ライフサイエンスコーパス: negative feedback

1 ster than the timescales of mutation and the negative feedback.

2 gene expression control by genetic, in vitro negative feedback.

3 y activates the HER2-AKT1 axis, resulting in negative feedback.

4 that the internal model is suppressed after negative feedback.

5 niformly regulates thalamic activity through negative feedback.

6 eased LH pulse frequency, indicating loss of negative feedback.

7 g SL biosynthetic genes from an SL-dependent negative feedback.

8 l and task-related areas was increased after negative feedback.

9 emporoparietal electrodes was stronger after negative feedback.

10 gulate cortical actomyosin contractility via negative feedback.

11 tially mediate plant species coexistence via negative feedbacks.

12 response on the silty clay arose from a net negative feedback among exp(H), species turnover, and so

13 Many competing positive and negative feedbacks among stomatal sensitivity to carbon

14 firing is suppressed in the morning (AM) by negative feedback and activated in the afternoon (PM) by

15 ression in cultured ECs inactivates YAP in a negative feedback and causes its nuclear exclusion.

16 es showed greater frontal theta, an index of negative feedback and emotion regulation.

17 AKT inhibition relieved this negative feedback and enhanced activation of BCR-proxima

18 receptor recruitment increases expression of negative feedback and feedforward regulators, including

19 he VS lesion monkeys were more influenced by negative feedback and had lower choice consistency than

20 also reveal the discriminatory role of early negative feedback and necessary amplification conferred

21 for fundamental events underlying circadian negative feedback and output, key aspects of circadian b

22 is was likely due to the silicate weathering-negative feedback and the expansion of land plants that

23 ian estradiol regulates the pattern of GnRH (negative feedback) and initiates a surge of release that

24 Sequestration-based regulatory cascades with negative feedback are often found in biology, and thus o

25 homeostatic, interosensory plasma osmolality negative feedback as well as by novel, exterosensory, an

26 Here, we develop positive and negative feedback-based synthetic gene circuits to decou

27 he combination of a fast positive and a slow negative feedback between environment, population, and e

28 Our results reveal a hitherto unrecognized negative feedback between glaciation and atmospheric CO2

29 teractions for root litter decomposition and negative feedback between plants and soil biota.

30 signaling, effectively uncoupling the normal negative feedback between these two pathways.

31 ncrease water use efficiency thus minimizing negative feedbacks between carbon and nutrient balance.

32 and highlight a crucial role for positive or negative feedbacks between limiting resources and plant

33 change in pH is thought to be the signal for negative feedback, but its spatial profile in the synapt

34 rs during phage infection and the subsequent negative feedback by AcrIIA1(NTD) is required for optima

35 Breaking this negative feedback by blocking the phosphorylation of the

36 The circuit also features negative feedback by PDF to truncate the s-LNv Ca(2+) wa

37 Positive and negative feedback can play disparate roles in the synchr

38 Our analyses reveal that negative feedback channeled through the Ras1/2 GTPase is

39 this issue of Neuron, Wang et al. identify a negative feedback circuit in mouse preoptic area of the

40 elease, CITED2 activates a highly responsive negative feedback circuit that rapidly and efficiently a

41 m cell homeostasis within a deeply conserved negative feedback circuit(1,2).

42 the transcription factors RELA and RELB in a negative feedback circuit.

43 Accordingly, the low-noise, negative-feedback circuit can maintain resistance by acq

44 These results demonstrate a CRY-BIC negative-feedback circuitry that regulates the activity

45 reviously shown that this pathway includes a negative-feedback component in which MPK-1/ERK activity

46 hm's and Kirchhoff's laws, and thanks to the negative feedback connection in the cross-point circuit.

47 Rs serve as autoregulatory elements allowing negative feedback control at the post-transcriptional le

48 e mechanosensory monitoring of ingestion and negative feedback control of intake behaviours upon dist

49 SOCS1 induction is required to maintain the negative feedback control of macrophage activation in re

50 ction mutation of TTP impairs IL-10-mediated negative feedback control of macrophage function in vitr

51 Diurnal leaf-level measurements revealed a negative feedback control of photosynthesis, resulting i

52 ese regulating proteins, with DAD exerting a negative feedback control on OXI1 expression.

