ライフサイエンスコーパス: neural induction

1 nhibition is necessary and/or sufficient for neural induction.

2 ication and competence prior to the onset of neural induction.

3 nhibition of BMP signaling is sufficient for neural induction.

4 f the affected cell relative to the field of neural induction.

5 ns an undifferentiated neural ectoderm after neural induction.

6 p42 Erk MAP kinase (MAPK) in the response to neural induction.

7 terior neural tissues but is dispensable for neural induction.

8 re not required for the initial processes of neural induction.

9 al, which can initiate, and is required for, neural induction.

10 hin the BMP/Noggin field of epidermal versus neural induction.

11 ng the roles of classical signaling in human neural induction.

12 overlying ectoderm, but are insufficient for neural induction.

13 suggested a requirement for FGF in anterior neural induction.

14 ding to dorsalization of mesoderm and direct neural induction.

15 nction of FGF signalling specifically during neural induction.

16 ate within the frame of the default model of neural induction.

17 activation and a transformation step during neural induction.

18 evelopment and we examine the routes of this neural induction.

19 s at very early differentiation steps before neural induction.

20 bias the field of cells that can respond to neural induction.

21 node, notochord and somites, and there is no neural induction.

22 developing neural tube, and possibly also in neural induction.

23 es and there is no morphological evidence of neural induction.

24 s systems despite a putative role for FGF in neural induction.

25 interactions, each at an individual stage of neural induction.

26 in human embryonic stem cells (hESCs) during neural induction.

27 , dNSCs, respectively) during the process of neural induction.

28 0 and miR-96 families coordinate to regulate neural induction.

29 of Ca(2+) transients, in Ciona intestinalis neural induction.

30 dow corresponding to the period of a-lineage neural induction.

31 tween FGF and PKC signalling pathways during neural induction.

32 suitable for studying instructive signals in neural induction.

33 egion involved in body axis organization and neural induction.

34 arding the sufficiency of BMP inhibition for neural induction.

35 specification of the neural ectoderm during neural induction.

36 type IB activin receptor leads to efficient neural induction.

37 mis-inducing Smad signals leads to efficient neural induction.

38 n support a coherent framework for mammalian neural induction.

39 Neither Smad4 was involved directly in neural induction.

40 stem cells from powerful signals that drive neural induction.

41 ition plays a central role in the process of neural induction.

42 d for Smad4beta/10 actions in mesodermal and neural induction.

43 ition is required only as a late step during neural induction.

44 FGF signalling has been implicated in early neural induction [3-5], a late role for FGFs in neural d

45 Upon neural induction(5,6), neural ectoderm folds into a mill

46 teristics, the FGF signaling blockade during neural induction also directs a midbrain fate in the ant

47 ount for previous reports implicating PKC in neural induction and allow us to propose a link between

48 signaling mechanisms that are important for neural induction and anterior-posterior neural patternin

49 rk has led to contradictory roles for FGF in neural induction and anteroposterior neural patterning.

50 rio) embryogenesis with which we demonstrate neural induction and anteroposterior patterning.

51 Here, we show that neural induction and caudalization of hPSCs can be accel

52 tensive dorsal-ventral (D-V) patterning, and neural induction and D-V patterning may share common mol

53 ng differential roles of Htt and mHtt during neural induction and early neurogenesis using an in vitr

54 rning the necessity of the shield region for neural induction and embryonic patterning after the form

55 coding for transcription factors involved in neural induction and forebrain development, and the abil

56 This is called neural induction and has generally been imagined as a si

57 nes and regulatory elements that orchestrate neural induction and illuminate temporal frameworks duri

58 ecent studies have identified impairments in neural induction and in striatal and cortical neurogenes

59 before the onset of zygotic transcription or neural induction and may bias the field of cells that ca

60 Neural induction and mesoderm dorsalization are antagoni

61 during NSC specification is dispensable for neural induction and neuronal differentiation but critic

62 neurons using a monolayer-based culture for neural induction and neurosphere-based culture for neura

63 on and is required in the eye field for both neural induction and normal eye formation in Xenopus lae

64 loped an improved model system for analyzing neural induction and patterning using transverse blastod

65 n, two types of molecules proposed as key to neural induction and patterning, bone morphogenetic prot

66 equivalent of the AVE) in the early steps of neural induction and patterning.

67 t in both mesoderm and neurectoderm and that neural induction and posteriorization represent separabl

68 tissue formation and, strikingly, initiates neural induction and primary neurogenesis in the entire

69 ensory organs requires precise regulation of neural induction and repression.

70 Furthermore, left-right axis determination, neural induction and somite formation also display dynam

71 ggest that Cerr1 may play a role in anterior neural induction and somite formation during mouse devel

72 is an important biophysical cue influencing neural induction and subtype specification, and that mic

73 uously that the organizer is responsible for neural induction and that it dorsalizes the mesoderm.

