ライフサイエンスコーパス: neddylation

1 d, sometimes, by ubiquitin enzymes (atypical neddylation).

2 bunit with the ubiquitin-like protein Nedd8 (neddylation).

3 vities of SCCRO and its paralogues in cullin neddylation.

4 MJ formation, possibly by regulation of AChR neddylation.

5 domain, which regulates its E3 activity for neddylation.

6 rane, raises questions about its function in neddylation.

7 through the UB transfer cascade for protein neddylation.

8 east to explore the effects of CIF on cullin neddylation.

9 /Erk pathway, was identified as a target for neddylation.

10 tivity of which is most likely controlled by neddylation.

11 leading to a decrease in steady-state cullin neddylation.

12 ide onto Cullin proteins in a process called neddylation.

13 and genes that are involved in autophagy and neddylation.

14 nces recruitment of Ubc12 to Cul1 to promote neddylation.

15 obic pocket in the E3, Dcn1, promotes cullin neddylation.

16 hat CAND-1 is a negative regulator of cullin neddylation.

17 -mediated retinoblastoma degradation and p53 NEDDylation.

18 unneddylated CUL1 and is dissociated by CUL1 neddylation.

19 hat depends on a protein modification termed neddylation.

20 conjugating enzyme, as a substrate for auto-neddylation.

21 esses is activated by Nedd8 through covalent neddylation.

22 ly conserved gene that functions as an E3 in neddylation.

23 indirect inhibitor of CRL by blocking cullin neddylation.

24 rcinoma-related oncogene/defective in cullin neddylation 1 domain containing 1/defective in cullin ne

25 the five co-E3 ligases, defective in cullin neddylation 1 domain-containing 1-5 (DCNL1-5); however,

26 hiometry reveals that, independent of cullin neddylation, a large fraction of cullins are assembled w

27 CRL complex, whose activity requires cullin neddylation, a posttranslational modification that can b

28 pe ubiquitination E3 ligases is regulated by neddylation, a process analogous to ubiquitination that

29 CRLs are activated upon cullin neddylation, a process of covalent conjugation of a ubiq

30 rovide evidence for an indispensable role of neddylation, a ubiquitylation-like protein modification,

31 Activation of atypical neddylation accumulated a surrogate misfolded protein, G

32 Inhibition of Skp2 using the neddylation-activating enzyme inhibitor pevonedistat dec

33 , ATF3, and NAEbeta (the beta-subunit of the neddylation activation enzyme).

34 Elevated neddylation activity has been observed in the liver and

35 quitin chains to the UBA domain inhibits the neddylation activity of SCCRO in vivo by inhibiting SCCR

36 ns as a tumor suppressor by antagonizing the neddylation activity of SCCRO.

37 Pharmacologic targeting of neddylation activity with MLN4924 (IC50, 4.7 nM) stabili

38 o apoptosis in clones with a net decrease in neddylation activity.

39 an be effectively modulated by CSN, and that neddylation allows Cul1 to form larger protein complexes

40 Targeting neddylation also suppressed the ability of DCs to stimul

41 argets of the posttranslational modification neddylation, although how these lead to myelin defects i

42 ce of adaptor modules, rather than cycles of neddylation and CAND1 binding, drives CRL network organi

43 ing and antagonistic activity that regulates neddylation and cell proliferation activities in vivo.

44 In flies, both dSCCRO and dSCCRO3 promote neddylation and cell proliferation, whereas dSCCRO4 nega

45 SCCRO family members cooperatively regulate neddylation and cell proliferation.

46 g in complete but transient loss of cullin-1 neddylation and consequent effects on NF-kappaB and beta

47 ptors cooperatively provide tight control of neddylation and cullin-RING-ligase activity in vivo.

48 We provide evidence that cullin neddylation and deneddylation is highly dynamic, that it

49 dylating enzymes besides CSN and the role of neddylation and deneddylation of their substrates.

50 n of enzymes and complexes known to regulate neddylation and deneddylation, including the COP9 signal

51 nding to Cul4-DDB1[VprBP] leads to increased neddylation and elevated intrinsic ubiquitin ligase acti

52 conclude that DEN-1 is a regulator of cullin neddylation and fine-tunes the inflammatory response in

53 inhibitor MLN4924 reportedly blocked cullin neddylation and inactivated CRLs, which resulted in apop

54 been documented that MLN4924 blocks Cullins neddylation and inactivates CRLs and, in turn, triggers

55 ion pathway, targeting effector caspases for neddylation and inactivation.

