ライフサイエンスコーパス: neural tube

1 tinct subpopulations within the chick dorsal neural tube.

2 aling-dependent tissues such as the limb and neural tube.

3 t are initially located at the border of the neural tube.

4 l cell types are not specified in the mutant neural tube.

5 r excitatory neuronal lineages in the dorsal neural tube.

6 istinct progenitor domains in the developing neural tube.

7 ar behaviors underlying morphogenesis of the neural tube.

8 the level from which cells emerge along the neural tube.

9 closure, axial turning and patterning of the neural tube.

10 movements underlying the organization of the neural tube.

11 resolution during morphogenesis of the mouse neural tube.

12 for dorsoventral patterning of the overlying neural tube.

13 es, often manifested in the palate, heart or neural tube.

14 on that stem from the cranial portion of the neural tube.

15 icular zone and floor plate of the embryonic neural tube.

16 rom later-differentiating neurons toward the neural tube.

17 planin, which is expressed on the developing neural tube.

18 al folds, which meet and adhere to close the neural tube.

19 o complete the developmental transition to a neural tube.

20 chanics, pattern formation and growth in the neural tube.

21 s and phagocytose cellular debris around the neural tube.

22 senchymal cells at the dorsal midline of the neural tube.

23 In the vertebrate neural tube, a morphogen-induced transcriptional network

24 Irf6 is also required for development of the neural tube and associated structures.

25 -migrating cells, originating from the trunk neural tube and associated with nerve fibres, differenti

26 results in severe patterning defects in the neural tube and defective Hedgehog signaling.

27 R-BI(-/-) embryos fail to close the anterior neural tube and develop exencephaly, a perinatal lethal

28 CEP120 morphants, cilia are shortened in the neural tube and disorganized in the pronephros.

29 defects leading to deformities of the limbs, neural tube and inner ear.

30 ), which is known to guide axons outside the neural tube and interneurons in the cortex, is expressed

31 sduction specifies ventral cell fates in the neural tube and is mediated by the Gli transcription fac

32 ng is antagonized by signals from the dorsal neural tube and loss of Hh leads to loss of ventral patt

33 he generation of motor neurons in both chick neural tube and mouse embryonic stem cells, suggesting t

34 way patterning the dorso-ventral axis of the neural tube and muscles, by controlling the degradation

35 nsion, resulting in compression of the axial neural tube and notochord; second, elongation of axial t

36 developing embryo and promote closing of the neural tube and other morphologic processes during devel

37 y symmetric interfaces between the zebrafish neural tube and paraxial mesoderm function as optimally

38 Ssdp2 (Ssdp1/2) are highly expressed in the neural tube and promote motor neuron differentiation in

39 ify the Shh gradient in the developing mouse neural tube and show that while the amplitude of the gra

40 11 are required for proper patterning of the neural tube and somites by regulating notochord formatio

41 trunk-like structures" (TLSs) comprising the neural tube and somites.

42 ate as a continuous mass of tissue along the neural tube and subsequently split into spatially distin

43 epithelial cells, as seen in the vertebrate neural tube and the Drosophila ventral furrow.

44 h temporal and spatial precision in both the neural tube and the embryo's enveloping layer epithelium

45 environmental barrier dorsal and lateral to neural tube and the somites that is normally formed by P

46 gical progression of MMC involves failure in neural tube and vertebral arch closure at early gestatio

47 ced the contribution of their progeny to the neural tube, and dramatically expanded the unsegmented m

48 asts differentiate in close contact with the neural tube, and they never loose contact with the neura

49 developing tissues in mice such as somites, neural tubes, and limb buds.

50 The Drosophila blastoderm and the vertebrate neural tube are archetypal examples of morphogen-pattern

51 Using the zebrafish neural tube as a model, we uncover the in vivo mechanism

52 nic hedgehog (Shh) patterning of the ventral neural tube as an example, we show that the framework ca

53 red in the carapacial staging area above the neural tube at G16, and differentiated into pigment-form

54 etween the different posterior tissues (e.g. neural tube, axial and paraxial mesoderm, lateral plate,

55 and thoracic regions of the developing mouse neural tube between embryonic days 9.5-13.5.

56 ed with a morphological change in the dorsal neural tube between stages mature G15 and G16.

57 and reduce the risk of folic acid-responsive neural tube birth defects (NTDs).

58 tify staple foods with folic acid to prevent neural tube birth defects.

