ライフサイエンスコーパス: necessitate

1 of interest and the mathematical operations necessitated.

2 er- and intra-tumor angiogenic heterogeneity necessitate 3D microvascular data from 'whole-tumors' as

3 ific patients, slow-transit constipation may necessitate a colectomy.

4 y-dependent processes that exist in the cell necessitate a diverse array of macromolecular machines t

5 brid treatment systems because larger scales necessitate a higher proportion of recycled water underg

6 spaces and high sampling variability(3,6,7) necessitate a large number of experiments.

7 Laparoscopic liver resections necessitate a long learning curve trough a stepwise fulf

8 n for many acquired and autosomal conditions necessitate a method for accurately detecting somatic an

9 inaccuracies in terminology and definitions necessitate a reappraisal of nomenclature to inform clin

10 These findings necessitate a reexamination of the mechanisms by which t

11 such as hyponatraemia and water intoxication necessitate a strict fluid intake, thus motivating the s

12 target the influenza A M2 proton channel has necessitated a continued drug design effort, supported b

13 number of new variants being identified has necessitated a dedicated resource with custom tools for

14 The COVID-19 pandemic has necessitated a multifaceted rapid response by the scient

15 The rise of antibiotic resistance has necessitated a search for new antimicrobials with potent

16 The current opioid epidemic necessitates a better understanding of human addiction n

17 terdisciplinary nature of the topics covered necessitates a common language to integrate ideas from t

18 This dilemma necessitates a computational model that can predict NN t

19 mor microenvironment, but each such antibody necessitates a custom design.

20 This necessitates a deeper understanding of the underlying lo

21 Polyplacotoma mediterranea also necessitates a different view of placozoan mitochondrial

22 Survival in complex environments necessitates a flexible navigation system that incorpora

23 toxic food sources for survival, a fact that necessitates a mechanism for associating taste experienc

24 This mode of forward transport necessitates a mechanism to prevent membrane mixing betw

25 This necessitates a model to identify a population at higher

26 on of OXPHOS components in cristae membranes necessitates a re-examination of the equipotential repre

27 This necessitates a refocus of deep-time diversification stud

28 when often the desperate need for solutions necessitates a response.

29 This necessitates a standard data format to underpin research

30 Generally, ISC necessitates a strong driving force from efficient spin-

31 d regarding adverse effects from GC, thereby necessitating a better understanding of how GCs modulate

32 iral protection in various viral infections, necessitating a detailed understanding of how this diver

33 lso lead to growth arrest in infected cells, necessitating a means to deactivate the ribonuclease onc

34 volumes of water for extensive time-periods, necessitating a precipitation-driven hydrological cycle.

35 ydrocarbons (PAHs, or namely nanographenes), necessitating a rational and atomically precise syntheti

36 data analysis have undergone a large change necessitating a significant re-development of BMDExpress

37 grand challenge to farmers and society, and necessitates achieving improved N use efficiency (NUE) i

38 n important niche of persistence and relapse necessitating adapted antibiotic treatments.

39 zation of vermicomposting for commercial use necessitates additional knowledge of the underlying biol

40 Limited data for these treatments necessitates advocating caution to physicians and patien

41 he complete realization of Li-O(2) batteries necessitates ambient air operations, which presents quit

42 However, PS exposure did not necessitate an increase in [Ca(2+)](i).

43 ient exploration of this vast chemical space necessitates an accelerated discovery pipeline that supe

44 risk assessment of these emerging pesticides necessitates an understanding of the fate of dsRNA molec

45 source-separation for fertilizer production necessitates an understanding of the presence and impact

46 for antiviral and antitumor immunity, which necessitates an understanding of their development.

47 1.1-4.4, P = 0.030) and a higher risk of PVR necessitating an additional procedure (HR, 2.7; 95% CI,

48 was not associated with a higher risk of PVR necessitating an additional procedure and did not show a

49 y degree of PVR and an increased risk of PVR necessitating an additional procedure.

