ライフサイエンスコーパス: nephrogenesis

1 nd FGF20, another FGF ligand, FGF8, promotes nephrogenesis.

2 tage distal convoluted tubules (DCTs) during nephrogenesis.

3 ation and cell survival at distinct steps in nephrogenesis.

4 atiotemporal expression and functions during nephrogenesis.

5 e of the secreted signaling molecule FGF8 in nephrogenesis.

6 teric tree, while delaying and disorganizing nephrogenesis.

7 e intricately linked to the control of fetal nephrogenesis.

8 with paxillin plays an important role during nephrogenesis.

9 nt, and required for BaP-induced deficits in nephrogenesis.

10 4 integrin receptors, in UB branching during nephrogenesis.

11 patterns or groups of gene expression during nephrogenesis.

12 branching and inhibited glomerulogenesis and nephrogenesis.

13 oquois 2a (irx2a) is requisite for zebrafish nephrogenesis.

14 II cadherin expressed during early stages of nephrogenesis.

15 they complete both early and late aspects of nephrogenesis.

16 ic proteins (BMPs) play an important role in nephrogenesis.

17 the collecting duct system and also induces nephrogenesis.

18 nephric duct formation and the initiation of nephrogenesis.

19 dney, and its expression is synchronous with nephrogenesis.

20 they are expressed and during all stages of nephrogenesis.

21 ssion, and that Sp1 may have a wider role in nephrogenesis.

22 of DNA synthesis during the latter stages of nephrogenesis.

23 very after acute renal injury, as well as in nephrogenesis.

24 ith PBN arcades, but not with lateral branch nephrogenesis.

25 idney offers a simplified model for studying nephrogenesis.

26 results in hypoplastic kidneys with extended nephrogenesis.

27 High CHIR activated nephrogenesis.

28 s (PBN) periods: arcading and lateral branch nephrogenesis.

29 lay a critical (non-redundant) role in early nephrogenesis.

30 solution informs the regulatory hierarchy of nephrogenesis.

31 aling plays important roles during mammalian nephrogenesis.

32 f these Fox factors, Foxp1, is important for nephrogenesis.

33 ming, regeneration after injury, and ex vivo nephrogenesis.

34 ecular studies of late gestation, human-like nephrogenesis.

35 hways, with distinct morphogenesis, to human nephrogenesis.

36 and favors NPC maintenance without hindering nephrogenesis.

37 renal transcriptional network that controls nephrogenesis.

38 ms to the morphogenesis of NPCs in mammalian nephrogenesis.

39 ovide insights into the genetic circuitry of nephrogenesis.

40 nsight into Wnt targets initiating mammalian nephrogenesis.

41 solution will inform the basic mechanisms of nephrogenesis.

42 or status and by a differentiation signal in nephrogenesis.

43 er progenitor self-renewal from the onset of nephrogenesis.

44 Here, we present a novel role of Notch in nephrogenesis.

45 tem cell to activated progenitor cell during nephrogenesis.

46 inued SIX1 and SIX2 expression during active nephrogenesis.

47 ity prefigures, and is essential for, active nephrogenesis.

48 classic tubule induction model for studying nephrogenesis.

49 genitor interactions that drive cessation of nephrogenesis.

50 enance of the multipotent progenitors during nephrogenesis.

51 ential role for the progenitor cell niche in nephrogenesis.

52 ulates sim1a, directly or indirectly, during nephrogenesis.

53 undifferentiated progenitor cells for future nephrogenesis.

54 ling-directed commitment regulates mammalian nephrogenesis.

55 ition and placental dysfunction impair fetal nephrogenesis.

56 Gdnf in the metanephric mesenchyme to drive nephrogenesis.

57 y of beta-catenin into this complex promotes nephrogenesis.

58 nes involved in neurogenesis, myogenesis and nephrogenesis.

59 critical regulator of beta-catenin-mediated nephrogenesis.

60 nical Calcium/NFAT Wnt signalling pathway in nephrogenesis.

61 ne WID and further suggest a role for WID in nephrogenesis.

62 eteric duct that occur prior to the onset of nephrogenesis.

63 replenishment of progenitor cells throughout nephrogenesis.

64 to characterize branching morphogenesis and nephrogenesis.

65 ctors as well as the CX3CL1 chemokine during nephrogenesis.

66 on of the domains that control branching and nephrogenesis.

