ライフサイエンスコーパス: neural crest cell

1 he progression from progenitor to definitive neural crest cell.

2 cification and maintained in migrating chick neural crest cells.

3 afish embryo, chromatophores derive from the neural crest cells.

4 s required to produce a sufficient number of neural crest cells.

5 d cellular dynamics that affects the NNE and neural crest cells.

6 that establish axial-specific populations of neural crest cells.

7 ted with aberrant differentiation of cranial neural crest cells.

8 ubsequently directed its novel expression in neural crest cells.

9 al tube border cells with the cooperation of neural crest cells.

10 nglia--arise from glial cells in nerves, not neural crest cells.

11 ink between the two phenotypes, possibly via neural crest cells.

12 nctional association of Aebp2 with migratory neural crest cells.

13 in combination with BMP signaling to induce neural crest cells.

14 sal neural tube cells to generate emigrating neural crest cells.

15 is not due to a direct function of Prdm1 in neural crest cells.

16 s are abundant in the cytoplasm of migratory neural crest cells.

17 umptive cornea despite dynamic ingression of neural crest cells.

18 anchial arches that are populated by cranial neural crest cells.

19 ally expressed in premigratory and migratory neural crest cells.

20 the growth, survival and differentiation of neural crest cells.

21 rates EMT and chemotaxis during migration of neural crest cells.

22 epressing core apoptotic pathways in cranial neural crest cells.

23 pithelial to mesenchymal transition (EMT) of neural crest cells.

24 the neural plate border and specification of neural crest cells.

25 s of cell types such as cranial placodes and neural crest cells.

26 (GN) is a rare benign tumor arising from the neural crest cells.

27 onent and are believed to differentiate from neural crest cells.

28 eved to originate from either mesenchymal or neural crest cells.

29 ically in endothelial, but not myocardial or neural crest, cells.

30 ermines this differential behavior, we study neural crest cells, a migratory stem cell population who

31 minate from the neural tube, whereas cranial neural crest cells acquire ectomesenchyme potential depe

32 Here, to investigate how the evolution of neural crest cells affected the vertebrate body plan, we

33 e to pulp cells and odontoblasts derive from neural crest cells after their migration in the early he

34 nts Eed, Ezh2 and Suz12 are expressed in the neural crest cells and are required for neural crest mar

35 re enriched for enhancer activity in cranial neural crest cells and craniofacial tissues, several reg

36 Chd7 morphants have impaired migration of neural crest cells and deregulation of sox10 expression

37 essing markers of human sensory neurons from neural crest cells and established a critical role for t

38 am leads and engulfs the later emerging HMP, neural crest cells and hypoglossal nerve.

39 onstrated the migratory pathways followed by neural crest cells and increased knowledge about their d

40 ar3 is localised to the cell-cell contact in neural crest cells and is essential for CIL.

41 e craniofacial skeleton is derived from both neural crest cells and mesodermal cells; however, the ma

42 acterized by reciprocal interactions between neural crest cells and neighboring cell populations of e

43 sightful view of the regulatory landscape of neural crest cells and offer a new perspective on develo

44 expression states of the early E8.5 pioneer neural crest cells and paraxial mesoderm.

45 productively infects stem-cell-derived human neural crest cells and peripheral neurons in vitro, lead

46 arapacial pigmentation as both the migratory neural crest cells and pigment localized only to PNA-fre

47 nose of the zebrafish are derived from both neural crest cells and placode cells.

48 Neural crest cells and repulsive slit1/robo2 signals the

49 CAX is expressed in neural crest cells and required for their migration in v

50 as Hertwig's epithelial root sheath, cranial neural crest cells and stem cells residing in developing

51 the ability of neural tube cells to produce neural crest cells and the timing of peripheral neuron d

52 t dependent on the genetic sex of gonadal or neural crest cells, and may be blocked by repressive gui

53 Neural crest cells are a population of multipotent stem

54 Neural crest cells are a transient stem cell-like popula

55 Neural crest cells are an embryonic cell population that

56 Neural crest cells are both highly migratory and signifi

57 l circuit results in a fate switch, in which neural crest cells are converted into progenitors of the