59 ifferentiated peripheral sensory neurons and neural tube border cells with the cooperation of neural

60 d observed expression in the developing eye, neural tube, brain and kidney.

61 ially Sox2+ cells can contribute not only to neural tube but also to neural crest and epidermis.

62 er of neural crest cells arise from the head neural tube by epithelial-to-mesenchymal transition (EMT

63 DNA methylation in regulating the ability of neural tube cells to produce neural crest cells and the

64 terning process in the developing vertebrate neural tube (central nervous system, CNS), depends on So

65 eometry and packing that arise from the open neural tube characteristic of PCP mutants.

66 athway mediated by folate compromises normal neural tube closure (NTC) and ciliogenesis.

67 to regulate neural progenitor proliferation, neural tube closure and apical constriction.

68 K-AKT signaling and AJ biology, required for neural tube closure and CNCC delamination.

69 ts were embryonic lethal and showed impaired neural tube closure and CNCC delamination.

70 mmary, Myo10 is important for both prenatal (neural tube closure and digit formation) and postnatal d

71 croglia begin colonizing the forebrain after neural tube closure and during later stages of neurogene

72 evelopmental processes such as gastrulation, neural tube closure and hearing.

73 During neural tube closure and spinal cord development, many ce

74 he organization of the neural epithelium and neural tube closure are affected when actin dynamics are

75 However, the mechanisms of cranial neural tube closure are not well understood.

76 ocked, we examined the cellular basis of the neural tube closure defect in mouse mutants that lack th

77 of mutant embryos developed exencephalus, a neural tube closure defect.

78 n the organizer and along the axial midline, neural tube closure defects (NTDs) arose and dorsal exte

79 Folic acid prevents neural tube closure defects (NTDs), but the causal metab

80 Neural tube closure defects are a major cause of infant

81 w that a decrease in ephrinB2 protein causes neural tube closure defects during Xenopus laevis embryo

82 n lead to human congenital disorders such as neural tube closure defects.

83 lly results in early embryonic lethality and neural tube closure defects.

84 Loss of XTRPM6 produced gastrulation and neural tube closure defects.

85 genital malformations caused by a failure of neural tube closure during early embryonic development.

86 fects (NTDs), which result from a failure of neural tube closure during embryogenesis.

87 Failure of neural tube closure during embryonic development can res

88 bifida (SB) is a complex disorder of failed neural tube closure during the first month of human gest

89 Neural tube closure has been studied for many decades, a

90 g tissue boundaries to control zippering and neural tube closure in the basal chordate, Ciona robusta

91 erior across the epidermis, is important for neural tube closure in the invertebrate chordate Ciona i

92 The process of neural tube closure is complex and involves cellular eve

93 Neural tube closure is sensitive to environmental influe

94 Failure of neural tube closure results in severe birth defects and

95 Unidirectional zippering is a key step in neural tube closure that remains poorly understood.

96 1 in mouse embryos causes defects in cranial neural tube closure, accompanied by an increase in the p

97 After neural tube closure, amniotic fluid (AF) captured inside

98 lineage differentiation in embryos, delayed neural tube closure, and altered exon skipping.

99 in pure AF and nascent CSF, before and after neural tube closure, and to define how the AF and CSF pr

100 mplete key developmental processes including neural tube closure, axial turning and patterning of the

101 lar and biomechanical mechanisms involved in neural tube closure, based on studies of various vertebr

102 Apical F-actin is known to be important for neural tube closure, but the precise roles of actin dyna

103 MARCKS is required for neural tube closure, but the regulation and of its biolo

104 nent thought absent in neuroepithelium after neural tube closure, OCLN isoform-specific expression ex

105 ine the mechanisms by which TRPM6 influences neural tube closure, we functionally characterized the r

106 ism underlying zippering during mouse spinal neural tube closure.

107 sensitive metabolic processes at the time of neural tube closure.

108 ng of the neural plate midline and defective neural tube closure.

109 multiple ectodermal lineages until or beyond neural tube closure.

110 but have distinct and essential roles during neural tube closure.

111 ation of septins governs ciliogenesis during neural tube closure.

112 s exhibiting exencephaly, a severe defect in neural tube closure.

113 bryonic vitamin E to the mouse embryo during neural tube closure.

114 in embryonic vitamin E uptake during murine neural tube closure.

