ライフサイエンスコーパス: negatively modulate

1 e helical association might be positively or negatively modulated.

2 androgens suppress Bcl-2 expression through negatively modulating activities of the E2F site in the

3 ation reduces dendritic excitability and may negatively modulate activity-dependent dendritic synapti

4 ge ectodermal cells from becoming AER cells; negatively modulate AER activity and thus fine-tune the

5 These data indicate that TNF-alpha can negatively modulate airway responsiveness, controlling a

6 ker expression in vitro, while ERK signaling negatively modulates Akt activation and VSMC marker gene

7 e phosphatase and tensin homolog (PTEN) that negatively modulates AKT-mTOR pathway, enhanced auditory

8 d gamma(c) isoforms indicate that the latter negatively modulates alpha isoform activity, possibly by

9 Conversely, overexpressed RACK1 negatively modulates alpha2(I) collagen transcriptional

10 LYPD6B also negatively modulates alpha3beta4 nAChRs that include the

11 te a novel mechanism by which beta1 integrin negatively modulates alphavbeta3 integrin-ligand binding

12 utrophils revealed a unique role for C5L2 in negatively modulating anaphylatoxin receptor mediated ce

13 defective receptor tyrosine kinase (RTK) and negatively modulates angiogenesis by acting as a decoy r

14 These findings demonstrate that PDE4B negatively modulates anti-inflammatory cytokine expressi

15 hat TID1 gene products act to positively and negatively modulate apoptotic signal transduction or eff

16 val of growth-arrested cells, potentially by negatively modulating apoptotic response via signaling p

17 ) signaling, and cyclin D1 has been shown to negatively modulate AR-dependent expression of prostate-

18 e catalytic alpha subunits of SnRK1, thereby negatively modulating autophagy and plant tolerance to e

19 ive regulator of vascular initiation through negatively modulating auxin transport and sheds new ligh

20 RTN) family proteins interact with BACE1 and negatively modulate BACE1 activity through preventing ac

21 ifies a novel cellular pathway by which SNX6 negatively modulates BACE1-mediated cleavage of APP.

22 SAG-CUL5, but not RBX1-CUL1, negatively modulates beta-TrCP1 levels by shortening its

23 dothelial cell-intrinsic decoy receptor that negatively modulates blood vessel morphogenesis.

24 The ability of pneumococci to make PcpA negatively modulated both the infiltration and apoptosis

25 In contrast, age at priming negatively modulated both the magnitude and duration of

26 lts provide a novel mechanism for decorin in negatively modulating both IGF-I and its receptor.

27 Sprouty negatively modulates branching morphogenesis in the Dros

28 The receptor is negatively modulated by 5beta-reduced steroids, sulfated

29 enously administered PGD(2), however, can be negatively modulated by a mechanism dependent upon ANG I

30 coa transcription was negatively modulated by agr and occurred mainly during t

31 ulated through beta-adrenergic receptors was negatively modulated by alpha 1-adrenergic activation.

32 ique to this system, the activity of TraR is negatively modulated by an antiactivator called TraM.

33 ToxT activity is negatively modulated by bile and unsaturated fatty acids

34 enhanced current density, both of which were negatively modulated by cAMP.

35 s in which proliferation of arterial SMCs is negatively modulated by cyclic nucleotides.

36 f MSNs from both the cortex and thalamus was negatively modulated by histamine acting at presynaptic

37 inhibitory input to both classes of MSNs was negatively modulated by histamine.

38 The data show that CXCR4 is negatively modulated by long-term morphine treatments bo

39 d protein eukaryotic initiation factor 4G is negatively modulated by Mnk activity.

40 ranscription of the HLgene in HepG2 cells is negatively modulated by multiple cis-acting negative ele

41 microRNAs is positively regulated by p53 and negatively modulated by NF-kB p65.

42 that the activity of ESE-1 is positively and negatively modulated by other interacting proteins inclu

43 interleukin-9 (IL-9) as the soluble factor, negatively modulated by p66Shc, that is responsible for

44 The anti-HIV-1 activity of SAMHD1 is negatively modulated by phosphorylation at residue Thr-5

45 PLCbeta1 and PLCbeta3 activities are negatively modulated by phosphorylation.

46 we demonstrate that the activity of Gis1 is negatively modulated by proteasome-mediated limited prot

47 ly through a PTX-sensitive G protein that is negatively modulated by protein kinase C, possibly at th

48 RecA filament stability is negatively modulated by RecX and UvrD.

49 tested the hypothesis that ETS1 activity is negatively modulated by SP100 in endothelial cells.

