ライフサイエンスコーパス: negative feedback loop

1 nd miR-1010 to reduce nAcRbeta2 mRNA levels (negative feedback loop).

2 t can control neuronal firing frequency in a negative feedback loop.

3 maB network to function as an ultrasensitive negative feedback loop.

4 scade reactions "OFF", thus establishing the negative feedback loop.

5 (IFNs) and limits their production through a negative feedback loop.

6 with the growth regulator melted in a double-negative feedback loop.

7 R-200, independent of Zeb1, to form a double-negative feedback loop.

8 rwhelming immune reaction by engagement of a negative feedback loop.

9 it bone resorption by osteoclasts, forming a negative feedback loop.

10 egrin receptors at the RPE cell surface as a negative feedback loop.

11 tive inhibition by L-methionine, much like a negative feedback loop.

12 nd regulates cell proliferation by forming a negative feedback loop.

13 ing it constitutes a key component of an IFN negative feedback loop.

14 stent viral infection via an IL-10-dependent negative feedback loop.

15 ed the generation of Th1 effector cells in a negative feedback loop.

16 ole in controlling Th2 development through a negative feedback loop.

17 bitor thrombospondin-1, thereby triggering a negative feedback loop.

18 ced TSH suppresses osteoclast formation in a negative feedback loop.

19 er targeted DNMT-1 expression resulting in a negative feedback loop.

20 N, AURKB, and LIN28, the latter via a double-negative feedback loop.

21 by NPY, but stress overrides this autocrine negative feedback loop.

22 xpression, thus disturbing the CRY1-mediated negative feedback loop.

23 gnaling 1, a key regulator that enhances the negative feedback loop.

24 g evidence, thus creating a self-reinforcing negative feedback loop.

25 expression of amino acid-related genes in a negative feedback loop.

26 tor PDLP5 in cells overlying LRP, creating a negative feedback loop.

27 r factor (NF)-kappaB activation as part of a negative feedback loop.

28 ates its translation, thereby constituting a negative feedback loop.

29 activity of FlrA is down-regulated through a negative feedback loop.

30 1 interaction has two roles in the circadian negative feedback loop.

31 ed mobilization of IRF3, thus constituting a negative feedback loop.

32 ional output owing to disruption of the MDM2-negative feedback loop.

33 critical to autoregulate GH secretion via a negative-feedback loop.

34 for the autoregulation of GH secretion via a negative-feedback loop.

35 single Cdk/cyclin complex and APC wired in a negative-feedback loop.

36 the miR-203 locus is directed by SNAIL2 in a negative-feedback loop.

37 on in mammary adipose tissue through a novel negative-feedback loop.

38 -bacterial interactions in both positive and negative feedback loops.

39 found that AKT was involved in all detected negative feedback loops.

40 inuria with hypertriglyceridemia through two negative feedback loops.

41 d by a delicate balance between positive and negative feedback loops.

42 ith oscillatory features mediated by delayed negative feedback loops.

43 ealing a network of interlocked positive and negative feedback loops.

44 and limiting activation of Ca(2+)-dependent negative feedback loops.

45 generated via transcriptional-translational negative feedback loops.

46 e their own signaling output via positive or negative feedback loops.

47 effect driven by the partial preservation of negative feedback loops.

48 teoclast signaling intermediaries or through negative feedback loops.

49 ling regulates corolla limb opening and a JA-negative feedback loop; (2) production of floral volatil

50 of macroH2A1 from SASP genes results from a negative feedback loop activated by SASP-mediated endopl

51 nstrate that microRNA-144 targets Dicer in a negative feedback loop, affecting global canonical micro

52 cavernous malformations-3), participate in a negative feedback loop among RhoA and its cytoskeletal e

53 mediated NMD inhibition, breaking the normal negative feedback loop and allowing the aberrant increas

54 uency is a hard-wired feature of the primary negative feedback loop and not a function of the stimulu

55 d miR-155 relieves chronic inflammation by a negative feedback loop and plays a protective role durin

56 lar modules, including genetic components, a negative feedback loop and the size of the crowding mole

57 sufficient to maintain both the T4-dependent negative feedback loop and thyroid economy.

58 ian rhythms are generated by transcriptional negative feedback loops and require histone modification

59 iod depends on the sum of delays inherent to negative-feedback loops and inhibitor half-lives.

