ライフサイエンスコーパス: neural crest

1 ring the development of melanocytes from the neural crest.

2 ovements in the developing optic cup require neural crest.

3 nsory neurons, which arise from placodes and neural crest.

4 igenomic landscape to define the presumptive neural crest.

5 Here we report that the neural crest, a migratory stem cell population in verteb

6 hemical suppressor screen for restoration of neural crest after leflunomide treatment.

7 The neural crest, an embryonic stem-cell population, is a ve

8 shift occurs as pigment cells arise from the neural crest and depends on mitfa, an ortholog of MITF,

9 ntribute not only to neural tube but also to neural crest and epidermis.

10 ss is detrimental for the development of the neural crest and for hematopoiesis.

11 Tgif1, Ets1, and Sox8, critical for cardiac neural crest and heart development.

12 neural system tumor that originates from the neural crest and is the most common and deadly tumor of

13 urrent understanding of the evolution of the neural crest and its contribution to the vertebrate body

14 an important role in the homeostasis of the neural crest and its derivatives, which give rise to pig

15 pecific transcripts and the clearly distinct neural crest and mesenchymal origin of human SCs and fib

16 Cranial neural crest and metastatic melanoma cells avoid DAN pro

17 of vertebrate embryos contains precursors of neural crest and placode cells, both defining vertebrate

18 separable function in early mesoderm versus neural crest and placode development.

19 taposition to central neural fates specifies neural crest and placodes, modulated by fibroblast growt

20 prolonged PRDM1 expression inhibits neural, neural crest and sensory progenitor genes, suggesting th

21 luripotency markers and the onset of neural, neural crest and sensory progenitor specifier genes.

22 ectoderm is rapidly subdivided into neural, neural crest and sensory progenitors.

23 emerge from the interaction of the hindbrain neural crest and the neighboring epibranchial placodal t

24 nct ectodermal cell populations, such as the neural crest and the neural plate.

25 s not ameliorate Znf703 effects on mesoderm, neural crest, and placodes.

26 the jaw and hyoid arch skeleton derive from neural crest, and the pectoral fin skeleton from mesoder

27 cells of vertebrates, derived from embryonic neural crest, are a useful system for elucidating mechan

28 The cardiac neural crest arises in the hindbrain, then migrates to t

29 dressing this question, we used the cephalic neural crest as a model system and looked at the roles o

30 Our results indicate that the ancestral neural crest at the base of the vertebrate lineage posse

31 ound the developing eye is also dependent on neural crest, but only specifically around the retinal p

32 We propose that the emergence of the cranial neural crest, by progressive assembly of an axial-specif

33 a surprisingly restricted defect in cranial neural crest cell (cNCC) development.

34 sponsiveness was diminished in local cranial neural crest cell (CNCC) populations in both mutants, wi

35 hymal transition, acquisition of avian trunk neural crest cell (NCC) polarity is prerequisite for dir

36 urotransmission and early vascularization of neural crest cell (NCC)-derived perivascular cells in th

37 severe cranial facial defects, arising from neural crest cell differentiation and migration problems

38 sis has been an essential tool for exploring neural crest cell fate and migration routes.

39 gs expand the repertoire of vertebrate trunk neural crest cell fates during normal development, highl

40 2B, a transcription factor that orchestrates neural crest cell migration and differentiation; this mu

41 ingle-cell transcriptome analysis of cranial neural crest cell migration at three progressive stages

42 ng is of crucial importance during embryonic neural crest cell migration, proliferation and different

43 e onset of brain development, beginning with neural crest cell migration.

44 to better identify the role of the different neural crest cell populations in distal gut innervation,

45 Loss of Ift88 also resulted in a decrease in neural crest cell proliferation during early stages of p

46 Differential AQP-1 levels affect neural crest cell speed and direction, as well as the le

47 l developmental processes and play a crucial neural crest cell-autonomous role in frontonasal morphog

48 of mucosal immunity, in mice with homozygous neural crest cell-conditional deletion of EdnrB (EdnrB(N

49 A and protein levels are both upregulated in neural crest cell-derived mesenchyme surrounding Meckel'

50 variants affecting genes involved in enteric neural-crest cell fate that exacerbate the widespread ge

51 iants in 24 genes that play roles in enteric neural-crest cell fate, 7 of which were novel, were also

52 chromosome 22 (22q) result in meningiomas in neural-crest cell-derived meninges, while variants affec

53 Genetic repression of placodal, but not neural crest, cell fate results in pineal hypoplasia in

54 Cardiac neural crest cells (cNCCs) are a migratory cell populati

55 hat Mitf activity is required within cranial neural crest cells (cNCCs) during CF closure.

