ライフサイエンスコーパス: neural plate border

1 d a multipotent progenitor population at the neural plate border.

2 ural crest gene expression is induced at the neural plate border.

3 functional, direct targets of Prdm1a at the neural plate border.

4 ork that controls cell fate decisions at the neural plate border.

5 erm are specified in adjacent domains at the neural plate border.

6 l crest specifiers, foxd3 and tfap2a, at the neural plate border.

7 crest induction in neuralized tissues or the neural plate border.

8 ads to loss of NC precursor formation at the neural plate border.

9 the total number of progenitor cells at the neural plate border.

10 + cells, disrupting the SoxB1 balance at the neural plate border.

11 within a pre-placodal domain at the cranial neural plate border.

12 anisms regulating cell fate decisions at the neural plate border.

13 ent progenitors that arise at the vertebrate neural plate border.

14 ired for the generation of cell fates at the neural plate border.

15 babilistic model for cell fate choice at the neural plate border.

16 plate, while it is strongly activated at the neural plate border, a region which is populated by cell

17 We find that neural plate border and adjacent cells are characterised

18 neural crest development takes place at the neural plate border and consists in the induction of Pax

19 k if cephalochordates deploy Id genes at the neural plate border and dorsal neural tube in a manner s

20 s and vertebrates, expression in the lateral neural plate border and dorsal neural tube is a vertebra

21 nts contain cells fated to contribute to the neural plate border and even to the anterior neural plat

22 animal hemisphere at blastula stages and the neural plate border and neural crest at neurula stages.

23 r klf17 expanded expression of pluripotency, neural plate border and neural crest factors in neurula

24 precursor survival, leading to reduction of neural plate border and neural crest specifier genes Msx

25 and in reprogrammed explants while expanding neural plate border and neural plate domains.

26 The neural plate border and RBs were induced at the transpla

27 s of genomic regions during induction of the neural plate border and specification of neural crest ce

28 the cranial neural crest (CNC) forms at the neural plate border and subsequently migrates and differ

29 Notch in the regulation of cell fate at the neural plate border and that Notch regulates the total n

30 DNMT3A is expressed in the neural plate border, and its knockdown causes ectopic So

31 development to regulate specification at the neural plate border, and subsequent emigration from the

32 tion of neural crest-specific factors at the neural plate border appears to be a vertebrate novelty.

33 inductive roles of FGF, Wnt, and BMP at the neural plate border are well established, but the signal

34 ine transcriptional changes in the emerging 'neural plate border' as well as other regions of the epi

35 ion, neural crest cells are specified at the neural plate border, as characterized by Pax7 expression

36 Foxi3 transcription factor, expressed in the neural plate border at the end of gastrulation, is neces

37 Arising from the neural plate border at the intersection of Wnt and Bmp s

38 tent precursor cells that are induced at the neural plate border by a series of complex signaling and

39 Neural crest cells are induced at the neural plate border by the combined action of transcript

40 ory state upstream of multiple, pre-existing neural plate border cell differentiation programs.

41 s an integral role in the development of the neural plate border cell fates, including neural crest c

42 By simultaneously knocking out Foxi3 in neural plate border cells and following their fates, we

43 chordates (cephalochordates and tunicates), neural plate border cells express conserved factors such

44 However, invertebrate neural plate border cells have not been shown to generat

45 ells and following their fates, we show that neural plate border cells lacking Foxi3 contribute to al

46 changes in chromatin accessibility as chick neural plate border cells segregate into neural, neural

47 ar tail neuron precursors derive from caudal neural plate border cells, delaminate and migrate along

48 in the absence of further signals develop as neural plate border derivatives and eventually express l

49 , suggesting a permissive role for prdm1a in neural plate border-derived cell fates.

50 Despite prominent expression in other neural plate border-derived cranial and sensory domains,

51 signaling and suggest a later involvement in neural plate border development, likely due to widesprea

52 These cells arise at the neural plate border during a time in development when pr

53 Id3 is localized at the neural plate border during gastrulation and neurulation,

54 Neural crest arises at the neural plate border, expresses a core set of regulatory

55 evel of BMP4 signaling is required to induce neural plate border fates, we directly tested BMP4's abi

56 that the contribution of dlx3b and dlx4b to neural plate border formation is partially non-cell-auto

57 and NSD3 is necessary for expression of the neural plate border gene Msx1, as well as the key neural

58 evaluated the effects of knocking down known neural plate border genes and early neural crest specifi

59 xogenous BMP affects expression of amphioxus neural plate border genes as in vertebrates, suggesting