67 Transient PI3K inhibition during early nephrogenesis activates Notch signaling, shifting nephro

68 to epithelial transformation that underpins nephrogenesis adding another level of complexity in the

69 ta suggests a conserved role for Six2 during nephrogenesis and a role in the morphogenesis of the pro

70 WT1 and BASP1 are co-expressed during nephrogenesis and both proteins ultimately become restri

71 ne was sufficient to shorten the duration of nephrogenesis and cause premature differentiation of nep

72 This interaction triggers the process of nephrogenesis and culminates in the formation of the mat

73 During nephrogenesis and early kidney growth, single proximal t

74 nsient overexpression of LIN28B, can prolong nephrogenesis and enhance kidney function potentially vi

75 aling is important during the late stages of nephrogenesis and for the lineage specification of parie

76 redentialed clear cell RCC driver) disrupted nephrogenesis and glomerular development, causing neonat

77 on important genetic factors that influence nephrogenesis and highlight important human disorders th

78 etion or Slit2 ligand trap at birth affected nephrogenesis and inhibited vascularization of developin

79 Given the importance of BMP signaling in nephrogenesis and its putative role in the response to i

80 ecular examinations of the mechanisms behind nephrogenesis and kidney organogenesis in an ex vivo org

81 on during pregnancy on NPCs, contributing to nephrogenesis and later, to kidney health in adulthood.

82 a role for this kinase in the regulation of nephrogenesis and of collecting system development in th

83 ent and uncover new avenues for manipulating nephrogenesis and preventing adult kidney disease.

84 entiation, resulting in early termination of nephrogenesis and severe renal dysgenesis.

85 ur cancer genes with a non-redundant role in nephrogenesis and targeting the fetal renal transcriptom

86 cell division in the proximal tubules during nephrogenesis and that perturbations in Notch signaling

87 progenitor programs such as the duration of nephrogenesis and the final nephron count.

88 orphologically characterize the processes of nephrogenesis and ureteric branching during kidney devel

89 oundation for further analysis of MET during nephrogenesis, and have implications for understanding t

90 formed after the cessation of developmental nephrogenesis, and lifelong renal function therefore dep

91 rogenitor cells and the decision to initiate nephrogenesis are crucial events directing kidney develo

92 thways along which hypoxia exerts effects on nephrogenesis are not well understood.

93 e normally, but subsequent bud branching and nephrogenesis are retarded, resulting in severe renal hy

94 Active nephrogenesis as defined by the presence of SIX1 + naive

95 s plasticity may enable robust regulation of nephrogenesis as niches remodel and grow during organoge

96 controls nephron progenitor survival during nephrogenesis, as one potential means of regulating neph

97 progression of gene expression states during nephrogenesis, as well as discovery of potential growth

98 de key insights into normal and dysregulated nephrogenesis, as well as into regenerative processes th

99 nic program made available through the Human Nephrogenesis Atlas will facilitate an understanding of

100 of the cycle of branching morphogenesis and nephrogenesis began with the loss of mesenchyme that res

101 During nephrogenesis, Bmp7 is required for renewal of the mesen

102 thus describing a role for HNF1B not only in nephrogenesis but also in the maintenance of tubular fun

103 gested that the notochord is dispensable for nephrogenesis but required for the correct positioning o

104 (DTA)-mediated cell ablation did not disrupt nephrogenesis, but resulted in kidney fusions, resemblin

105 Wnt4 and beta-catenin are both required for nephrogenesis, but studies using TCF-reporter mice sugge

106 A model for the regulation of nephrogenesis by FGF and BMP signaling is presented.

107 -1 regulates cell proliferation during early nephrogenesis by inhibiting expression of p27.

108 ly plays a critical role in ciliogenesis and nephrogenesis by regulating Cdc42 activity.

109 ance of nephron progenitors during mammalian nephrogenesis by stabilizing TCF-Groucho transcriptional

110 Many stages of nephrogenesis can be studied using cultured embryonic ki

111 osure to nephrotoxins during early postnatal nephrogenesis causes AKI but may have less impact on lon

112 ing RTK signalling may overcome the abnormal nephrogenesis characteristic of Fraser syndrome, we intr

113 nilin deficiency in the kidney led to severe nephrogenesis defects and virtually no comma- or S-shape

114 Tracing of Troy(+) cells during nephrogenesis demonstrates that Troy(+) cells clonally g

115 Early inductive events in mammalian nephrogenesis depend on an interaction between the urete

116 Mammalian nephrogenesis depends on the interaction between the ure

117 nt nephrons do not express Wnt4 or Lim1, and nephrogenesis does not progress to the S-shaped body sta

118 During nephrogenesis, dynamic changes in the expression of cell

119 During the period when nephrogenesis ends in mice, we examined the morphology,

120 Human nephrogenesis ends prior to birth in term infants (34-36

121 and contribute to the premature cessation of nephrogenesis following preterm birth.