56 r event is innervation of the gut by enteric neural crest cells (ENCCs) to establish the enteric nerv

57 rung disease is caused by failure of enteric neural crest cells (ENCCs) to fully colonize the bowel,

58 enomic regions that are active in both human neural crest cells (hNCC) and mouse embryonic craniofaci

59 ers essential for TFAP2A expression in human neural crest cells (hNCCs).

60 ator complex subunit protein, Med23 in mouse neural crest cells (Med23(fx/fx);Wnt1-Cre), results in m

61 elopment is governed by interactions between neural crest cells (NCC) and the extracellular matrix (E

62 with Wnt1-Cre, we show that primary cilia of neural crest cells (NCC), precursors of most AS structur

63 S development by combining human-PSC-derived neural crest cells (NCCs) and developing human intestina

64 d the Clpex phenotype is due to apoptosis of neural crest cells (NCCs) and the cranial neuroepitheliu

65 Neural crest cells (NCCs) are migratory, multipotent emb

66 study, we establish that deletion of Chd7 in neural crest cells (NCCs) causes severe conotruncal defe

67 ve imaging in zebrafish, we demonstrate that neural crest cells (NCCs) respond rapidly to dying cells

68 We mutated KMT2D in neural crest cells (NCCs) to study cellular and molecula

69 Using Xenopus, we identified defects in neural crest cells (NCCs) upon emc1 depletion.

70 t splicing factor Rbfox2 is expressed in the neural crest cells (NCCs), and deletion of Rbfox2 in NCC

71 In birds, sacral neural crest cells (sNCCs) first give rise to an extramu

72 minate from the neural tube, whereas cranial neural crest cells acquire ectomesenchyme potential depe

73 Here, to investigate how the evolution of neural crest cells affected the vertebrate body plan, we

74 re enriched for enhancer activity in cranial neural crest cells and craniofacial tissues, several reg

75 essing markers of human sensory neurons from neural crest cells and established a critical role for t

76 productively infects stem-cell-derived human neural crest cells and peripheral neurons in vitro, lead

77 arapacial pigmentation as both the migratory neural crest cells and pigment localized only to PNA-fre

78 as Hertwig's epithelial root sheath, cranial neural crest cells and stem cells residing in developing

79 l circuit results in a fate switch, in which neural crest cells are converted into progenitors of the

80 Neural crest cells are embryonic progenitors that genera

81 However, trunk neural crest cells are generally regarded as nonskeletog

82 During gastrulation, neural crest cells are specified at the neural plate bor

83 r axons enter the DREZ before the arrival of neural crest cells at the DREZ.

84 ngle-cell analysis, we show that mouse trunk neural crest cells become biased toward neuronal lineage

85 Individual neural crest cells colonize the ovary, differentiate int

86 To test the intriguing possibility that neural crest cells contribute to heart repair, we examin

87 Cardiac neural crest cells contribute to important portions of t

88 The results suggest that neural crest cells contribute to many cardiovascular str

89 During vertebrate development, neural crest cells differentiate as a continuous mass of

90 e tracing, we further demonstrate that trunk neural crest cells do, in fact, give rise to odontoblast

91 for proper migration and differentiation of neural crest cells during neuritogenesis.

92 and impaired recruitment of endocardial and neural crest cells during the early stages of VIC develo

93 We find that migrating lead cranial neural crest cells express AQP-1 mRNA and protein, impli

94 nohistochemistry that, in del10 homozygotes, neural crest cells fail to infiltrate the developing SV

95 FNB39 noncoding variant, we demonstrate that neural crest cells fail to migrate into the stria vascul

96 Neural crest cells give rise to a diverse array of deriv

97 In the head, cranial neural crest cells give rise to the dentine-producing ce

98 phB guidance receptors in the same migrating neural crest cells has novel implications for the concep

99 Neural crest cells have different developmental potencie

100 s, a role that was largely subsumed by vagal neural crest cells in early gnathostomes.