50 ) T cells whose development and function are negatively modulated by Stat5.

51 se regions and model-free valuation areas is negatively modulated by the degree of model-based contro

52 sor gene that we have previously shown to be negatively modulated by the MYCN proto-oncogene, but the

53 The activity of TRPM3 in DRG neurons is also negatively modulated by tonic, constitutive GPCR activit

54 This association was negatively modulated by TrkB receptor signaling.

55 ummary, these studies demonstrate that TIP60 negatively modulates c-Myb transcriptional activity by r

56 reports suggest that protein kinase A (PKA) negatively modulates calcineurin-mediated NF-ATc activat

57 e the mechanism by which CB(2) receptors can negatively modulate CB(1) receptor function.

58 h in proteins which are involved in pathways negatively modulating cell death and apoptosis while pro

59 ne or more allosteric cembranoid sites which negatively modulate cembranoid affinity for the inhibito

60 identified Spt4 as a factor that appears to negatively modulate Chd1 binding to chromatin.

61 ed that histamine, acting at H(3) receptors, negatively modulates corticostriatal synaptic transmissi

62 echanism by which the cannabinoid system can negatively modulate CXCR4 receptor function and perhaps

63 RGS9-2 is a striatum-enriched protein that negatively modulates dopamine and opioid receptor signal

64 ate that nesfatin-1 reduces energy intake by negatively modulating dopaminergic neuron activity and,

65 tionally, the connection from FEF to TPJ was negatively modulated during target-similar trials, consi

66 ressed in cells, all variants were unable to negatively modulate EGF-promoted RAF1, MEK, and ERK phos

67 CLN3 negatively modulates endogenous ceramide levels in NT2 c

68 Hence, Lnk, through its SH2 domain, negatively modulates EpoR signaling by attenuating JAK2

69 S1 is able to act as an adaptor for p97 that negatively modulates ERAD.

70 SP100 negatively modulates ETS1 transcriptional activation of

71 EAPII negatively modulates ETS1 transcriptional activity and a

72 Collectively, these data indicate that SP100 negatively modulates ETS1-dependent downstream biologica

73 YdgG was found to negatively modulate expression of flagellum- and motilit

74 MicroRNAs (miRNAs) negatively modulate expression of genes that are involve

75 which limits VEGFR2 transcript stability and negatively modulates expression of MYO1C, a regulator of

76 danger: the opportunity to seek food reward negatively modulates expression of species-typical defen

77 sults support a model in which PDF signaling negatively modulates EYA levels to regulate seasonal phy

78 TNF limits the normal reparative process by negatively modulating factors that regulate bone.

79 suggesting that distinctly from SM1, SM2 may negatively modulate force development during smooth musc

80 tly present in mouse liver after weaning and negatively modulates forkhead box O hepatic expression.

81 This suggests that some TM4SF members may negatively modulate function of c-kit receptor tyrosine

82 RY 008 also failed to negatively modulate GABAergic function at alpha1beta2gam

83 BAG-1 negatively modulates GADD34-bound PP1 activity, and the

84 Neurosteroids positively and negatively modulate gamma-aminobutyric acid (GABA)(A) re

85 nserved RNA molecules of 22 nucleotides that negatively modulate gene expression primarily through ba

86 tant finding is that PGE2, which is known to negatively modulate glucose-induced insulin secretion, h

87 ntestinal microbiota can both positively and negatively modulate gluten-induced immunopathology in mi

88 we show that H(+) gating both positively and negatively modulates GPCR signaling.

89 data indicate that platelet-associated IgAs negatively modulate GPVI signaling and function in WIP K

90 ed these effects in the positively or in the negatively modulated group of neurons, respectively; thi

91 ect interaction with the RBD of Raf, thereby negatively modulating growth factor-stimulated Raf activ

92 turated fatty acids, such as oleic acid, and negatively modulates HCV replication.

93 recent reports that phosphorylation of NS5A negatively modulates HCV RNA replication.