115 ace ectoderm, are required for completion of neural tube closure.

116 ivator with ED-rich tail 2) is essential for neural tube closure.

117 FKBP8 is critical for proper mammalian neural tube closure.

118 activation of apical actomyosin required for neural tube closure.

119 sac, and embryo proper, as well as abnormal neural tube closure.

120 ion of de novo thymidylate synthesis impairs neural tube closure.

121 etal processes that govern cell shape during neural tube closure.

122 rainyhead-like2 (Grhl2), each prevent spinal neural tube closure.

123 ryonic days E8.5 and E10.5 (before and after neural tube closure; NTC) (Chau et al., 2018).

124 bation of the Fibronectin matrix rescues the neural tube convergence defect of cadherin 2 mutants.

125 namely an increase from two to four ectopic neural tubes, corresponding to the switch in NMP niche,

126 ms produced offspring at a rate of 11.3% for neural tube defect (NTD) formation, whereas no embryos i

127 nd B12, choline, betaine, and methionine and neural tube defect (NTD) outcomes among mothers meeting

128 aternal periconceptional NSD use between 334 neural tube defect cases and 7,619 nonmalformed controls

129 Caudal regression syndrome is a rare, neural tube defect characterized by an abnormal developm

130 assuming that a woman having a child with a neural tube defect incurs an extra DALY per year for the

131 become an obstacle to the wider adoption of neural tube defect prevention programs and have called f

132 without the potential for childbearing, and neural tube defect recurrence; and studies conducted in

133 rol this process is expected to reveal novel neural tube defect risk factors and increase our underst

134 Neural tube defect risk was associated with maternal per

135 ession of Irf6 caused exencephaly, a rostral neural tube defect, through suppression of Tfap2a and Gr

136 potential treatment for spina bifida (SB), a neural tube defect.

137 Neural tube defects (NTDs) are a group of severe congeni

138 Planar cell polarity (PCP) and neural tube defects (NTDs) are linked, with a subset of

139 Neural tube defects (NTDs) are the most severe congenita

140 Lin28a/b double knockout (dKO) mice display neural tube defects (NTDs) coupled with reduced prolifer

141 The Botswana Tsepamo study reported neural tube defects (NTDs) in 4 of 426 (0.94%) infants o

142 abetes mellitus in early pregnancy can cause neural tube defects (NTDs) in embryos by perturbing prot

143 rhl2 loss results in fully penetrant cranial neural tube defects (NTDs) in mice.

144 Gpr161 null and hypomorphic mutations cause neural tube defects (NTDs) in mouse models.

145 may be associated with an increased risk for neural tube defects (NTDs) in newborns if used by women

146 ART has been reported to be associated with neural tube defects (NTDs) in offspring.

147 Mouse models of folate-responsive neural tube defects (NTDs) indicate that impaired de nov

148 The risk of neural tube defects (NTDs) is influenced by nutritional

149 Neural tube defects (NTDs) represent a failure of the ne

150 ess is susceptible to disruption, leading to neural tube defects (NTDs), a common birth defect.

151 supplementation can reduce the prevalence of neural tube defects (NTDs), although just how folates be

152 he risk in infants of birth defects, such as neural tube defects (NTDs), known as diabetic embryopath

153 letion-induced autophagy deficiency leads to neural tube defects (NTDs), similar to those in diabetic

154 Folate supplementation prevents up to 70% of neural tube defects (NTDs), which result from a failure

155 ptions in neural tube (NT) closure result in neural tube defects (NTDs).

156 ly pregnancy causes birth defects, including neural tube defects (NTDs).

157 High glucose in vivo and in vitro induces neural tube defects (NTDs).

158 suboptimal RBC folate for protection against neural tube defects (NTDs); among nonconsumers of folic

159 s have also been identified in patients with neural tube defects (NTDs); however, the relationship be

160 6, 0.43), and a 41% reduction in the odds of neural tube defects (OR: 0.59; 95% CI: 0.49, 0.70).

161 MP-SMX was associated with increased risk of neural tube defects (pooled OR 2.5, 95% CI 1.4-4.3), spo

162 tural pesticide use has been associated with neural tube defects and autism, but more subtle outcomes

163 similar to the testing/screening method for neural tube defects and common chromosomal anomalies dur

164 ulthood, heterotaxia, pre-axial polydactyly, neural tube defects and hydrocephalus.