101 nd molecular perturbation of migrating chick neural crest cells in vivo.

102 s showed that developmental incorporation of neural crest cells into the SV depends on signaling from

103 The choices that neural crest cells make to become sensory, glial, autono

104 Neural crest cells migrate throughout the embryo, but ho

105 ed the restricted developmental potential of neural crest cells originating in the head.

106 strate Rdh10 is specifically required in non-neural crest cells prior to E10.5 for proper choanae for

107 Neural crest cells produce the extracellular matrix prot

108 Lineage tracing of cranial neural crest cells revealed that the cleft resulted not

109 ENS cells originate from vagal and sacral neural crest cells that are initially located at the bor

110 ress response, inducing apoptosis in cranial neural crest cells that would result in craniofacial abn

111 s previously associated with the decision of neural crest cells to become sympathetic in other system

112 the epithelial-to-mesenchymal transition of neural crest cells to emigrate from the neural tube, miR

113 ys to co-induce cranial epithelial cells and neural crest cells within a spherical cell aggregate.

114 t dependent on the genetic sex of gonadal or neural crest cells, and may be blocked by repressive gui

115 Along with neural crest cells, cranial placodes are considered ecto

116 t a cell-autonomous requirement for Med23 in neural crest cells, potentially linking the global trans

117 ted genes in neuroblastoma cells compared to neural crest cells, the presumptive precursors cells for

118 cient to confer cardiac potential onto trunk neural crest cells, thus implicating new genes in cardio

119 When interrogated in cranial neural crest cells, we identified discrete functions for

120 s of cell types such as cranial placodes and neural crest cells.

121 cification and maintained in migrating chick neural crest cells.

122 (GN) is a rare benign tumor arising from the neural crest cells.

123 onent and are believed to differentiate from neural crest cells.

124 eved to originate from either mesenchymal or neural crest cells.

125 that establish axial-specific populations of neural crest cells.

126 ink between the two phenotypes, possibly via neural crest cells.

127 the neural plate border and specification of neural crest cells.

128 surface metalloprotease critical for cranial neural crest (CNC) cell migration.

129 During vertebrate embryogenesis, the cranial neural crest (CNC) forms at the neural plate border and

130 secretory immunoglobulinA production in the neural crest-conditional deletion of endothelin receptor

131 nalysis, we uncover a previously undescribed neural crest contribution to cardiomyocytes of the ventr

132 d expression of numerous genes essential for neural crest/craniofacial development.

133 ollowing a pre-existing pattern, the cranial neural crest creates their own migratory pathway by inte

134 ibits FGF-stimulated PI3K/Akt signaling, and neural crest defects in CAPE-treated embryos are suppres

135 ulting from Paf complex deficiency, rescuing neural crest defects in ctr9 morphant and paf1(aln(z24))

136 Using genetic lineage-tracing and neural crest-deficient mutants in zebrafish, and physica

137 l cells, new developmental processes such as neural crest delamination, and new tissue organizations

138 al expression pattern with key regulators of neural crest delamination, Phf12 and Snail2, and interac

139 ge' vector or morpholinos promotes premature neural crest delamination.

140 latory network that influences the timing of neural crest delamination.

141 a putative enhancer in HAND2-AS1 (heart and neural crest derivatives expressed 2 antisense RNA1, a n

142 resulted in the down-regulation of heart and neural crest derivatives expressed 2, Kruppel-like facto

143 s in vitro, suggesting that ADAR1 safeguards neural crest derivatives from aberrant MDA5-mediated int

144 stoma is mysterious due to the complexity of neural crest derivatives.

145 quired for regulating the development of two neural crest derivatives: melanocytes and Schwann cells.

