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1 ts that membrane HJV shedding is mediated by neogenin.
2 Type 2A HH did not co-immunoprecipitate with neogenin.
3 e secreted factor netrin-3 and its receptor, neogenin.
4 the Deleted in Colorectal Cancer protein and Neogenin.
5 hat specifically lowers its interaction with neogenin.
6 ubiquitously expressed cell surface receptor neogenin.
7 ectors is dependent on its interactions with neogenin.
8 rs DCC (deleted in colorectal carcinoma) and Neogenin.
9 ds both bone morphogenic proteins (BMPs) and neogenin.
10  ligands and BMP receptors, independently of neogenin.
11 res it to bind to the transmembrane receptor neogenin.
12     The Repulsive Guidance Molecule a (Rgma)/Neogenin 1 (Neo1) signaling pathway plays a conserved ro
13                            Here, we identify Neogenin-1 (NEO1) as a unique surface marker on a fracti
14                                      DCC and neogenin-1 act as netrin and repulsive guidance molecule
15   Here we identify the cell surface receptor neogenin-1 as specifically expressed in dormant HSCs.
16 e gyrus granule cells, and that postsynaptic neogenin-1 deletions in dentate granule cells blocked EC
17 reserves HSC quiescence and self-renewal via neogenin-1 function.
18                                      Loss of neogenin-1 initially leads to increased HSC expansion bu
19 omplexes, and that as such receptors, DCC or neogenin-1 might mediate EC->DG LTP that depends on Cbln
20  compensatory but reversible upregulation of neogenin-1 on HSCs.
21 binding of presynaptic Cbln4 to postsynaptic neogenin-1 renders EC->DG synapses competent for LTP, bu
22                     Indeed, we observed that neogenin-1, but not DCC, is abundantly expressed in dent
23 naptic DCC (deleted in colorectal cancer) or neogenin-1.
24                                              Neogenin, a deleted in colorectal cancer (DCC) family me
25  study showing that knock-down of endogenous neogenin, a HJV receptor, in C2C12 cells suppresses HJV
26                               HJV also binds neogenin, a membrane protein widely expressed in many ti
27                                              Neogenin, a protein with nearly 50% amino acid identity
28                                  Lrig2 binds Neogenin, a receptor for repulsive guidance molecules (R
29               HJV co-immunoprecipitated with neogenin, a receptor involved in a variety of cellular s
30                      HJV also interacts with neogenin, a ubiquitously expressed transmembrane protein
31 Together these data support a model in which neogenin acts as a scaffold to facilitate assembly of th
32 nin interactions, providing ADAM17 access to Neogenin and allowing this protease to induce ectodomain
33 roteins, including the cell surface receptor neogenin and bone morphogenetic protein (BMP) cytokines,
34 s a GPI-anchored protein, binds the proteins neogenin and bone morphogenetic proteins (BMP2 and BMP4)
35 ng cells also expressed the netrin receptors neogenin and Deleted in Colorectal Carcinoma (DCC).
36                  The identification of human neogenin and its chromosomal location provides a basis f
37                                Specifically, neogenin and restin were found to exhibit proproliferati
38                            Antisense ODNs to neogenin and restin, but not an antisense ODN to rap1GAP
39 nositol-anchored protein that interacts with neogenin and suppresses its secretion.
40 lease is coupled to lysosomal degradation of neogenin and that cholesterol depletion by filipin block
41 e observed a cytoplasmic staining pattern of neogenin and UNC5A/B that also increased following activ
42 ce of several factors, including DKK3, BMP1, neogenin and vasorin in the Calvarial-CM.
43 a-/- mice include c-Jun N-terminal kinase 2, neogenin, and gephyrin; the latter encodes a protein tha
44 ncoding GTPase activating protein (rap1GAP), neogenin, and restin in HOSE and OVCA cells.
45                    Interestingly, dynorphin, neogenin, and synaptotagmin VII, genes that possess cAMP
46 ceptors [deleted in colorectal cancer (DCC), neogenin, and the adenosine A2b receptor] are expressed
47 eceptors DCC (deleted in colorectal cancer), Neogenin, and Unc-5.
48 vates FAK and ERK in cultured myoblasts in a neogenin- and Cdo-dependent manner, whereas recombinant
49 eleted in colorectal cancer) family [DCC and neogenin] and the UNC5 family (UNC5H1, UNC5H2 and UNC5H3
50 eoblasts showed that DKK3, BMP1, vasorin and neogenin are mainly expressed by osteoblasts, while MIA,
51                      Netrin and its receptor Neogenin are thought to be regulators of axonal guidance
52          Although Netrin receptors Unc5B and neogenin, are expressed by human lymphatic endothelial c
53 nflamed lung, suggesting that an innate RGMb-neogenin axis might modulate allergic asthma.
