ライフサイエンスコーパス: neural plate

1 opulations, such as the neural crest and the neural plate.

2 I dependent internalisation of the zebrafish neural plate.

3 s that arise at the border of the vertebrate neural plate.

4 ical epithelial organisation - the zebrafish neural plate.

5 lial character prior to other regions of the neural plate.

6 promote the transition to a differentiating neural plate.

7 sly proposed role in patterning the anterior neural plate.

8 superficial and deep layers of the anterior neural plate.

9 elated with the BMP activity gradient in the neural plate.

10 n the prospective eye fields in the anterior neural plate.

11 between their homologues in the Xenopus open neural plate.

12 cal constriction during morphogenesis of the neural plate.

13 l constriction and subsequent bending of the neural plate.

14 h superficial and deep layers of the Xenopus neural plate.

15 y been implicated in posteriorization of the neural plate.

16 ting to the medial-lateral patterning of the neural plate.

17 n arrest of cell convergence in the anterior neural plate.

18 orsal ectoderm and becomes restricted to the neural plate.

19 acode that arises at the anterior end of the neural plate.

20 organization similar to that of the chordate neural plate.

21 nate from the lateral border of the anterior neural plate.

22 is found as a radial gradient in the forming neural plate.

23 icroinjected into the precardiac mesoderm or neural plate.

24 together with the hindbrain, from the caudal neural plate.

25 ical surface of the lulu mutant epiblast and neural plate.

26 ngle eye anlage is specified in the anterior neural plate.

27 s from a single contiguous domain within the neural plate.

28 g of cells between the notoplate and lateral neural plate.

29 ral and definitive endoderm and the cephalic neural plate.

30 l crest induction, and A-P patterning of the neural plate.

31 al intercalation in the medial region of the neural plate.

32 se as a result of patterning of the anterior neural plate.

33 tions in the apical and basal domains of the neural plate.

34 ise from a zone of ectoderm that borders the neural plate.

35 artially redundant functions in the anterior neural plate.

36 sis, we examined its function in the Xenopus neural plate.

37 iation and morphogenesis of the mesoderm and neural plate.

38 ral crest and epidermis and expansion of the neural plate.

39 ipheral nervous systems (PNS) arise from the neural plate.

40 ional Wnt/Fgf/RA signals to posteriorize the neural plate.

41 t reduction in tubulin polymerization in the neural plate.

42 concomitant lengthening and narrowing of the neural plate, a morphogenetic process defined as converg

43 and LPGDS induction by Zic1 at the anterior neural plate allows for the localized production and tra

44 Dorsolateral bending of the neural plate, an undifferentiated pseudostratified epith

45 the chick, Miz1 is expressed throughout the neural plate and closing neural tube.

46 ntagonists are required for formation of the neural plate and dorsal mesoderm.

47 ral crest cells arise from the border of the neural plate and epidermal ectoderm, migrate extensively

48 It is known the interactions between the neural plate and epidermis generate neural crest (NC), b

49 cells originate along the border between the neural plate and epidermis, migrate extensively and gene

50 stabilization of planar cell packing in the neural plate and for the formation of stable apical-basa

51 for the expression of neural markers in the neural plate and in neuralised animal caps.

52 erfamily, which is expressed in the anterior neural plate and is required for brain morphogenesis.

53 mblastoporal ring, then later throughout the neural plate and its border, and subsequently in the mid

54 from a common preplacodal domain around the neural plate and its development is directed by signals

55 ole during regionalisation of the vertebrate neural plate and its inhibition in the most anterior neu

56 C were present on the lateral margins of the neural plate and later became localized adjacent to the

57 Lrig3 was expressed in the neural plate and neural crest (NC) at neurula stages, an

58 replacodal gene expression, while repressing neural plate and neural crest fates.

59 xpression of MIM is enriched in the anterior neural plate and neural folds, and depletion of MIM spec

60 t mediate cell adhesion within the embryonic neural plate and neural folds.