53 tly reported for transcriptional regulators, negative feedback control relies on binding of a transcr

54 1 substrates in M. marinum are fine-tuned by negative feedback control, linking the expression of the

55 Estradiol-negative feedback decreased glutamatergic transmission t

56 ve feedback loops, such that the effect of a negative feedback depends on its position with respect t

57 ous studies focused on what happens when the negative feedback dominates the dynamics.

58 ptin is believed to mediate the positive and negative feedback effects of oestradiol in the hypothala

59 at strong soma-to-axon coupling promotes the negative feedback effects of sodium inactivation and is,

60 ordant pairs of users is allowed even with a negative feedback, either with the rewiring step (RUCM)

61 t cholesterol esters, thereby preventing the negative feedback elicited by unesterified cholesterol.

62 wn how positive feedback generates switches, negative feedback enables gradient detection, and cohere

63 tilized activator-based proteins, neglecting negative feedback except for in silico control.

64 photosynthesis of land plants-may provide a negative feedback for climate change.

65 dent inflammatory cytokine outcomes included negative feedback from autocrine/paracrine IL-10, TGF-be

66 cts a weaker response to therapy if there is negative feedback from differentiated tumor cells that i

67 x versus the deep cerebellar nuclei; and (4) negative feedback from the cerebellum to the inferior ol

68 clophilin LRT2 are essential components in a negative feedback gene regulation circuit that controls

69 Negative feedback HSP, also known as synaptic scaling, m

70 that affect ice sheets and show a projected negative feedback in grounding line migration of 38% for

71 urrents that provide dynamic, voltage-gated, negative feedback in subthreshold voltage range: sodium

72 vitro, that this complex relieves NadE(Gln) negative feedback inhibition by NAD(+) This mechanism is

73 dynamics emerge from nonlinear positive and negative feedback interactions mediated through neurokin

74 ow-diffusing membrane components with slower negative feedbacks involving faster diffusing cytoplasmi

75 In Neurospora crassa, negative feedback is executed by a complex of Frequency

76 If this negative feedback is less pronounced, the treatment resp

77 be deleterious for the host, and therefore, negative feedback is needed.

78 rawal from escalated cocaine SA disrupts how negative feedback is used to guide goal-directed behavio

79 onger timescales, CO2 release could act as a negative feedback, limiting progress of glaciation, depe

80 elf-sustaining transcriptional-translational negative feedback loop (TTFL) in which the negative regu

81 cavernous malformations-3), participate in a negative feedback loop among RhoA and its cytoskeletal e

82 e find that changes to the parameters of the negative feedback loop are much stronger inputs for shif

83 Additionally, we uncover a negative feedback loop between actin remodeling and flg2

84 These results revealed a negative feedback loop between appressorium formation an

85 Here the authors show a negative feedback loop between C/EBPalpha and miR-182 an

86 regulation of ERK and define a novel double-negative feedback loop between EpCAM and ERK that contri

87 Our results describe a double-negative feedback loop between MIR100HG and the transcri

88 The negative feedback loop between NMDARs and SK channels wa

89 This negative feedback loop between pressure and transport al

90 us transcription factors, including a double-negative feedback loop between the microRNA-200 (miR-200

91 Model analysis further predicted a negative feedback loop between the persistent and resurg

92 In the negative feedback loop driving fungal and animal circadi

93 replication forks, revealing an ATR-mediated negative feedback loop during replication.

94 ) that mediates body temperature decrease, a negative feedback loop for thermoregulation.

95 ons of airway collapsibility, chemoreceptive negative feedback loop gain, and arousal threshold.

96 e Polycomb group protein EZH2 disrupted this negative feedback loop in both CRPC and enzalutamide-res

97 Overall, our results reveal a negative feedback loop in the miRNA pathway mediated by

98 lly repressed by p53, defining an additional negative feedback loop in the p53 network.

99 irst time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced

100 cillation can be generated by a time-delayed negative feedback loop in which Plk4 inactivates the int

101 used a knock-in mouse in which the p53-Mdm2 negative feedback loop is genetically disrupted.

102 This negative feedback loop is mediated by two translation in

103 induced FBXL5 protein level, demonstrating a negative feedback loop limiting excessive accumulation o

104 hat IL-17 signaling is regulated by a robust negative feedback loop mediated by TBK1 and IKKepsilon.