94 t protein kinase IV (CaM KIV) is required to negatively modulate hematopoietic functions of BMPs down

95 equency of inhibitory neurons, which in turn negatively modulated high-frequency population oscillati

96 Tertiary amides 15d and 17d negatively modulated hUII-induced vasoconstriction witho

97 an explanation for the function of IFI44L in negatively modulating IFN responses.

98 Thus, PTP1 over-expression negatively modulated IL-3 signal transduction.

99 hat does not activate these factors, instead negatively modulates immune responses.

100 Hence, overexpression of IFN-gamma negatively modulates immunity, and the presence of Helio

101 Exon 2 negatively modulates in vitro cooperative transformation

102 Caspase-12 has been shown to negatively modulate inflammasome signaling during bacter

103 be a completely novel function for IFI44L in negatively modulating innate immune responses induced af

104 FN)-induced protein 44-like (IFI44L) gene in negatively modulating innate immune responses induced af

105 lation of HO-1 by a specific inducer, hemin, negatively modulates iNOS expression and activity in ant

106 CD45 functions in a manner similar to LAR by negatively modulating insulin receptor signaling in hema

107 ence recognition by SRP but, rather, that it negatively modulates interactions that occur between SRP

108 ed mechanistic studies demonstrated that NMI negatively modulates IRE1alpha-dependent activation of J

109 s a negative regulator, and to contribute to negatively modulate its activity.

110 atory region of the CNKSR3 gene chromatin to negatively modulate its expression.

111 ate a master regulator of apoptosis, p53, to negatively modulate its transcriptional and apoptotic ac

112 fy an autoregulatory mechanism by which AIRE negatively modulates its own expression.

113 or suppressor protein with high affinity and negatively modulates its transcriptional activity and st

114 e previously shown to interact with BACE1 by negatively modulating its secretase activity.

115 DVA both positively and negatively modulates locomotion, providing a unique mech

116 ation unmasks tonic NR1/NR2A activation that negatively modulates LTP.

117 We hypothesized that PKA might negatively modulate m-calpain in an unexpected manner by

118 3 mRNA occurs through TLR4/TRIF/IRF3/PKC, it negatively modulates mA3 mRNA via TLR4/MyD88/MAPK-signal

119 the DNA-binding and transactivation domains negatively modulates Mac1p activity.

120 talized selectively to fungal phagosomes and negatively modulates macrophage antifungal effector func

121 receptors and NET, indicating that MCH1r may negatively modulate mesolimbic monoamine function.

122 revealed dozens of genes that positively and negatively modulate MHC-I cell surface expression.

123 h FGF signaling regulates gene expression by negatively modulating microRNA abundance through both LI

124 MKK-independent p38 kinase activation while negatively modulating MKK-dependent p38 function.

125 aldarius, where they act synergistically and negatively modulate motility.

126 Thus, Lnk negatively modulates mpl signaling pathways and is impor

127 Hence, AMY-R signaling negatively modulates mu-OR-mediated appetitive responses

128 first evidence that acetylcholine receptors negatively modulate muscle spindle responses to stretch.

129 decline during myogenesis and that miR-125b negatively modulates myoblast differentiation in culture

130 l muscle myogenesis, which functions through negatively modulating myostatin activity via a mechanism

131 vely modulates GABA(A) receptor function and negatively modulates N-methyl-D-aspartate (NMDA) recepto

132 Transition probability first negatively modulated neural responses, followed by posit

133 t the neonicotinoid insecticide clothianidin negatively modulates NF-kappaB immune signaling in insec

134 ikewise, DAF-37 pheromone receptor signaling negatively modulated nlp-24 expression in the ASI neuron

135 mily that has the potential to positively or negatively modulate nuclear NF-kappaB activity in a cont

136 gic local regulator of OCL activity that can negatively modulate OCL formation and activity.

137 Together, these data suggest that RDL negatively modulates olfactory associative learning, pos

138 Here we show that H2 receptor activation negatively modulates outward currents through Kv3.2-cont

139 ced feedforward inhibition, but no change in negatively modulating PCs.