60 ion by Cdc42-GTP inhibit Cdc42 activity in a negative feedback loop, and this inhibition depends on C

61 e find that changes to the parameters of the negative feedback loop are much stronger inputs for shif

62 dic dynamics, the elements with two positive/negative feedback loops are the minimalist elements to h

63 PKC activation amplifies negative feedback loops at the level of G protein-couple

64 plants, is more complex than expected, with negative feedback loops based on the repression of gene

65 In essence, these results suggest a double-negative feedback loop between a tumor suppressor (miR-1

66 Additionally, we uncover a negative feedback loop between actin remodeling and flg2

67 These results revealed a negative feedback loop between appressorium formation an

68 Here the authors show a negative feedback loop between C/EBPalpha and miR-182 an

69 These findings reveal a negative feedback loop between CCN2 and HIF-1alpha in NP

70 s a novel AR-repressed gene, suggestive of a negative feedback loop between CHK2 and AR.

71 regulation of ERK and define a novel double-negative feedback loop between EpCAM and ERK that contri

72 We describe the negative feedback loop between graft mesenchymal and Tef

73 the mature, processed microRNA, suggesting a negative feedback loop between miR-1247 and its target S

74 lated by the insulin signaling pathway via a negative feedback loop between miR-34 and DAF-16/FOXO.

75 Our results describe a double-negative feedback loop between MIR100HG and the transcri

76 The negative feedback loop between NMDARs and SK channels wa

77 This negative feedback loop between pressure and transport al

78 sults reveal a previously undescribed double-negative feedback loop between sponge lncRNA and target

79 pools of stem cells that are maintained by a negative feedback loop between the CLAVATA pathway and t

80 of miR-31 transcription, suggesting a cross-negative feedback loop between the expression of miR-31

81 us transcription factors, including a double-negative feedback loop between the microRNA-200 (miR-200

82 The double-negative feedback loop between the microRNA-200 family a

83 Model analysis further predicted a negative feedback loop between the persistent and resurg

84 We report a negative feedback loop between the signaling protein pho

85 Here we identified a double-negative feedback loop between the transcription factors

86 A double negative feedback loop between the Warts kinase of the H

87 Our data point to the existence of negative feedback loops between these two regulatory pro

88 Furthermore, a negative-feedback loop between Cxcl12 and its clearance

89 Here, we define a negative-feedback loop between the Caenorhabditis elegan

90 Negative-feedback loops between transcription factors an

91 l assays confirmed that the L1 interrupted a negative feedback loop by blocking ST18 repression of it

92 Interrupting this negative feedback loop by PMEPA1 knockdown increased pro

93 BXL3) ubiquitin ligase complex controls this negative feedback loop by promoting CRY ubiquitination a

94 loop and that MMP-9-SDC1 activity creates a negative feedback loop by regulating the expression of m

95 rectly represses the MDFIC gene, revealing a negative feedback loop by which glucocorticoids limit MD

96 By contrast, Ripply1 induces a negative-feedback loop by promoting Tbx6 protein degrada

97 Circadian negative feedback loop (CNFL) genes play important roles

98 gether, these results describe a tri-element negative feedback loop composed of p53, Apela, and hnRNP

99 mness-regulatory mechanism in which a double-negative feedback loop consisting of PRMT7 and miR-24-3p

100 tructure unbiasedly reveals four interlocked negative feedback loops contributing to circadian rhythm

101 These models suggested that a negative-feedback loop controlled by Wnt is crucial for

102 ell surface expression of c-Mpl, whereas the negative feedback loop controlling THPO serum levels req

103 ilon therefore create a spatially restricted negative feedback loop counteracting Aurora B in anaphas

104 ich enables their rapid removal; and (iii) a negative-feedback loop created by CsrA repression of Csr

105 d Dok2 proteins are involved in an intrinsic negative feedback loop downstream of NK-cell-activating

106 In the negative feedback loop driving fungal and animal circadi

107 atially and temporally coordinated through a negative-feedback loop driving pathological angiogenesis

108 The model also includes a negative feedback loop due to inhibition of calcium infl

109 replication forks, revealing an ATR-mediated negative feedback loop during replication.

110 s overcome when miR-144 represses Dicer in a negative-feedback loop during erythropoiesis.

