ライフサイエンスコーパス: netrin receptor

1 rovided by secreted Netrin-B and Frazzled, a netrin receptor.

2 ctions, suggesting that Dscam could act as a Netrin receptor.

3 surface of retinal fibers, possibly another Netrin receptor.

4 opulations, according to their expression of Netrin receptors.

5 nd as heterophilic repulsive ligands of Unc5/Netrin receptors.

6 hat this stimulation is independent of known netrin receptors.

7 ans counterpart, define a family of putative netrin receptors.

8 hypothesis that UNC-5 and its relatives are netrin receptors.

9 We find that the UNC-40/netrin receptor and a novel transmembrane protein DPY-19

10 , in transcriptional regulation of the unc-5 netrin receptor and zmp-1 zinc matrix metalloprotease, a

11 Netrin-G1 does not bind any of the known netrin receptors and its function is not known.

12 RNAi analyses indicate that Smed-netR (netrin receptor) and Smed-netrin2 are required for prope

13 binding allows for the association of other netrin receptors at the generic binding site, eliciting

14 onal link between the expression of distinct Netrin receptor combinations and the transcriptional con

15 that expression and requirement of different Netrin receptor combinations correlate with distinct dor

16 homologs are proposed to form a heteromeric netrin-receptor complex to mediate a chemorepellent resp

17 .75 [95% CI, -305.23 to -112.26]), and unc-5 netrin receptor D (UNC5D; birth weight: coefficient, -20

18 Here we report that the netrin receptor DCC (deleted in colorectal cancer) inter

19 es have shown that the direct interaction of netrin receptor DCC and DSCAM with polymerized TUBB3, a

20 The Netrin receptor Dcc and its Drosophila homolog Frazzled

21 The Netrin receptor DCC is expressed in olfactory sensory ne

22 observation, tyrosine phosphorylation of the Netrin receptor DCC or its Drosophila ortholog, Frazzled

23 -enriched E3 ubiquitin ligase that binds the netrin receptor DCC, and is also required for netrin-med

24 at localizes to filopodia tips and binds the netrin receptor DCC, interacts with and ubiquitinates th

25 , which attracts the axons by activating the netrin receptor DCC.

26 he cytoplasmic domain of Robo to that of the netrin receptor DCC.

27 DD-4, which also activates the transmembrane netrin receptor DCC.

28 and express apparently normal levels of the Netrin receptors DCC (deleted in colorectal carcinoma) a

29 Oligodendrocyte precursors express the netrin receptors DCC and UNC5 and function-blocking anti

30 otype was observed in B6 embryos lacking the netrin receptors DCC or Neogenin1, or the ligand netrin1

31 exiting RGC axons, and RGC axons express the netrin receptor, DCC (deleted in colorectal cancer).

32 The crest-derived cells express the netrin receptor deleted in colorectal cancer (DCC) and m

33 action complex that included DOCK180 and the netrin receptor deleted in colorectal carcinoma (DCC).

34 ns-1 and -3 mice and netrin-2 in chicks) and netrin receptors [deleted in colorectal cancer (DCC), ne

35 y this year provide evidence that in humans, Netrin receptor, Deleted in Colorectal Cancer (DCC), is

36 nteraction fractions of fluorescently tagged netrin receptors expressed in HEK293T cells.

37 we characterize two netrin homologs and one netrin receptor family member from Schmidtea mediterrane

38 tractant and Unc5 contributes as a repellant Netrin receptor for glia migration.