140 Furthermore, PLC gamma and RasGAP negatively modulate PDGF-dependent PI3K activation.

141 PKC phosphorylation negatively modulates phospholipase C (PLC)beta, enzymes

142 that inhibit neutrophil oxidative burst and negatively modulate platelet aggregation by a unique sal

143 Light chains negatively modulate polymerization so that intracellular

144 gulate drought, salt, and cold tolerance and negatively modulate PR gene expression and broad-spectru

145 scular injury response, at least in part, by negatively modulating proinflammatory mediator expressio

146 /p44 mitogen-activated protein kinase (MAPK) negatively modulates protein secretion stimulated by cho

147 We showed that CD13 negatively modulates receptor-mediated Ag uptake in dend

148 phila and mammalian sprouty gene families to negatively modulate respiratory organogenesis.

149 teracted with RhoGDI via its RING domain and negatively modulated RhoGDI SUMOylation and HCT116 cance

150 nts overexpressing ANIP1 revealed that ANIP1 negatively modulates rice basal defense against M. oryza

151 Rph1 is a labile protein, and Rad53 negatively modulates Rph1 protein level.

152 downstream of BPV-1 splicing enhancer 1 and negatively modulates selection of a suboptimal 3' splice

153 lator of G-protein signaling 4 (RGS4), which negatively modulates signal transduction at G-protein-co

154 Regulator of G protein signaling 2 (RGS2) negatively modulates signaling downstream of G protein-c

155 I occurs in dermal fibroblasts and that CD44 negatively modulates signaling via these receptors.

156 ER signaling upregulates MTA3 levels to negatively modulate Snail-mediated repression of E-cadhe

157 ment of MPM cell lines with mir-145 agonists negatively modulated some protumorigenic properties of M

158 into dendritic spines and that its knockdown negatively modulates spine shape in culture.

159 We demonstrate that PC190723 negatively modulates Staphylococcus aureus FtsZ polymeri

160 Importantly, serine 727 phosphorylation negatively modulates STAT3 tyrosine phosphorylation, whi

161 y the JAK2.prolactin receptor complex, while negatively modulating Stat3 activity before the onset of

162 iquitination activity of PUB1 is required to negatively modulate successive stages of infection and d

163 Finally, Hei10 positively and negatively modulates SUMO localization along SCs by its

164 nse toward enhanced expression of genes that negatively modulate T cell activation and are associated

165 we identify that HIV-1 Vpr (viral protein R) negatively modulates telomerase activity.

166 nce that NMI activates STAT signaling, which negatively modulates TGF-beta/SMAD signaling.

167 These results suggest that heparan sulfate negatively modulates TGF-beta1 responsiveness by decreas

168 from their association with Smad4 and hence negatively modulates TGFbeta-dependent transcriptional r

169 degradation of transcription factor PU.1 to negatively modulate TH9 homeostasis and antitumour immun

170 Fringe proteins can positively and negatively modulate the ability of Notch ligands to acti

171 cesses by its ability to both positively and negatively modulate the activities of Smad-dependent pat

172 expression of Smad8, which then functions to negatively modulate the amplitude or duration of signali

173 mer of a dopamine D2 receptor (D2R) dimer to negatively modulate the binding of dopamine at the other

174 ated receptor-like kinases, CRLK1 and CRLK2, negatively modulate the cold activation of MPK3/6.

175 K, coding for two aspartyl phosphatases that negatively modulate the flow of phosphoryl groups to Spo

176 on secreted glycoproteins can positively and negatively modulate the immune response.

177 dimer interface mutations to positively and negatively modulate the immunosuppressive activity of th

178 They also negatively modulate the PI 3-kinase catalytic activity b

179 vealed that the Nup205 nucleoporin NPP-3 can negatively modulate the timing of mitotic onset.

180 ific TFZFs that significantly positively and negatively modulate the transcription of the ICAM-1 gene

181 ed that fasting and chronic aerobic training negatively modulated the ACSL6 mRNA and other genes of l

182 In the gut, sepsis negatively modulated the alpha- and beta-diversity indic

183 Interestingly, pRb2/p130 expression negatively modulated the binding of p27Kip1 to JCV TAg.

184 In addition, HCV negatively modulated the expression of proprotein conver

185 In vitro studies revealed that FKBP5 negatively modulated the protein levels of hypoxia-induc

186 stry, we found that in maize (Zea mays), KN1 negatively modulates the accumulation of gibberellin (GA

187 Our results indicate that Hsc70 not only negatively modulates the activation of HRI in heme-defic

188 ed that the heat shock cognate protein Hsc70 negatively modulates the activation of HRI in RRL in res

189 virus production and that IFI44L expression negatively modulates the antiviral state induced by an a

190 virus production and that IFI44L expression negatively modulates the antiviral state induced by an a

191 To determine how the CTD negatively modulates the chaperone activity of HTLV-1 NC

192 iver results in increased ROS production and negatively modulates the control of cell cycle.