58 Neural crest cells are embryonic progenitors that genera

59 ey initiate migration in vertebrate embryos, neural crest cells are enriched for methylation cycle en

60 However, trunk neural crest cells are generally regarded as nonskeletog

61 Neural crest cells are induced at the neural plate borde

62 During embryonic development, multipotent neural crest cells are specified at the lateral borders

63 During gastrulation, neural crest cells are specified at the neural plate bor

64 Neural crest cells arise from the border of the neural p

65 Neural crest cells arise from the edges of the nascent c

66 During the hypoxic stage, a large number of neural crest cells arise from the head neural tube by ep

67 r axons enter the DREZ before the arrival of neural crest cells at the DREZ.

68 l developmental processes and play a crucial neural crest cell-autonomous role in frontonasal morphog

69 ngle-cell analysis, we show that mouse trunk neural crest cells become biased toward neuronal lineage

70 At E8.5, as migrating neural crest cells begin to exit the neural fold/epiderm

71 These defects were associated with aberrant neural crest cell behavior.

72 l crest cell EMT by controlling premigratory neural crest cell cadherin levels.

73 n to the trigeminal ganglia and also changes neural crest cell Cadherin-7 levels and localization.

74 idence that transgenic expression of Bmp4 in neural crest cells causes a series of craniofacial malfo

75 the BMP type IA receptor (BMPR1A) in cranial neural crest cells causes craniosynostosis during postna

76 a surprisingly restricted defect in cranial neural crest cell (cNCC) development.

77 gehog (Shh)-induced proliferation of cranial neural crest cell (cNCC) mesenchyme is required for uppe

78 sponsiveness was diminished in local cranial neural crest cell (CNCC) populations in both mutants, wi

79 Specifically, cranial neural crest cells (CNCC) lead the initiation of tongue

80 lucose levels, which is derived from cranial neural crest cells (CNCC).

81 The cardiac neural crest cells (cNCCs) and the second heart field (S

82 Cardiac neural crest cells (cNCCs) are a migratory cell populati

83 Cranial neural crest cells (CNCCs) delaminate from embryonic neu

84 hat Mitf activity is required within cranial neural crest cells (cNCCs) during CF closure.

85 ant stem cell populations, including cranial neural crest cells (CNCCs), have not been assessed.

86 iofacial tissues that originate from cranial neural crest cells (CNCCs).

87 Individual neural crest cells colonize the ovary, differentiate int

88 of mucosal immunity, in mice with homozygous neural crest cell-conditional deletion of EdnrB (EdnrB(N

89 To test the intriguing possibility that neural crest cells contribute to heart repair, we examin

90 Cardiac neural crest cells contribute to important portions of t

91 The results suggest that neural crest cells contribute to many cardiovascular str

92 rigin along the body axis, with only cranial neural crest cells contributing to facial skeleton.

93 Along with neural crest cells, cranial placodes are considered ecto

94 Cranial neural crest cells (crNCCs) migrate from the neural tube

95 Local increase in neural crest cell death and impaired neural crest adhesi

96 During vertebrate development, trunk neural crest cells delaminate along the entire length of

97 Neural crest cells deleted for beta1 integrin were able

98 ammals and that it has specific functions in neural crest cell derivatives.

99 Dental follicle cells (DFCs) are neural crest cell-derived cells and the genuine precurso

100 se embryonic development, a subpopulation of neural crest cell-derived melanocytes migrates and incor

101 A and protein levels are both upregulated in neural crest cell-derived mesenchyme surrounding Meckel'

102 chromosome 22 (22q) result in meningiomas in neural-crest cell-derived meninges, while variants affec

103 These findings demonstrate that trunk neural crest cell development in C. punctatum follows th

104 Among the genes that are involved in neural crest cell development, some genes are more sensi

105 rders are typically attributed to defects in neural crest cell development.

106 During vertebrate development, neural crest cells differentiate as a continuous mass of

107 severe cranial facial defects, arising from neural crest cell differentiation and migration problems

108 lysis revealed that hcfc1b regulates cranial neural crest cell differentiation and proliferation with

109 e tracing, we further demonstrate that trunk neural crest cells do, in fact, give rise to odontoblast

110 in a discrete apical region of premigratory neural crest cells during EMT, and Rho-ROCK signaling is

111 for proper migration and differentiation of neural crest cells during neuritogenesis.