105 action, limiting further glucose uptake in a negative feedback loop of "glucose-dependent" insulin re

106 robe, which upon irradiation strengthens the negative feedback loop of a CRN that produces oscillatio

107 n sigma factor in spatially coordinating the negative feedback loop of its own genetic circuit.

108 Thus, mGluRs establish a local negative feedback loop positioned to regulate IHC activi

109 Thus, disparate triggering of a cytokine negative feedback loop promotes tuning of macrophage res

110 d resistance mediated by FOXM1-Nedd4-VDAC2/3 negative feedback loop provides an initial framework for

111 we describe a GC-specific, AKT-kinase-driven negative feedback loop that attenuates BCR signaling.

112 by aldosterone-induced miRs may represent a negative feedback loop that contributes to a form of ald

113 sis may constitute a previously unrecognized negative feedback loop that contributes to CD8 T cell ad

114 tin with RPEL-family rhoGAPs thus provides a negative feedback loop that couples Rac activity to acti

115 matic activity of these proteins, creating a negative feedback loop that dampens upstream BCR signali

116 like responses to inputs, is nested within a negative feedback loop that encompasses RAS and RAF, MEK

117 s Hsp70 and Hsp90, in turn, participate in a negative feedback loop that ensures appropriate coordina

118 These mutants thus appear to lack a negative feedback loop that inhibits DSB formation when

119 porulation sigma factor sigma(F) to create a negative feedback loop that inhibits sigma(F) -directed

120 n provide the basis for the formation of the negative feedback loop that interrelates cell volume and

121 tion, thus FBP1 and PRC2 are part of a novel negative feedback loop that is deregulated in liver and

122 ting that microglial phagocytosis provides a negative feedback loop that is necessary for the long-te

123 ed phosphorylation at Ser(384) constitutes a negative feedback loop that regulates DSB repair.

124 ls are functionally coupled, forming a local negative feedback loop that restrains the excitatory eff

125 channels form a functional Ca(2+) -dependent negative feedback loop that restrains the excitatory eff

126 s alternative pre-mRNA splicing represents a negative feedback loop that terminates TLR signaling and

127 activation of HCA2 during sepsis activates a negative feedback loop to attenuate the inflammatory res

128 CCN3/NOV inhibits AR signaling and acts in a negative feedback loop to block AR function.

129 Our data suggest that miR-323-3p acts in a negative feedback loop to control the production of IL-2

130 ivated protein kinase Snf1 is coupled with a negative feedback loop to generate the characteristic pu

131 umor growth both in vitro and in vivo, and a negative feedback loop was discovered between DGAT1, PED

132 to be decent substrates of OGT, exhibiting a negative feedback loop when phosphorylated at the P-3 si

133 positive feedforward loop with Stat1/2 and a negative feedback loop with Stat3.

134 he type 1 effector acquisition which forms a negative feedback loop with T-bet to preserve the identi

135 nd miR-1010 to reduce nAcRbeta2 mRNA levels (negative feedback loop).

136 nstrate that microRNA-144 targets Dicer in a negative feedback loop, affecting global canonical micro

137 h CAL-101 [idelalisib]), interrupts a double-negative feedback loop, enhancing GC-regulated transcrip

138 Here we describe evidence of a negative feedback loop, in which PGE2 augments the expre

139 (RBP) regulate their expression levels by a negative feedback loop, in which RBP binds its own pre-m

140 We propose a negative feedback loop, in which sphingosine inhibits GB

141 -acting positive feedback loop and a delayed negative feedback loop, mediated by upregulation of ubiq

142 rprisingly, however, instead of generating a negative feedback loop, the signals oppositely polarize,

143 We propose a model based on a double-negative feedback loop, vertically transmitted via the e

144 tor PDLP5 in cells overlying LRP, creating a negative feedback loop.

145 activity of FlrA is down-regulated through a negative feedback loop.

146 1 interaction has two roles in the circadian negative feedback loop.

147 ional output owing to disruption of the MDM2-negative feedback loop.

148 ed mobilization of IRF3, thus constituting a negative feedback loop.

149 t can control neuronal firing frequency in a negative feedback loop.

150 g evidence, thus creating a self-reinforcing negative feedback loop.