39 etic knockout of the two Dscam genes and the Netrin receptor fra produces a midline crossing defect t

40 The attractive Netrin receptor Frazzled (Fra), and the signaling molecu

41 t the timely and threshold expression of the Netrin receptor Frazzled triggers the initiation of glia

42 cts both physically and genetically with the Netrin receptor Frazzled, and that disrupting this inter

43 The Netrin receptor Frazzled/Dcc (Fra in Drosophila) functio

44 mutation, T835M (rs137875858), in the UNC5C netrin receptor gene that segregated with disease in an

45 Now, members of a family of netrin receptors have been identified in all three anima

46 suggest that Frazzled does not function as a Netrin receptor in attracting retinal fibers to the targ

47 Frazzled (Fra) is the DCC-like Netrin receptor in Drosophila that mediates attraction;

48 Thus, UNC5B functions as a repulsive netrin receptor in endothelial cells controlling morphog

49 The migrating cells also expressed the netrin receptors neogenin and Deleted in Colorectal Carc

50 Our evidence indicates that the netrin receptor, Neogenin, mediates netrin signaling in

51 e proteins, including protocadherins, ROBOs, netrin receptors, neuroligins, GPCRs, and channels.

52 cytoplasmic domain) functions as a repulsive Netrin receptor; neurons expressing Fra-Robo avoid the N

53 The murine netrin-3 protein binds to netrin receptors of the DCC (deleted in colorectal cance

54 Netrin receptors of the Deleted in Colorectal Cancer (DC

55 to netrins is dictated by the composition of netrin receptors on the cell surface and the internal st

56 Whether UNC-5 is a netrin receptor or simply an accessory to such a recepto

57 to glial biology: we show unc-5 (a repulsive netrin receptor) orients glial migrations and the draper

58 nervous system and may act primarily through netrin receptors other than DCC.

59 echanisms that lie immediately downstream of netrin receptors remain poorly understood.

60 obo4 specifically binds to UNC5B, a vascular Netrin receptor, revealing unexpected interactions betwe

61 in receptor heterodimer INA-1/PAT-3 promotes netrin receptor UNC-40 (DCC) localization to the invasiv

62 We find that the netrin receptor UNC-40 (DCC) specifically enriches at th

63 ole in AC invasion, in part by targeting the netrin receptor UNC-40 (DCC) to the AC's plasma membrane

64 In the postsynaptic neuron RIA, the netrin receptor UNC-40 (DCC, deleted in colorectal cance

65 roteasome system promotes degradation of the netrin receptor UNC-40 in a particular neuron only in on

66 In C. elegans the netrin receptor UNC-40/DCC controls the growth of dendri

67 Here we identify a mechanism by which the Netrin receptor UNC-40/DCC instructs synaptic vesicle cl

68 he C. elegans NSM neuron is dependent on the Netrin receptor UNC-40/DCC.

69 nexpected Netrin-independent function of the Netrin receptor UNC-40/DCC.

70 that MAX-2 functions downstream of the UNC-6/netrin receptor UNC-5 during axon repulsion and is an in

71 ated thrombospondin type 1 repeats (TSRs) of netrin receptor UNC-5.

72 This activity depends on the netrin receptors UNC-5 and UNC-40.

73 somal and axon guidance genes, including the netrin receptor, Unc-5, as key modulators of UBQLN2 toxi

74 The netrin guidance cue, UNC-6, and the netrin receptors, UNC-5 and UNC-40, guide SDQR cell and

75 The two extracellular TSRs of the netrin receptor UNC5A contain WxxWxxWxxC motifs that can

76 We show here that the repulsive netrin receptor UNC5B is expressed by endothelial tip ce

77 , which selectively binds and phosphorylates netrin receptor UNC5B on T428 residue, promoting its apo

78 rally similar to the ZU5 domain found in the netrin receptor UNC5b supramodule, suggesting that it co

79 Although Netrin receptors Unc5B and neogenin, are expressed by hu

80 nd Netrin-1 integration demonstrate that the Netrin receptor Unc5c and the ephrin receptor EphB2 can

81 strate that mice with a null mutation in the netrin receptor Unc5c on the inbred C57BL/6J (B6) geneti

82 T835M mutation in netrin receptor UNC5C predisposes to the late-onset Alzh

83 Expression of netrin receptors, Unc5H2 (Unc-5 homolog B, C. elegans) a