ライフサイエンスコーパス: necessity

1 rough sustainable methodologies is an urgent necessity.

2 contrast to the adage ascribing this role to necessity.

3 rical developments rather than a fundamental necessity.

4 ive identification of these cases a clinical necessity.

5 lantation, adequate preclinical models are a necessity.

6 ous levels and spatiotemporal distribution a necessity.

7 and discovery of new therapies is a pressing necessity.

8 , adrenaline auto-injector prescription is a necessity.

9 ogression, withdrawal of consent, or medical necessity.

10 gh throughput and reproducible evaluations a necessity.

11 ferent insect species in food and feed are a necessity.

12 moneduloides), use tools depending on their necessity.

13 e effective vaccines remains a public health necessity.

14 arch moves from being a luxury to becoming a necessity.

15 partitions that can be reversed according to necessity.

16 s, but there is conflicting evidence for its necessity.

17 Combining both permissibility and perceived necessity, additional studies (studies 6 and 7) demonstr

18 In a reverse approach, eliminations of these necessities allow the modified oleosin to enter the ER l

19 icular focus in our article, we envision the necessities and challenges of nanotechnology in the deve

20 uestioned on the basis of eventual treatment necessity and concerns of safety; however, the role of a

21 The transplant community has debated the necessity and merits of broader organ distribution for s

22 However, the necessity and origin of this assemblance is unknown.

23 While those algorithms are heuristic by necessity and should be used with strict settings to min

24 h neural manipulations that allow testing of necessity and sufficiency claims.

25 This study aimed to demonstrate both the necessity and sufficiency of a patient-specific variant

26 odulated promoter activity, illustrating the necessity and sufficiency of a TE for oncogene activatio

27 rol cells (disease modeled) to determine the necessity and sufficiency of the p.Gly23Val-MRAS variant

28 no current evidence-based guidelines on its necessity and use for periodontal treatment planning.

29 cover treatment modalities for COVID-19 is a necessity, and therapeutic interventions such as heparin

30 e likely to be doing an activity of economic necessity at the time of injury.

31 a are yet available, expert opinions are, by necessity, based on case experience and reports from pat

32 Neither medication necessity (beta = 0.044; P = .138) nor illness beliefs (

33 cedural preparedness were based on practical necessities, but comparative evidence was not identified

34 f balancing varied electronic and structural necessities can be an important route to further develop

35 ts in shaded leaves resulted in feedback and necessity consumption patterns.

36 tical difficulties with cryotherapy (eg, the necessity, costs, and supply chain difficulties of refri

37 mice but also in WT mice, highlighting their necessity during nerve degeneration in the peripheral ne

38 rties of organic molecules in respect of the necessities for applications such as for organic electro

39 small molecules into cells and point to the necessity for a more complex model.

40 It highlights the necessity for a paradigmatic change of our disease-conce

41 rties dominated by the topological states, a necessity for a topological device, are clarified.

42 We reveal an independent necessity for active-beta-catenin in the fusion and diff

43 kyl acids (PFAAs) from AFFFs resulted in the necessity for alternatives, and short-chained PFAAs and

44 The necessity for an accurate, but at the same time, inexpen

45 ted by technical limitations, especially the necessity for an acidic pH.

46 ) is a leading cause of death and there is a necessity for animal models that accurately represent hu

47 and prone to observer errors, leading to the necessity for automated methods.

48 The necessity for bone marrow aspiration and the lack of hig

49 ing each of these pathways and testing their necessity for both extinction and relapse.

50 ular cysteine pairs in CSF3R and suggest the necessity for broader screening of CSF3R extracellular d

51 The necessity for changes in allocation in response to chang

52 ough an in vitro approach, thus reducing the necessity for clinical studies.

