes.

291 Imaging studies are necessary to rule out the presence of retained foreign b

292 rofabrication and soft lithography protocols necessary to shape these hydrogels to match the dimensio

293 und 100 individual Fab':TCR interactions are necessary to stimulate early T cell activation.

294 g past and anticipated future GPP changes is necessary to support carbon management, the factors driv

295 ir altering the colonic microbiota, which is necessary to suppress the infection.

296 However, delineating the aetiology of UC is necessary to ultimately achieve disease cure.

297 providers involved in postoperative care is necessary to understand prescribing practices, identify

298 This is necessary to understand the relationship between cellula

299 e targets than governments, thus driving the necessary transition to ensure that humanity remains wit

300 s advantages, limitations, and challenges is necessary when choosing between them.