146 In zebrafish, TH has opposite effects on neural crest derived pigment cells of the adult stripe p

147 Finally, we identify similar neural-crest derived cells in both the avian and non-hum

148 d (SHF-derived), but not neighboring cardiac neural crest-derived (CNC-derived), VSMCs showed impaire

149 In support of this role of ES to regulate neural crest-derived cell fate and differentiation in vi

150 FP mice showing stable YFP expression in all neural crest-derived cell populations despite loss of Wn

151 combinatorial labeling of zebrafish cranial neural crest-derived cells (CNCCs) to define global gene

152 is expressed selectively in isolated enteric neural crest-derived cells (ENCDC), which also express t

153 ovel model of aganglionosis in which enteric neural crest-derived cells (ENCDCs) express diphtheria t

154 Mice lacking Jagged1 or Notch2 in neural crest-derived cells (NCCs) of the pharyngeal arch

155 nsory neurons (Phox2b-Cre; p75(fx/fx)) or in neural crest-derived cells (P0-Cre; p75(fx/fx)) and exam

156 es into the PAAs, and (3) differentiation of neural crest-derived cells adjacent to the PAA endotheli

157 xt to induce iridophore differentiation from neural crest-derived cells and pigment progenitor cells.

158 These cranial neural crest-derived cells migrate to populate a mesoder

159 Cranial neural crest-derived cells provide important regulatory

160 rs while adrenal chromaffin cells arise from neural crest-derived cells that express Schwann cell mar

161 individual transcriptomes from thousands of neural crest-derived cells, reconstructed developmental

162 1/2 (ERK1/2) signaling in neuroblastoma and neural crest-derived cells.

163 se cells proliferate and are joined by a few neural crest-derived cells.

164 roportions of cranial placode versus cranial neural crest-derived CNgV cells.

165 a major role in hyaluronan synthesis in the neural crest-derived craniofacial mesenchyme during pala

166 marks for the bud initiation stage, when the neural crest-derived ectomesenchyme predominates in the

167 ssical glia in the ENS further suggests that neural crest-derived enteric glia might have evolved aft

168 nd never invades the interior of the testis, neural crest-derived innervation invades the interior of

169 and homeostasis in the neural crest, several neural crest-derived lineages and myelinating glia.

170 ecific inactivation of hedgehog signaling in neural crest-derived mandibular mesenchyme led to expans

171 lls formed during embryogenesis, such as the neural crest-derived melanocyte.

172 pment of vertebrate jaws involves patterning neural crest-derived mesenchyme cells into distinct subp

173 ively than shRNAs for Pten repression in rat neural crest-derived PC-12 cells, and enhanced neurite o

174 notch2 and notch3 lost mesoderm- as well as neural crest-derived pdgfrb (high) MCs.

175 rresponding decrease in iridophores, another neural crest-derived pigment cell type in zebrafish.

176 Melanocytes are the neural crest-derived pigment-producing cells of the skin

177 apping clonal units founded by postmigratory neural crest-derived progenitors.

178 Conditional ablation of Nf1 and Arf in the neural crest-derived SC lineage allows escape from senes

179 t-embryonic enteric neurons arise from trunk neural crest-derived Schwann cell precursors that migrat

180 ults from re-specification of cells from the neural crest-derived sox9a(+)/sox10(+) skeletal lineage.

181 lop entirely within mesoderm-derived tissue, neural crest-derived tissue, or at the boundary of the t

182 CPAMD8 expression was highest in neural crest-derived tissues of the adult anterior segme

183 een proposed between glomus cells, which are neural crest-derived, and the hypoxia-sensitive 'neuroep

184 frog and lamprey, we find that NECs are not neural crest-derived, but endoderm-derived, like PNECs,

185 MITF) that regulate melanosome transport and neural-crest-derived melanocyte development, respectivel

186 Our results suggest that neural-crest-derived Schwann cell precursors made an imp

187 (wild-like genes), involved in cognition and neural crest development (domestic-like genes), or assoc

188 examined the molecular circuits that control neural crest development along the anteroposterior axis

189 landscape of ADAR1 function to the fields of neural crest development and disease.

190 anscription elongation of genes required for neural crest development and melanoma growth in vivo(1).

191 gdf6a or inhibition of BMP signaling during neural crest development disrupts normal pigment cell de

192 However, their cell-autonomous function in neural crest development has not been explored.

193 hed, but the signals required for subsequent neural crest development remain poorly characterized.

194 t Hmga1 functions in a bimodal manner during neural crest development to regulate specification at th

195 h embryo cultures for chemicals that disrupt neural crest development, as read out by crestin:EGFP ex

196 or GDF6 orthologs during early embryonic and neural crest development, but have not identified direct

197 ically relevant groups (e.g., Wnt signaling, neural crest development, sensory placode specification,

198 young children that arises from anomalies in neural crest development.