53 is the need for new antiviral agents and the necessity for combination therapies as has been shown to

54 We highlight the necessity for consideration of alternative (e.g., hybrid

55 ll- and large-scale laboratories suggest the necessity for continued microbiology-based understanding

56 This study highlights the necessity for developing a parameterization of dust IRI

57 virus (ZIKV) outbreaks have highlighted the necessity for development of novel vector control strate

58 ns at such high frequencies, notably with no necessity for doping.

59 Growing necessity for efficient nuclear waste management is a dr

60 HCC) are presently limited, underscoring the necessity for further elucidating molecular mechanisms u

61 growth in recent decades, thus implying the necessity for further investigations on both the interna

62 This study highlights the necessity for further research focused on recurrence pre

63 The economic burden of CP highlights the necessity for further research into management options.

64 Numerous failed clinical trials suggest the necessity for greater mechanistic understanding in order

65 tification of matrix elements, have become a necessity for investigating targets of trace metal bindi

66 rates of glaucoma, higher IOP, or a greater necessity for IOP-lowering surgery.

67 enges for any future hydrogen economy is the necessity for large scale hydrogen production not involv

68 g steps, which has made robustness testing a necessity for many technical aspects of feature extracti

69 f the guide-specific approach highlights the necessity for meticulous guide design and assessment, as

70 M synthesis and recycling and explaining the necessity for MTHFR to be regulated by SAM.

71 ne, rosetteless, and thereby demonstrate its necessity for multicellular rosette development.

72 l in treating hepatocellular carcinomas, the necessity for multiple treatments, injection of large fl

73 Conclusion: Abnormal CSF flow and the necessity for neurosurgical intervention must be conside

74 idence has indicated metabolic rewiring as a necessity for pancreatic cancer (PC) growth, invasion, a

75 confident imaging diagnosis of HCC, without necessity for pathologic confirmation.

76 sion requires CD4 T cell help, this is not a necessity for proliferation-competent progenitor cells i

77 uss has provided insights that emphasize the necessity for proper levels of stress response activatio

78 Thus, there is a necessity for prospective multicenter studies focusing o

79 mmunologically (durability of antibodies and necessity for protection from reinfection), seropositive

80 ic fracture, spinal cord compression, or the necessity for radiation or surgery to bone metastasis ca

81 er, an adequate sample size as a statistical necessity for radiomics studies is often difficult to ac

82 The necessity for rapid evaluation and treatment of acute is

83 rting and cloning methods by eliminating the necessity for repetitive purification steps and increasi

84 ic UBC-GFP mice and focuses attention on the necessity for rigor and reproducibility in scientific re

85 inhibition of glial TLR4 and illustrate the necessity for sex-specific research and individualized t

86 to endothelial dysfunction, highlighting the necessity for simple assessment of endothelial function.

87 the requirement of volatile buffers, and the necessity for specialized instrumentation to preserve we

88 erence for 2 + 2 cycloaddition is due to the necessity for syn-pyramidalization of the two CF(2) grou

89 bility conditions of measurement, which is a necessity for the analysis of low abundant stereoisomers

90 linker is not merely a consequence of, but a necessity for the desensitization process in ASICs.

91 Here we address catalytic necessity for the first time, using the prototypic inver

92 method for wine authentication has become a necessity for the global wine industry.

93 ontrol as risk factors, thus emphasizing the necessity for therapeutic options that allow interferenc

94 equirements for selected recipients, and the necessity for traceability of blood components.

95 The results showed the necessity for using samples with an original concentrati

96 network structure from small sample sizes, a necessity given the technical difficulty inherent in sim

97 electively mark long-term HSCs; however, its necessity in adult HSCs is unknown due to embryonic leth

98 ing a retro-AAV construct and assessed their necessity in aversive and appetitive taste learning.

99 itionally, these observations underscore the necessity in correcting both the nervous system patholog

100 the scans were obtained without any medical necessity (indication 12).

101 28) when the scans were obtained for medical necessities (indications 1-11), and in 5.6% of the scans

102 promising therapy for P-MS, elaborate on the necessities of clinical trial validation and formalized

103 The necessities of developing fast, portable, cheap and easy

104 echanisms of long runout landslides, and the necessity of a basal ice layer remain poorly understood.