54                   Our finding that BMP-2 and neogenin bind simultaneously to hemojuvelin raises the p
55                                 Furthermore, neogenin binds to CDO in a cis fashion, and myoblasts la
56                                              Neogenin binds to cleaved and noncleaved hemojuvelin, as
57 otein, transferrin receptor 2, matriptase-2, neogenin, BMP receptors, and transferrin.
58    HJV has also been demonstrated to bind to neogenin, but it is not known whether this interaction h
59           Mechanistically, DKK3, vasorin and neogenin, but not BMP1, increased dormancy through activ
60                Regulation of ADAM17-mediated Neogenin cleavage by Lrig2 is required for neurite growt
61                Further studies revealed that neogenin co-immunoprecipitated with ALK3, an essential t
62 in-mediated HJV release occurs after the HJV-neogenin complex is internalized from the cell surface.
63 ated protein Cdo (also Cdon) was a potential neogenin coreceptor in myoblasts.
64                                 Knockdown of neogenin decreased BMP4-induced hepcidin mRNA levels by
65                                    Wid-type, neogenin deficient and chimeric mice.
66 to Smad, but not p38 MAPK, was diminished in neogenin-deficient chondrocytes.
67                                              Neogenin-deficient mice were impaired in digit/limb deve
68 ne-trap mutation in the Neo1 locus (encoding neogenin) develop myotomes normally but have small myofi
69                                              Neogenin does not, however, play a role in HJV trafficki
70                    The addition of a soluble neogenin ectodomain to cells markedly inhibits HJV relea
71 rs of magnitude more tightly than the entire neogenin ectodomain.
72 n of netrin-1 canonical receptors, Unc5B and neogenin, expressed by lymphatic endothelial cells, do n
73 skin enhanced inflammation and the number of neogenin-expressing CD3(+) T cell infiltrates.
74                                              Neogenin expression was evaluated during inflammatory st
75 verexpression or by inhibition of endogenous neogenin expression.
76              Consistently, DKK3, vasorin and neogenin failed to induce dormancy in cells expressing d
77 ssion of soluble versions of hemojuvelin and neogenin for biochemical characterization of their inter
78                   These results suggest that neogenin forms a ternary complex with both MT2 and HJV a
79 pattern to that of hepcidin, suggesting that neogenin functions in a cell nonautonomous manner.
80 e deleted in colorectal cancer (DCC) homolog neogenin functions in both netrin- and repulsive guidanc
81                                          How neogenin functions in mediating BMP signaling is not wel
82        The chromosomal location of the human neogenin gene (HGMW-approved symbol NEO1) was determined
83                                              Neogenin has also been shown to facilitate the cleavage
84                                              Neogenin has been identified as a receptor for the neuro
85                     However, the role of the neogenin-HJV interaction in the function of HJV is unkno
86         We show that the sole C. elegans DCC/neogenin homolog UNC-40 positively modulates a BMP-like
87 sses HJV shedding and that overexpression of neogenin in HEK293 cells markedly enhances this process,
88   In this study we characterized the role of neogenin in HJV-regulated hepcidin expression.
89 l-length neogenin with a soluble fragment of neogenin in mice.
90                 Here we provide evidence for neogenin in regulating endochondral bone development and
91 ey 293 cells is dependent on the presence of neogenin in the cells, thus linking these two proteins t
92                In this study, we showed that neogenin interacted with MT2 as well as with HJV and fac
93 Together, these results suggest that the HJV-neogenin interaction is required for the BMP-mediated in
94 studies indicated that disruption of the HJV-neogenin interaction is responsible for a marked suppres
95          Furthermore, RGMs appear to mediate neogenin interaction with BMP receptors in chondrocytes.
96 vely, our findings demonstrate that Netrin-1/neogenin interactions augment CD4(+) T cell chemokinesis
97                           RGMa reduces Lrig2-Neogenin interactions, providing ADAM17 access to Neogen
98 on the plasma membrane, suggesting a lack of neogenin involvement in their trafficking to the cell su
99                                              Neogenin is a receptor for ligands of the netrin and rep
100  We provide evidence that its close relative neogenin is also a functional netrin-1 receptor that act
101                                              Neogenin is also expressed in other embryonic tissues, s
102                            The ectodomain of neogenin is composed of four immunoglobulin-like (Ig) do
103 cidin mRNA, suggesting that interaction with neogenin is critical for the iron regulatory function of
104 ressed in prelumenal cells, and its receptor neogenin is expressed in a complementary pattern in adja
105                                              Neogenin is expressed in liver cells in a reciprocal pat
106 y to hemojuvelin raises the possibility that neogenin is part of a multiprotein complex at the hepato
107                                              Neogenin is required for the processing and release of H
108             The increase in MT2 and HJV upon neogenin knockdown was likely due to the inhibition of c
109                                        Mouse neogenin lacking the intracellular domain is also capabl
110                      Knockdown of endogenous neogenin markedly suppresses HJV release but has no evid
111 ding to the most membrane-proximal region of neogenin may play a role in regulating the levels of sol