165 Association of folate deficiency with neural tube defects and impact of fortification programs

166 an essential nutrient, increase the risk of neural tube defects and lead to low performance on cogni

167 tes to delineate the genetic architecture of neural tube defects and new therapeutic targets to preve

168 abnormalities with or without microcephaly, neural tube defects and other early brain malformations,

169 ously reported positive associations between neural tube defects and periconceptional exposure to NSD

170 lly lethal and recapitulates JBTS, including neural tube defects and polydactyly; however, the underl

171 during the periconception period to prevent neural tube defects and to ensure normal brain developme

172 Neural tube defects are among the most common congenital

173 Neural tube defects are among the most common major cong

174 Few genetic risk factors for neural tube defects are known in humans, highlighting th

175 r Down syndrome, fetal alcohol syndrome, and neural tube defects combined.

176 from Hungary initiated in 1984, incidence of neural tube defects for folic acid supplementation compa

177 tudies such as Tsepamo are critically needed.Neural tube defects have been reported among infants bor

178 ance spread and a possible increased risk of neural tube defects in infants if used in women at the t

179 en of childbearing age for the prevention of neural tube defects in infants.

180 ant dam's drinking water on the incidence of neural tube defects in some genetic models.

181 sufficiency on the basis of elevated risk of neural tube defects in women 12-49 y old (e.g., RBC fola

182 dults to consider information on the risk of neural tube defects in women taking dolutegravir at time

183 fold fusion during neurulation leads to open neural tube defects including spina bifida.

184 Neural tube defects occur frequently, yet underlying gen

185 supplementation and birth defects other than neural tube defects remains unclear.

186 on folic acid supplementation for preventing neural tube defects to inform the US Preventive Services

187 ew of the severe congenital malformations - 'neural tube defects' - that result when closure fails.

188 ngl2 loss is embryonically lethal because of neural tube defects, and mutations in Vangl2 are associa

189 2, which had been previously associated with neural tube defects, and vitamin B-12 status, as well as

190 Neural tube defects, harms of treatment (twinning, respi

191 Some relate to birth defects other than neural tube defects, neurological functions or varied as

192 death, pneumonia, congenital heart disease, neural tube defects, preterm birth and low birth weight,

193 n in the periconceptional period can prevent neural tube defects.

194 sociation of folic acid supplementation with neural tube defects.

195 supplementation provided protection against neural tube defects.

196 in the prevention of many diseases including neural tube defects.

197 ood fortification are recommended to prevent neural tube defects.

198 s in lamin B1 are susceptibility factors for neural tube defects.

199 genetic basis underlying the pathogenesis of neural tube defects.

200 implications for a population-level risk of neural tube defects.

201 utations in Vangl2 are associated with human neural tube defects.

202 FR) 677C>T polymorphism is a risk factor for neural tube defects.

203 nesis in the neuroepithelium and ameliorated neural tube defects.

204 The prevalence of neural-tube defects and major external structural defect

205 The prevalence of neural-tube defects was higher in association with dolut

206 A preliminary safety signal for neural-tube defects was previously reported in associati

207 The prevalence of neural-tube defects was slightly higher in association w

208 her was taking dolutegravir at conception, 5 neural-tube defects were found (0.30% of deliveries); th

209 In comparison, 15 neural-tube defects were found among 14,792 deliveries (

210 examination that could be evaluated, and 98 neural-tube defects were identified (0.08% of deliveries

211 is an indicator of folate status and risk of neural-tube defects.

212 , each predetermined epigenetically prior to neural tube delamination.

213 e we show that the development of the dorsal neural tube-derived melanoblasts in turtle Trachemys scr

214 ulation of gene expression in the vertebrate neural tube determines the identity of neural progenitor

215 ensitivity to Hh ligand in vitro, and during neural tube development in vivo.

216 cluding probes annotated to SKI (involved in neural tube development), ZNF544 (previously implicated

217 irmed that the data accurately recapitulates neural tube development, allowing us to identify new mar

218 ll types that will support future studies of neural tube development, function and disease.

219 f Wnt3a and Nkx2.9 during the early stage of neural tube development, perhaps also contributing to ca

220 l chemical environments found in vivo during neural tube development.

221 ristic hyperpolarization of cells lining the neural tube; disruption of this spatial gradient of the

222 the paraxial mesoderm on either side of the neural tube, eventually differentiating into afferent ne

223 he time and distance to first division after neural tube exit were stochastic.