61 bryos generate the border region between the neural plate and non-neural ectoderm from which multiple

62 C develops only at the lateral border of the neural plate and not in the anterior fold.

63 ibited mainly wild-type cells in the midline neural plate and notochordal plate, consistent with a ce

64 arly expression in the anterior endoderm and neural plate and regulatory elements in the 3' region ar

65 f the regulatory network specifying anterior neural plate and retina.

66 system have different embryonic origins, the neural plate and sensory placodes.

67 jor components of the body plan, such as the neural plate and somites.

68 ogeny from the superficial epithelium of the neural plate and that these deep cells have a correspond

69 eural crest arises at the border between the neural plate and the adjacent non-neural ectoderm.

70 n ectodermal domain adjacent to the anterior neural plate, and a number of genes have been recently i

71 r the neural crest that lies adjacent to the neural plate, and a precursor field for the placodes, ca

72 ly twice as stiff as either the notochord or neural plate, and at least 10-fold stiffer than the endo

73 is expressed in the gastrula marginal zone, neural plate, and cranial and trunk neural crest.

74 forms at the border surrounding the anterior neural plate, and expresses a unique set of evolutionari

75 signals interferes with the induction of the neural plate, and this activity can be separated experim

76 Thus, like in the neural plate antagonistic interaction between Otx2 and G

77 y during gastrulation and well before proper neural plate appearance.

78 efects in both the lulu primitive streak and neural plate are associated with disruption of the norma

79 te as well as apical constriction within the neural plate are perturbed in Xena knockdown embryos.

80 it is coupled to the emergence of the dorsal neural plate are unknown.

81 Changes in the shape of the neural plate as well as apical constriction within the n

82 means, dramatically expanded the size of the neural plate, as evidenced by the increased expression o

83 rsely, stimulation of Smad2 signaling in the neural plate at gastrula stages results in inhibition of

84 ctive midbrain-hindbrain border (MHB) in the neural plate at the end of gastrulation.

85 , results in the same phenotype: an expanded neural plate at the expense of epidermis and delayed neu

86 Sox8 accumulates at the lateral edges of the neural plate at the mid-gastrula stage; in contrast to i

87 ation of the biomechanical properties of the neural plate at the tissue-level.

88 then turned off in the dorsal ectoderm, the neural plate, at the neurula stage.

89 are specified at the lateral borders of the neural plate before delaminating, migrating and differen

90 erally symmetric distribution in the Xenopus neural plate, being enriched at medial apical cell junct

91 oepithelial cells, and that ultimately drive neural plate bending, whereas in the deep neural cells m

92 tion of neuroepithelial cells and subsequent neural plate bending.

93 mbryonic brain and spinal cord begins as the neural plate bends to form the neural folds, which meet

94 ble to promote the expression of a subset of neural plate border (NPB) makers without the presence of

95 NC cells arise during gastrulation at the neural plate border (NPB), which is later elevated as th

96 central nervous system, a domain called the neural plate border (NPB).

97 NC and placodes form at the neural plate border (NPB).

98 neural crest development takes place at the neural plate border and consists in the induction of Pax

99 nts contain cells fated to contribute to the neural plate border and even to the anterior neural plat

100 animal hemisphere at blastula stages and the neural plate border and neural crest at neurula stages.

101 precursor survival, leading to reduction of neural plate border and neural crest specifier genes Msx

102 The neural plate border and RBs were induced at the transpla

103 s of genomic regions during induction of the neural plate border and specification of neural crest ce

104 the cranial neural crest (CNC) forms at the neural plate border and subsequently migrates and differ

105 Notch in the regulation of cell fate at the neural plate border and that Notch regulates the total n

106 inductive roles of FGF, Wnt, and BMP at the neural plate border are well established, but the signal

107 Arising from the neural plate border at the intersection of Wnt and Bmp s

108 tent precursor cells that are induced at the neural plate border by a series of complex signaling and

109 Neural crest cells are induced at the neural plate border by the combined action of transcript

110 ory state upstream of multiple, pre-existing neural plate border cell differentiation programs.