122 Lineage analysis shows that during nephrogenesis, FoxD1-positive((+)) mesenchymal cells giv

123 and immunohistological assessments of rabbit nephrogenesis from birth (post-conceptual day 31 or 32)

124 Mutations of nephrogenesis genes have been defined in multiorgan dysm

125 with diverse cellular functions critical for nephrogenesis, genitourinary development, haematopoiesis

126 ic epithelium arising at different stages of nephrogenesis has distinct spatial distribution in the a

127 ory mechanisms of HNF4 family genes in human nephrogenesis have not yet been investigated.

128 In the kidney, the ECM is critical for nephrogenesis; however, the dynamics of ECM composition

129 Profiling of miRNA expression during nephrogenesis identified several highly expressed miRNAs

130 this work reveals new roles for irx2a during nephrogenesis, identifying irx2a as a crucial connection

131 1 alpha ), which (acting in concert) promote nephrogenesis in a hypoxic low-tubular-workload environm

132 PURPOSE OF REVIEW: Although nephrogenesis in a term infant is complete, there are a

133 s downregulation of important regulators for nephrogenesis in Brg1-deficient cells, including Lin28,

134 ival of metanephric mesenchyme and to induce nephrogenesis in culture.

135 Inhibition of glycolysis enhanced nephrogenesis in cultured embryonic kidneys, without inc

136 rogenitor pool is essential to understanding nephrogenesis in developmental and regenerative contexts

137 /HIF-2beta is required at high levels during nephrogenesis in distal tubules and later exclusively in

138 Tracing nephrogenesis in embryonic conditional beta-catenin knoc

139 s determined by the coordinated cessation of nephrogenesis in independent niches.

140 ave also facilitated efforts to recapitulate nephrogenesis in kidney organoids in vitro, by providing

141 Truncated extrauterine nephrogenesis in premature infants results in fewer neph

142 organ culture, a model known to recapitulate nephrogenesis in the absence of vessels.

143 organ culture, a model known to recapitulate nephrogenesis in the absence of vessels.

144 genital system and show many similarities to nephrogenesis in the definitive kidney.

145 Nephrogenesis in the mouse kidney begins at embryonic da

146 The cessation of nephrogenesis in utero or shortly after birth is synchro

147 ligand activation of Ahr signaling disrupts nephrogenesis in vitro, and that this response involves

148 to evaluate the role of the Ahr signaling in nephrogenesis in vitro.

149 ign of regenerative scaffolds that can guide nephrogenesis in vitro.

150 defects, as well as efforts to recapitulate nephrogenesis in vivo to facilitate drug discovery and r

151 rate a continuous requirement for WT1 during nephrogenesis, in particular, in the formation of mature

152 ved previously unrecognized abnormalities in nephrogenesis, including a gradual increase in volume an

153 Pathways include genes controlling nephrogenesis, including glomerulotubular development, t

154 during early to mid-gestation impairs renal nephrogenesis, increases MAP, and alters expression of A

155 propagate kidney epithelium from d7+18 (post nephrogenesis) iPSC-derived organoids.

156 eterm neonates born before the completion of nephrogenesis is a noninvasive source of highly potent s

157 Nephrogenesis is completed before term birth, but preter

158 with a high risk of CKD in adulthood because nephrogenesis is completed in utero.

159 In humans, nephrogenesis is completed prenatally, with nephrons for

160 In vivo, nephrogenesis is coordinated with renal vascularization.

161 les in this simple in vitro system for early nephrogenesis is highly sensitive to the matrix environm

162 erentiation of stem cells, but their role in nephrogenesis is incompletely understood.

163 tiation in mice, but their function in human nephrogenesis is not fully defined.

164 ation capacity, indicating that cessation of nephrogenesis is related to factors other than an intrin

165 n that a critical role for WT1 during normal nephrogenesis is to suppress transcription of the Polyco

166 and Lim1 expression, which is essential for nephrogenesis, is absent in MM.