199 normal developmental role in the context of neural crest development.

200 pioneer factor TFAP2A at discrete stages of neural crest development.

201 uncovered two distinct functions of Hmga1 in neural crest development.

202 hondrial DNA against oxidative damage during neural crest differentiation.

203 s a novel intracellular pathway required for neural crest differentiation.

204 ever, reminiscent of Waardenburg syndrome, a neural crest disorder, Myo10(tm2/tm2) mice exhibited pig

205 ing strongly suppressed leflunomide-mediated neural crest effects in zebrafish.

206 onal circuit that is specific to the cranial neural crest emerged via the gradual addition of network

207 ent, during the second phase of turtle trunk neural crest emigration.

208 ate that inappropriate p53 activation in the neural crest, facial ectoderm, anterior heart field, and

209 istent truncus arteriosus (PTA), which trunk neural crest fails to rescue.

210 ters the apportionment of neural tube versus neural crest fates.

211 r subtypes; (3) key neural functions such as neural crest formation are predicted to enhance adaptive

212 sidual disease cells that was enriched for a neural crest G(0)-like state that preexisted in the prim

213 caffeic acid phenethyl ester (CAPE) disrupts neural crest gene expression, migration, and melanocytic

214 in loss of SRCAP nuclear localization, alter neural crest gene programs in human in vitro models and

215 DF6-induced BMP signaling maintained a trunk neural crest gene signature in melanomas.

216 d the dorsal midline with high expression of neural crest genes, pluripotency factors, and lineage ma

217 The neural crest gives rise to numerous cell types, dysfunct

218 Since its discovery 150 years ago, the neural crest has intrigued investigators owing to its re

219 onal circuit that is specific to the cranial neural crest in amniotes and confers the ability to form

220 Notably, analysis of the cranial neural crest in little skate and zebrafish embryos demon

221 s that control the normal development of the neural crest into cardiomyocytes and reactivation of the

222 pattern of negative signals that channel the neural crest into streams.

223 r model suggests that the initial collective neural crest invasion is based on short-range repulsion

224 The neural crest is an embryonic population of multipotent s

225 anscriptional profile of the lamprey cranial neural crest is more similar to the trunk neural crest o

226 The neural crest is regionalized along the anteroposterior a

227 embryonic origin of enteric neurons from the neural crest is well established, conflicting evidence e

228 pecification of the melanocytic lineage from neural crest is well established, its significance in th

229 as well as with morphogenesis of tissues of neural crest-like origin (melanocytes and neurons, bone

230 compared with dental pulp cells, periodontal neural crest lineage differentiation is characterized by

231 inactivation of Has2 throughout the cranial neural crest lineage or specifically in developing palat

232 Inactivation of Has2 either throughout the neural crest lineage or specifically in the developing p

233 plate border, Hmga1 regulates Pax7-dependent neural crest lineage specification.

234 -resolution imaging, can extend the scope of neural crest lineage studies beyond development to regen

235 Here, we review major discoveries in neural crest lineage tracing from a historical perspecti

236 grammed normal human melanocytes express the neural crest marker p75 and become multipotent.

237 rived from a stem cell population called the neural crest, mechanisms that dictate final neuropil ple

238 he EOMs, which do not arise exclusively from neural crest mesenchyme as previously thought.

239 Melanoblasts deriving from the neural crest migrate along the developing embryo and tra

240 we show that inhibition of eIF2B also drives neural crest migration and yeast invasiveness, our resul

241 that ectopic maintenance of miR-203 inhibits neural crest migration in chick, whereas its functional

242 Similarly, NA transiently inhibits neural crest migration in Xenopus embryos in a Snail1-de

243 ne and uncovered its function in maintaining neural crest migration pattern.

244 s still lacking, all computational models of neural crest migration published so far have assumed a p

245 Neural crest migration requires cells to move through an

246 Wnt8, Znf703 disrupts patterning of distinct neural crest migratory streams normally delineated by So

247 ng embryo, melanoblasts originating from the neural crest must traverse the dermis to reach the epide

248 mation, but mechanisms coupling Hox genes to neural crest (NC) are unknown.