105 or if indeed available, then limited by the necessity of a comparable reference genome as an adjunct

106 versible beta-hydride transfer, negating the necessity of a discrete iron hydride intermediate.

107 This strongly supports the necessity of a lifelong follow-up and suggests that ther

108 urable, treatment success is hampered by the necessity of a long and side effect prone treatment.

109 This task is challenging due to the necessity of a microscopic dioxygen (O(2)) concentration

110 ussed, and an emphasis will be placed on the necessity of a multidisciplinary approach.

111 owth and Form, D'Arcy Thompson discussed the necessity of a physical and mathematical approach to und

112 ferative vitreoretinopathy (PVR), and/or the necessity of a primary silicone oil fill.

113 zation (DWPDS)) on LF-(1)H NMR to exempt the necessity of a recalibration procedure when moving from

114 me to healthy human volunteers to assess the necessity of ABA for Imprime-mediated immunopharmacodyna

115 Recent work has demonstrated the necessity of Abeta-low-threshold mechanoreceptors (Abeta

116 Our findings demonstrate the necessity of accounting for oxygenated aromatics from bi

117 iated by illumination with light without the necessity of adding additional reagents such as acids or

118 ent into the 2-position of AOPCP without the necessity of additional bulky N(6)-substituents.

119 te the sensitive nature of this tool and the necessity of additional verification of the physical mec

120 emiological data and modelling underline the necessity of addressing latent tuberculosis infection if

121 The necessity of advanced techniques to maintain technical s

122 Considering the necessity of alternative therapies for this disease of h

123 te generally good outcomes and highlight the necessity of an experienced multidisciplinary team appro

124 of Fibromodulin and Adamtsl2 indicating the necessity of an intermediate.

125 With the increasing necessity of animal models in biomedical research, there

126 rs with arylboronic acid, thus obviating the necessity of any exogenous photosensitizer.

127 However, the necessity of APBs and their function in the ALT pathway

128 Our results thus underscore the necessity of applying new analytical technologies to cli

129 These results demonstrate the necessity of appropriate developmental timing of the cel

130 This work demonstrates the necessity of assessing the effect of intrinsic intermedi

131 The present work demonstrates the necessity of atomically resolved electron microscopy and

132 Specifically, after first confirming the necessity of auditory cortical activity for fear learnin

133 raight running as tracking data revealed the necessity of avoiding interpenetration of body segments.

134 outbreak by diverse EV-D68 strains, and the necessity of awareness and more surveillance on their ac

135 We propose that the necessity of balancing SAC strength and responsiveness d

136 tralizing antibody was performed to test the necessity of BDNF release in driving scopolamine-induced

137 quiring substantial user interaction and the necessity of building intuition, all of which are time a

138 nce of even a few mutations demonstrates the necessity of clone screening during process development.

139 The necessity of cMyBP-C phosphorylation for proper contract

140 f Mendelian origins, whilst highlighting the necessity of complete mitochondrial genome sequencing in

141 We discuss the necessity of complex, codependent plasticity mechanisms

142 entation of sequence information without the necessity of computing secondary structure features whic

143 e biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and expa

144 Our findings underscore the necessity of considering ecological memory in experiment

145 s could occur (ie, Namibia), and discuss the necessity of considering mobility-driven transmission wh

146 Our findings indicate the necessity of controlling for population structure and fa

147 particle refractivity indices, delineate the necessity of creating a calibration curve to adjust the

148 d related functional diversity emphasize the necessity of developing an approach that can fill this s

149 able among cohorts of studies, prompting the necessity of developing improved biomarkers.

150 Here we tested the necessity of direct hippocampal input to the PL for the

151 further use this data set to demonstrate the necessity of disease-specific classifiers and to train P

152 g a tonal language, the results point to the necessity of early intervention for the individuals with

153 ty at both the daytime and nighttime with no necessity of energy storage remains challenging.