111 h CAL-101 [idelalisib]), interrupts a double-negative feedback loop, enhancing GC-regulated transcrip

112 e speed of Sic1 destruction through a double-negative feedback loop, ensuring a robust all-or-none tr

113 ent cullin and proteasome activity provide a negative feedback loop, ensuring that adhesion assembly

114 ts GIV's GEF function and generates a unique negative feedback loop for downregulating the GIV-Gi axi

115 ) that mediates body temperature decrease, a negative feedback loop for thermoregulation.

116 n-generating/consuming enzymes with pairs of negative-feedback loops for pH homeostasis.

117 odels simulations suggest that, although the negative feedback loop formed by cAMP, cAMP-dependent pr

118 A double-negative feedback loop formed by the morning genes CIRCA

119 Two auxiliary negative feedback loops, from ERK to MEK and RAF, placed

120 lations demonstrate that the CSP-1-dependent negative feedback loop functions in glucose compensation

121 ons of airway collapsibility, chemoreceptive negative feedback loop gain, and arousal threshold.

122 This potentially constitutes a negative feedback loop governing this critical checkpoin

123 e Polycomb group protein EZH2 disrupted this negative feedback loop in both CRPC and enzalutamide-res

124 ishes the molecular basis of a Mg(2+)-driven negative feedback loop in CorA as the key physiological

125 nse signaling molecule salicylic acid form a negative feedback loop in defense and cell death control

126 rotein stabilizes DUX4 mRNA through a double-negative feedback loop in FSHD muscle cells.

127 We uncovered a negative feedback loop in M2 myeloid cells, wherein inte

128 by a conserved transcriptional/translational negative feedback loop in mammals.

129 and inflammatory cytokines form a functional negative feedback loop in NP cells that may be important

130 ed AR/miR-190a/YB-1 forms an auto-regulatory negative feedback loop in prostate cancer: miR-190a expr

131 ygenase type 2 (COX-2), which functions in a negative feedback loop in TGFbeta and ERbeta signaling p

132 Overall, our results reveal a negative feedback loop in the miRNA pathway mediated by

133 lly repressed by p53, defining an additional negative feedback loop in the p53 network.

134 irst time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced

135 derstood from mathematical modeling of a key negative feedback loop in the underlying regulatory circ

136 Thus, our results uncover a negative feedback loop in which CREBH regulates NEFA flu

137 on to all circadian systems, consisting of a negative feedback loop in which KaiC regulates its own p

138 us, Treg cell development is controlled by a negative feedback loop in which mature progeny cells ret

139 mmalian circadian rhythms are generated by a negative feedback loop in which PERIOD (PER) proteins ac

140 cillation can be generated by a time-delayed negative feedback loop in which Plk4 inactivates the int

141 Our results identified a negative feedback loop in which SET9 controls DNA methyl

142 Circadian clocks in mammals are built on a negative feedback loop in which the heterodimeric transc

143 ds to a downregulation of Sox2, suggesting a negative-feedback loop in the tooth.

144 Here we describe evidence of a negative feedback loop, in which PGE2 augments the expre

145 (RBP) regulate their expression levels by a negative feedback loop, in which RBP binds its own pre-m

146 We propose a negative feedback loop, in which sphingosine inhibits GB

147 Ca(2+)-dependent negative feedback loops, including activation of phospho

148 tion is predicted to depend on delays in the negative-feedback loop, including, most importantly, the

149 Here, we report the definition of a double-negative feedback loop involving AP4 and miR-15a/16-1 th

150 We further demonstrate that a negative feedback loop involving miR-135a can restore AR

151 In summary, our results define a double-negative feedback loop involving miR-15a/16-1 and AP4 th

152 antly induce miR-132 expression via a double-negative feedback loop involving Rest inhibition.

153 SAC silencing is thus promoted by a negative feedback loop involving the Mps1-dependent recr

154 how that partial adaptation arises through a negative feedback loop involving the small protein MgrB.

155 used a knock-in mouse in which the p53-Mdm2 negative feedback loop is genetically disrupted.

156 This negative feedback loop is mediated by two translation in

157 The SNAIL1/miR-34 double-negative feedback loop is responsible for the reversible

158 e to IFNs and its modulation by positive and negative feedback loops is incompletely understood.

