ライフサイエンスコーパス: neopterin

1 ha-1-antitrypsin (AAT), myeloperoxidase, and neopterin.

2 apolipoprotein serum amyloid protein A, and neopterin.

3 /ml for myeloperoxidase, and 1562 nmol/l for neopterin.

4 s/mL was associated with higher CSF level of neopterin.

5 ociated with baseline levels of beta-2 m and neopterin.

6 h and inflammation, including citrulline and neopterin.

7 itive autoantibodies showed higher levels of neopterin.

8 .0001) over a 3-mo lag and moderately so for neopterin (13.97; P = 0.0074).

9 7,8-Dihydro-D-neopterin 2',3'-cyclic phosphate (H(2)N-cP) is the first

10 hydrolase that converts GTP to 7,8-dihydro-d-neopterin 2',3'-cyclic phosphate, the first intermediate

11 nd converts it to a mixture of 7,8-dihydro-D-neopterin 2'-monophosphate and 7,8-dihydro-d-neopterin 3

12 neopterin 2'-monophosphate and 7,8-dihydro-d-neopterin 3'-monophosphate.

13 , 1.2 x 10(6); biopterin, 1.0 x 10(6); d-(+)-neopterin, 3.1 x 10(5); isoxanthopterin, 2.8 x 10(5); se

14 by increases in C-reactive protein (6/8) and neopterin (4/8), which correlated with the onset of a fe

15 ndings indicate that high maternal levels of neopterin, a marker of cellular immune activation, durin

16 The aim of this study was to assess neopterin, a marker of interferon gamma (IFN-gamma) indu

17 Neopterin, a product of activated white blood cells, is

18 Neopterin, a propane triol derivative of pterin, also bi

19 Stool neopterin, a-1 antitrypsin, myeloperoxidase, and regener

20 osite of faecal biomarkers (myeloperoxidase, neopterin, alpha(1)-antitrypsin).

21 .5%), myeloperoxidase among 168 (71.5%), and neopterin among 188 (80%) of the stool samples were abov

22 Measurement of neopterin, an inflammatory metabolite, enabled stratific

23 s of PEG-IFN and two immunologic surrogates, neopterin and 2'-5' oligoadenylate synthetase (OAS).

24 COVID-19 CSF showed higher levels of neopterin and ANNA-1, markers of neuroinflammation and a

25 d, and there were greater decreases in serum neopterin and beta2-microglobulin levels.

26 ect inflammatory states, we also quantitated neopterin and C reactive protein.

27 kers, specifically cerebrospinal fluid (CSF) neopterin and CSF and serum cytokines.

28 ociated with higher values of CSF and plasma neopterin and CSF sTNFR-II (abeta=.22, P = .004).

29 Plasma neopterin and cytokines were measured by enzyme-linked i

30 rs revealed increases in median beta-2 m and neopterin and decreases in CD4% over this period and the

31 catabolite PA was positively associated with neopterin and KTR before and after treatment.

32 The immunologic surrogates, neopterin and OAS, were induced at all doses with a sust

33 ammation and macrophage activation, that is, neopterin and sCD14, which remained elevated in ART(+) p

34 Together with growing research on neopterin and specific diseases, our results demonstrate

35 ation of betaeta-2 microglobulin (beta-2 m), neopterin and suPAR soluble urokinase-type plasminogen a

36 TAT1 (specifically the phosphorylated form), neopterin and the chemokine CXCL9.

37 Neopterin and the kynurenine/tryptophan ratio (KTR) are

38 een HIV-associated immune activation (plasma neopterin) and plasma selenium concentrations.

39 uble (s) markers of monocyte (sCD14, sCD163, neopterin) and T-cell (sCD25) activation as well as B-ce

40 st), inflammation (fecal myeloperoxidase and neopterin), and repair (fecal regenerating gene 1beta).

41 a HIV-RNA, CSF white blood cell count (WBC), neopterin, and albumin ratio were included when availabl

42 TNF receptor (R)II, soluble interleukin-2R, neopterin, and beta2-microglobulin (beta2M) were documen

43 ays post transmission) had CSF HIV RNA, WBC, neopterin, and CXCL10 concentrations similar to the chro

44 t of PP on lymphocyte subpopulations, plasma neopterin, and cytokines in renal transplant recipients

45 l fluid levels of tetrahydrobiopterin (BH4), neopterin, and homovanillic acid and low levels of tyros

46 of the CYP2U1 enzyme, as well as coenzyme Q, neopterin, and IFN-a levels as putative biomarkers in mi

47 C-reactive protein, white blood cell count, neopterin, and kynurenine:tryptophan collectively accoun

48 al enteric dysfunction (Alpha-1-antitrypsin, neopterin, and myeloperoxidase) using commercial enzyme-

49 d erythrocyte sedimentation rate (ESR), IgG, neopterin, and TNF-alpha found in these patients suggest

50 CANCE: Our results suggest that beta-2 m and neopterin are useful tools for disease monitoring in bot

51 6-biopterin and pterin structural analogs of neopterin as well as glucose and creatinine.