154 eresting outlook in the understanding of the necessity of epitope clusters for effective mAb recognit

155 nce of synergy between host defenses and the necessity of evaluating the contribution of virulence fa

156 e(4+) and Si(4+)) on the Ti site suggest the necessity of experimental verification.

157 the NF-kappaB signaling network to test the necessity of feedback loops for responses to pulsatile a

158 This elegant model demonstrates the necessity of feedforward and feedback interactions betwe

159 To directly assess the necessity of fl-mHTT in astrocytes for HD pathogenesis,

160 Our work further demonstrates the necessity of globally fitting isotherms collected under

161 To address the necessity of GluA2 phospho-Y876 in synaptic plasticity,

162 excitotoxic mechanisms are unknown, and the necessity of glutamate for synapse loss or regeneration

163 allenges for molecular catalysts remains the necessity of high overpotentials, which can be overcome

164 As the functional necessity of hippocampal CA2 for social memory processin

165 Due to the necessity of human involvement in the process, current p

166 The goal of this work was to test the necessity of IC projections to NAc during social affecti

167 nteractions, and point to the difficulty and necessity of identifying the patients at risk.

168 ted by the number of deceased donors and the necessity of immunosuppression.

169 es in decoding AS patterns, highlighting the necessity of including the epigenetic properties when as

170 We highlight the necessity of incorporating water scarcity assessment at

171 Mechanistically, our data reveal the necessity of inducible T-cell costimulator (ICOS)-ICOS l

172 These data prove the necessity of intact MTORC1 signaling to regulate two syn

173 The effect of these advances on the necessity of intestinal resections and the risk of re-re

174 anslated after fertilization and without the necessity of invoking canonical receptor activation.

175 se neurons, we highlight the sufficiency and necessity of IRS4(PVH) neurons in normal feeding and ene

176 in AA TNBC patients, potentially due to the necessity of KIFC1 for migration in AA TNBC cells.

177 nd rate parameters automatically without the necessity of knowing any details of the chemistry.

178 Our data illustrate the necessity of l-citrulline metabolism for myeloid defense

179 s of simplicity, cost-effectiveness, limited necessity of laboratory infrastructure and skilled perso

180 Sleep is a fundamental necessity of life.

181 suggested method are the elimination of the necessity of manual IS addition and samples density meas

182 However, the necessity of MASP-3 for pro-FD cleavage has been questio

183 Our results underline the necessity of measures targeted at specific vulnerable gr

184 However, the functional necessity of minus-end-directed movement along actin is

185 itophagy reporter mt-Rosella, suggesting the necessity of mitochondrial fragmentation in Dox-induced

186 ty pattern for plants exposed to Ag-NPs, the necessity of monitoring several markers to accurately ev

187 ty in sensorimotor cortex and underscore the necessity of monitoring sleep-wake states to ensure accu

188 The necessity of more comprehensive public health strategies

189 validity of the TLICS classification and the necessity of MRI.

190 We demonstrate the necessity of multiclass modeling for accurate genetic va

191 rmal growth factor (EGF) and demonstrate the necessity of near-infrared emission to overcome intrinsi

192 The necessity of neurohumoral blockers in patients with hear

193 Furthermore, the necessity of NL docking for transport of membrane-bound

194 However, the necessity of NLGN3 for glioma growth, the proteolytic me

195 rly and evolving MS lesions, and suggest the necessity of ongoing studies of the mechanisms underlyin

196 Despite the necessity of oocyte meiosis for successful reproduction,

197 thods (POA, WOA and GOA) which indicates the necessity of optimization and also efficiency of the pre

198 bial nature of respiratory specimens and the necessity of ordering specific tests to identify viral a

199 ral regions of the world has resulted in the necessity of performing keratoplasty with imported donor

200 les with smaller size, which underscores the necessity of performing representative sampling.

