ライフサイエンスコーパス: negative inotropic

1 Although a negative inotropic action is associated with application

2 Given that IL-1beta has a negative inotropic action on the heart, and that both it

3 lated by meningococci in vitro abolished the negative inotropic activity.

4 The negative inotropic agents BDM (5 mm) or blebbistatin (10

5 restored both eNOS coupled activity and the negative inotropic and [Ca(2+)](i) transient response to

6 telets, we speculate that Edg-mediated Sph1P negative inotropic and cardiotoxic effects may play impo

7 ause cardiac contractile dysfunction via the negative inotropic and cytotoxic actions of NO.

8 ardiovascular decompensation related through negative inotropic and hypotensive effects.

9 n of the classical PKC isoforms relieved the negative inotropic and lusitropic effects of ET-1 after

10 ting local production of cytokines that have negative inotropic and proapoptotic effects.

11 These data provide in vivo evidence for a negative inotropic and restrictive diastolic effect from

12 entirely clear how long-term application of negative inotropic compounds improves cardiac performanc

13 ological strategies with currently available negative inotropic drugs can control symptoms over the s

14 SNP and 8-bromo-cGMP cause a negative inotropic effect and depress the rate of recove

15 In contrast, after CHF, Ang II produced a negative inotropic effect and slowed the rate of relengt

16 Drugs with negative inotropic effect are widely used to decrease ob

17 have investigated the possibility that this negative inotropic effect is due to the interaction of c

18 A negative inotropic effect is suggested.

19 s of NO induce large increases in cGMP and a negative inotropic effect mediated by a PKG-dependent re

20 ne Ca2+ channel activity and contribute to a negative inotropic effect of ANP.

21 ly uncouples eNOS activity and abolishes the negative inotropic effect of beta(3)-AR stimulation in n

22 it myocytes using adenovirus potentiated the negative inotropic effect of ICI 118,551.

23 Thus, we conclude that the negative inotropic effect of p38 MAPK is mediated by dec

24 ular ejection fraction was increased and the negative inotropic effect of propranolol was prevented,

25 We suggest that the negative inotropic effect of taxol may, at least in part

26 Nitric oxide (NO) exerts a negative inotropic effect on the myocardium and is produ

27 EPA has a maintained negative inotropic effect on voltage clamped myocytes.

28 -adrenergic receptor (beta(3)-AR) produces a negative inotropic effect that is dependent on eNOS.

29 roduced a dose-dependent, atropine-sensitive negative inotropic effect that was greatest in sub-epica

30 ion of the beta(3)-adrenoceptor results in a negative inotropic effect through NO signaling.

31 ressed in cardiomyocytes and exerts a direct negative inotropic effect when activated by SCFA butyrat

32 volume when delivered with Emerade(R), but a negative inotropic effect with Epipen(R) (p < 0.05).

33 All the APnA tested had a direct negative inotropic effect, by reducing in a concentratio

34 atients with congestive heart failure have a negative inotropic effect, resulting in reduced cardiac

35 d 225 mg BID; chosen to reduce dronedarone's negative inotropic effect-see text below) over 12 weeks

36 e heart) predispose to the appearance of the negative inotropic effect.

37 e G(i)-coupled beta(2)AR, producing a direct negative inotropic effect.

38 7+/-0.7 mm, p < .05), consistent with a mild negative inotropic effect.

39 ay reach the coronary circulation and have a negative inotropic effect.

40 ng of the action potential and, therefore, a negative inotropic effect.

41 o IK,ACh and, therefore, it has little or no negative inotropic effect.

42 subjects, which suggests that ET-1 may cause negative inotropic effects in the failing heart.

43 is a proinflammatory cytokine that produces negative inotropic effects in the heart.

44 c calcium, indicating that conoCAP-a cardiac negative inotropic effects might be mediated via impairm

45 This phenomenon may contribute to the negative inotropic effects of acidosis.

46 lease at the myocyte "surface" mimicking the negative inotropic effects of bath-applied PKC activator

47 cGMP) has been associated with NO-associated negative inotropic effects of IL-6 during acute exposure

48 e is caused both by loss of heart muscle and negative inotropic effects of inflammation in viable mus

49 endothelial nitric oxide synthase mutes the negative inotropic effects of Piezo1 activation, intimat

50 observed direct (noncatecholamine-blocking) negative inotropic effects of the selective beta(2)-adre

51 gest that sphingosine mediates the immediate negative inotropic effects of TNF-alpha in isolated card

52 cellular calcium homeostasis, as well as the negative inotropic effects of TNF-alpha in isolated cont

53 oleoylethanolamine, completely abrogated the negative inotropic effects of TNF-alpha in isolated cont

54 e likely to be responsible for the immediate negative inotropic effects of TNF-alpha.

55 was responsible for the immediate (<30 min) negative inotropic effects of tumor necrosis factor-alph

56 s should be avoided due to proarrhythmic and negative inotropic effects that may be responsible for i

57 In human, rabbit, and mouse myocytes, the negative inotropic effects were blocked after treatment

58 at decrease atrioventricular conduction have negative inotropic effects which could worsen concomitan

59 uman heart and that its stimulation leads to negative inotropic effects.

60 Antiarrhythmic drugs exert significant negative inotropic effects.

61 )-adrenergic enhancement of NO production, a negative inotropic event, in neighboring fibroblasts.

62 re consistent with a role for annexin 6 as a negative inotropic factor in the regulation of cardiomyo

63 In summary, the negative inotropic mechanism of B-CTX was discovered.

64 Although LTCC inhibition is negative inotropic, NCX inhibition has the opposite effe

65 ht microscopic distribution of preganglionic negative inotropic neurons in the CNS which are retrogra

66 ced calcium changes and improved LPS-induced negative inotropic (P<.01) and negative lusitropic (P<.0

67 on contains a functionally selective pool of negative inotropic parasympathetic postganglionic neuron

68 se in twitch amplitude), followed by a large negative inotropic phase (>80% decrease).

69 mal basal contractility but showed a similar negative inotropic response to ICI 118,551.

70 inated the positive inotropic phase, but the negative inotropic response was largely unaltered.

71 obstructive hypertrophic cardiomyopathy with negative inotropic therapy and myosin inhibition, as wel

72 terminals formed axo-dendritic synapses upon negative inotropic vagal motoneurons, however the origin

73 othesis that SP nerve terminals synapse upon negative inotropic VPNs of NA-VL, retrogradely labeled f