56 to conformational changes in CRLs that allow neddylation and initiation of ubiquitination.

57 s of SCCRO on abscission involve its role in neddylation and localization of Cul3 to the midbody.

58 The mechanistic link between Cullin neddylation and Myc ubiquitination/degradation is unclea

59 we investigated the contribution of Cullin-1 neddylation and NF-kappaB signaling to mucosal inflammat

60 treatment led to rapid inhibition of Cullin1 neddylation and notably suppressed growth and survival a

61 wn of L30 or L29 significantly increased the NEDDylation and nuclear retention of L11.

62 and, to a lesser extent, dSCCRO3 rescue the neddylation and proliferation defects promoted by expres

63 localization of Cul1 accompanying decreased neddylation and proliferation in SCCRO(-/-) mouse embryo

64 d SCCRO4 promote, and human SCCRO3 inhibits, neddylation and proliferation when expressed in flies.

65 data indicate that NUB1L suppresses atypical neddylation and promotes the degradation of misfolded pr

66 dentify SENP8 as a proximal regulator of Cul neddylation and provide an important role for SENP8 in f

67 s the nucleolus as a target of inhibitors of NEDDylation and provides a mechanism for p53 activation

68 er cells, MLN4924 rapidly inhibited cullin 1 neddylation and remarkably suppressed growth and surviva

69 (20-100 nmol/L) effectively inhibited cullin neddylation and sensitized pancreatic cancer cells to io

70 rupt Smurf interaction with Nedd8 reduce its neddylation and stabilize the protein.

71 ggest that parkin and PINK1 are regulated by neddylation and that impaired NEDD8 modification of thes

72 lthough the effects of NUB1 on p53 depend on NEDDylation and the murine double minute 2 (Mdm2) E3-lig

73 These results provide a crucial link between neddylation and transcriptional regulation by SIRT1, a N

74 lyubiquitinated proteins, and have increased neddylation and transformation activities.

75 hibitory effects of SCCRO3 on SCCRO-promoted neddylation and transformation require both an intact my

76 SCCRO/DCUN1D1 plays a key regulatory role in neddylation and, consequently, cullin-RING ligase activi

77 expressed Developmentally Down-regulated 8) (neddylation) and deactivated by NEDD8 removal (deneddyla

78 mediated by NEDD8-specific enzymes (typical neddylation) and, sometimes, by ubiquitin enzymes (atypi

79 Decreased nuclear localization, neddylation, and defective proliferation in SCCRO(-/-) m

80 t with their gene products normally opposing neddylation, and GFP fusions to several suppressors were

81 as the protease that counteracts Ubc12 auto-neddylation, and observed aberrant neddylation of Ubc12

82 t, the stability of stonin 2 is regulated by neddylation, another CSN-associated activity.

83 tion inhibition reduces fibrosis, suggesting neddylation as a potential and attractive therapeutic ta

84 pression of p27 in SI-NET, and inhibition of neddylation as a putative therapeutic strategy in SI-NET

85 fold subunits of E3 ubiquitin ligases, where neddylation as well as deneddylation, facilitated by the

86 ntified a new class of inhibitors of protein neddylation based on the profiles of the UB C-terminal s

87 ation not only isolated the known targets of neddylation but also the constellation of enzymes and co

88 Csn6 haplo-insufficiency decreased Cullin-1 neddylation but increased Fbxw7 stability to compromise

89 in neddylation) serves as an accessory E3 in neddylation by binding to cullin and Ubc12 to allow effi

90 rt that pharmacological inhibition of cullin neddylation by MLN4924 (Pevonedistat) rapidly decreases

91 Inversely, inhibition of NEDDylation by MLN4924 blocked proinflammatory gene expr

92 In contrast, suppression of atypical neddylation by NUB1L overexpression enhanced GFPu degrad

93 Expression of SCCRO3 inhibits SCCRO-promoted neddylation by sequestering cullins to the membrane, the

94 Further dissection of the mechanisms such as neddylation, by which these genes regulate immune respon

95 inally, we have shown that affinity-directed NEDDylation can be applied to two other protein-ligand i

96 Neddylation can be prevented by MLN4924, a drug that inh

97 e COP9 signalosome, Nub1, and enzymes in the neddylation cascade.