112             It is proposed that netrin-3 and neogenin may promote myogenic differentiation by an auto
113             Further studies demonstrate that neogenin may stabilize HJV, a glycosylphosphatidylinosit
114 HJV endocytosis and HJV release suggest that neogenin-mediated HJV release occurs after the HJV-neoge
115     Cell aggregation assays demonstrate that neogenin mediates netrin-1-dependent cell clustering.
116 evidence indicates that the netrin receptor, Neogenin, mediates netrin signaling in vascular smooth m
117       Recombinant human DKK3, BMP1, vasorin, neogenin, MIA and NGAL treatment increased cellular quie
118                                    Livers of neogenin mutant mice exhibit iron overload, low levels o
119 activation, was reduced in chondrocytes from neogenin mutant mice.
120                                              Neogenin (NEO1) acts as an attractive guidance receptor
121                                              Neogenin (NEO1) is a ubiquitously expressed multifunctio
122                                              Neogenin (NEO1) is a ubiquitously expressed transmembran
123 ical role for the neuronal guidance receptor neogenin (Neo1) outside the nervous system in mediating
124 fferentiation by direct interaction with the Neogenin (NEO1) receptor and function as coreceptors for
125        Here, we provide evidence for loss of neogenin (NEO1), a coreceptor for multiple ligands, incl
126  through their common cell-surface receptor, neogenin (NEO1).
127 ted in mice with gene targeted repression of neogenin (Neo1-/-), bone marrow chimeric animals and con
128              To explore a role for the human neogenin (NGN) gene in cancer, we have isolated cDNAs fo
129 netrin-1 region, alone and in complexes with neogenin or DCC.
130  DCC (deleted in colorectal cancer), but not neogenin or Unc5h2.
131 gh expression of UNC5B but not UNC5C, UNC5D, neogenin, or deleted in colorectal cancer.
132 g and hepcidin expression are not altered by neogenin overexpression or by inhibition of endogenous n
133 for SCI and uncovers a new role for the RGMa/Neogenin pathway on neuropathic pain.
134  Radiation hybrid mapping of Nope, Punc, and Neogenin placed all three genes in close vicinity on mou
135                Here we provide evidence that neogenin plays a critical role in iron homeostasis by re
136                                The role that neogenin plays in HJV trafficking was investigated, usin
137 us studies, our results support that hepatic neogenin possesses two functions, mediation of cellular
138                  We reported previously that neogenin promoted myotube formation by C2C12 myoblasts i
139    Taken together, our results indicate that neogenin promotes chondrogenesis in vitro and in vivo, r
140                                Like DCC, the neogenin protein consists of four immunoglobulin-like (I
141 quencing of cDNA clones coding for the human neogenin protein.
142 sults suggest that netrin-1 and its receptor neogenin provide an adhesive, rather than a guidance, fu
143 were mediated via binding of Netrin-1 to the Neogenin receptor and activation of SHP-2, resulting in
144 erting its repulsive activity by binding the Neogenin receptor.
145 ting as an axon guidance cue through Dcc and neogenin receptors, it is also thought to regulate neuro
146                                      DCC and neogenin, receptors implicated in mediating the attracta
147 gether, our results lead the hypothesis that neogenin regulates iron homeostasis via inhibiting secre
148 ings reveal an unexpected mode of action for neogenin regulation of BMP signaling.
149 revealing an unexpected mechanism underlying neogenin regulation of BMP signaling.
150  results reveal a novel mechanism underlying neogenin regulation of HJV-BMP signaling.
151                                        Human neogenin shares 87% identity with its chicken homolog, a
152 nce molecules (RGMs), and prevents premature Neogenin shedding by ADAM17 (TACE).
153                             Together, netrin-neogenin signaling is an important extracellular cue in
154 4 (FN4) and FN5, which differs among DCC and neogenin splice variants, providing a basis for diverse
155                           We also found that neogenin, the canonical receptor for RGMb, was expressed
156 petes with its homologue RGMa for binding to Neogenin, thereby blocking RGMa-induced downregulation o
157 hus, netrin-1 appears to act locally through neogenin to stabilize the multipotent progenitor (cap) c
158 We localized the hemojuvelin binding site on neogenin to the membrane-proximal fifth and sixth FNIII
159                                              Neogenin, uncoordinated-5 (UNC5)A, and UNC5B were expres
160                                              Neogenin, unlike the CAMs, is closely related to a uniqu
161                                              Neogenin was also observed on CD3(+) T cell infiltrates
162                                              Neogenin was first identified in the chick embryo, and l
163                                 In contrast, neogenin was not cleaved by MT2, indicating some degree
164        In addition, functional inhibition of neogenin was performed using antibody injection.
165                                 Both HJV and neogenin were expressed in liver hepatocytes.
166 king the interaction of HJV with full-length neogenin with a soluble fragment of neogenin in mice.
167                           Down-regulation of neogenin with siRNA increased the amount of MT2 and HJV

 
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