201 the number of threatened species, (iii) the necessity of phylogenomic methods that are aware of diff

202 detection of harmful microalgae without the necessity of pre-concentration or dialysis steps.

203 The use of oligos avoids the necessity of preparing adaptors and the problems associa

204 erall yield of 53% from 4 and eliminated the necessity of preparing the diamide 13.

205 and in dopamine (DA) neurons to evaluate the necessity of protein expression for natural and drug rew

206 ng global challenges, while underscoring the necessity of pursuing these goals synergistically.

207 ion and response to treatment, prompting the necessity of recognizing specific phenotypes.

208 This suggests the necessity of recurrent processing in these computations.

209 e regeneration strategies is hindered by the necessity of removing a healthy nerve to obtain the ther

210 ationally have been hitherto hampered by the necessity of reweighting molecular dynamics (MD) results

211 t failure with aging and stress, showing the necessity of RNA methylation for the maintenance of card

212 The necessity of S831 GluA1 was further demonstrated by the

213 To determine the necessity of satellite cells during muscle recovery foll

214 Altogether, our work establishes necessity of SCN(VIP) neurons for the LMA circadian rhyt

215 diagnosed at or before 6 months, validating necessity of short-interval follow-up of mammographic BI

216 we demonstrate both the feasibility and the necessity of signal demixing to understand the narrowban

217 based on a least action method, without the necessity of simulating the steady-state distribution.

218 lymphocytes, which highlights the power and necessity of single-cell approaches.

219 The necessity of six similar but non-identical subunits has

220 nts that can target solid tumors without the necessity of specific antigen presentation on tumors are

221 athways in humans, while also discussing the necessity of specific energy substrates (glucose, fatty

222 ctivated by cisplatin in rats and reveal the necessity of specific hindbrain-forebrain projections fo

223 luster cost of $8.00 USD, while avoiding the necessity of storing large quantities of intermediate al

224 These findings highlighted the necessity of suspect and nontarget screening and reveale

225 lvement of HSV1 and cytomegalovirus (and the necessity of taking into account any marked differences

226 Matrix effect assessment revealed the necessity of taking into account such effect.

227 However, the necessity of TBC1D4 for this phenomenon has not been pro

228 viding an excellent model system to test the necessity of the decarboxylation step.

229 Necessity of the divalent ions to retain the suspension

230 pecific antibody lineages and highlights the necessity of the long vaccine boost.

231 We show the necessity of the pmf for motility and growth of C. jejun

232 We determined the necessity of the primary visual cortex (V1) and three ke

233 en subclinical; this invariably reflects the necessity of the virus to preserve its host, balanced wi

234 coupling motifs in retinal circuitry and the necessity of their detection in connectomics studies.

235 The dispensability of TAD boundaries and the necessity of these "early replication control elements"

236 Here, we ruled out the necessity of these events for the beta-band modulation o

237 domains have been identified, the catalytic necessity of these kinase domains remains unknown.

238 various habitats in the human body, and the necessity of these microbes for the maintenance of human

239 The necessity of these projections was limited to situations

240 The functional necessity of this interaction, combined with the uniquen

241 rprisingly little attention, considering the necessity of this step for infections to propagate.

242 ug resistance landscape, which highlight the necessity of timely genotypic drug resistance monitoring

243 sticular cells to a MEC fate, indicating the necessity of tissue specific components of the mECM.

244 ochondrial complex III, which highlights the necessity of ubiquinone as an electron acceptor for tumo

245 the central nervous system and highlight the necessity of unbiased high-throughput and high-dimension

246 ective use of eDNA methods, highlighting the necessity of understanding these parameters for use in f

247 To handle the growing necessity of unification, CellBase was created as an int

248 Structure-activity correlation indicated the necessity of unsubstituted triazoles and leucine linker

249 enemies on herbivorous insects, and thus the necessity of using a tri-trophic approach when studying

250 We posit the necessity of using high-resolution regional models with

251 ical climate prediction information, and the necessity of using the new benchmark skill for verifying