98 We provide evidence that augmented neddylation characterizes activated HSCs, suggesting tha

99 on in vivo involving nuclear localization of neddylation components and recruitment and proper positi

100 ting SCCRO-promoted nuclear translocation of neddylation components and results in a corresponding de

101 s neurite outgrowth, suggesting that cofilin neddylation contributes to the regulation of neuronal ac

102 Thus, blocking neddylation could be a novel strategy for mitigating imm

103 Hepatic neddylation deficiency triggers oxidative stress, mitoch

104 SENP8, a NEDD8-specific protease, but not by neddylation-deficient BCA3 or a SENP8 mutant.

105 ines which ectopically express wild-type and NEDDylation-deficient HBx and found that NEDDylation-def

106 HBx NEDDylation sites and observed that the NEDDylation-deficient HBx has shorter half-life.

107 and NEDDylation-deficient HBx and found that NEDDylation-deficient HBx showed less chromatin localiza

108 CRL activity and demonstrate that the cullin neddylation-deneddylation cycle is not only required to

109 ination in vivo, raising the question of how neddylation/deneddylation exerts its effects.

110 SN is physically recruited to DSB sites in a neddylation-dependent manner, and is required for timely

111 L4A) is recruited to DSB sites in a CSN- and neddylation-dependent manner, suggesting that CSN partne

112 ve degradation of the methyltransferase in a neddylation-dependent manner.

113 bind to p65 and the cyclin D1 promoter in a neddylation-dependent manner.

114 These results highlight a neddylation-dependent mechanism regulating gene expressi

115 al approaches, and the CULLIN-ASSOCIATED AND NEDDYLATION DISSOCIATED 1 (CAND1) and TRANSPORT INHIBITO

116 ulatory protein CAND1 (cullin associated and neddylation dissociated) are disrupted.

117 psis ortholog of human Cullin Associated and Neddylation-Dissociated (CAND1)/TIP120A, a protein recen

118 erpart of human CAND1 (cullin-associated and neddylation-dissociated) and demonstrate that it can pre

119 activity of SCCRO requires its potentiating neddylation domain, which regulates its E3 activity for

120 Dcn1's "potentiating neddylation" domain (Dcn1(P)) acts as an additional E3,

121 that SCCRO is an important component of the neddylation E3 complex that functions to recruit charged

122 oncogene (SCCRO)/DCUN1D1, a component of the neddylation E3 complex, regulates the activity of the cu

123 In addition, we have been able to improve NEDDylation efficiency through rational mutagenesis.

124 Our results demonstrate that blocking neddylation, either pharmacologically or using siRNA, ab

125 We find that AXR1 as well as other neddylation enzymes are autoneddylated at multiple lysin

126 12 of the actin regulator cofilin as a novel neddylation event.

127 mily of E3 ubiquitin ligase, requires cullin neddylation for its activity, MLN4924, therefore, acts a

128 per elaboration of dendrites and may require neddylation for its proper function.

129 gest family of E3 ligases and require cullin neddylation for their activation.

130 The combined effects of neddylation greatly enhance the probability that a subst

131 Neddylation has an important role in ubiquitin-mediated

132 nized function of the CSN in regulating EGFR neddylation has broad-reaching implications for understa

133 however, physiological regulation of cullin neddylation has not been described in mammalian systems.

134 HuR is stabilized by Mdm2-mediated NEDDylation in at least three lysine residues, ensuring

135 r findings demonstrate the essential role of neddylation in cardiogenesis at least in part by driving

136 otoxic stresses induced typical and atypical neddylation in cardiomyocytes.

137 Our results show deregulated neddylation in clinical fibrosis and both in mouse biled

138 ed Nae1, an obligative subunit of the E1 for neddylation in cortical progenitors.

139 Global inhibition of neddylation in developing neurons leads to cytoskeletal

140 Here, we investigated the role of neddylation in early cardiac development by deleting the

141 in vivo and define conditions for targeting neddylation in models of mucosal inflammation.

142 mined the mechanism and consequences of AXR1 neddylation in more detail.

143 me the inhibitory effects of CAND1 on cullin neddylation in purified protein assays.

144 and augments but is not required for cullin neddylation in reactions using purified recombinant prot

145 Here we investigated the role of protein neddylation in regulating T-cell function using an in vi

146 ecific suppressors partially restored Cullin neddylation in rfl-1(or198ts) mutants, consistent with t

147 d enzymatic function of rapsyn and a role of neddylation in synapse formation, and reveals a potentia

148 hus identifies an important role for protein neddylation in T-cell function, which may serve as a the

149 onse to CG-12, leading to increased cullin 1 neddylation in the Skp1-cullin1-F-box protein complex an

150 suggest that SCCRO has an essential role in neddylation in vivo involving nuclear localization of ne

151 tropic effects that are essential for cullin neddylation in vivo.