112 and impaired recruitment of endocardial and neural crest cells during the early stages of VIC develo

113 blasts develop from multipotent craniofacial neural crest cells during tooth and jawbone development,

114 ion alpha-catenin protein, regulates cranial neural crest cell EMT by controlling premigratory neural

115 enin down-regulation is critical for initial neural crest cell EMT, a potential role for alphaN-caten

116 ivo, we demonstrate Cad6B proteolysis during neural crest cell EMT, which generates a Cad6B N-termina

117 , along with gamma-secretase, during cranial neural crest cell EMT.

118 ure network directs the migration of enteric neural crest cells (ENCC) along the gut to promote the f

119 e (HSCR) is caused by a reduction of enteric neural crest cells (ENCCs) in the gut and gastrointestin

120 r event is innervation of the gut by enteric neural crest cells (ENCCs) to establish the enteric nerv

121 rung disease is caused by failure of enteric neural crest cells (ENCCs) to fully colonize the bowel,

122 omplete colonization of the bowel by enteric neural crest cells (eNCCs), the ENS precursors.

123 During development, vagal neural crest cells enter the foregut and migrate in a ro

124 expression of these two SoxE genes in trunk neural crest cells, especially Sox9, matched the Sox10 m

125 Using murine genetics, we show that neural crest cells exhibit a requirement for the class I

126 A previous study suggests that rudimentary neural crest cells existed in ancestral chordates.

127 Our analysis shows that, before neural crest cell exit from the hindbrain, DAN is expres

128 We find that migrating lead cranial neural crest cells express AQP-1 mRNA and protein, impli

129 However, all neural crest cells express Sox10 and the mechanisms dire

130 nohistochemistry that, in del10 homozygotes, neural crest cells fail to infiltrate the developing SV

131 FNB39 noncoding variant, we demonstrate that neural crest cells fail to migrate into the stria vascul

132 ll imaging we show that in lh3 null mutants, neural crest cells fail to transition from a sheet to a

133 Interestingly, neural crest cells failed to populate the heart and inst

134 sis has been an essential tool for exploring neural crest cell fate and migration routes.

135 Genetic repression of placodal, but not neural crest, cell fate results in pineal hypoplasia in

136 variants affecting genes involved in enteric neural-crest cell fate that exacerbate the widespread ge

137 iants in 24 genes that play roles in enteric neural-crest cell fate, 7 of which were novel, were also

138 ector of the regulatory networks that define neural-crest cell-fate specification and subsequent meso

139 During development, vagal neural crest cells fated to contribute to the enteric ne

140 gs expand the repertoire of vertebrate trunk neural crest cell fates during normal development, highl

141 Sox8 and Sox9 probes demonstrated that trunk neural crest cells follow a pattern similar to the migra

142 Neural crest cells form diverse derivatives that vary ac

143 difications regulate the transition of trunk neural crest cells from a non-segmental sheet like migra

144 Neural crest cells generate a range of cells and tissues

145 Neural crest cells give rise to a diverse array of deriv

146 In the head, cranial neural crest cells give rise to the dentine-producing ce

147 ansformation than it does to modulate normal neural crest cell growth.

148 phB guidance receptors in the same migrating neural crest cells has novel implications for the concep

149 Neural crest cells have different developmental potencie

150 Because collagenous cellular cartilage and neural crest cells have not been described in invertebra

151 In neural crest cells, HDAC1/2 induced expression of the tr

152 enomic regions that are active in both human neural crest cells (hNCC) and mouse embryonic craniofaci

153 ers essential for TFAP2A expression in human neural crest cells (hNCCs).

154 c, lysine-methylated proteins from migratory neural crest cells identified 182 proteins, several of w

155 Moreover, alphaN-catenin perturbation in neural crest cells impacts the placode cell contribution

156 s, a role that was largely subsumed by vagal neural crest cells in early gnathostomes.