111 s an integral role in the development of the neural plate border cell fates, including neural crest c

112 chordates (cephalochordates and tunicates), neural plate border cells express conserved factors such

113 However, invertebrate neural plate border cells have not been shown to generat

114 ar tail neuron precursors derive from caudal neural plate border cells, delaminate and migrate along

115 in the absence of further signals develop as neural plate border derivatives and eventually express l

116 signaling and suggest a later involvement in neural plate border development, likely due to widesprea

117 evel of BMP4 signaling is required to induce neural plate border fates, we directly tested BMP4's abi

118 and NSD3 is necessary for expression of the neural plate border gene Msx1, as well as the key neural

119 evaluated the effects of knocking down known neural plate border genes and early neural crest specifi

120 xogenous BMP affects expression of amphioxus neural plate border genes as in vertebrates, suggesting

121 Furthermore, it physically interacts with neural plate border genes Pax7 and Msx1 in vivo to direc

122 results putatively place Elk3 downstream of neural plate border genes, but upstream of neural crest

123 In Xenopus, the neural plate border gives rise to at least three cell po

124 stem cell-like progenitors that arise at the neural plate border in vertebrates and migrate extensive

125 stem cell-like progenitors that arise at the neural plate border in vertebrates, migrate extensively,

126 2A/C heterodimers activate components of the neural plate border induction program.

127 e that the control of Sox8 expression at the neural plate border is a key process in initiating neura

128 ith dynamic confocal imaging reveal that the neural plate border is considerably broader and extends

129 t acquisition of AmphiSoxE expression in the neural plate border led to NCC emergence while duplicati

130 ound the neural plate, overriding the normal neural plate border limit of the early neural crest terr

131 BMP antagonists can induce neural plate border markers in both ventral Xenopus epid

132 is of transcription factor expression in the neural plate border of chick embryos.

133 est induction rather than general defects in neural plate border or dorso-ventral patterning.

134 xpression shows that early inducing signals, neural plate border patterning genes, and melanocyte dif

135 ebrate-specific elaborations on an ancestral neural plate border program, through acquisition of migr

136 lamprey AP-2 appears to function early as a neural plate border rather than a neural crest specifier

137 Further, the complexity of neural plate border specification has made it difficult

138 rparts of these genes function downstream of neural plate border specification in the regulatory netw

139 uggesting that conserved signals specify the neural plate border throughout chordates.

140 b transcription factors are expressed at the neural plate border where they play partially redundant

141 The 'neural plate border' of vertebrate embryos contains prec

142 DNMT3A is expressed in the neural plate border, and its knockdown causes ectopic So

143 development to regulate specification at the neural plate border, and subsequent emigration from the

144 ion, neural crest cells are specified at the neural plate border, as characterized by Pax7 expression

145 Neural crest arises at the neural plate border, expresses a core set of regulatory

146 At the neural plate border, Hmga1 regulates Pax7-dependent neur

147 affecting cell death or proliferation at the neural plate border, prdm1a acts explicitly on cell fate

148 es of transcription factors expressed at the neural plate border, Sox proteins have been shown to reg

149 e neural crest migrates from its origin, the neural plate border, to form diverse derivatives.

150 are multipotent progenitors that form at the neural plate border, undergo epithelial-mesenchymal tran

151 To establish regulatory relationships at the neural plate border, we assess relative expression of 6

152 zic2b influences the induction of NC at the neural plate border, while both zic2a and zic2b regulate

153 , suggesting a permissive role for prdm1a in neural plate border-derived cell fates.

154 Despite prominent expression in other neural plate border-derived cranial and sensory domains,

155 the earliest genes activated in response to neural plate border-inducing signals.

156 functional, direct targets of Prdm1a at the neural plate border.

157 ork that controls cell fate decisions at the neural plate border.