52 ecrosis factor type II receptors (sTNFR-II), neopterin, beta2-microglobulin, or CD4 cell counts can b

53 ne concentrations, albumin ratio, IgG index, neopterin, beta2M, or in CSF biomarkers of neuronal inju

54 seases, our results demonstrate that urinary neopterin can be a powerful tool for assessing multiple

55 ut rarely are studies able to assess whether neopterin can capture multiple concurrent dimensions of

56 inting, a synthetic polymer receptor for the neopterin cancer biomarker was devised and used as a rec

57 We tested whether neopterin captures age-related variation in inflammation

58 anges in urinary cortisol (stress response), neopterin (cell-mediated immunity), and total triiodothy

59 ted with plasma HIV-RNA (r = 0.44, P < .01), neopterin concentration in CSF (r = 0.49, P < .01) and i

60 associated with higher hs-CRP (P < .001) and neopterin concentrations (P < .001), while kynurenic aci

61 associated with lower hs-CRP (P = .025) and neopterin concentrations (P = .034).

62 We measured circulating concentrations of neopterin, CRP, tryptophan and seven kynurenines in 5314

63 We compared neopterin, CXCL10, CCL2, and interleukin 6 (IL-6) levels

64 Urinary neopterin excretion is increased in patients with both p

65 o had infections during the study, increased neopterin excretion was noted for periods of up to 6 wee

66 tudy, and all were associated with increased neopterin excretion, which tended to be greater than tha

67 Renal NO and neopterin excretions were significantly heritable, as we

68 levels of soluble IL-2 receptor (sIL-2R) and neopterin, flow cytometry, and natural killer cell (NK)

69 ansformation of GTP to 7,8-dihydro-D-erythro-neopterin (H2neopterin), the precursor to the modified f

70 We found that neopterin had a U-shaped relationship with age, no assoc

71 ted and analyzed for kynurenine metabolites, neopterin, high-sensitivity C-reactive protein (hs-CRP),

72 oxymethyldihydropterin, dihydroxanthopterin, neopterin, hydroxymethylpterin, xanthopterin, 6-formylpt

73 y based determination of 6 aromatic pterins (neopterin, hydroxymethylpterin, xanthopterin, 6-formylpt

74 post-PP lymphocyte subpopulations and plasma neopterin in 37, and cytokine plasma levels in 30, poten

75 reproductive status as predictors of urinary neopterin in 70 sexually mature chimpanzees (Pan troglod

76 feron gamma, interleukin 6, soluble CD14, or neopterin in cerebrospinal fluid.

77 Neopterin in CSF was elevated in all ten patients who we

78 Moreover, it determined neopterin in synthetic serum samples.

79 jection analysis conditions (FIA) determined neopterin in the concentration range of 0.15-2.5mM with

80 We conclude that volatility of neopterin in urine may enable stratification of those at

81 The associations of neopterin, KTR and CRP with kynurenines were investigate

82 Plasma levels of inflammatory markers (neopterin, kynurenine:tryptophan ratio, and C-reactive p

83 mation and the kynurenine pathway, including neopterin, kynurenine:tryptophan ratio, C-reactive prote

84 ased on how often in a 12-month period their neopterin level was raised.

85 The monocyte count and neopterin level were significantly higher in the autisti

86 l, Alpha-1-antitrypsin, myeloperoxidase, and neopterin levels among the children in the studied regio

87 ought to examine the association of maternal neopterin levels and KTRs during pregnancy with asthma i

88 ed the associations of maternal plasma total neopterin levels and KTRs in midpregnancy with asthma at

89 Neopterin levels and kynurenine/tryptophan ratios (KTRs)

90 asma CCL2 levels at week 24 and lower plasma neopterin levels at week 96.