167 yme to epithelium during the early stages of nephrogenesis, it was found that the Smad4-interacting t

168 rved as a model to understand lateral branch nephrogenesis (LBN) at the molecular level.

169 a technological platform for studying human nephrogenesis, modeling and diagnosing renal diseases, a

170 ureteric bud/collecting duct lineage during nephrogenesis, modulates collecting duct growth/differen

171 During nephrogenesis, multipotent mesenchymal nephron progenito

172 d but did not entirely block the increase in nephrogenesis observed after glycolysis inhibition.

173 pericytes and fibroblasts had no bearing on nephrogenesis or kidney homeostasis but exacerbated infl

174 injury (AKI) immediately after birth (during nephrogenesis) or later in postnatal development, and if

175 cell fates such that at the onset of active nephrogenesis, Osr1 activity is restricted to the Six2(+

176 ming in late gestation in two post-branching nephrogenesis (PBN) periods: arcading and lateral branch

177 identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute t

178 hat recapitulated defective neurogenesis and nephrogenesis, polycystic kidney disease (PKD) and other

179 gral to other developmental processes during nephrogenesis, possibly involving the MM.

180 ment and is required for complete MET during nephrogenesis, potentially acting downstream of Wnt4.

181 pathways through which ENL mutations disrupt nephrogenesis, providing a foundation for further invest

182 fective ureteric branching morphogenesis and nephrogenesis, ranks as one of the major causes of renal

183 aintain their terminal differentiation after nephrogenesis remain largely unknown.

184 lopment when mature nephrons are present yet nephrogenesis remains extremely active.

185 They are also required for the normal nephrogenesis response of the metanephric mesenchyme to

186 erm gestation undergo premature cessation of nephrogenesis, resulting in a lower glomerular density.

187 During nephrogenesis, sidekick expression was observed first in

188 Nephrogenesis starts with the reciprocal induction of tw

189 perimental studies support its importance in nephrogenesis, successful tissue repair, and in opposing

190 Morphological perturbations of nephrogenesis, such as those seen in inherited renal dis

191 Nephrogenesis, systolic blood pressure, renal hyperfiltr

192 The rabbit exhibits longer postnatal nephrogenesis than the mouse but whether it forms nephro

193 ibuting to knowledge regarding events during nephrogenesis, the demonstrated rescue of renal agenesis

194 nt WNT signaling in renal progenitors during nephrogenesis, this mutation caused significant loss of

195 or cells give rise to mesangial cells during nephrogenesis, this study tested the hypothesis that the

196 IF and TGF beta 2/FGF2 cooperate to regulate nephrogenesis through a common Wnt-dependent mechanism.

197 xcess GDNF maintains nephron progenitors and nephrogenesis through increased expression of its secret

198 maa as a novel link between ciliogenesis and nephrogenesis through regulation of prostaglandin signal

199 nephrons, cartilaginous fish kidneys display nephrogenesis throughout life.

200 -derived renal organoids, which recapitulate nephrogenesis, to investigate mechanisms controlling ren

201 During postnatal nephrogenesis, Troy(+) cells are present in the cortex a

202 premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferenti

203 leotide exchange factor, in ciliogenesis and nephrogenesis using Tuba knockdown Madin-Darby canine ki

204 s characterized, and its relevance in murine nephrogenesis was investigated.

205 he negative effect of caloric restriction on nephrogenesis was prevented by adding methionine to the

206 pression profiling to gain new insights into nephrogenesis, we discovered that the gene single minded

207 In order to identify factors involved in nephrogenesis, we performed a high-resolution, spatial p

208 To establish a framework for human nephrogenesis, we spatially resolved a stereotypical pro

209 Molecular and cellular features of early nephrogenesis were driven in the absence of CHIR by a mu

210 chondrichthyan species exhibit postembryonic nephrogenesis, where new nephrons are continuously added

211 biting METTL3 blocks NPC differentiation and nephrogenesis, whereas enhancing transmethylation or inc

212 n progenitor cells does not affect mammalian nephrogenesis, whereas its inactivation in collecting du

213 ron progenitors of mice led to disruption of nephrogenesis, with an accumulation of spindle-shaped ce

214 egulation of genes crucial for initiation of nephrogenesis, Wt1 and its target Wnt4.