158 erm are specified in adjacent domains at the neural plate border.

159 l crest specifiers, foxd3 and tfap2a, at the neural plate border.

160 crest induction in neuralized tissues or the neural plate border.

161 + cells, disrupting the SoxB1 balance at the neural plate border.

162 ads to loss of NC precursor formation at the neural plate border.

163 the total number of progenitor cells at the neural plate border.

164 within a pre-placodal domain at the cranial neural plate border.

165 anisms regulating cell fate decisions at the neural plate border.

166 ent progenitors that arise at the vertebrate neural plate border.

167 ity evolves into two distinct domains at the neural plate border: one coinciding with the neural cres

168 We propose that the neural plate borders of the chordate ancestor already pr

169 rate embryos within a discrete domain at the neural plate boundary and eventually gives rise to a mig

170 During embryogenesis, CNC is induced at the neural plate boundary through the interplay of several m

171 encroaches anteriorly into node ectoderm and neural plate, but its expression in presomitic mesoderm

172 rest is induced at the lateral border of the neural plate by the combined action of signaling molecul

173 ck, however, only cells at the border of the neural plate can be neuralized by BMP inhibition.

174 Tumorhead (TH) regulates neural plate cell proliferation during Xenopus early dev

175 a conventional epithelium, medially located neural plate cells adopt strategies typical of epithelia

176 Folr1-deficient neural plate cells fail to constrict, resulting in widen

177 Folr1 knockdown in neural plate cells only is necessary and sufficient to i

178 ith the frimousse mutation, the anteriormost neural plate cells, which are products of an FGF inducti

179 ors to neural progenitors to differentiating neural plate cells.

180 y observed longer range induction in lateral neural plate cells.

181 dynamic in early vertebrate embryos and that neural-plate cells contain less PRC1 than do epidermal c

182 ne (frimousse) with a profound disruption in neural plate development.

183 teral cell intercalation, and bending of the neural plate driven largely by cellular apical constrict

184 rc expression is highly enriched in the open neural plate during neurula stages and in the neural tis

185 the complex reorganisation of the forebrain neural plate during neurulation, which must fold a sheet

186 ve eyes and adjacent regions of the anterior neural plate during the early stages of forebrain morpho

187 nchyme determinants, such as Twist, into the neural plate ectoderm was crucial to the emergence of th

188 to the blastopore, which are fated to become neural plate ectoderm, are polarized and have straight b

189 TH gain of function phenotype and results in neural plate expansion and inhibition of neuronal differ

190 neural plate border and even to the anterior neural plate, explaining why they are so easily neuraliz

191 polarity (PCP) signalling, was necessary for neural plate folding and was accompanied by the polariza

192 ling and cytoskeletal dynamics necessary for neural plate folding.

193 tone H2AX (XH2AX) has a role in the anterior neural plate for eye field formation during Xenopus embr

194 pressor that is required within the anterior neural plate for normal forebrain development in mouse a

195 It is also required in the anterior neural plate for the development of the mammalian rostra

196 al plate specifiers Geminin and Sox2 and for neural plate formation.

197 RB sensory neurons, the medial region of the neural plate from donor Xenopus laevis embryos was trans

198 preventing the posterior-most region of the neural plate from following a hindbrain developmental pr

199 Cells at the margin of the neural plate give rise to neural crest cells, which migr

200 The mouse posterior primitive streak at neural plate/headfold stages (NP/HF, ~7.5 dpc-8 dpc) rep

201 d to disrupt the development of the anterior neural plate in a similar way to the frimousse mutation.

202 t is transiently expressed in the developing neural plate in a temporal window corresponding to the p

203 tebrate eye formation begins in the anterior neural plate in the eye field.

204 demonstrate that neurogenesis in the Xenopus neural plate in vivo and mammalian neural progenitors in

205 calcium transients throughout the developing neural plate in wild-type embryos, but not in mutant emb

206 Notum is expressed in naive ectoderm and neural plate in Xenopus and is required for neural and h

207 ntercalation and convergent extension of the neural plate in Xenopus.