50 ighly variable estimates within risk groups, necessitating an individualized approach to risk stratif

51 Vi was defined as CMV viremia and/or disease necessitating antiviral therapy.

52 complex data generated by mass spectrometry necessitates automated tools for the extraction of usefu

53 Of 14 patients, 1 (7%) had an adverse event necessitating bedaquiline discontinuation.

54 The COVID-19 pandemic necessitates better understanding of the kinetics of ant

55 effective, less toxic antivirals are needed, necessitating better models to study these viruses and e

56 o manage the combinatorial explosion without necessitating bias or loss in biological accuracy, we us

57 rom other renal lesions at imaging and often necessitate biopsy or surgery.

58 nd other bunodont therians is derived; it is necessitated by a secondarily fused jaw symphysis, and p

59 r frequently at maxillary anterior teeth and necessitate careful treatment planning to prevent future

60 f noise inherent in current scHi-C protocols necessitates careful assessment of data quality before b

61 hout compromising survival is compelling and necessitates careful study and the analysis of well-desi

62 mals could serve as reservoirs of the virus, necessitating careful ongoing animal management and surv

63 ed with substantial morbidity and mortality, necessitating careful patient evaluation before operativ

64 tion, and antibiotic-related adverse effects necessitating change in therapy.

65 Thus, our findings necessitate changes to long-standing dogma on mechanisms

66 sensor enable sensor response tuning without necessitating changes to the biomolecular affinities.

67 unsuccessful attempts at rehabilitation that necessitate chronic use of parenteral nutrition (PN).

68 oscopy sometimes technically challenging and necessitating clear and frequent communication with the

69 r wave property for a particular application necessitates components capable of discriminating in the

70 The large quantity of data generated necessitates computer-aided quality control (QC) methodo

71 ve management of antiplatelet therapy, which necessitates concomitant evaluation of the individual th

72 lth during the current COVID-19 pandemic has necessitated conference cancellations on an unprecedente

73 ive yet has a low positive predictive value, necessitating confirmatory testing.

74 erstanding how reproduction is regulated and necessitates consideration by clinicians treating women

75 the field of translational neuroscience that necessitate continued focus on fundamental research and

76 The crisis of antibiotic resistance necessitates creative and innovative approaches, from ch

77 always reported consistent results, thereby necessitating cross-study comparisons.

78 e investments for the COVID-19 era, and will necessitate data-driven decision making, political will

79 12 mo) because policy implementation timing necessitated data collection during holidays when SSB de

80 assay and its enhanced sensitivity, without necessitating deep sequencing, represent important steps

81 mprising many isomeric and isobaric species, necessitating detailed analysis to enable interpretation

82 ke the detection of synapses challenging and necessitates developing a new tool to easily and accurat

83 vering thousands of disease-associated genes necessitates developing novel high-throughput functional

84 The residuals from this model necessitated development of a new combined RL model whic

85 interest in extracellular vesicles (EV) has necessitated development of protocols to improve EV char

86 The increasing popularity of nuclear energy necessitates development of new methods to treat water t

87 possess distinct chemical substructures and necessitate deviating synthetic platforms.

88 more limited in terms of resources, and this necessitates different approaches to the drug discovery

89 complex startup and feedback protocols that necessitate difficult-to-integrate optical and electrica

90 ful treatment with antibiotics is high, thus necessitating discovery of novel therapeutics against th

91 This temporary pivot will necessitate distance teaching and learning across almost

92 production in the context of climate change necessitates diversification of agriculture and a more e

93 peripheral neurotoxicity occurs frequently, necessitates dose reduction or treatment cessation, and

94 nerally have a less favourable prognosis and necessitate early diagnosis.

95 are directly produced by solid-state lasers, necessitating efficient high-power frequency conversion.