152 ant but less understood type of PTM, namely, neddylation, in regulating DC functions.

153 ggests a role for an additional modification-neddylation-in negative regulation of p53 transcriptiona

154 As a result, neddylation inactivation exhibits lower chemotaxis of mo

155 Mechanistically, neddylation inactivation inhibits the activity of Cullin

156 RNA-sequencing analysis revealed that neddylation inactivation suppresses the transactivation

157 n is neddylated; and inhibiting beta-catenin neddylation increases its nuclear accumulation and Wnt/b

158 with a nuclear localization sequence allowed neddylation independent of SCCRO, but at a lower level.

159 S we show that CRL2 activates CSN5/CSN6 in a neddylation-independent manner.

160 of EGFR modifications from ubiquitination to neddylation, inhibiting EGFR dynamics in response to an

161 duced apoptosis in mouse hepatocytes whereas neddylation inhibition ameliorated apoptosis through red

162 haracterizes activated HSCs, suggesting that neddylation inhibition could be important for resolving

163 hepatocyte cell death and inflammation after neddylation inhibition could partly account for reductio

164 Indeed, neddylation inhibition in activated HSCs induces apoptos

165 in activated macrophages, were reduced after neddylation inhibition in mouse Kupffer cells.

166 ignalosome strongly mitigated the effects of neddylation inhibition in small cell carcinoma, includin

167 Finally, NEDDylation inhibition is identified as a potential ther

168 Neddylation inhibition prevented the degradation of inhi

169 Neddylation inhibition reduces fibrosis, suggesting nedd

170 stologic analysis of the colon revealed that neddylation inhibition results in increased tissue damag

171 Importantly, neddylation inhibition, by using the pharmacological inh

172 f PDX models were exceptionally sensitive to neddylation inhibition.

173 on chelator deferoxamine (Desferal [DFO]), a neddylation inhibitor (pevonedistat [MLN-4924]), and a p

174 MLN4924 is a neddylation inhibitor currently under investigation in m

175 ddylation sites dynamically regulated by the neddylation inhibitor MLN4924 and the de-neddylating enz

176 Nedd8 silencing or treating cells with the neddylation inhibitor MLN4924 led to diminished caspase-

177 ntestinal epithelial cells revealed that the neddylation inhibitor MLN4924 prominently induces the de

178 Here, we report that pan neddylation inhibitor TAS4464 treatment reversed obesity

179 PS depends on SKP2; inhibiting SKP2 with the neddylation inhibitor, pevonedistat, halts tumor growth

180 Emerging evidence has also shown that neddylation inhibitors possess antiobesity and hypoglyce

181 on that can be pharmacologically targeted by neddylation inhibitors.

182 Neddylation is a biochemical event associated with diver

183 Neddylation is a post-translational protein modification

184 Neddylation is a posttranslational modification that con

185 Neddylation is a posttranslational modification that pla

186 Chemical control of cullin neddylation is attracting increased attention based larg

187 These studies reveal that intact Cullin-1 neddylation is central to resolution of acute inflammati

188 Neddylation is commonly mediated by NEDD8-specific enzym

189 This cullin neddylation is essential for a plethora of CRL-regulated

190 Although typical neddylation is known to regulate protein function in man

191 Cullin neddylation is modulated by a scaffolding DCN protein th

192 In mammals, neddylation is promoted by the five co-E3 ligases, defec

193 CULLIN1-neddylation is required for SCF(TIR1/AFB) functionality,

194 Neddylation is shown to facilitate E3 complex assembly;

195 Neddylation is the conjugation of the molecule neural pr

196 Neddylation is the post-translational protein modificati

197 The essential contribution of SCCRO to neddylation is to promote nuclear translocation of the c

198 of ubiquitin-like protein Nedd8 to cullins (neddylation) is essential for the function of cullin-RIN

199 ugation of Nedd8 to a cullin protein, termed neddylation, is an evolutionarily conserved process that

200 Here, we demonstrate that inhibiting neddylation leads to a notable absence of peripheral mye

201 he importance of SENP8 in maintaining proper neddylation levels for CRL-dependent proteostasis.