60 Furthermore, it physically interacts with neural plate border genes Pax7 and Msx1 in vivo to direc

61 f Xash-3A may suppress further expression of neural plate border genes within the prospective neural

62 results putatively place Elk3 downstream of neural plate border genes, but upstream of neural crest

63 In Xenopus, the neural plate border gives rise to at least three cell po

64 At the neural plate border, Hmga1 regulates Pax7-dependent neur

65 g feature of vertebrate embryos, form at the neural plate border in response to inductive signals fro

66 Neural crest precursor cells arise at the neural plate border in response to inductive signals, bu

67 complex network of genes is activated at the neural plate border in response to neural crest-inducing

68 otent population of cells that arises at the neural plate border in the vertebrate embryo.

69 stem cell-like progenitors that arise at the neural plate border in vertebrates and migrate extensive

70 stem cell-like progenitors that arise at the neural plate border in vertebrates, migrate extensively,

71 the earliest genes activated in response to neural plate border-inducing signals.

72 2A/C heterodimers activate components of the neural plate border induction program.

73 ue to vertebrate embryos and emerge from the neural plate borders into multiple cell lineages that di

74 e that the control of Sox8 expression at the neural plate border is a key process in initiating neura

75 ith dynamic confocal imaging reveal that the neural plate border is considerably broader and extends

76 The vertebrate 'neural plate border' is a transient territory located at

77 t acquisition of AmphiSoxE expression in the neural plate border led to NCC emergence while duplicati

78 ound the neural plate, overriding the normal neural plate border limit of the early neural crest terr

79 ajectory analysis infers that segregation of neural plate border lineages only commences at early neu

80 BMP antagonists can induce neural plate border markers in both ventral Xenopus epid

81 ble to promote the expression of a subset of neural plate border (NPB) makers without the presence of

82 NC cells arise during gastrulation at the neural plate border (NPB), which is later elevated as th

83 on-neural ectodermal cell types, such as the neural plate border (NPB).

84 central nervous system, a domain called the neural plate border (NPB).

85 NC and placodes form at the neural plate border (NPB).

86 is of transcription factor expression in the neural plate border of chick embryos.

87 We propose that the neural plate borders of the chordate ancestor already pr

88 The 'neural plate border' of vertebrate embryos contains prec

89 ity evolves into two distinct domains at the neural plate border: one coinciding with the neural cres

90 est induction rather than general defects in neural plate border or dorso-ventral patterning.

91 xpression shows that early inducing signals, neural plate border patterning genes, and melanocyte dif

92 ovel properties upon the evolving vertebrate neural plate border, potentiating the evolution of defin

93 affecting cell death or proliferation at the neural plate border, prdm1a acts explicitly on cell fate

94 c-myc is localized at the neural plate border prior to the expression of early neu

95 ube and epidermis, and that Foxi3-expressing neural plate border progenitors contribute primarily to

96 ebrate-specific elaborations on an ancestral neural plate border program, through acquisition of migr

97 lamprey AP-2 appears to function early as a neural plate border rather than a neural crest specifier

98 The inductive signals at the neural plate border region are likely to involve a gradi

99 e of a preplacodal domain within the cranial neural plate border region.

100 ether, our results suggest that cells at the neural plate border remain heterogeneous until early neu

101 crest or placodal fates, revealing that the neural plate border should be seen as a heterogeneous ec

102 eveal gradual establishment of heterogeneous neural plate border signatures, including novel genes th

103 es of transcription factors expressed at the neural plate border, Sox proteins have been shown to reg

104 Further, the complexity of neural plate border specification has made it difficult

105 rparts of these genes function downstream of neural plate border specification in the regulatory netw

106 we find that genes previously classified as neural plate border 'specifiers' typically exhibit dynam

107 lly upregulates genes expressed early in the neural plate border such as Xsna, Xslu, Pax-3 and XANF a

108 uggesting that conserved signals specify the neural plate border throughout chordates.

109 trates that Foxi3 uniquely acts early at the neural plate border to restrict progenitors to a placoda

110 e neural crest migrates from its origin, the neural plate border, to form diverse derivatives.

111 We contrast Foxi3 with another neural plate border transcription factor, Zic5, the prog

112 are multipotent progenitors that form at the neural plate border, undergo epithelial-mesenchymal tran

113 To establish regulatory relationships at the neural plate border, we assess relative expression of 6

114 eural crest, with earliest expression at the neural plate border where neural crest is induced.

115 b transcription factors are expressed at the neural plate border where they play partially redundant

116 zic2b influences the induction of NC at the neural plate border, while both zic2a and zic2b regulate