74 ed to debate regarding both the mechanism of neural induction and the appropriateness of animal caps

75 aling during gastrulation, thereby promoting neural induction and the development of anterior structu

76 ily, whose diverse functions include primary neural induction and the dorsoventral patterning of the

77 ation protocol relies on SMAD inhibition for neural induction and the use of FGF2 and EGF for prolife

78 From the time of their specification during neural induction and throughout the building of the nerv

79 2 is first detected at the earliest steps of neural induction and thus is among the earliest human em

80 P-type ligands act as morphogens to suppress neural induction and to specify the formation of dorsal

81 model difficult-to-study processes (such as neural induction); and (d) identify putatively functiona

82 netic basis of rostral-caudal specification, neural induction, and head development require knowledge

83 ty in establishing dorso-ventral patterning, neural induction, and the neural crest.

84 f neural development and function, including neural induction, anteroposterior and dorsoventral regio

85 uced, suggesting that anterior and posterior neural induction are separable events.

86 d follistatin, all of which are critical for neural induction, are at near normal levels.

87 ate neurogenesis on its own, is required for neural induction as well as for posteriorization.

88 g ERNI as a marker, we present evidence that neural induction begins before gastrulation--much earlie

89 essor, we find that SMARCB1 is essential for neural induction but dispensable for mesodermal or endod

90 ies of IGF, FGF, and BMP signals not only in neural induction, but also in other aspects of vertebrat

91 the Eh-1 motif; FoxD4/5 accomplishes ectopic neural induction by both activating neural precursor gen

92 Here, we show that neural induction by forskolin and IBMX is dependent on d

93 acquire stable neural characteristics during neural induction by going through a hierarchy of states:

94 boz promotes neural induction by positively regulating organizer-deri

95 esting that Ca(2+)/CaMKII signaling promotes neural induction by preventing the alternative epidermal

96 Since the discovery of the phenomenon of neural induction by Spemann and Mangold in 1924, conside

97 Neural induction by Syn4 through the PKC pathway require

98 of mesoderm formation and DN-IGFR inhibited neural induction by the BMP antagonist Chordin.

99 chick embryo loses its ability to respond to neural induction by the organizer (Hensen's node) betwee

100 s the earliest demonstration of regionalized neural induction by the Xenopus organizer.

101 Neural induction can be considered as the dorsalization

102 alpha1-PDX-mediated neural induction can be reversed by co-expression of dow

103 lated and how they relate to the rest of the neural induction cascade is unknown.

104 ous aspects of neural development, including neural induction, CNS patterning and neurogenesis.

105 This neural induction correlates with the expression of chord

106 The ability of activated Smad2 to block neural induction declines by the end of gastrulation.

107 The neural induction defect was correlated with decreased ch

108 The response to neural induction depends on the presence of inducing sig

109 nimal caps by the shield, demonstrating that neural induction did not require co-induction of mesoder

110 fore being exposed to media formulations for neural induction, differentiation and maturation.

111 xpression, while knockdown of Oct91 inhibits neural induction driven by either Sox2 or Sox3.

112 Neural patterning occurs soon after neural induction during early development.

113 zinc-containing protein that is involved in neural induction during embryogenesis.

114 letion of cyclin D1 from the EVs reduced the neural induction effect.

115 This review summarizes neural induction events in different species and highlig

116 Although Noggin has been implicated in neural induction, examination of null mutants in the mou

117 cantly higher in Tlx3-expressing cells after neural induction for 4 days compared with those in cells

118 Using neural induction from human pluripotent stem cells (hPSC

119 ntiation platforms were established to model neural induction from stem cells, and we characterized t

120 Previous studies on neural induction have identified regionally localized in

121 te the signaling pathways that contribute to neural induction have remained unclear.

122 tively active form of Notch, a suppressor of neural induction, impairs the normal hyperpolarization p

123 , chordin, in primitive streak formation and neural induction in amniote embryos.

124 pathway, a central player in the process of neural induction in amniotes.

125 was restricted to an early time period after neural induction in culture, with peak CPEC competency c

126 t BMP inhibition is a sufficient trigger for neural induction in different vertebrates.

127 ventral side of intact embryos and to direct neural induction in ectodermal explants.

128 response to planar inductive signals during neural induction in explants.

129 usly unknown molecular mechanisms underlying neural induction in humans.

130 tion during gastrulation is insufficient for neural induction in intact embryos, arguing against a BM

131 s with secondary ectopic heads and to direct neural induction in intact explants.

132 of BMP signalling has a central role during neural induction in mammals and suggest that FGFs do not

133 We conclude that neural induction in the absence of organizer in A. macul

134 st that BMP inhibition is not sufficient for neural induction in the chick embryo.

135 netic protein (BMP) pathway is essential for neural induction in the developing embryo.

136 tes may provide an improved understanding of neural induction in the early embryo.

137 odel is very similar to the default model of neural induction in the frog, thus bridging the evolutio

138 analyze classic and cutting-edge findings on neural induction in the mouse.

139 ttle is known about the signals required for neural induction in the mouse.

140 s retinoic acid; second, eve1 is involved in neural induction in the posterior ectoderm by attenuatin

141 ests that many of the same signals affecting neural induction in vertebrate embryos also regulate emb

142 criptional control of gene expression during neural induction in vertebrates and present a model wher

143 at is an early and highly specific marker of neural induction in vertebrates.