202 bition or depletion of key components of the neddylation machinery concomitantly inhibits stress-indu

203 Therefore, neddylation may also impact survival and proliferation o

204 Pharmacologic inhibition of cullin neddylation may provide a therapeutic opportunity in muc

205 Thus, in plants, neddylation may serve as a regulatory mechanism for cull

206 isome proliferator-activated receptor gamma) neddylation mediated by TOLLIP (toll-interacting protein

207 isms, including acetylation, ubiquitination, neddylation, methylation, and sumoylation.

208 Pharmacological targeting of neddylation (MLN4924) significantly abrogated NF-kappaB

209 e found that the small molecule inhibitor of NEDDylation, MLN4924, alters the morphology and increase

210 Taken together, our study suggest that neddylation modification and CRL E3 ligase are attractiv

211 at CRLs components are up-regulated, whereas neddylation modification is over-activated in a number o

212 Loss of DNA damage-induced neddylation negatively regulated DNA damage-induced foci

213 y showed a time-dependent induction of Cul-1 neddylation, nuclear translocation of NF-kappaB, stabili

214 tinib, we have shown that dasatinib-directed NEDDylation occurs for known endogenous protein binders

215 Neddylation occurs through a multistep enzymatic process

216 mics simulations, we demonstrate that before neddylation occurs, the linker flexibility of Rbx1, a CR

217 g as an adaptor protein that can mediate the neddylation of a non-cullin substrate.

218 PD neurotoxin MPP(+) inhibits neddylation of both parkin and PINK1.

219 se-1 (and CARD) and Nedd8 suggested possible neddylation of caspase-1 CARD.

220 te growth impairments, whereas site-specific neddylation of cofilin at K112 regulates neurite outgrow

221 We report that MLN4924 inhibits the neddylation of CRL4, blocking Vpx-induced degradation of

222 ase of p62 and that ATG16L1 is essential for neddylation of Cul-3, a step required for Cul-3 activati

223 lls, and selectively reduce the steady-state neddylation of Cul1 and Cul3 in two squamous carcinoma c

224 Neddylation of CUL1 or the presence of SKP1 and ATP caus

225 Neddylation of Cul3 on Lys 712 is required for Keap1-dep

226 l3Delta9 to the E3 ubiquitin ligase Rbx1 and neddylation of Cul3Delta9 were impaired significantly co

227 We demonstrate that dysregulation of NRF2 by neddylation of cullin 3 was linked to AGER1 downregulati

228 e of the DCN1-UBC12 interaction for cellular neddylation of cullin 3.

229 gase type of ubiquitination E3s by promoting neddylation of cullin family members.

230 g Myc, while COP9 signalosome (CSN) controls neddylation of Cullin in CRL.

231 Nedd8 activating enzymes, thereby preventing neddylation of Cullin proteins and preventing the degrad

232 CSN6 enhanced neddylation of Cullin-1 and facilitated autoubiquitinati

233 reactive oxygen species (ROS) that modulated neddylation of Cullin-1 and resulted in suppressive effe

234 ement for SCCRO in nuclear translocation and neddylation of cullins in vivo.

235 Our studies indicate that the defective NEDDylation of HBx negatively affects its ability to act

236 on, we revealed that E3 ligase HDM2 promotes NEDDylation of HBx to enhance HBx stability and chromati

237 We found that E3 ligase HDM2 promotes NEDDylation of HBx to enhance HBx stability by preventin

238 These results demonstrate that NEDDylation of L11 plays a critical role in mediating p5

239 We show that FBXO11 promotes the neddylation of p53 both in vitro and in vivo.

240 edd8 conjugation to Lys-320 and Lys-321, and neddylation of p53 leads to suppression of p53 function.

241 Neddylation of parkin and PINK1 results in increased E3

242 llular proteins and their activation require neddylation of their cullin subunit.

243 bc12 auto-neddylation, and observed aberrant neddylation of Ubc12 and other NEDD8 conjugation pathway

244 promoted its degradation through suppressing neddylation of ubiquitinated proteins in cardiomyocytes.