151 r factor (NF)-kappaB activation as part of a negative feedback loop.

152 ates its translation, thereby constituting a negative feedback loop.

153 Furthermore, a negative-feedback loop between Cxcl12 and its clearance

154 s overcome when miR-144 represses Dicer in a negative-feedback loop during erythropoiesis.

155 ds to a downregulation of Sox2, suggesting a negative-feedback loop in the tooth.

156 ry HD-ZIP III genes, and thereby establish a negative-feedback loop that forms a robust boundary that

157 mmation subsides, placing the receptors in a negative-feedback loop that may contribute to the resolu

158 d EIF4E2 to collided ribosomes to initiate a negative-feedback loop that prevents new ribosomes from

159 the miR-203 locus is directed by SNAIL2 in a negative-feedback loop.

160 on in mammary adipose tissue through a novel negative-feedback loop.

161 critical to autoregulate GH secretion via a negative-feedback loop.

162 for the autoregulation of GH secretion via a negative-feedback loop.

163 Only two circuit motifs generate adaptation: negative feedback loops (NFLs) and incoherent feed-forwa

164 d on intracellular transcription-translation negative feedback loops (TTFLs).

165 ian rhythms are generated by transcriptional negative feedback loops and require histone modification

166 Our data point to the existence of negative feedback loops between these two regulatory pro

167 to investigate how interlinked positive and negative feedback loops process EGF signals into ERK pul

168 of ancestral RNAi by, for example, employing negative feedback loops to reset the transmission of epi

169 would form a regulatory system consisting of negative feedback loops with time delays and that BMP9 w

170 shold, observations that define positive and negative feedback loops within the network.

171 Two auxiliary negative feedback loops, from ERK to MEK and RAF, placed

172 sitive feedback introduces a hierarchy among negative feedback loops, such that the effect of a negat

173 e analyzed dynamics-determining positive and negative feedback loops, thereby elucidating the attract

174 e their own signaling output via positive or negative feedback loops.

175 effect driven by the partial preservation of negative feedback loops.

176 teoclast signaling intermediaries or through negative feedback loops.

177 generated via transcriptional-translational negative feedback loops.

178 owth hormone (GH) secretion is controlled by negative-feedback loops mediated by GH-releasing hormone

179 mbining a robust stress response with strong negative feedback may be important for persisting in unp

180 ermined to be regulated by a transcriptional negative feedback mechanism composed of a dozen core clo

181 The sAHP is an intrinsic neuronal negative feedback mechanism consisting normally of two p

182 Decreased wetland CH4 emissions can act as a negative feedback mechanism for future climate warming a

183 TAAR1-KO versus wild-type mice, suggesting a negative feedback mechanism for TAAR1 in sensing tyramin

184 density, which introduces implications of a negative feedback mechanism for the uptake of atmospheri

185 can mediate repression of ainS, providing a negative feedback mechanism in the Ain/Lux signaling cas

186 onditionally stable motifs suggest a general negative feedback mechanism leading to sustained oscilla

187 findings suggest that this microglia-driven negative feedback mechanism operates similarly to inhibi

188 D deficiency in diabetes and reveals a novel negative feedback mechanism that controls crosstalk betw

189 om activity generates an error signal in the negative feedback mechanism that controls firing rates.

190 on of kinesin-II from IFT trains serves as a negative feedback mechanism that facilitates flagellar l

191 Finally, we propose the existence of a negative feedback mechanism that governs the pore format

192 dulation of synaptic plasticity represents a negative feedback mechanism that may limit runaway enhan

193 y NRARP and provide insights into a critical negative feedback mechanism that regulates Notch signali

194 2+)-activated K(+) (BK) channels, a critical negative feedback mechanism that regulates smooth muscle

195 pamine, which may contribute to an ultrafast negative feedback mechanism to constrain TIDA electrical

196 elves repressed by this pathway, providing a negative feedback mechanism to ensure chromatin homeosta

197 onged stimulation, which may be considered a negative feedback mechanism to limit their uncontrolled

198 This was thought to be a negative feedback mechanism to suppress inflammation.

199 Our findings unveil a negative feedback mechanism triggered by ABA that acts v

200 s reduced via self-attenuation, a protective negative feedback mechanism, masking EADs.

