ライフサイエンスコーパス: negative elongation factor

1 nner, the accumulation of the pause-inducing negative elongation factor.

2 gation complexes are completely resistant to negative elongation factors.

3 ith HIV-1 Tat protein and these positive and negative elongation factors.

4 Depletion through RNA interference of negative elongation factor, a mediator of Pol II stallin

5 ns with TEAD to regulate binding of the NELF negative elongation factor and block SMAD2,3 induction o

6 By antagonizing negative elongation factors and phosphorylating the C-te

7 By phosphorylating negative elongation factors and the C-terminal domain of

8 By phosphorylating negative elongation factors and the C-terminal domain of

9 s we describe are the pausing factors--NELF (negative elongation factor) and DSIF (DRB sensitivity-in

10 rylation of DRB sensitivity-inducing factor, negative elongation factor, and C-terminal domain (CTD)

11 start site upstream transcripts at multiple negative elongation factor-associated genes.

12 ck-in mouse with a FKBP12(F36V) tag fused to negative elongation factor b (Nelfb) locus, a ubiquitous

13 oter of the Arc gene, facilitating increased negative elongation factor binding to the Arc promoter a

14 Furthermore, we show that negative elongation factor binds to estrogen target prom

15 After Pol II initiates, negative elongation factors cause it to pause in a promo

16 e [DRB]-sensitivity-inducing factor) and the negative elongation factor complex (NELF).

17 ntrolled genes was abolished specifically in negative elongation factor-deficient macrophages.

18 is functional interaction between CE and the negative elongation factor documents a dynamic role of C

19 oncogenic activation of a top candidate RBP, negative elongation factor E (NELFE), via somatic copy-n

20 cs and prognostic value, we have developed a Negative Elongation Factor E (NELFE)-Dependent MYC Targe

21 provides an easy passage for pol II, and the negative elongation factor facilitates termination at th

22 or of BRCA1 (COBRA1), a subunit of the human negative elongation factor, has been shown to repress es

23 E relieves transcriptional repression by the negative elongation factor, indicating a critical role o

24 Negative elongation factor is essential for endometrial

25 , Cdk7 inhibition reduced recruitment of the negative elongation factor NELF at start sites.

26 enes are also associated with the polymerase negative elongation factor NELF.

27 the promoter in a complex that includes the negative elongation factor NELF.

28 n of transcript elongation by the complex of negative elongation factor (NELF) and 5,6-dichloro-1-bet

29 Negative elongation factor (NELF) and 5,6-dichloro-1-bet

30 Negative elongation factor (NELF) and DRB sensitivity in

31 osophila and vertebrates, DSIF together with negative elongation factor (NELF) associates with RNA po

32 P1) mRNA levels and reduced occupancy of the negative elongation factor (NELF) at the p21(CIP1) promo

33 iated transcription is stalled by the host's negative elongation factor (NELF) at the promoter region

34 rophages is marked by co-localization of the negative elongation factor (NELF) complex and facilitate

35 triggers rapid and transient release of the negative elongation factor (NELF) complex and productive

36 g this method, we find that depletion of the Negative Elongation Factor (NELF) complex increases both

37 r organoids, we demonstrate that loss of the negative elongation factor (NELF) complex inhibits breas

38 The four-subunit negative elongation factor (NELF) complex mediates RNA p

39 tive elongation by acting as a decoy for the negative elongation factor (NELF) complex upon induction

40 during early transcription, mediated by the negative elongation factor (NELF) complex, allows cells

41 nit (with NELF-A, -C/D, and -E) of the human negative elongation factor (NELF) complex, which partici

42 gene expression requires the pause-inducing negative elongation factor (NELF) complex.

43 BRA1) is a newly characterized member of the negative elongation factor (NELF) complex.

44 The principal negative elongation factor (NELF) contains four polypept

45 s study, we investigated mechanisms by which negative elongation factor (NELF) establishes and mainta

46 Genetic ablation of a pause-stabilizing negative elongation factor (NELF) in macrophages did not

47 The role of the negative elongation factor (NELF) in maintaining HIV lat

48 Negative elongation factor (NELF) induces RNAP II promot

49 Negative elongation factor (NELF) is a critical transcri

50 The human negative elongation factor (NELF) is a four-subunit prot

51 The Negative Elongation Factor (NELF) is a transcription reg

52 To downregulate transcription, the negative elongation factor (NELF) is recruited to gene p

53 e transcriptional pausing pathway, including negative elongation factor (NELF) that pauses RNA polyme

54 ntrary to current expectations, depletion of negative elongation factor (NELF), a key factor in setti

55 und that PARP-1 ADP-ribosylates and inhibits negative elongation factor (NELF), a protein complex tha

56 azole sensitivity-inducing factor (DSIF) and negative elongation factor (NELF), act as negative trans

57 Here we show that negative elongation factor (NELF), an RNA polymerase II

58 tion complex (LEC)-Cap binding complex (CBC)-Negative elongation factor (NELF), components of CBs, in

59 1 (COBRA1), an integral subunit of the human negative elongation factor (NELF), directly binds to ERa

60 the transcriptional elongation factors PAF1, negative elongation factor (NELF), SPT4/5, and SPT6 usin

61 ds to Pol II and prevents the release of the negative elongation factor (NELF), thus stabilizing Pol

62 w used to identify two new factors (BRD4 and negative elongation factor (NELF)-E) and to define their

63 es, this function has been attributed to the negative elongation factor (NELF).

64 erase (Pol) II, which requires the 4-subunit negative elongation factor (NELF).

65 sensitivity inducing factors (DSIF) and the negative elongation factor (NELF).

66 s DRB-sensitivity inducing factor (DSIF) and Negative Elongation Factor (NELF).

67 ty-inducing factor (DSIF) and the inhibitory negative elongation factor (NELF).

68 nditionally knock out the b subunit of mouse negative elongation factor (Nelf-b), a key pol II-pausin

69 using, in contrast to depletion of the NELF (negative elongation factor) pausing complex.

70 ZC3H4 is proximal to the negative elongation factor, PNUTS, which we show enables

71 K1A are auto-activated and phosphorylate the negative elongation factor SPT5, the transcription facto

72 -RAP to analyze interactions of the EGFP and negative elongation factor subunit E (NELF-E) proteins w

73 made possible by the reversal of effects of negative elongation factors that include NELF and DSIF.

74 rge subunit C-terminal domain as well as the negative elongation factor to release paused Pol II, the

75 Hence, Pcf11 can act as a negative elongation factor to repress RNA Pol II gene ex

76 es the C-terminal domain (CTD) of Pol II and negative elongation factors to release Pol II from promo

77 P-TEFb phosphorylates RNA polymerase II and negative elongation factors to stimulate general transcr

78 f RNA polymerase II (RNA pol II), as well as negative elongation factors, which block elongation by R