96 f Lewis basic atoms into metal centers often necessitate elevated temperature, high catalyst loading,

97 The primary outcome was incarceration necessitating emergent operation.

98 ader therapeutic applications of CAR-T cells necessitates engineering approaches on multiple levels t

99 ic markedly changed human mobility patterns, necessitating epidemiological models that can capture th

100 Generics do not necessitate essentialist beliefs.

101 nations of Central Africa, where efforts may necessitate establishing rapid conservation intervention

102 ies (GWAS), especially on rare diseases, may necessitate exchange of sensitive genomic data between m

103 of how sequence impacts functionality often necessitates expensive, time-consuming screens to identi

104 monitoring of samples very sophisticated and necessitates exploiting chemometric data processing tech

105 e, changes in membrane lipid composition may necessitate extensive adaptation of the membrane-associa

106 o yield control of rhodopsin activation, and necessitate factors beyond proteolipid solvation energy

107 This necessitates frequent re-formulation of vaccines and han

108 isting medicolegal and regulatory challenges necessitate further research and clinical assessment in

109 of commercially available starches, however, necessitates further chemical treatment to increase thei

110 The latter may necessitate glaucoma surgery after the resolved episode

111 s of HIV diagnosis, funding constraints have necessitated greater focus on more efficient testing app

112 mber of times a coyote approached a human to necessitate hazing.

113 nanomaterials since high-performance devices necessitate high mobility values.

114 Escalating global water scarcity necessitates high-performance desalination membranes, fo

115 on of somatostatin interneurons in circuits, necessitating high-frequency activity for somatostatin i

116 nd cooperative protein-protein interactions, necessitating high-throughput experimental approaches fo

117 hologist discordance and rising biopsy rates necessitate higher efficiency and diagnostic reproducibi

118 Moreover, it necessitates hippocampal protein degradation at the prot

119 ypothesize that susceptibility to severe RSV necessitating hospitalization in children without predef

120 hibit photophysical artifacts that typically necessitate human expert screening, which is time-consum

121 n patients with life-threatening arrhythmias necessitating ICD implantation, we compared outcomes of

122 equent survival compared with other diseases necessitating ICU admission such as patients admitted du

123 Successful management of allergic diseases necessitates identifying their specific causes (ie, iden

124 he impact of stigma mitigation interventions necessitates improved measurement of stigma for MSM arou

125 ontaminant delivery to receiving waterbodies necessitates improved understanding of stormwater-contam

126 tween patients and various adverse reactions necessitate improvement in delivery methods.

127 ite for transplanting large volume of islets necessitated in islet autotransplantation.

128 Commonly necessitated in their study is the capability to image a

129 Rather, our results necessitate incorporation of oxygen atoms from alternati

130 rsistence of CML stem cells hinders cure and necessitates indefinite TKI therapy.

131 nts requiring a procedure or medical therapy necessitating inpatient care.

132 An evolving urban biodiversity necessitates integrating evolutionary insights into mana

133 ose hospitalized, experience severe symptoms necessitating intensive care.

134 ) of 7366 thyroidectomy patients, with 83.2% necessitating intravenous calcium treatment.

135 TNBC), but the rapid emergence of resistance necessitates investigation of combination therapies and

136 rapidly enough to alter ecological dynamics necessitates investigation of the reciprocal links betwe

137 nti-VEGF loading dose from 3 to 6 injections necessitates investing euro 5882.77 (8 injections), euro

138 lth beyond blood coagulation and bone health necessitates its further research.

139 become clear that appropriate use of the BAT necessitates knowledge about degranulation metrics and g

140 ic behavior, the detection of bed bugs often necessitates labor-intensive, time-consuming and invasiv

141 sonnel (n = 24), who developed mild symptoms necessitating leave of absence and self-isolation, but n

142 rt disease with mechanical valve replacement necessitates lifelong anticoagulation with a vitamin K a

143 ted cells, which resupply active virus, thus necessitating lifelong treatment with associated complia

144 vere neonatal cholestasis (lethal in one and necessitating liver transplant in two).

145 iseases result in chronic ductular scarring, necessitating liver transplantation.

146 that Cu has limited capacity to be oxidized necessitates localization of electron hole character on

147 The chronic nature of EoE necessitates long-term therapy to avoid disease recurren

148 bits growth instead of killing fungal cells, necessitating long treatments.

149 e also less likely to be discharged home and necessitated longer hospital stays and greater hospitali

150 Monoresistance to rifamycins necessitates longer and more toxic regimens for tubercul

151 environmental stress and memory development necessitates longitudinal studies.