193 dent effects but clearly both positively and negatively modulates the effects of VEGFR-2.

194 CO or NO(*) binding at the ferrous heme negatively modulates the enzyme activity.

195 In turn, Roe negatively modulates the expression of target genes of N

196 regulator gene, csrA, encodes a factor which negatively modulates the expression of the glycogen bios

197 We show that calsarcin-1 negatively modulates the functions of calcineurin, such

198 JMJ27 negatively modulates the major flowering regulator CONST

199 n's disease, and PKCdelta, in which alphasyn negatively modulates the p300- and nuclear factor-kappaB

200 hat endogenous activation of these receptors negatively modulates the reinforcing properties of thala

201 These data suggest that 36-kDa AnxA3 negatively modulates the response to adipogenic treatmen

202 nce of cell volume, and that recombinant p38 negatively modulates the set point for volume-sensitive

203 ll cycle-dependent accumulation of cyclin D1 negatively modulates the transcriptional regulation of A

204 Dickkopf-1 (Dkk1) is a secreted protein that negatively modulates the Wnt/beta catenin pathway.

205 fector pathways, and the role of each GAP in negatively modulating the activity of each Ras isoform i

206 alternative splicing by both positively and negatively modulating the activity of other SR proteins

207 alternative splicing by both positively and negatively modulating the activity of other SR proteins

208 lating the K(M) of the peptide substrate and negatively modulating the apparent K(M) for ATP with inc

209 into tubular structures while simultaneously negatively modulating the branching effects of HGF.

210 Sprouty2 plays a key role in negatively modulating the fibroblast growth factor signa

211 (i.e., PPARgamma, PGC-1alpha), presumably by negatively modulating the glucocorticoid signaling pathw

212 nuating the stimulus for leukocyte entry and negatively modulating the injury response.

213 l and metastasis and tissue regeneration, by negatively modulating the interactions of cells and prot

214 acting partner DOT-1.1 have a global role in negatively modulating the level of polymerase II (Pol II

215 t its pleiotropic effects may be mediated by negatively modulating the transcription of downstream ge

216 nimal estrogenicity themselves could reduce (negatively modulate) the effect of a mixture of estrogen

217 cal FQ-resistant S. Typhimurium isolates may negatively modulate their invasiveness but this is strai

218 al levels of type I receptor, whereas Bdelta negatively modulates these pathways by restricting recep

219 the two variable regions of Pi SLF) together negatively modulate this interaction, with a greater eff

220 gene expression, whereas activation of PI3-K negatively modulates this response in Jurkat T cells.

221 /Tolloid, however, Chordin activity would be negatively modulated through proteolytic cleavage, there

222 BRIL promoter activity was also found to be negatively modulated through two different mechanisms.

223 trol reverse cholesterol transport, but also negatively modulate TLR-mediated inflammatory pathways.

224 hibiting caspases, the IKK/NF-kappaB pathway negatively modulates TNF-alpha-mediated JNK activation,

225 normal cellular function for ZFM1 may be to negatively modulate transcription of target genes coordi

226 of proteinuria on the tubulointerstitium by negatively modulating TRPV5.

227 Here we report that PlGF positively and negatively modulate tumor growth, angiogenesis, and vasc

228 findings demonstrate that tumor-derived PlGF negatively modulates tumor angiogenesis and tumor growth

229 Thus, PlGF positively and negatively modulates tumor growth, angiogenesis, and vas

230 ycogen synthase) and glgS was observed to be negatively modulated via csrA.

231 ty and suggest that bacteria by-products may negatively modulate virus infection.IMPORTANCE In this a

232 at sensitivity to ethanol's aversive effects negatively modulates voluntary alcohol intake and thus m

233 ponent regulating vascular wall formation by negatively modulating VSMC contractility.

234 that only lateral inhibition between MSNs is negatively modulated, whereas feedforward inhibition fro

235 Further, Rif1 negatively modulates Zscan4 expression by maintaining H3