252 This finding strengthens the necessity of V1 models that are multiple nonlinearities

253 Discussion: This study highlights the necessity of validating and deploying vector control mea

254 ics, and Western blot analysis to define the necessity of various proteins involved in Siglec-8 funct

255 ts and soils (e.g., when judging remediation necessity or interpreting results of toxicity assays per

256 By necessity, participants were not masked to group allocat

257 hat the disappearance of Rauber's layer is a necessity, presumably to avoid excessive signaling inter

258 equired for the ALT mechanism, and that this necessity stems from APBs' role in localizing the BLM-TO

259 Necessity tests, using mature adipocyte-specific Prdm16

260 The success of this model reflects both "necessity"-the paucity of new therapies introduced throu

261 By necessity, the sampling is often stochastic, and must be

262 Our results also show the necessity to adequately account for changing circulation

263 The necessity to analyze medium-throughput data in epidemiol

264 ty of responses among species highlights the necessity to assess the effect of environmental stressor

265 in cannabis legalization have increased the necessity to better understand the effects of cannabis u

266 robe and microbial biomass; resulting in the necessity to clean or replace the probes between analyse

267 behavior that arose evolutionarily from the necessity to compete for limited resources and survival.

268 l- and ex vivo/in vitro experiments, and the necessity to conduct long-term (several years) human tri

269 With the growing necessity to consider environmental impacts when synthes

270 These data highlight the necessity to define how the resting f(H) is estimated at

271 lts from mean squared error highlighting the necessity to define model optimality with respect to the

272 rnal supply of Cas9 to the zygote avoids the necessity to deliver the relatively large Cas9 protein,

273 The presented platform emphasizes the necessity to develop new strategies to make MIP sensors

274 Our results highlight the necessity to develop therapeutic strategies to remedy ad

275 continuously available, there is rarely any necessity to eat something not tasty.

276 To illustrate the necessity to evaluate the efficacy of malaria control me

277 a multidomain protein, achieved without the necessity to express the individual subunits separately.

278 se techniques have limitations including the necessity to generate separate calibration curves for ea

279 Hence, there is a necessity to handle multi-allelic genotype data.

280 Thus, tele-oncology has become a necessity to improve cancer care.

281 onse to warming and eCO(2), highlighting the necessity to improve the genetic adaptability of plant t

282 rawbacks of existing therapies emphasise the necessity to improve therapeutic strategies.

283 This result highlights the basic necessity to include "very polar" compounds in water mon

284 Findings pinpoint the urgent necessity to investigate the ecotoxicity of fecal sterol

285 ssible chemical modifications highlights the necessity to obtain structural information about the bin

286 at laparotomy (aOR 3.1 95% CI 1.05-9.3), and necessity to perform a clip and drop procedure (aOR 30,

287 These findings indicate the necessity to refine therapeutic approaches that stimulat

288 oid these planetary nitrogen burdens and the necessity to remediate this problem, we foresee the abso

289 ns with unsuitable signal levels without the necessity to repeat the analysis.

290 derable programmatic implications (e.g., the necessity to screen for iron status before interventions

291 photochemical efficiency and highlights the necessity to screen transition-metal complexes for simil

292 ct sizes of single genetic variants, and the necessity to statistically correct for testing millions

293 CO(2)/d/m(3) in addition to alleviating the necessity to stop nitrification at nitrate, allowing eas

294 The analysis stresses the necessity to strengthen the ongoing research on cultivar

295 We stress the necessity to understand individual amino acids and their

296 disability disorders, thus highlighting the necessity to understand Las1 regulation and function.

297 ponse elicited with diltiazem highlights the necessity to understand mutation-dependent progression a

298 role of an efficient testing policy and the necessity to upscale testing capacity.

299 d towards single origin products induced the necessity to verify and certify cocoa beans origin for q

300 When we demonstrate necessity, we show that Fmr1 expression in either the la