157 nt the specification and emigration of trunk neural crest cells in embryos of a cartilaginous fish, t

158 in branchial arch ectoderm and a failure of neural crest cells in the arches to express FGF-responsi

159 he oxygen supply helps to stop emigration of neural crest cells in the head.

160 ebrafish, our experiments suggest that trunk neural crest cells in the last common ancestor of tetrap

161 cy, cell number, and the mitotic activity of neural crest cells in the vicinity of the gut but has no

162 ional, the embryonic head no longer produces neural crest cells in vivo, despite the capability to do

163 nd molecular perturbation of migrating chick neural crest cells in vivo.

164 control multiple steps in the development of neural crest cells, including the acquisition of stem ce

165 SAHH is required for emigration of polarized neural crest cells, indicating that methylation is essen

166 s express Sox10 and the mechanisms directing neural crest cells into a specific lineage are poorly un

167 human pluripotent stem cell-derived enteric neural crest cells into developing human intestinal orga

168 t genes, HDAC1/2 direct the specification of neural crest cells into peripheral glia.

169 C1/2) are essential for the specification of neural crest cells into Schwann cell precursors and sate

170 s showed that developmental incorporation of neural crest cells into the SV depends on signaling from

171 of the ENS is controlled by the interplay of neural crest cell-intrinsic factors and instructive cues

172 s one component of EMT and, in chick cranial neural crest cells, involves cadherin-6B (Cad6B) down-re

173 ppearance of cellular cartilage derived from neural crest cells is considered a turning point in vert

174 ens junction disassembly within premigratory neural crest cells is one component of EMT and, in chick

175 in vivo genetic deletion of HDAC1/2 in mouse neural crest cells led to strongly decreased Sox10 expre

176 NA methylation plays a role in neural versus neural crest cell lineage decisions.

177 l for survival and proper differentiation of neural crest cell lineages, where it plays an important

178 The choices that neural crest cells make to become sensory, glial, autono

179 We propose that these trunk-derived neural crest cells may be homologous to Schwann cell pre

180 We suggest that neural crest cells may have evolved as a consequence of

181 ator complex subunit protein, Med23 in mouse neural crest cells (Med23(fx/fx);Wnt1-Cre), results in m

182 Neural crest cells migrate extensively and contribute to

183 Neural crest cells migrate extensively and give rise to

184 Neural crest cells migrate throughout the embryo, but ho

185 2B, a transcription factor that orchestrates neural crest cell migration and differentiation; this mu

186 ingle-cell transcriptome analysis of cranial neural crest cell migration at three progressive stages

187 loss of function of DAN results in enhanced neural crest cell migration by increasing speed and dire

188 ith the notion that Lh3 exerts its effect on neural crest cell migration by regulating post-translati

189 Consistently, Lpd regulates mesenchymal neural crest cell migration cell autonomously in Xenopus

190 Lh3 substrate Collagen18A1 recapitulates the neural crest cell migration defects observed in lh3 muta

191 ring palate morphogenesis, defective cranial neural crest cell migration in capzb(-/-) mutants result

192 However, the signals that regulate neural crest cell migration remain unclear.

193 a potential role for alphaN-catenin in later neural crest cell migration, and formation of the crania

194 ent aspects of neural development, including neural crest cell migration, axon guidance and cerebella

195 ng is of crucial importance during embryonic neural crest cell migration, proliferation and different

196 a mutants have cleft palate due to defective neural crest cell migration, whereas pdgfra heterozygote

197 eoglycans that are known to be inhibitory to neural crest cell migration.

198 e onset of brain development, beginning with neural crest cell migration.

199 sheet to stream migration restores segmental neural crest cell migration.

200 L1/K1 hetero-oligomer, which impacts cardiac neural crest cell migration.

201 promoter of CXCR4, a gene involved in embryo neural crest cell migration.

202 form of tumor plasticity with reversion to a neural crest cell migratory phenotype.

203 he molecular diversity and dynamics within a neural crest cell migratory stream that underlie complex

204 he dynamic phases of precursor and migratory neural crest cell movements from the neural keel stage t

205 raniofacial abnormalities to deficiencies in neural crest cell (NCC) craniofacial precursors early in

206 e found to be enriched for genes involved in neural crest cell (NCC) development and vasculogenesis.