208 terning of highly dynamic tissue such as the neural plate in zebrafish.

209 sistance to deformation ("stiffness") in the neural plate, indicating that the cytoskeleton-organizin

210 ox2 promoter and N-1 enhancer at the time of neural plate induction.

211 moter of the Sox2 locus before and after the neural plate induction.

212 cell behaviors necessary for converting the neural plate into a neural tube.

213 extensive cell movements transform the flat neural plate into the neural tube.

214 The rest of the neural plate invaginates to form the neural tube, which

215 The mouse neural plate is a cuboidal epithelium that remodels into

216 Contrary to previous reports, the zebrafish neural plate is a multi-layered structure, composed of d

217 The mouse neural plate is a simple epithelium that is transformed

218 cified but does not form a gut tube, and the neural plate is broad and forms ectopic folds rather tha

219 This ensures that the neural plate is flexible enough to be focally bent and s

220 l classes of mesoderm are specified, and the neural plate is formed.

221 ption factor Zic1, expressed at the anterior neural plate, is necessary and sufficient to promote pla

222 e embryo and is rapidly downregulated in the neural plate, its role in neural and epidermal gene expr

223 On the basal side of the neural plate, loss of CFL1 has the opposite effect on my

224 enesis as well as expression of intermediate neural plate markers.

225 l to constrict, resulting in widening of the neural plate midline and defective neural tube closure.

226 Extension of the somites and neural plate mirrors that of the notochord in these embr

227 calised internalisation events and defective neural plate morphogenesis.

228 ll shape change and is required for lens and neural plate morphogenesis.

229 e essential for neural crest development and neural plate morphogenesis.

230 reveal a novel role for Smurf1 and Smad1 in neural plate morphogenesis.

231 rm is patterned into lineage progenitors for neural plate, neural crest, placodes and epidermis.

232 For most of the neural plate-neural tube transition, cells are polarized

233 proximity to each other at the border of the neural plate: neural crest precursors abut the future ce

234 ressed early in a large region of the medial neural plate, Nkx6.1 is restricted to a region overlappi

235 Wnt signals from the neural plate, non-neural ectoderm and paraxial mesoderm

236 esis are the node ectoderm and the posterior neural plate, not the presomitic mesoderm.

237 ry2a and Dlx5, compared to the expression of neural plate (NP) and NC genes.

238 end we tested the ability of segments of the neural plate (NP), isolated from different axial levels,

239 mechanisms: (1) convergent extension in the neural plate (NP); (2) cell wedging along the anterior N

240 a enhancer, which mediates expression in the neural plate of Ciona embryos in response to fibroblast

241 ne DMRT is expressed throughout the anterior neural plate of neurulating embryos.

242 disorders, is expressed specifically in the neural plate of Xenopus laevis embryos to trigger a G pr

243 Transcripts for lpar6 are enriched in the neural plate of Xenopus neurulae and loss of function ca

244 ral marker Sox2 or the formation of a mature neural plate or a forebrain, suggesting that the hypobla

245 rm a continuous trail connecting them to the neural plate or its border, suggesting that homeogenetic

246 are co-expressed in lateral ectoderm, medial neural plate or posterior-lateral mesoderm, Pax7 early e

247 direct cells to form central nervous system (neural plate) or sensory placodes.

248 ing the anterior posterior patterning of the neural plate, or placodal specification.

249 o ectopically induce neural crest around the neural plate, overriding the normal neural plate border

250 scription factors that control neurogenesis, neural plate patterning, and neuronal differentiation.

251 neural ectodermal population to a committed neural plate population poised to begin differentiation.

252 ow that FGF/MAPK activity in the prospective neural plate prevents the ectopic expression of lateral

253 In vertebrates, specification of the neural plate requires repression of bone morphogenetic p

254 ormation of mesendodermal precursors and the neural plate, respectively.

