ライフサイエンスコーパス: need

1 Sleep is a basic need.

2 -acquired pneumonia remains an unmet medical need.

3 educational attainment and contraceptive met need.

4 or determination of analytes at the point-of-need.

5 ow executable computational models meet this need.

6 tailor microbial membranes to meet specific needs.

7 of state-of-the-art diagnostics and current needs.

8 ariable instances tied to situation-specific needs.

9 m's survival when they support physiological needs.

10 statistical analyses over encrypted data are needed.

11 ich further complicates the analysis methods needed.

12 sure to different salt concentrations may be needed.

13 ity of the contrast agent, but more data are needed.

14 accurate predictions for these proteins are needed.

15 alysis challenging and better approaches are needed.

16 porary cardiovascular imaging parameters are needed.

17 oxychloroquine in patients with Covid-19 are needed.

18 free survival benefit, longer-term data were needed.

19 ive, imaging-based biomarkers are critically needed.

20 xposure to broader-spectrum antibiotics than needed.

21 s between Maori and Pacific patients is also needed.

22 atment-resistant depression, has been sorely needed.

23 ens for which new treatments are desperately needed.

24 -term risks for users and their offspring is needed.

25 r, and thus novel therapeutic approaches are needed.

26 for predicting risk of dementia in LMICs is needed.

27 nisms of immunotherapy resistance are likely needed.

28 , especially if renal replacement therapy is needed.

29 egradation to stock production parameters is needed.

30 nts with factor Xa inhibitor-related ICH are needed.

31 Twenty-five patients required 1 IMT and 4 needed 2 drugs.

32 Second, we need a better mechanistic understanding of how physical

33 To achieve this goal, we need a clearer understanding of the molecular pathways t

34 mation or connection with other nanocrystals needs a solvent as medium.

35 Therefore, predictive brains need abstract value representations.

36 To identify the highest priority research needs across the prostate cancer biomedical research dom

37 ociated with implementing the 5 practices is needed, along with system-level interventions to create

38 ing neurons are acutely activated by caloric need, and this acute activation promotes increased food

39 individuals will seek healthcare when it is needed, as well as providing an evidence base for effici

40 Needs assessments can be done using existing methods, su

41 termine whether an RCT with hard outcomes is needed before policy recommendations.

42 First, we need better descriptions of the multivariate physical ch

43 hate and 67% with antepartum haemorrhage who needed blood received it.

44 e obstacle to overcome is the amount of data needed by learning systems of this type.

45 Providers need decision-making support with virtual examination tr

46 analytical process, extra procedures may be needed during sample preparation and clean-up to address

47 rapies to ablate remaining tumor tissues are needed during surgical resection of prostate adenocarcin

48 er crescentus is a species that has met this need effectively, as its dimorphic lifestyle showcases d

49 e NIV trial (n = 18) compared with those who needed endotracheal intubation (n = 12) (median [interqu

50 than other high-risk patients, and an unmet need exists for improved CVD preventive measures for pat

51 CUD among current cannabis users, an urgent need exists for more research to identify effective phar

52 vel electroanalytical platform that does not need expertise-required tasks.

53 lladium (Pd) loading (e.g., 10 mole %) and a need for (super)stoichiometric quantities of undesirable

54 However, there is a need for a better understanding and user instructions on

55 crease of global temperatures highlights the need for a clear assessment of how sex ratios of organis

56 Our study demonstrates the need for a combination of biosystematics with biological

57 macovigilance databases, indicating a strong need for a more robust system of reporting.

58 tient-specific cellular therapy, without the need for a priori knowledge of tumor antigen, ex vivo ce

59 Inconclusive results prompted the need for a second biopsy in 18 patients: 13 of 125 (10.4

60 of known risk factors, reflecting either the need for a threshold of HCV for sexual transmission and/

61 The need for active and stable oxidation catalysts is driven

62 participants undergoing CAC-CT, without the need for additional imaging or radiation exposure.

63 The need for additional treatment is much less with the addi

64 d the development of neovascular sequelae or need for adjunct therapies were recorded for consecutive

65 There is an unmet need for an effective pain management strategy in this g

66 The need for an ester versus carboxylic acid-functionalized

67 ating coherent neuronal dynamics without the need for an oscillatory generator.SIGNIFICANCE STATEMENT

68 estinal organoids, potentially replacing the need for animal-derived matrices, while also allowing sy

69 cion of BL hypersensitivity and an immediate need for antibiotic therapy, when referral to an allergi

70 a personalized assessment for the continued need for antifungal therapy.