207 mouse models, to demonstrate that defective neural crest cell (NCC) development explains RCPS cranio

208 of growth factors, and its functions include neural crest cell (NCC) maintenance, specifically NCC mi

209 hymal transition, acquisition of avian trunk neural crest cell (NCC) polarity is prerequisite for dir

210 ogenitors that give rise to neurons, and the neural crest cell (NCC) progenitors that give rise to gl

211 urotransmission and early vascularization of neural crest cell (NCC)-derived perivascular cells in th

212 for the development of multiple endoderm and neural crest cell (NCC)-derived structures in the pharyn

213 elopment is governed by interactions between neural crest cells (NCC) and the extracellular matrix (E

214 Neural crest cells (NCC) are a transient, embryonic cell

215 Neural crest cells (NCC) are multi-potent cells of ectod

216 Neural crest cells (NCC) are stem cells that generate di

217 on proper dorsal-ventral (D-V) patterning of neural crest cells (NCC) within the pharyngeal arches.

218 with Wnt1-Cre, we show that primary cilia of neural crest cells (NCC), precursors of most AS structur

219 ll enteric neurons and glia are derived from neural crest cells (NCC).

220 S development by combining human-PSC-derived neural crest cells (NCCs) and developing human intestina

221 d the Clpex phenotype is due to apoptosis of neural crest cells (NCCs) and the cranial neuroepitheliu

222 Here we show that neural crest cells (NCCs) and their derivatives provide

223 Neural crest cells (NCCs) are highly patterned embryonic

224 Neural crest cells (NCCs) are migratory, multipotent emb

225 Neural crest cells (NCCs) are physically responsible for

226 study, we establish that deletion of Chd7 in neural crest cells (NCCs) causes severe conotruncal defe

227 how that the in vivo collective migration of neural crest cells (NCCs) depends on such confinement.

228 Neural crest cells (NCCs) migrate over incredible distan

229 ng Hand1 phosphoregulation in the developing neural crest cells (NCCs) of mice.

230 ing sensory neuroblasts and emigrant cranial neural crest cells (NCCs) play a role in coordinating th

231 ve imaging in zebrafish, we demonstrate that neural crest cells (NCCs) respond rapidly to dying cells

232 ort the oral cavity are derived from cranial neural crest cells (NCCs) that develop in the maxillary

233 iac outflow tract (OFT) requires multipotent neural crest cells (NCCs) that migrate from the neural t

234 We mutated KMT2D in neural crest cells (NCCs) to study cellular and molecula

235 Using Xenopus, we identified defects in neural crest cells (NCCs) upon emc1 depletion.

236 endocardial cushions and repositions cardiac neural crest cells (NCCs) within the OFT, 2 processes th

237 t splicing factor Rbfox2 is expressed in the neural crest cells (NCCs), and deletion of Rbfox2 in NCC

238 of vertebrate traits, including emergence of neural crest cells (NCCs), in which neofunctionalization

239 studying NBL based on the transformation of neural crest cells (NCCs), the progenitor cells of the S

240 Hoxa1 is expressed in precursors of cardiac neural crest cells (NCCs), which populate the heart.

241 Neural crest cells (NCCs), which undergo EMT during deve

242 t in enteric neurons, which are derived from neural crest cells (NCCs).

243 system (ENS) and are derived from migratory neural crest cells (NCCs).

244 To test this idea, we infected migrating neural crest cells of chicken embryos with replication-c

245 Although cranial neural crest cells of Foxi3 mutants are able to migrate,

246 Introducing components of this circuit into neural crest cells of the trunk alters their identity an

247 ver cranial vessels, MCs derived from either neural crest cells or mesoderm emerged around the prefor

248 p53 expression, and that CHD7 loss in mouse neural crest cells or samples from patients with CHARGE

249 he migration of the lateral line primordium, neural crest cells, or head mesendoderm.

250 ed the restricted developmental potential of neural crest cells originating in the head.

251 tion may also be involved in the survival of neural crest cell population during development.