144 Insights into neural induction in vivo help to guide paradigms for pro

145 nclude that BMP inhibition is sufficient for neural induction in vivo, and that in the absence of ven

146 ion similar to some of those observed during neural induction in vivo.

147 Here, we examine neural induction in Xenopus embryos in which mesoderm in

148 A growing body of evidence suggests that neural induction in Xenopus proceeds as the default in t

149 be both required and sufficient for anterior neural induction in Xenopus.

150 Here we describe a new role for Syn4 in neural induction in Xenopus.

151 find that cx35b is expressed at the time of neural induction, indicating a possible early role in ne

152 nt model of taste-bud development was one of neural induction: ingrowing sensory fibers were thought

153 We propose that neural induction involves additional signalling events t

154 role of fibroblast growth factors (FGFs) in neural induction is controversial [1,2].

155 We find that neural induction is dependent on the Ca(2+)-activated ph

156 ve FGF receptor in chd-injected animal caps, neural induction is inhibited and most of the explant is

157 relevance of intracellular BMP inhibitors in neural induction is not clear.

158 , and show that the competence to respond to neural induction is not entirely autonomous to the respo

159 One of the earliest manifestations of neural induction is onset of expression of the neural ma

160 A dominant molecular explanation for neural induction is the 'default model', which proposes

161 hanism involved in both in vivo and in vitro neural induction is the inhibition of bone morphogenetic

162 m that are largely inseparable from those of neural induction itself.

163 rajectories and genetic programs involved in neural induction, lateral plate mesoderm differentiation

164 nhibition of BMP signaling is sufficient for neural induction, leading to the idea that neural fate i

165 A growing body of work indicates that neural induction may be initiated prior to the establish

166 strated a role for beta-Catenin signaling in neural induction mediated by the transcriptional down-re

167 3 were grown in the presence or absence of a neural induction medium.

168 ition, several genes expressed shortly after neural induction (N-CAM, nrp1, and Xanf1) are not pertur

169 The detection of PCD during neural induction, neural plate patterning, and later dur

170 However, neural induction now appears to be more complex than onc

171 This default type of neural induction occurs in the absence of Spemann's orga

172 to address the potential involvement during neural induction of genes identified in the array, we pe

173 overexpressing cyclin D1 are more potent in neural induction of mESC cells.

174 d from in vitro differentiated cells promote neural induction of mESCs.

175 The initial differentiation and neural induction of the neurosphere occurred within the

176 ifferentiation of the neural tissues but not neural induction or determination through its effect on

177 enopus, loss of Brg1 function did not affect neural induction or neural cell fate determination.

178 erm formation and also activates the default neural induction pathway.

179 ng of the pre-gastrula embryo and subsequent neural induction post-gastrulation are very complex and

180 The default model for neural induction postulates that neural fate specificati

181 Current neural induction protocols for human embryonic stem (hES

182 tion, which ventralizes embryos and inhibits neural induction, reduced the expression of PACAP and PA

183 -patterned explants, and the extent to which neural induction requires FGF signaling.

184 Vertebrate neural induction requires inhibition of bone morphogenet

185 Neural induction results from the combined inhibition of

186 Noggin/SB431542-based neural induction should facilitate the use of hES and hi

187 plants, which rely on endogenous factors for neural induction, similar increases in En-2 are observed

188 mediated Xnr3 and siamois induction, but not neural induction, suggesting an alternative mechanism fo

189 ely, dnTCF blocks both Wnt-mediated Xnr3 and neural induction, suggesting that both pathways require

190 2 and constructs that overcome repression of neural induction (tBMP-4R, lim-m3 and Xbra delta 304).

191 on in Xenopus laevis Although sufficient for neural induction, Tbx3-expressing pluripotent cells only

192 During neural induction, the 'organizer' of the vertebrate embr

193 During neural induction, the embryonic neural plate is specifie

194 GF signalling underlies a specific aspect of neural induction, the initiation of the programme that l

195 of progressive tissue specification in which neural induction then Otx2-driven neural patterning prim

196 During the first week of neural induction, these ES-NPCs begin to express genes t

197 iminates self-regulation, causing ubiquitous neural induction throughout the ectoderm.

198 n our understanding of events that lead from neural induction to the generation of neurons within thr

199 We further demonstrate that neural induction triggers a switch from a poised to an a

200 The process of neural induction was discovered nearly 70 years ago in v

201 iven the essential roles of ZEBs and PAX6 in neural induction, we propose a model by which miR-200 an

202 These abnormalities in neural induction were associated with differential alter

203 more, neither BMP-4 nor BMP-7 interfere with neural induction when misexpressed in the presumptive ne

204 At 7 days after neural induction, whereas expression of the proneural ge

205 that Htt is required for multiple stages of neural induction, whereas mHtt enhances this process and

206 evelopment of the nervous system begins with neural induction, which is controlled by complex signali

207 tted to neural fate through a process called neural induction, which may involve proteins that antago

208 ecular explanation is the 'default model' of neural induction, which proposes that ectodermal cells g

209 After neural induction with retinoic acid, the majority of cel

210 vation has been proposed to be necessary for neural induction, yet N17Ras inhibits the phosphorylatio