159 CTH2 transcript, we demonstrate that a Cth2 negative-feedback loop is required for the efficient dec

160 et gene expression abrogates their intrinsic negative feedback loops, leading to accumulation of phos

161 induced FBXL5 protein level, demonstrating a negative feedback loop limiting excessive accumulation o

162 This negative-feedback loop may provide a safety mechanism to

163 hat IL-17 signaling is regulated by a robust negative feedback loop mediated by TBK1 and IKKepsilon.

164 paBalpha protein and impaired NF-kappaB self-negative feedback loop mediated less newly synthesis of

165 owth hormone (GH) secretion is controlled by negative-feedback loops mediated by GH-releasing hormone

166 A different negative feedback loop, mediated by phosphodiesterase-2

167 -acting positive feedback loop and a delayed negative feedback loop, mediated by upregulation of ubiq

168 This regulation establishes a negative feedback loop necessary to maintain cAMP/CaMKII

169 n still be grouped into two general classes: negative feedback loop (NFBL) and incoherent feed-forwar

170 Only two circuit motifs generate adaptation: negative feedback loops (NFLs) and incoherent feed-forwa

171 action, limiting further glucose uptake in a negative feedback loop of "glucose-dependent" insulin re

172 robe, which upon irradiation strengthens the negative feedback loop of a CRN that produces oscillatio

173 ulation results suggest that, while a single negative feedback loop of either one- or two-gene elemen

174 n sigma factor in spatially coordinating the negative feedback loop of its own genetic circuit.

175 he nuclear response of NF-kappaB through the negative feedback loop of NF-kappaB pathway.

176 induced RNA (TMEPAI), which is involved in a negative feedback loop of TGF-beta signaling.

177 mor suppressor 1/2) kinases, to constitute a negative feedback loop of the Hippo pathway in both cult

178 searches to demonstrate that autoregulatory negative-feedback loops of the redundant repressor Her d

179 This revealed that Ca(2+) entry exerted a negative feedback loop on rituximab-induced apoptosis, s

180 iron transport and utilization enzymes with negative-feedback loop pairs for iron homeostasis.

181 at a combination of interlinked positive and negative feedback loops plays an important role in setti

182 Thus, mGluRs establish a local negative feedback loop positioned to regulate IHC activi

183 n summary, pneumococci recognition induces a negative feedback loop, preventing excessive inflammatio

184 to investigate how interlinked positive and negative feedback loops process EGF signals into ERK pul

185 to ICAM-1, suggesting that a tension-induced negative feedback loop promotes ICAM-1-mediated neutroph

186 Thus, disparate triggering of a cytokine negative feedback loop promotes tuning of macrophage res

187 d resistance mediated by FOXM1-Nedd4-VDAC2/3 negative feedback loop provides an initial framework for

188 and it is widely accepted that intracellular negative-feedback loops regulate oscillatory gene expres

189 200 family and ZEB1, which exist in a double-negative feedback loop regulated by TGF-beta, serve impo

190 The regulatory core is controlled by two negative feedback loops (regulated by Mdm2 and Wip1) res

191 hat AtMYB93 is part of a novel auxin-induced negative feedback loop stimulated in a select few endode

192 sitive feedback introduces a hierarchy among negative feedback loops, such that the effect of a negat

193 we describe a GC-specific, AKT-kinase-driven negative feedback loop that attenuates BCR signaling.

194 plication stress and is thereby engaged in a negative feedback loop that attenuates oncogene-dependen

195 SUMOylation and degradation, establishing a negative feedback loop that attenuates SnRK1 signaling a

196 fear-induced miRNAs, act as components of a negative feedback loop that blocks neuronal hyperactivit

197 cadian transcription factor, WC-1, forming a negative feedback loop that can influence the core oscil

198 on of SK channels by mGluR1, which removes a negative feedback loop that constitutively regulates NMD

199 by aldosterone-induced miRs may represent a negative feedback loop that contributes to a form of ald

200 sis may constitute a previously unrecognized negative feedback loop that contributes to CD8 T cell ad

201 tin with RPEL-family rhoGAPs thus provides a negative feedback loop that couples Rac activity to acti

202 matic activity of these proteins, creating a negative feedback loop that dampens upstream BCR signali

203 it is also part of a previously unidentified negative feedback loop that degrades glucagon and regula

204 like responses to inputs, is nested within a negative feedback loop that encompasses RAS and RAF, MEK

205 s Hsp70 and Hsp90, in turn, participate in a negative feedback loop that ensures appropriate coordina