255 ranscription in the primitive streak and the neural plate, respectively.

256 In the absence of Cdx function, the caudal neural plate retains hindbrain characteristics and remai

257 of a GFP expression vector into the midline neural plate, revealed defective convergent extension in

258 stula and gastrula stages, initially express neural plate-specific genes but fail to maintain the ind

259 t forms by internalization of the ectodermal neural plate specified via inhibition of BMP signaling d

260 lfacilitin is required for expression of the neural plate specifiers Geminin and Sox2 and for neural

261 in the ventral telencephalon from the early neural plate stage and functionally cooperates with FoxG

262 eneral functions for beta-catenin beyond the neural plate stage during brain development and a partic

263 be derived from human and mouse ESCs or from neural plate stage embryos.

264 ntrast, activation of Notch signaling at the neural plate stage produces excess KA' interneurons and

265 Our data reveal that Gli3 is required at the neural plate stage to regulate Wnt expression and Wnt/be

266 Fate mapping at the open neural plate stage was carried out using orthotopic graf

267 tor cells (NPCs) specified as neurons at the neural plate stage, it delays their delamination and dif

268 ned by the mid-gastrula stage but are by the neural plate stage.

269 not mediated through genetic compensation at neural plate stage; instead, the smaller optic vesicle o

270 aspect of the central nervous system at open neural plate stages in Xenopus.

271 At neural plate stages most of these genes remain reduced,

272 astomeres suppressed hnRNP K expression from neural plate stages through to at least stage 40.

273 ls/activity of each protein at two different neural plate stages.

274 This process is initiated from a neural plate that has a distinct organization compared t

275 lops its central nervous system (CNS) from a neural plate that is homologous to that of vertebrates,

276 canonical BMP activity gradient in the chick neural plate that results in low and temporally pulsed B

277 ion of rostroventral markers of the anterior neural plate that will give rise to the basal forebrain.

278 d Wnt8b at the lateral edges of the anterior neural plate that will give rise to the pallium.

279 Second, the axial regionalization of the neural plate that will result in the specification of ne

280 m on the overlying ectoderm that generates a neural plate that, after rolling into a neural tube, act

281 cation in the ectoderm, at the border of the neural plate, the neural crest (NC) population leaves it

282 ll survival and proliferation throughout the neural plate, the neural progenitor marker Sox2 was unaf

283 rom a common precursor field anterior to the neural plate, the pre-placodal region (PPR).

284 vergent extension in the mouse notochord and neural plate, the results indicate that chato regulates

285 ion factors Tfap2a and Tfap2c in the lateral neural plate, thereby specifying neural crest fate.

286 vitro by adding soluble Wnt to intermediate neural plate tissue cultured in collagen, and induced ve

287 Conversely, RBs fail to form when neural plate tissue from embryos with decreased BMP acti

288 conferring resistance to deformation to the neural plate tissue.

289 10 ng/ml were able to induce RBs in cultured neural plate tissue.

290 be defects (NTDs) represent a failure of the neural plate to complete the developmental transition to

291 trict six3b expression, and later within the neural plate to for attenuation of rx3 expression indepe

292 ier genes are not expressed at the amphioxus neural plate/tube border, raising the intriguing possibi

293 tively abolish FGF signaling in the anterior neural plate via deletion of three FGF receptor (FGFR) g

294 stages in an intermediate region of the open neural plate where primary interneurons form.

295 different responses: Hensen's node induces a neural plate whereas the head mesoderm induces placodes.

296 ion from XTRPM7 in the region lateral to the neural plate, whereas XTRPM7 is mainly involved in regul

297 e, we examine the patterning of the anterior neural plate, which produces placodal derivatives such a

298 ganizer and its derivatives have endowed the neural plate with a coarse pattern along its anteroposte

299 sufficient to induce posterior fates in the neural plate, yet a mechanistic understanding of the pro

300 issue constriction in the caudal and ventral neural plate zone.