249 Neural crest (NC) cells are multipotent stem cells that

250 Here, we have used chick neural crest (NC) cells, a highly migratory stem cell po

251 inical features are modeled in mice carrying neural crest (NC) deletion of UTX, including craniofacia

252 RN underlying development of the multipotent neural crest (NC) embryonic cell population.

253 WNT/beta-catenin signaling is crucial for neural crest (NC) formation, yet the effects of the magn

254 The neural crest (NC) is an embryonic cell population that c

255 d to maintain multipotent progenitors of the neural crest (NC) lineage in zebrafish.

256 A fundamental property of neural crest (NC) migration is contact inhibition of loc

257 types that develops entirely from migratory neural crest (NC) progenitor cells.

258 cells (LNC) in maintaining the phenotype of neural crest (NC) progenitors to support LEPC.

259 expressed in the pre-migratory and migratory neural crest (NC), and has been implicated in the delami

260 nd reproducible derivation of neuroectoderm, neural crest (NC), cranial placode (CP), and non-neural

261 Neuroblastoma (NB), derived from the neural crest (NC), is the most common pediatric extracra

262 into lateral mesoderm (LM, aortic root) and neural crest (NC, ascending aorta/transverse arch) SMC l

263 al neural crest is more similar to the trunk neural crest of amniotes.

264 radual addition of network components to the neural crest of gnathostomes, which subsequently became

265 showed that the cranial subpopulation of the neural crest of the lamprey lacks most components of a t

266 from the anterior mandibular-stream cranial neural crest or from multiple embryonic cell populations

267 nique properties based on their origins from neural crest or glial cells.

268 tial of this cell population, and point to a neural crest origin of dentine throughout the ancestral

269 The neural crest origin of DPSC makes them a useful source o

270 Neuroblastoma, an embryonal cancer of neural crest origin, shows metastases frequently at diag

271 and the mutant PDGFRA transgenes in cells of neural crest origin.

272 gly, expression of nidogen in the absence of neural crest partially restores optic cup morphogenesis.

273 r the existence of a vagally derived enteric neural crest population in the lamprey.

274 rams melanocytes and melanoma cells toward a neural crest precursor-like state.

275 th sympathetic neurons derived directly from neural crest precursors while adrenal chromaffin cells a

276 amines, and both cell types are derived from neural crest precursors.

277 l loss of nuclear Pax6 (46 kDa) staining and neural crest progenitor status defined by the expression

278 We found that neural crest progenitors display elevated expression of

279 into cardiomyocytes and reactivation of the neural crest program upon regeneration may open potentia

280 d by heterozygous mutations within TFAP2A, a neural crest regulator for which humans, but not mice, a

281 ew sox10+ cells in the apex, sox10 and other neural crest regulatory network genes are upregulated in

282 rigins of these structures from mesoderm and neural crest, respectively.

283 of neuruloids harboring neural progenitors, neural crest, sensory placode and epidermis.

284 velopmental processes and homeostasis in the neural crest, several neural crest-derived lineages and

285 Neural crest specific conditional deletion of Adar1 in m

286 ng activin-betaA ( Inhba(-/-)) and mice with neural crest-specific inactivation of Bmp4 ( Bmp4(ncko/n

287 Furthermore, we show that neural crest-specific inactivation of Six1 in Six2 (-/-)

288 r receptor-alpha) under control of the sox10 neural crest-specific promoter.

289 mic landscape of progenitor cells to promote neural crest specification.

290 Here we identify a neural crest stem cell niche that centers around the dor

291 disease showed enrichment of mesenchymal and neural crest stem cell signatures similar to human thera

292 Neural crest stem cells (NCSCs) and Schwann cells (NCSC-

293 s and a common cellular basis developed from neural crest stem cells.

294 ent explanation for the formation of cranial neural crest streams in concert with previously reported

295 form craniofacial cartilage onto non-cranial neural crest subpopulations(3).

296 ng is essential for the establishment of the neural crest territory.

297 scription factors that define one subtype of neural crest, the cardiac crest, and demonstrate their a

298 velopment of the endodermal, mesodermal, and neural crest tissues.

299 Danio rerio adult heart regeneration in the neural crest transgenic line, Tg(-4.9sox10:eGFP).

300 em (ENS) predominantly originates from vagal neural crest (VNC) cells that emerge from the caudal hin