206 L4P activity (L4-22K/33K), which establish a negative feedback loop that ensures the transient activi

207 RSPO2-induced, LGR5-dependent Wnt signaling-negative feedback loop that exerts a net growth-suppress

208 These elements typically have one negative feedback loop that generates oscillations, and

209 These mutants thus appear to lack a negative feedback loop that inhibits DSB formation when

210 This allows plasma T4 to signal a negative feedback loop that inhibits production of thyro

211 porulation sigma factor sigma(F) to create a negative feedback loop that inhibits sigma(F) -directed

212 n provide the basis for the formation of the negative feedback loop that interrelates cell volume and

213 tion, thus FBP1 and PRC2 are part of a novel negative feedback loop that is deregulated in liver and

214 rq and qrf transcription thus forms a double negative feedback loop that is interlocked with the core

215 ting that microglial phagocytosis provides a negative feedback loop that is necessary for the long-te

216 pic glutamate signalling establishes a local negative feedback loop that is positioned to regulate in

217 We show that it is part of a negative feedback loop that limits proinflammatory and p

218 ne that functions as an afferent signal in a negative feedback loop that maintains homeostatic contro

219 ator of TGFbeta signalling, thus mediating a negative feedback loop that may potentially restrain TGF

220 on, epigenetic barrier crossing coupled to a negative feedback loop that mechanistically differs from

221 d CaMKI and PME-1 networks thus constitute a negative feedback loop that modulates the phosphatase ac

222 d CaN in a complex on the InsP3R, creating a negative feedback loop that prevents exaggerated Ca(2+)

223 hat the paracrine actions of Ucn3 activate a negative feedback loop that promotes somatostatin releas

224 ed phosphorylation at Ser(384) constitutes a negative feedback loop that regulates DSB repair.

225 08, and Blimp1 and Otx2 were shown to form a negative feedback loop that regulates the level of Otx2,

226 A negative feedback loop that relies on the coordination-c

227 These results suggest a negative feedback loop that responds to signaling events

228 ls are functionally coupled, forming a local negative feedback loop that restrains the excitatory eff

229 channels form a functional Ca(2+) -dependent negative feedback loop that restrains the excitatory eff

230 egf and Dll4/Notch signalling cooperate in a negative feedback loop that specifies endothelial tip an

231 suppresses AR expression, this results in a negative feedback loop that suppresses AR protein expres

232 anism that is responsible for generating the negative feedback loop that sustains the clock.

233 s alternative pre-mRNA splicing represents a negative feedback loop that terminates TLR signaling and

234 or degradation, suggesting both positive and negative feedback loops that control Nod factor levels d

235 Eukaryotic circadian oscillators consist of negative feedback loops that generate endogenous rhythmi

236 ated computational models to interrogate the negative feedback loops that regulate the dynamic activi

237 The intensity of ERK signaling, negative feedback loops that regulate the pathway, and c

238 is complex, involving multiple positive and negative feedback loops that result in the establishment

239 dsDNA viruses induces a regulatory temporary negative-feedback loop that blocks TLR9 transcription an

240 l secretory cells, establishing a reciprocal negative-feedback loop that ensures the full differentia

241 ry HD-ZIP III genes, and thereby establish a negative-feedback loop that forms a robust boundary that

242 article, we report that STAT3 also drives a negative-feedback loop that limits the formation of IL-1

243 mmation subsides, placing the receptors in a negative-feedback loop that may contribute to the resolu

244 d EIF4E2 to collided ribosomes to initiate a negative-feedback loop that prevents new ribosomes from

245 critical involvement of Dok-1 and Dok-2 in a negative-feedback loop that prevents overactivation of C

246 f the chemicals is regulated by a biomimetic negative feedback loop, the "repressilator" network.

247 rprisingly, however, instead of generating a negative feedback loop, the signals oppositely polarize,

248 The resulting bioelectronic and microfluidic negative-feedback loop then serves to regulate the conce

249 e analyzed dynamics-determining positive and negative feedback loops, thereby elucidating the attract

250 s and dopamine release of SN DA neurons in a negative feedback loop through activation of G-protein c

251 n modeled, and we provide evidence for a new negative feedback loop through PPM1A upregulation.