252 experiments reveal effects on the migratory neural crest cell population that include subsequent def

253 to better identify the role of the different neural crest cell populations in distal gut innervation,

254 t a cell-autonomous requirement for Med23 in neural crest cells, potentially linking the global trans

255 depletion of either ADAM within premigratory neural crest cells prematurely reduces or maintains Cad6

256 strate Rdh10 is specifically required in non-neural crest cells prior to E10.5 for proper choanae for

257 Neural crest cells produce the extracellular matrix prot

258 Loss of Ift88 also resulted in a decrease in neural crest cell proliferation during early stages of p

259 F9-PITX2 signaling cascade regulates cranial neural crest cell proliferation during palate formation.

260 As they enter the somites, neural crest cells rearrange into spatially restricted s

261 Chick premigratory cranial neural crest cells reduce Cadherin-6B (Cad6B) levels thr

262 Subsequently, clumps of adherent neural crest cells remained adjacent to the neural tube

263 ferentiation of both myogenic stem cells and neural crest cells requires capzb.

264 we show that loss of Tgfbr2 in mouse cranial neural crest cells results in elevated expression of TGF

265 Lineage tracing of cranial neural crest cells revealed that the cleft resulted not

266 In birds, sacral neural crest cells (sNCCs) first give rise to an extramu

267 Neural crest cell specification and differentiation to a

268 Differential AQP-1 levels affect neural crest cell speed and direction, as well as the le

269 l tube closure, and the formation of cranial neural crest cell-streams were detected by light and sca

270 ll subset of somitic cells adjacent to where neural crest cells switch from sheet to stream migration

271 We show that in neural crest cells Tfap2 directly activates expression o

272 ous system (PNS), originate from multipotent neural crest cells that also give rise to other cells, i

273 ENS cells originate from vagal and sacral neural crest cells that are initially located at the bor

274 o neurons, they are derived from pluripotent neural crest cells that differentiate into numerous cell

275 vel function for alphaN-catenin in migratory neural crest cells that form the trigeminal ganglia.

276 e enteric nervous system (ENS) develops from neural crest cells that migrate along the intestine, dif

277 awed vertebrates arises primarily from vagal neural crest cells that migrate to the foregut and subse

278 ystem (ENS) is derived from vagal and sacral neural crest cells that migrate, proliferate, and differ

279 is initiated by migrating Delta1-expressing neural crest cells that trigger NOTCH signaling and myog

280 y, we show for the first time that migratory neural crest cells that will give rise to the cranial tr

281 ress response, inducing apoptosis in cranial neural crest cells that would result in craniofacial abn

282 ted genes in neuroblastoma cells compared to neural crest cells, the presumptive precursors cells for

283 ther with epidermally-derived placode cells, neural crest cells then form the cranial sensory ganglia

284 cient to confer cardiac potential onto trunk neural crest cells, thus implicating new genes in cardio

285 s previously associated with the decision of neural crest cells to become sympathetic in other system

286 an forms a physical boundary that constrains neural crest cells to discrete streams, in turn facilita

287 the epithelial-to-mesenchymal transition of neural crest cells to emigrate from the neural tube, miR

288 profiling from human and chimpanzee cranial neural crest cells to systematically and quantitatively

289 ail-chick chimeras involving fate mapping of neural crest cells to the ultimobranchial glands that re

290 1, to provide extrinsic signals critical for neural crest cells to transition from a sheet-like migra

291 EMT, plays a critical role in promoting the neural crest cell transition to a mesenchymal state.

292 zed to the dorsal neural folds, premigratory neural crest cells undergo an epithelial-to-mesenchymal

293 Premigratory neural crest cells undergo EMT, migrate away from the ne

294 When interrogated in cranial neural crest cells, we identified discrete functions for

295 ollision outcomes observed experimentally in neural crest cells, we must either carefully tune our pa

296 By comparing pre-migratory and migratory neural crest cells, we show that the switch from E- to N

297 Neural crest cells, which are specific to vertebrates, a

298 the margin of the neural plate give rise to neural crest cells, which migrate extensively throughout

299 ys to co-induce cranial epithelial cells and neural crest cells within a spherical cell aggregate.

300 tly expressed in the cytoplasm of condensing neural crest cells within the pharyngeal arches.