71 e unbound acetaminophen fraction without the need for any additional steps.

72 While there is a need for better understanding of sex differences in immu

73 ventitious nanoparticle binding, without the need for complex surface chemistries acting as blocking

74 ce isoforms across 14,611 genes, without the need for computational reconstruction of gene models.

75 An urgent need for countermeasures during this crisis challenges t

76 this clinical setting further underlines the need for developing other technologies, such as phage th

77 the central role of nucleic acids there is a need for development of fluorophores that facilitate the

78 19 are predictive of in-hospital AKI and the need for dialysis.

79 d among younger and black PLWH highlight the need for early diagnosis and treatment of HIV infection.

80 These findings highlight the need for early interventions for dementia prevention to

81 ic patients with cancer, which decreases the need for ESAs.

82 ion from the molecular structure without the need for experimental data.

83 I shielding materials but also highlight the need for exploring fundamental mechanisms behind interac

84 Thus, the need for further investigation and development of effect

85 ions over the 4-year period suggest an unmet need for glaucoma therapies with durable and predictable

86 improving sgRNA design, there is a pressing need for greater sgRNA potency and generalizability acro

87 can guide spatial sampling and highlight the need for greater use of mixed-effects models that accoun

88 -phase microextraction while eliminating the need for heating and shaking samples.

89 by proteoglycan interactions and suggest the need for improved polyplex targeting materials that pene

90 nerability have been identified with a clear need for individualized intervention strategies, the neu

91 However, a major drawback is the need for invasive implantation of optical fibers.

92 occurrence of LSCD (OR 0.137, P = .004) and need for keratoplasty (OR 0.093, P = .003) favored alloS

93 Excluding patients with a need or likely need for laser or surgery, the reasons for inpatient FA

94 ets from donated pancreas tissue and (b) the need for life-long immunosuppression.

95 This study highlights the need for lung function surveillance and prevention of LR

96 ts production in pure form, highlighting the need for metabolic engineering approaches for high-level

97 genes being discovered, there is a pressing need for methods facilitating the expansion of computati

98 ict privacy requirements, creating an urgent need for methods that preserve the individual-level priv

99 Consequently, there is an unequivocal need for more active and specialised metrics for reliabl

100 isk and polygenic scores, substantiating the need for multi-ethnic genome references.

101 inical care, hurdles to be overcome, and the need for multidisciplinary collaboration.

102 neural marker of awareness and highlight the need for new approaches to the neuroscience of conscious

103 ons can be made from standard output with no need for new engineering.

104 he high incidence of recurrence suggests the need for new treatments to prevent recurrent bacterial v

105 robial-resistance crisis, there is an urgent need for novel bacterial targets and antibiotics with no

106 testing against P. aeruginosa and stress the need for P. aeruginosa-specific breakpoints.

107 of COVID-19 lung disease and highlights the need for peripheral blood biomarkers that inform about p

108 on either 48-hour AKI, 7-day AKI, or on the need for postoperative renal replacement therapy after a

109 This critical review discusses how the need for reduced clinical turnaround times has influence

110 There is a need for reference genomes from multiple human populatio

111 inical and clinical phases have prompted the need for reliable and noninvasive assays to validate tra

112 Currently, there is a need for reliable tests that allow identification of ind

113 based on analysis of mutants that bypass the need for relief of SpoIVFB inhibition.

114 derive from tropical reefs, highlighting the need for research in other ecosystems and habitat types.

115 ist pipeline in a field that has a perpetual need for research.

116 ons on energy metabolism and demonstrate the need for sex-specific approaches in obesity research and

117 s (IOL), visual acuity (VA) outcome, and the need for surgery for visual axis opacification.

118 elicobacter pylori has resulted in a greater need for susceptibility-guided treatment.

119 There is a great need for the development of next generation instrumentat

120 ew therapeutic strategy and address an unmet need for this difficult to treat disease.See related art

121 ng tools for stratifying risk of IE, and the need for undergoing a TEE, among cases of SAB. We also i

122 ory shock (< 12 hr duration), defined as the need for vasopressors to maintain mean arterial pressure

123 nal DBS-fMRI, however, lacks the sensitivity needed for decoding multidimensional information such as

124 enges the paradigm that extended opioids are needed for effective postoperative pain management.