152 Plate tectonics and mantle dynamics necessitate mantle recycling throughout Earth's history,

153 Seq] results, gene predictions, repeats) and necessitates many volunteers to participate in the work.

154 The lipophilic nature of cannabinoids necessitates mechanism(s) to facilitate their intracellu

155 illary nucleases that can be toxic to cells, necessitating mechanisms to remove cOA in systems that o

156 asing number of animal populations worldwide necessitate methods to reliably and efficiently estimate

157 interpret due to large spectral congestion, necessitating modeling to elucidate key spectral feature

158 ing; increased storm frequency and intensity necessitate modification of design standards, land-use p

159 +27.69; 95% CI 12.06-43.32; P = 0.0005) and necessitate more antireflux surgery (OR 2.12; 95% CI 1.0

160 of most enzymes towards H(2) O(2) , however, necessitates more efficient systems for in situ H(2) O(2

161 tency from molecular to morphologic relapse, necessitating MRD assessment at short intervals during t

162 019, 108 (15%) had acute neurologic symptoms necessitating neurologic imaging.

163 n and a limited therapeutic toolbox urgently necessitate new approaches to treat neurodegenerative di

164 in infant acute lymphoblastic leukemia (ALL) necessitate new treatments.

165 ncept and construct of the disease have also necessitated new classification criteria.

166 This necessitates new approaches that provide broader protect

167 with bone is a major clinical challenge that necessitates novel materials and engineering solutions.

168 of effective vaccines against some serotypes necessitates novel measures to control ERM.

169 ry, radiation, and temozolomide chemotherapy necessitating novel therapeutics.

170 This necessitates nucleocytoplasmic transport (NCT) to bypass

171 , food allergy, and failure to thrive, often necessitating nutritional supplementation via gastrostom

172 ined as severe intraocular inflammation that necessitated obtaining an intraocular culture sample and

173 ge for phosphoproteomics therefore typically necessitates offline liquid chromatography prefractionat

174 , biomarkers and genetics data will probably necessitate ongoing revision of axSpA classification cri

175 The approach necessitates only calculating the mean and variances of

176 Our genetic analyses implied that BCL9 necessitates other interaction partners in mediating its

177 lications, including cardiovascular disease, necessitates our understanding of the metabolic disturba

178 This risk necessitates particular care in vaccine design.

179 This increasingly persuasive evidence necessitates policies to reduce harmful exposures and th

180 ons directly to the environment and to crops necessitates precautionary measures to avoid unintended

181 taneous coronary intervention, but their use necessitates prolonged dual antiplatelet therapy, which

182 of the disease at a young age in most cases necessitates prompt but long-term treatment to prevent d

183 The prevalence of these infectious agents necessitates rapid, point-of-care sensors for their dete

184 ed global public health and economic crises, necessitating rapid development of vaccines and therapeu

185 interpretation of genetic variants and might necessitate re-evaluation of the patient in some cases.

186 llenge is the fibrillation propensity, which necessitates refrigeration for storage.

187 dataset increases rapidly with sample size, necessitating relatedness modeling and enabling pedigree

188 I 0.53-2.20), and pelviperineal complication necessitating reoperation (RR 1.06; 95% CI 0.80-1.42) as

189 fall will become more common in this system, necessitating research on these pulses and their ramific

190 uitable for certain applications (e.g. those necessitating reversible redox behaviour and/or long exc

191 these biological-nanoparticles (sub-100 nm) necessitate rigorous biophysical characterization of sin

192 has transformed severe asthma treatment, but necessitates robust clinical evaluation, biomarker profi

193 rocessively transcribe large genomic regions necessitates robust mechanisms to terminate transcriptio

194 Eight patients had severe AKI, necessitating RRT.

195 6-phosphate dehydrogenase (G6PD) deficiency, necessitating screening.

196 It necessitates selective and sensitive devices to analyse

197 This necessitates serial monitoring, traditionally through ti

198 change, the planet is facing challenges that necessitate significant and rapid changes in agricultura

199 sentation process can be incredibly complex, necessitating sophisticated strategies that are difficul

200 light averse, O. wendtii orients to stimuli necessitating spatial vision for detection, but O. pumil

201 genetic information to the next generation, necessitating special attention to their genome maintena

202 equencing gene panel, though some conditions necessitate specific types of test such as repeat expans

203 rformed in centralized clinical laboratories necessitating specimen transport and increasing the time

204 sequence antagonizes SRY protein stability, necessitating splicing of a novel intron.