91 Variation in females' neopterin levels by reproductive status is consistent wi

92 With the progression to AIDS, neopterin levels increased in BkMG138.

93 clinical signs of acute infectious disease, neopterin levels significantly increased with age in bot

94 valuated allergic versus nonallergic asthma, neopterin levels tended to be associated with nonallergi

95 Furthermore, males exhibited higher neopterin levels than females across adulthood.

96 individuals in our sample, exhibited higher neopterin levels than lactating females and cycling fema

97 Leukocyte counts and plasma neopterin levels were determined in autistic children an

98 CSF neopterin levels were measured by high-performance liqui

99 atio, and CSF white blood cell counts (WBC), neopterin levels, and concentrations of chemokines CXCL1

100 strength) by CD4+ lymphocyte count and serum neopterin levels, serum beta 2-microglobulin levels, and

101 ildren of mothers in the highest quartile of neopterin levels, whereas the risk was similar in the 3

102 ith 3 age-matched SIDS cases with normal CSF neopterin levels.

103 nocytes, and total leukocytes and for plasma neopterin levels.

104 level increase was associated with declining neopterin levels; however, T3 levels and behavioral meas

105 re oral candidiasis (thrush) or fever; serum neopterin levels; serum beta 2-microglobulin levels; num

106 For CSF neopterin measures, SIDS samples were from infants with

107 The accumulated pteridines included neopterin, monapterin, and hydroxymethylpterin; their re

108 dentified in some subjects with elevated CSF neopterin, monocyte chemotactic protein/CCL2, and interf

109 gically validated the measurement of urinary neopterin (NEO), a biomarker of cellular immune activati

110 n and permeability by myeloperoxidase (MPO), neopterin (NEO), and alpha-1-antitrypsin (AAT) concentra

111 l calprotectin (CAL), myeloperoxidase (MPO), neopterin (NEO), and urinary LR ratio and lactulose perc

112 -1-antitrypsin (AAT), myeloperoxidase (MPO), neopterin (NEO)].

113 cerebrospinal fluid levels of the following: neopterin; nitrite plus nitrate, a stable indicator of n

114 ococcus aureus DHNA (SaDHNA) in complex with neopterin (NP, an analog of DHNP) and with monapterin (M

115 ) HIV DNA was associated with plasma and CSF neopterin (p = 0.023) and with MRS markers of neuronal i

116 adjustment with binary logistic regression, neopterin (P<0.001), high-sensitivity C-reactive protein

117 phocytes:muL (P=0.001); and plasma levels of neopterin (P<;0.0001), soluble interleukin-1 receptor an

118 atients had significantly elevated levels of neopterin (P=.003) and kynurenine (P=.05) and a signific

119 arkers of gut inflammation (myeloperoxidase, neopterin), permeability (alpha-1-antitrypsin, lactulose

120 dines: 6-biopterin, 6-hydroxymethylpterin, d-neopterin, pterin, isoxanthopterin, and xanthopterin, as

121 The levels of neopterin, pterine, xanthopterin, and pterin-6-carboxyli

122 y with myeloperoxidase (r = 0.37, p < 0.05), neopterin (r = 0.33, p < 0.05) and EED score (r = 0.31,

123 controls (P = .0004) and correlated with CSF neopterin (r = 0.38; P = .0005), interferon gamma-induce

124 p < 0.001), DAS skin (r= -0.25, p = 0.003), neopterin (r= -0.41, p < 0.001), ESR (r= -0.25, p = 0.00

125 how that those in the highest risk category (neopterin raised greater than 50% of the time) saw great

126 es in wildlife point to lifetime patterns in neopterin related to immune development, aging, and cert

127 KTR and neopterin respectively explained 24.1% and 16.7% of the

128 We assessed the relationship between urinary neopterin stored on filter paper and multiple metrics of

129 Urinary neopterin to creatinine ratios (UNCRs) were measured dai

130 ts is the conversion of GTP to 7,8-dihydro-d-neopterin triphosphate catalyzed by GTP cyclohydrolase I

131 y has determined baseline inflammation using neopterin volatility in monthly urine samples of 45 inde

132 One SD higher neopterin was associated with 0.48, 0.44, 0.36 and 0.28

133 At age 3 months, compared to controls, neopterin was reduced by nutrition (-0.21 log nmol/L; 95

134 CSF neopterin was screened in 64 SIDS cases and 15 controls,

135 Plasma soluble CD163 and neopterin were decreased in HCV mono- and coinfected per

136 intestinal involvement, and higher levels of neopterin were identified in their stools, potentially r

137 A total of 6 SIDS cases (9.3%) with high CSF neopterin were identified, suggestive of neuroinflammati

138 ryptophan-kynurenine pathway metabolites and neopterin were measured using liquid chromatography-tand

139 ain tissue from SIDS cases with elevated CSF neopterin were subjected to metagenomic next-generation