125 talysts that operate at low temperatures are needed for electrocatalytic hydrogenation (ECH) to upgra

126 In addition, the PI4P effector Past1 is needed for formation of stable PI4KII-containing endosom

127 unambiguous atomic models for oxyfluorides, needed for materials design and structure-property contr

128 bout 73% of the originally planned 88% power needed for significance), 4-year overall survival was 77

129 This work provides basic information needed for the design of tandem mass spectrometry-based

130 ent's changing condition over time are often needed for the management of chronic diseases.

131 When beds were most needed for the treatment of acute COVID-19 cases, privat

132 ntributes to the noninflammatory environment needed for Y. pestis colonization and proliferation.

133 a highlighting evidence-based practices that need further dissemination.

134 rovide my perspective on four key areas that need further research to inform curative and preventive

135 investigating human astrocytes are urgently needed, given their critical role in the central nervous

136 treated with 3 monthly IAI and thereafter as-needed IAI over 12 months.

137 V implementation and sustainable scale-up is needed in Asia and beyond.

138 ee Drosophila opsins, Rh1, Rh4, and Rh7, are needed in gustatory receptor neurons to sense a plant-de

139 ve bacteria at single cell level is urgently needed in many fields including clinical diagnosis and e

140 One of the greatest unmet needs in the current preoperative evaluation is to asses

141 arch on key unmet therapeutic and diagnostic needs in the field of TB elimination using multidiscipli

142 s control the most fundamental physiological needs in vertebrates(1,2).

143 A broad treatment perspective is needed, including carer support.

144 Our study provides a framework for the much needed incorporation of plasmid data into genomic survei

145 Flies fed after appetitive conditioning needed increased sleep for memory consolidation, but fli

146 The most common therapeutic needs involved new drugs (n = 149, 51.0%), cell regenera

147 Further studies are needed, involving different types and sources of fiber.

148 have argued that these botanical dispersals need not have been human mediated(7).

149 It can act reciprocally and need not occur co-transcriptionally.

150 erimental platform for the discovery of much-needed novel therapeutic targets in this chronic disease

151 a competitive immunoassay format without the need of a secondary antibody, or washing steps.

152 nvestigators to focus on key aspects most in need of attention when reporting PROs in future trials o

153 n-mediated taxis, and highlight key areas in need of further investigation.

154 viable approach to meeting the mental health needs of a population.

155 nd humans has ensured that the micronutrient needs of both parties are met.

156 highlighting a need to address the holistic needs of people living with HIV beyond viral suppression

157 ction has been hampered by the idiosyncratic needs of the encoding DNA tag relegating DEL compatible

158 gulatory or effector cells, depending on the needs of the host.

159 pts and tools, tailoring the workflow to the needs of the individual researcher within a single softw

160 ntegrated care models to address the diverse needs of this population.

161 Studies are needed on the effects of screening high-risk persons and

162 tivations were thus a compensation mechanism needed only in subjects with lower spontaneous network i

163 Excluding patients with a need or likely need for laser or surgery, the reasons fo

164 uce rCDI, microbiota-restoring therapies are needed, particularly standardized, easy-to-administer fo

165 has long relied on reliever therapy with as-needed short-acting beta-agonists (SABAs), while anti-in

166 iased mortalities, more complex analyses are needed that incorporate various ecological and life hist

167 ss independent sources and researchers often need to access these separately.

168 ce of temperature-sensitive fluorescent dyes need to account for thermophoresis of the dyes.

169 eries that are highly dependent on reefs may need to adapt to declining productivity, but further res

170 itor the global HIV response, highlighting a need to address the holistic needs of people living with

171 However, the need to address the nuclei via oscillating magnetic fiel

172 As a result, there is a growing need to be able to store, update, explore, and analyze p

173 diseases are now recognised as diseases that need to be addressed in such crises.

174 questions and methodological challenges that need to be addressed to advance and solidify our compreh

175 men in HF guidelines and HF trial leadership need to be addressed.

176 erging technical opportunities that we argue need to be considered to maximize the added value and lo

177 ion, conductivity, and mass diffusivity also need to be considered.

178 he complexity of recruitment mechanisms that need to be coordinated in localizing an ARF GEF to an in

179 to more precise treatment, but more efforts need to be devoted to a better understanding of the rela

180 NCD services will need to be expanded in Kenya.

181 Alternative tumour suppressor pathways need to be explored to treat p53- deficient tumours.

182 tion pathways and their mode of action still need to be identified.