205 felong maintenance of a functional NSPC pool necessitates stringent mechanisms to preserve a pristine

206 association with neurological complications necessitates studies on the molecular mechanisms that re

207 The classical drug development pipeline necessitates studies using animal models of human diseas

208 ngly similar to that of other hallucinogens, necessitating studies of direct comparisons.

209 tion of SiGe in nanoscale electronic devices necessitates suppression of surface states dominating th

210 esent a case of an ileocolic intussusception necessitating surgery in a 7-month-old immunocompetent i

211 eneration, that increase mortality and often necessitate surgical intervention.

212 vere injuries in which transection of nerves necessitates surgical intervention.

213 .SIGNIFICANCE STATEMENT Memory consolidation necessitates synthesis of new proteins.

214 each individual procedure has limited data, necessitating synthesis of the entire literature to unde

215 eractions are sensitive to human activities, necessitating synthetic approaches to elucidate broad pa

216 The worldwide decline of coral reefs necessitates targeting management solutions that can sus

217 ation that a protein folds in water does not necessitate that water is a poor solvent for its unfolde

218 low CO(2) partial pressure (~40 mbar), which necessitates that candidate separation materials bind CO

219 l solids for electronic and photonic devices necessitates that their thermal-transport properties be

220 tion without adequate knowledge of the risks necessitate the characterization of the billions of nano

221 ium dissolution products in peri-implantitis necessitate the consideration of material properties in

222 orism using improvised nuclear devices (IND) necessitate the development of biodosimetry assays that

223 resistance and/or through biofilm formation necessitate the development of innovative 'outside of th

224 Accelerated timelines necessitate the discovery of fully human antibodies as b

225 of current progranulin-enhancing strategies necessitate the discovery of new targets.

226 in gene expression required for development necessitate the establishment of cis-regulatory modules

227 ts in low-income and middle-income countries necessitate the identification of cost-effective public

228 sent and future social-ecological challenges necessitate the maintenance and development of knowledge

229 s limited availability and inherent toxicity necessitate the strict regulation of iron homeostasis.

230 oncerns have public health implications that necessitate the thoughtful use of these therapies.

231 y and diversity of NTA and SSA methodologies necessitate the use of a comprehensive quality control s

232 n methods rely on fluorescent markers, which necessitate the use of costly reagents and time-consumin

233 ctional diversity of the human immune system necessitate the use of high-dimensional single-cell tool

234 es in microelectronic system technology have necessitated the development and miniaturization of ener

235 atics use for tagging and navigation and has necessitated the development of a new ontology developme

236 the generation of complex large datasets has necessitated the development of bioinformatics support c

237 The expansion of plants onto land necessitated the evolution of robust defense strategies

238 The size and complexity of these data have necessitated the generation of novel computational and a

239 tant clinical cases of tuberculosis (TB) has necessitated the rapid development of newer chemotherape

240 isolation and erroneously proposed structure necessitated the revision of the absolute configuration

241 s is likely to stall translation in vivo and necessitates the activation of ribosome-rescue pathways.

242 al correlated disorder in the structure that necessitates the additional parameters when modeling Bra

243 s is a significant public health problem and necessitates the annual evaluation of influenza vaccine

244 important drawbacks: (i) ChIP interpretation necessitates the assumption of perfect antibody specific

245 inated lesions as in multiple sclerosis (MS) necessitates the clearance of cholesterol-rich myelin de

246 g of biological systems at the protein level necessitates the continued development of efficient comp

247 rogen-containing small molecules in medicine necessitates the continued search for improved methods f

248 Reproductive development necessitates the coordinated regulation of meristem iden

249 This necessitates the development of alternate and effective

250 rgence of antibiotic resistance in pathogens necessitates the development of antibacterial agents inh

251 mental impact of fluorinated gases (F-gases) necessitates the development of green technologies to mi

252 This necessitates the development of high-throughput methodol

253 lastic pollution poses to soil and its biota necessitates the development of methods to detect microp

254 been a major threat in cancer therapies that necessitates the development of new strategies to overco

255 exhibiting resistance to current antifungals necessitates the development of new therapeutics.