245 ermined that posttranslational modification (neddylation) of Cullin-4 is required for the activation

246 narily conserved, is the NEDD8 modification (neddylation) of cullins, core subunits of the cullin-RIN

247 smaller, and, consequentially, the impact of neddylation on transfer of subsequent ubiquitins by Cdc3

248 ot efficiently bind to Ubc12, promote cullin neddylation, or conform to the reaction processivity par

249 n as DCUN1D1) binds to the components of the neddylation pathway (Cullin-ROC1, Ubc12, and CAND1) and

250 colon cancer cell line LS174T identified the neddylation pathway as a main regulator of goblet cell d

251 -promoting microenvironment, which validates neddylation pathway as a promising target for anti-TAMs

252 this study provides the first evidence that neddylation pathway is overactive in ccRCC and that MLN4

253 support the SG assembly, suggesting that the neddylation pathway plays an important role in SG assemb

254 Together, neddylation pathway promotes CCL2 transactivation and TA

255 regulators of neuronal age and show that the neddylation pathway regulates both cellular age and AD n

256 HMECs with an intact neddylation pathway showed a time-dependent induction of

257 Here, we show that inactivation of neddylation pathway significantly inhibits infiltration

258 onsistently, pharmacologic inhibition of the neddylation pathway with the small molecule inhibitor ML

259 ty of proteins known to be involved with the neddylation pathway.

260 Here we show that neddylation promotes SG assembly in response to arsenite

261 tants and monitored the cullin deneddylation/neddylation ratio during embryonic and early seedling de

262 stic studies demonstrated that inhibition of neddylation reduced both canonical and noncanonical nucl

263 Our results provide new insights into how neddylation regulates the conformation and activity of C

264 cullins by the ubiquitin-like protein NEDD8 (neddylation) regulates protein ubiquitination by promoti

265 nisms and biological consequence of atypical neddylation remain largely unexplored.

266 Thus, neddylation represents a novel molecular process in macr

267 Chemical inhibition of neddylation required by CUL5 activation, also enhances C

268 emerging evidence demonstrates that cellular neddylation requires the action of Dcn1, which, in human

269 eddylase-1 (SENP8) as a key regulator of Cul neddylation response in vitro and in vivo.

270 Like ubiquitination, neddylation results from an enzymatic cascade involving

271 As a component of the E3 for neddylation, SCCRO/DCUN1D1 plays a key regulatory role i

272 on 1 domain containing 1/defective in cullin neddylation) serves as an accessory E3 in neddylation by

273 s inactivated by a mutation in its conserved neddylation site, and Nedd8 mutant neurons exhibit simil

274 entified that HBx K91 and K95 as the key HBx NEDDylation sites and observed that the NEDDylation-defi

275 Using sNUSP, we identified 607 neddylation sites dynamically regulated by the neddylati

276 We also identified the major NEDDylation sites on HBx.

277 evelopmentally regulated shift in the cullin neddylation status is absent in csn mutants.

278 r switch of CRLs activity by reverting their neddylation status, but its contribution to embryonic an

279 sponses to LPS or TNF-alpha by assessing Cul neddylation status, NF-kappaB and HIF-1alpha stabilizati

280 phosphorylation of VACM-1/Cul5 controls its neddylation status, phosphorylation by PKC, and ultimate

281 Here, we show that neddylation stimulates CRL activity by multiple mechanis

282 Thus, our results imply that neddylation stimulates ubiquitination by CRL conformatio

283 While many non-cullin neddylation substrates have been proposed over the years

284 Inhibition of neddylation suppressed the release of proinflammatory cy

285 The best understood neddylation targets are the cullins, scaffold subunits o

286 uitin-like posttranslational modification of neddylation, that conjugates Nedd8 (neural precursor cel

287 Recent work has revealed a central role for neddylation (the conjugation of a Nedd8-moiety to Cullin

288 Inhibition of neddylation, the conjugation of the small ubiquitin-like

289 reas NUB1L overexpression repressed atypical neddylation through promoting the degradation of NEDD8.

290 We also used siRNA to block neddylation to assess the role of this molecular process

291 DD8 and that the HDM2 E3 ligase promotes HBx NEDDylation to enhance HBx stability by inhibiting its u

292 dent inhibition of downstream members of the neddylation trienzymatic cascade including the co-E3, DC

293 ers of mitotic clonal expansion and that the neddylation/ubiquitin pathway modulates insulin sensitiv

294 On one hand, increased neddylation was associated with augmented caspase 3 acti

295 To identify genes that influence neddylation, we used a synthetic screen to identify gene

296 Loss of NUB1L exaggerated atypical neddylation, whereas NUB1L overexpression repressed atyp

297 Neddylation, which involves NEDD8 transfer from E2 to E3

298 s FBXO11 interacts with p53 and promotes its neddylation, which suppressed the p53 transactivity.

299 Numerous mechanisms specify cullin neddylation while preventing noncognate ubiquitin ligati

300 In vitro inhibition of neddylation with the therapeutic agent pevonedistat (MLN