252 regulated by VEGF and therefore disrupts the negative-feedback loop, thus generating constant, but lo

253 n decreased miR863-3p levels, thus forming a negative feedback loop to attenuate immune responses aft

254 nd RagA(GTP) hydrolysis, thereby providing a negative feedback loop to attenuate mTORC1 lysosomal rec

255 activation of HCA2 during sepsis activates a negative feedback loop to attenuate the inflammatory res

256 CCN3/NOV inhibits AR signaling and acts in a negative feedback loop to block AR function.

257 ZEB1 acts in a negative feedback loop to block expression of miR-200, w

258 d translational repression combine to form a negative feedback loop to control Cpeb4 protein levels w

259 Our data suggest that miR-323-3p acts in a negative feedback loop to control the production of IL-2

260 data suggest that PIFs and HECs constitute a negative feedback loop to fine-tune photomorphogenesis i

261 ivated protein kinase Snf1 is coupled with a negative feedback loop to generate the characteristic pu

262 SNAI2 and miR-203 formed a double negative feedback loop to inhibit each other's expressio

263 gers assembly of the GADD34/PP1 complex in a negative feedback loop to inhibit Yap and promote apopto

264 200 expression via a self-reinforcing double negative feedback loop to promote the mesenchymal state.

265 e, which is used as a signal in an autocrine negative feedback loop to regulate cell proliferation.

266 It has been shown to provide a negative feedback loop to regulate glucose uptake into c

267 S6K in turn acted through a negative feedback loop to restrain Akt3 expression.

268 uodenum to sense nutrient influx and trigger negative feedback loops to inhibit glucose production an

269 of ancestral RNAi by, for example, employing negative feedback loops to reset the transmission of epi

270 he CUL7/Fbxw8 ubiquitin ligase constitutes a negative-feedback loop to restrain the activity of HPK1

271 elf-sustaining transcriptional-translational negative feedback loop (TTFL) in which the negative regu

272 d on intracellular transcription-translation negative feedback loops (TTFLs).

273 hese data suggest that Ub binding provides a negative feedback loop upon NOD-dependent activation of

274 We propose a model based on a double-negative feedback loop, vertically transmitted via the e

275 umor growth both in vitro and in vivo, and a negative feedback loop was discovered between DGAT1, PED

276 wo decades ago the WUSCHEL/CLAVATA (WUS/CLV) negative feedback loop was established as being essentia

277 to be decent substrates of OGT, exhibiting a negative feedback loop when phosphorylated at the P-3 si

278 pression is controlled via an autoregulatory negative feedback loop whereby Chtop binds its own mRNA

279 Finally, we show for the first time a negative feedback loop whereby miR-137 downregulates CAR

280 In addition, we discovered a negative feedback loop whereby the tumour suppressor FBX

281 to be a transcription-and-translation-based negative feedback loop, wherein progressive and controll

282 downmodulation of a phosphatase-mediated MET-negative feedback loop, which accompanies receptor inter

283 cytohesins and BRAGs, EFA6 is regulated by a negative feedback loop, which is mediated by an alloster

284 e the integrity of adherens junctions, and a negative feedback loop, which is used to limit beta-cate

285 and impaired dPER function in the circadian negative feedback loop, which manifests into changes in

286 a component of the Neurospora core circadian negative feedback loop, which was thought to generate su

287 ing the presence of interlinked positive and negative feedback loops, which are common in polarity pa

288 depends on a self-sustaining transcriptional negative feedback loop with a built-in time delay in fee

289 ntial for generating a slow, self-sustaining negative feedback loop with a period close to 24 hr, the

290 Importantly, Irf8 forms a negative feedback loop with Cebpb, a monocyte-derived DC

291 b gene of the M4 module (NaLRRK1) mediates a negative feedback loop with JA signaling.

292 positive feedforward loop with Stat1/2 and a negative feedback loop with Stat3.

293 he type 1 effector acquisition which forms a negative feedback loop with T-bet to preserve the identi

294 We then proposed a negative feedback loop with upregulation of the phosphat

295 nterplay between fast (min) and slow (min-h) negative feedback loops with maximal information transfe

296 Two negative feedback loops with Notch and Pros allow Kon to

297 would form a regulatory system consisting of negative feedback loops with time delays and that BMP9 w

298 shold, observations that define positive and negative feedback loops within the network.

299 ogy of highly druggable motifs consists of a negative feedback loop without any positive feedback loo

300 This negative feedback loop would cause a substantial drop in