183 These novel findings need to be investigated for consistency in other studies

184 Prenatal oestrogens need to be investigated, as they play a key role in syna

185 pies efficiently block HIV-1 replication but need to be maintained for life.

186 However, this will need to be maintained or triggered more frequently in th

187 rrently, all reported liquid metal batteries need to be operated at temperatures above 240 degrees C

188 Imaging biomarkers need to be quantitative and user and machine independent

189 Specifically, teduglutide cost would need to be reduced by >65% for it to reach the threshold

190 These candidate markers of disease activity need to be replicated in independent datasets and, if va

191 er Field Sieve, the quantum SAT solver would need to be superpolynomially faster than classical SAT s

192 divalent mercury Hg(II) chemical speciation need to be understood.

193 Physicians need to become competent in understanding the potential

194 There is a critical need to better understand the neural basis of antidepres

195 There is an urgent need to complement this traditional approach with experi

196 of lowering levels of gene products, and the need to consider both gain and loss of function to devel

197 further caution that behavioural experiments need to consider the possibility of context dependence i

198 And, we will need to demonstrate not only data stability but also the

199 Hereto, there is an urgent unmet need to develop mechanistic treatments directed at root

200 uffering from AMD and DR, there is an urgent need to develop new therapeutics targeting the mitochond

201 There is an urgent need to establish protocols specifically designed to ove

202 virulence genes during infection without the need to evolve binding sites for antisilencing proteins

203 Thus, there is still an urgent need to explore these areas to develop effective HIV cur

204 This is because we need to face not only a large amount of data but also it

205 lation variability in susceptibility and the need to fill data gaps using read-across approaches.

206 ble, major efforts in improving brain health need to focus on prevention, with emphasis on modifiable

207 and/or hypoxia matters, and underscores the need to further investigate the impacts of multiple stre

208 ected cardiovascular vulnerabilities and the need to improve cardiometabolic health.

209 This change implies a need to improve global coverage through routine immuniza

210 as patients age worldwide, highlighting the need to investigate the critical uncertainties regarding

211 nd models projecting their potential impact, need to look beyond the symptomatic cases if they are to

212 This recent impact creates a need to make these techniques and their accompanying vis

213 Surgeons need to optimize mental health assessment and services i

214 cellular uptake by passive diffusion with no need to postulate the existence of active uptake process

215 emerging applications are all united by the need to precisely control complex microbial dynamics in

216 rhoods information to phylogeny, researchers need to prepare all the necessary data and combine them

217 contamination in the U.K. and reinforce the need to prevent PCBs entering the marine environment to

218 The need to produce wheat with low asparagine concentration

219 Our results suggest the need to refine PSB and crack-initiation models in metals

220 dentification of BSE in two goats raised the need to reliably identify BSE in small ruminants.

221 Animals need to remember the locations of nourishing and toxic f

222 drink consumption is not, which supports the need to strengthen existing recommendations to reduce th

223 These findings highlight the need to study WD variants in both the homozygous and com

224 e world, this article aims to articulate the need to train students in computational and systems biol

225 iseases serves as a frequent reminder of the need to understand host-pathogen interactions.

226 Consequently, the need to understand the mechanisms supporting human-machi

227 Finally, our study highlights the need to understand the role of innate immune effectors i

228 generally overlooked and thus emphasize the need to use cellularly derived and biologically relevant

229 rt, along with prevention interventions, are needed to achieve HIV epidemic control.

230 The data standards and models needed to achieve this integration do not currently exis

231 ecruitment of general transcription factors, needed to assemble a transcription-competent preinitiati

232 Tools are needed to assess whether these drugs benefit patients on

233 gression, and lower hospitalization risk are needed to benefit patients and reduce CKD's economic bur

234 Novel antibiotics are urgently needed to combat multidrug-resistant pathogens.

235 Further studies are needed to confirm the nonsignificant trend towards a low

236 Further studies are needed to confirm these findings and realize the potenti

237 Future clinical trials are needed to confirm these findings.

238 including the use of either agent alone are needed to confirm these results.