201 esent a theoretical model to elucidate how a negative feedback mechanism, tied to the distance betwee

202 repressed YAP expression, contributing to a negative feedback mechanism.

203 tasis in murine P19 cells using an intricate negative feedback mechanism.

204 ty phosphatase (DUSP)-p38 MAPK, indicating a negative feedback mechanism.

205 IFN-LNK signaling is tightly regulated by a negative feedback mechanism; melanoma cells exposed to I

206 We describe a negative-feedback mechanism targeting RIG-I activity, wh

207 ption of normal Zap70 autoinhibition engaged negative feedback mechanisms by which negative selection

208 o control enteric infections but also employ negative feedback mechanisms to prevent chronic inflamma

209 f-resolving process supported by an array of negative feedback mechanisms to sustain tissue homeostas

210 resulting lines expressing crtI has revealed negative feedback mechanisms, acting predominantly at th

211 oxically hypoactive platelets resulting from negative feedback mechanisms, including upregulation of

212 ns are required to regulate GH secretion via negative-feedback mechanisms is unknown.

213 ally designed hairpins, positive-feedback or negative-feedback mechanisms operated by the CDNs are de

214 The approach curve was recorded in negative feedback mode of SECM and revealed the contact

215 rograming of multiple IFN receptors toward a negative-feedback mode of signaling, accompanied by supp

216 values and unobserved states of a stochastic negative feedback model to be inferred from univariate t

217 s paper, HT-SECM was studied in positive and negative feedback modes, for which approach curves and c

218 ation, which creates a combined positive and negative feedback network controlling NF-kappaB activity

219 ell activation and receptors involved in the negative feedback of immune cell activation.

220 The negative feedback of marine P cycle to terrestrial P inp

221 A key negative feedback of this warm climate was the organic c

222 urial that would have acted as an additional negative feedback on atmospheric pCO2 levels.

223 ive control over MAPK signaling as well as a negative feedback on cAMP concentration.

224 glacier retreat) losses generate a valuable negative feedback on climate change.

225 biological ocean carbon storage and act as a negative feedback on climate change.

226 lization effect (CFE)] sustains an important negative feedback on climate warming, but the temporal d

227 boxylate transporters (MCTs), resulting in a negative feedback on glycolytic rate.

228 hat upregulation of BCA2 provides regulatory negative feedback on NF-kappaB.

229 ertical mixing in the upper ocean, induced a negative feedback on phytoplankton productivity by reduc

230 iated suppression of mTORC1 and thus reduced negative feedback on PI3K flux.

231 Estradiol induces negative feedback on pulsatile GnRH/luteinizing hormone

232 This effect provides a modest negative feedback on seawater composition and (87)Sr/(86

233 gating" rather than a "magnifying" effect of negative feedback on stress responses.

234 sin modulated neural activity when receiving negative feedback on task performance from a study inves

235 nts of atmospheric CO(2) implies a weakening negative feedback on the climatic system and increased s

236 The reason is that negative feedback on the rate of tumor cell division pro

237 lex enabling CD5 to synchronize positive and negative feedbacks on TCR signaling through the other co

238 This negative feedback, operating on a longer time scale, cha

239 potentials in cells from OVX+E PM mice than negative feedback or OVX (open feedback loop) trains in

240 Surprisingly, LDTM exerts negative feedback over apoptotic signaling by inhibiting

241 acellular signal-regulated kinase (MAPK/ERK) negative feedback pathway diminishes oncogenic signals,

242 y p70S6K1 attenuate insulin action through a negative feedback pathway.

243 Inhibition of phosphorylation-dependent negative-feedback pathways is observed, defining mechani

244 In order to obtain negative feedback positioning control without risking da

245 d, it determines the efficiency of circadian negative feedback process by mediating FRQ-dependent WC

246 r is downregulated upon activation, whereas 'negative feedback' receptors are induced upon immune cel

247 This response is distinct from the negative feedback reflex mediated by aortic and carotid

248 Our results indicate a strong negative feedback regime when atmospheric oxygen concent

249 cysteine metabolism in cardiomyocytes, and a negative feedback regulation between CBS and CSE in the

250 Together, these findings demonstrate a negative feedback regulation between TRIM21 and HuR, whi

251 ased hepatic synthesis of BAs, with impaired negative feedback regulation by the ileal hormone fibrob

252 e reason that the resulting tissue selective negative feedback regulation is essential to establish s

253 nd inflammatory cytokine signaling through a negative feedback regulation loop involving down-regulat

254 Phosphorylation-mediated negative feedback regulation of cAMP levels by phosphodi

255 gest potentially physiologically significant negative feedback regulation of RyR activity on Na(v)1.4

256 to limit vascular fibrotic responses through negative feedback regulation of the TGF-beta pathway.