256 This necessitates the development of novel therapies that can

257 ntact between electronics and the human body necessitates the development of stretchable energy stora

258 The growing threat of antibiotic resistance necessitates the discovery of antibiotics that are activ

259 rapies are not effective against CSCs, which necessitates the discovery of CSC-specific biomarkers an

260 chromophore following photoactivation, which necessitates the existence of pathways that produce 11-c

261 Rapid development in this area necessitates the exploration of new cations with advance

262 o be both curative and transmission-blocking necessitates the identification of previously undiscover

263 ance represents a growing health crisis that necessitates the immediate discovery of novel treatment

264 ng to changes in environmental contingencies necessitates the interlacing of existing memories with u

265 gulator only in specific tissue contexts and necessitates the re-evaluation of an alternative ESCRT-i

266 elevant for future nanotechnological devices-necessitates the reduction of the spatial footprint of s

267 Continued light sensitivity necessitates the regeneration of 11-cis-retinal via a se

268 This necessitates the signaling networks in plants to be high

269 m a homogeneous environment to a porous film necessitates the transport of both charge and substrate

270 copper oxidative addition step, which often necessitates the use of electron-rich ligands, elevated

271 n collection, and the emitters' atomic scale necessitates the use of free space optical measurement s

272 ion using bulk cavities, which unfortunately necessitates the use of vacuum and also renders the lase

273 pathogens have a metabolic iron requirement, necessitating the acquisition of this nutrient in the ho

274 supply of biosynthetic precursors is needed, necessitating the concerted action of metabolism and pro

275 terial world is large and extremely diverse, necessitating the development of additional models that

276 idespread in medical and commercial devices, necessitating the development of automated interpretatio

277 ncreasingly serious threat to global health, necessitating the development of innovative antimicrobia

278 to our limited arsenal of antifungal agents, necessitating the development of novel therapeutic optio

279 ndition with increasing incidence worldwide, necessitating the development of novel therapeutic strat

280 mation has been linked to numerous diseases, necessitating the development of tools to monitor the fi

281 e motors is a root cause of many pathologies necessitating the need for intrinsic control over molecu

282 strate by signaling enzymes, it is consumed, necessitating the recycling of NAD(+) consumption produc

283 ngeal swabs (NPS) and viral transport media, necessitating the search for alternate diagnostic specim

284 ence of electric and thermal fields, without necessitating the use of any external heating or illumin

285 ges during the course of each catalytic run, necessitating the use of global kinetic modeling to extr

286 or SARS-CoV-2 in February and March 2020 and necessitating the use of serological testing to determin

287 operties and functions of perovskite oxides, necessitating the utilization of nonequilibrium patterns

288 rs such as benzil and related compounds that necessitates their chemical transformation through fluor

289 re flares (worsening of HES-related symptoms necessitating therapy escalation or >=2 courses of blind

290 of water from the furnish during processing, necessitating thorough understanding of the dewatering b

291 umulation of Orm2 at the ER in ESCRT mutants necessitated TORC2 signaling through its downstream kina

292 ensory-motor systems, cognition and behavior necessitate training animals to perform complex tasks.

293 d violence and personal and community health necessitates treating these issues as public health issu

294 odecakin until disease progression, toxicity necessitating treatment discontinuation, patient withdra

295 e by 70 points or more) or disease worsening necessitating treatment intensification.

296 nt, including separation and immobilization, necessitates understanding the molecular structure of th

297 on effects of universal treatment approaches necessitates understanding who is being supported with t

298 a high percentage developed a fever >=37.5oC necessitating urgent screening for Ebola virus and a sma

299 rcentage developed a fever >=37.5 degrees C, necessitating urgent screening for Ebola virus, and a sm

300 asing resistance to multiple antibiotics may necessitate waiting for culture-based diagnostics to sel