239 Additional interventions are needed to control and eliminate malaria.

240 Above the critical bacterial volume fraction needed to decrease the viscosity to zero, [Formula: see

241 Further research is needed to define the role of asymptomatic hyperuricaemia

242 e, intravascular imaging techniques might be needed to delineate the underlying aetiology, together w

243 However, further consideration is needed to determine if there is sufficient patient load

244 Studies are needed to determine the mechanisms of mucosal dysregulat

245 n active ingredients; additional studies are needed to determine the systemic absorption of additiona

246 Further studies are needed to determine whether statin use and/or dyslipidem

247 is to use initial and confirmatory tests as needed to develop a final assessment of true GFR.

248 tched control DNA and additional analysis is needed to distinguish somatic and unfiltered germline va

249 tal advances in CO(2) electrolysis are still needed to enable short-term and seasonal energy storage

250 f nature reserves connected by corridors are needed to enable the dispersal of flora and fauna.

251 search, policies, regulations, and practices needed to ensure optimal water intake by all in the Unit

252 However, more research is needed to establish the best treatment options for these

253 cially available FEVAR, but further study is needed to establish their long-term durability.

254 Research is needed to examine the impact of the pandemic-related inc

255 blocks the required F conformational change needed to facilitate membrane fusion and virus infection

256 n of temporal information in the human brain needed to form episodic memories.

257 le biomedical and engineering fields will be needed to fully realize the promise of OoCs for fundamen

258 ial, although larger prospective studies are needed to further evaluate possible enhancements to the

259 is not well characterized, despite estimates needed to identify future health priorities.

260 New drugs or combinations are needed to improve patient therapy and to enhance the eff

261 Conservation actions are urgently needed to improve the status of freshwater species globa

262 The energy needed to maintain suitable water quality, with associat

263 Lead structure optimization is needed to minimize the percentage of A9 unspecific bindi

264 ing the number and duration of design cycles needed to optimize hit or lead compounds into high-quali

265 chemical tools, we demonstrated that FACT is needed to overcome replication stress.

266 osis is an ethical mandate, more research is needed to provide an evidence base for teaching and prac

267 ongoing reforms in Queensland's fisheries is needed to quantitatively link reef degradation to stock

268 Further research is needed to refine strategies that may perhaps improve sur

269 Interventions are needed to reinforce awareness that pulmonary vasodilator

270 lenges are discussed as well as improvements needed to render them as mainstream quantitative analyti

271 find that a single gene, Hairy (H), which is needed to repress trichome fate, underlies variation in

272 show that WAPL-dependent cohesin removal is needed to restart DNA synthesis at stalled forks and pro

273 more effective alternative drugs are clearly needed to slow disease progression.

274 nderstanding both the nature of computations needed to successfully traverse the space of possible ac

275 cies, we determined the number of dimensions needed to summarise their tolerance combinations, and th

276 protein A064R possesses the three activities needed to synthetize the 2-OMe-alpha-l-Rha-(1->2)-beta-l

277 of spirochetes, further optimization will be needed to translate this strategy for diagnosis of Lyme

278 % CI: 0.53 to 1.00; p = 0.047) with a number needed to treat of 36 to prevent 1 death.

279 Research is needed to understand how to monitor immune response to v

280 Further research is needed to understand the clinical importance of the find

281 However, further research is needed to understand the clinical importance of the obse

282 Further studies are needed to understand the mechanisms underlying these bra

283 Further research is needed to understand the source of these associations wi

284 Further study is needed to understand which measurements best reflect tru

285 More long-term studies are needed to upscale this first NLCB estimate to less produ

286 This multisensory information needs to be appropriately integrated for us to effective

287 e cause of this selective loss of beta cells needs to be further elucidated but overall, our findings

288 suggesting that AKT-driven tumor metastasis needs to be further understood.

289 Although the methodology performance needs to be further validated, results support the appli

290 st be present at high densities, this effect needs to be included in supernova nucleosynthesis models

291 17-18 d after final insecticide application needs to be maintained before harvesting the crop.

292 ppearance in retina is a nonspecific sign it needs to be properly evaluated as there can be underlyin

293 Psychology needs to become a historical science if it wants to be a

294 tailed understanding of disturbance response needs to go beyond associations and incorporate features

295 A proper 3D/4D image fusion needs to take into account the difference in the dimensi

296 For long-running jobs or large memory needs we provide detailed guidance on high-performance c

297 To address this need, we systematically assess methods for reconstructin

298 To address these needs, we developed BrainIAK (brainiak.org), an open-sou

299 This is an unmet need which calls for the development of controlled-relea

300 s of data will be possible, and new research needs will be requested by the technology industrial sec