257 Negative feedback regulation, that is the ability of a g

258 ituitary ERalpha is involved in the estrogen negative feedback regulation, whereas hypothalamic ERalp

259 spective of COPD status, possibly reflecting negative feedback regulation.

260 rved LP(Q/E)L sequence that is essential for negative feedback regulation.

261 f Ahr, or constitutive overexpression of its negative feedback regulator CYP1A1, results in reduced p

262 yrin repeat protein (NRARP), which acts as a negative feedback regulator of Notch responses.

263 terferon messenger RNAs, and thus acted as a negative feedback regulator of the interferon response.

264 his is consistent with the role of CCN1 as a negative feedback regulator of vascular endothelial grow

265 of DDB2 was required for RNF43 function as a negative feedback regulator of Wnt signaling.

266 a ubiquitin ligase known to be a target and negative feedback regulator of Wnt-beta-catenin signalin

267 Our work reveals TiPARP as a negative-feedback regulator for multiple oncogenic trans

268 d DNA virus infection and identify OASL as a negative-feedback regulator of cGAS.

269 M3 protein is stabilized by JA, suggesting a negative feedback regulatory mechanism to control MYC ac

270 transcription, suggesting the existence of a negative-feedback regulatory loop that may account for s

271 These properties comprise a double-negative feedback relationship that sustains food or wat

272 Homeostatic synaptic scaling is a negative feedback response to fluctuations in synaptic s

273 tradiol (OVX+E) female mice during estradiol negative feedback revealed that estradiol reduced capaci

274 al myocyte metabolic state and communicate a negative feedback signal-correction upstream electricall

275 s, which confirms that these neurons mediate negative feedback signalling.

276 bition in the vertebrate retina depends on a negative feedback synapse between horizontal cells (HCs)

277 The arterial baroreflex is a rapid negative-feedback system that compensates changes in blo

278 at-derived leptin, revealing two independent negative feedback systems for fat mass regulation.

279 e loss of coral species richness may trigger negative feedback that causes further ecosystem decline.

280 In addition to negative feedback that curtails their activity, protein

281 one response pathway, the MAPK Fus3 triggers negative feedback that dampens its own activity.

282 These results suggest that BCALM promotes negative feedback that downmodulates BCR-mediated Ca(+)

283 This suggests some negative feedback that limits the extent of assembly, fo

284 ng also revealed that Gln4p depletion causes negative feedback that matches translational demand for

285 lpain-dependent MPS degradation, providing a negative feedback that modulates signaling strength.

286 D was introduced to the cascade via indirect negative feedback, the response time was significantly r

287 growth(1-5), thereby providing an important negative feedback to climate change by slowing the rate

288 have operated as both a direct and indirect negative feedback to end the T-OAE.

289 ncentrations from 1999 to 2006, resulting in negative feedback to global warming.

290 due, at least in part, to ineffective use of negative feedback to guide subsequent decisions.

291 cal range for optimal growth could provide a negative feedback to increasing atmospheric CO(2) concen

292 Osteocytes provide negative feedback to PDLSCs and inhibit their activities

293 The add-on provides real-time negative feedback to regulate the laser power delivered

294 ls, health-maintaining mechanisms, including negative feedback to the drivers, can maintain resilienc

295 increasing CO(2) concentrations, generating negative feedbacks to climate change.

296 ombogenesis, it also participates in its own negative feedback via activation of protein C, which dow

297 showed that increased DLPFC activation after negative feedback was associated with decreased aggressi

298 cs, arbuscular mycorrhizal trees experienced negative feedback, whereas ectomycorrhizal trees display

299 ss distorts LHb responsivity to positive and negative feedback, which could bias individuals toward n

300 stronger stress responses also had stronger negative feedback, which supports a "mitigating" rather