224 isolated from mouse embryonic day 9.5 trunk neural tube explants.

225 he development of many tissues including the neural tube, eye, intestines, and vasculature.

226 tor 1 (Folr1; also known as FRalpha) impairs neural tube formation and leads to NTDs.

227 ture of the NNE during the dynamic events of neural tube formation by both activating key epithelial

228 including gastrulation in many organisms and neural tube formation in vertebrates.

229 ient mouse embryos exhibit severe defects in neural tube formation, somitogenesis and cardiac develop

230 mechanisms involved in folate action during neural tube formation.

231 phogenetic events including gastrulation and neural tube formation.

232 ure, amniotic fluid (AF) captured inside the neural tube forms the nascent cerebrospinal fluid (CSF).

233 In the developing mouse and chick neural tube, hindbrain serotonergic neurons and spinal g

234 the embryonic ectoderm, delaminate from the neural tube in early vertebrate development and migrate

235 the context of the patterning of the ventral neural tube in response to a gradient of the morphogen S

236 in the p1 progenitor domain of the zebrafish neural tube in response to Sonic Hedgehog signaling.

237 This is the case in the vertebrate neural tube, in which neurons differentiate in a charact

238 The loss of Tsc1 in the mouse neural tube increases the number of the wild-type neuron

239 ces cranial crest emigration from the dorsal neural tube independent of Pax7.

240 otor and interneuron types in the vertebrate neural tube indicates conserved combinations, for exampl

241 and found that its expression in the caudal neural tube is dependent on retinoic acid and Pax6, and

242 a model, we show that, at the junction, the neural tube is elaborated by a unique developmental prog

243 Like many developing tissues, the vertebrate neural tube is patterned by antiparallel morphogen gradi

244 model revealed that the amphioxus incipient neural tube is unexpectedly complex, consisting of sever

245 Global transcriptome analyses on neural tubes isolated from E9.0 EpoR-null and littermate

246 lly establish NSC positional identity in the neural tube, it is unclear how such regional differences

247 ses affecting multiple organs, including the neural tube, kidney, and brain.

248 The initial rostrocaudal patterning of the neural tube leads to differential expression of Hox gene

249 etry-breaking events that ultimately lead to neural tube-like patterning along the dorsal-ventral (DV

250 deficiency did not prevent the formation of neural tube-like structures in teratomas.

251 In neural tube-like structures, endogenous NUAK2 colocalize

252 the normal development of the kidney, skin, neural tube, lung and limb, and many other organs and ti

253 n of neural crest cells to emigrate from the neural tube, miR-203 displays a reciprocal expression pa

254 Tbx6 knockout TLSs developed additional neural tubes mirroring the embryonic mutant phenotype, a

255 More recently, biomechanical inputs into neural tube morphogenesis have also been identified.

256 Whereas SR-BI(-/-) embryos with closed neural tubes (nSR-BI(-/-)) had high levels of reactive o

257 Disruptions in neural tube (NT) closure result in neural tube defects (

258 essential role for Geminin during mammalian neural tube (NT) formation and patterning.

259 Neural tube (NT) formation in the spinal region of the m

260 level morphogenetic movements that shape the neural tube (NT), the precursor of the brain and spinal

261 When transplanted into the neural tube of developing chick embryos, iPSCMNs selecti

262 e' that remodels to the lateral edges of the neural tube-paraxial mesoderm interfaces where shear str

263 l morphogens can be maintained, resulting in neural tube patterning analogous to that observed in viv

264 2 protein expression is downregulated during neural tube patterning and adaptation continues when the

265 pment requires a tight orchestration between neural tube patterning and growth.

266 . (2016) tackle this issue in the context of neural tube patterning, discovering that differential se

267 in), similar to that operating in vertebrate neural tube patterning, functions to distinguish cell fa

268 ecies that differ in size during the time of neural tube patterning.

269 how the duration of Shh signaling regulates neural tube patterning.

270 three key ventral determinants in mammalian neural tube patterning: Nkx2.2, Nkx6.1 and Olig2.

271 r, Wnt1(Cre2SOR) mutants had an open cranial neural tube phenotype that was not evident in Wnt1(Cre)

272 l lethality and SHH-related abnormal ventral neural tube phenotypes.

273 s per multiciliated cell, and the numbers of neural tube primary cilia; it also led to abnormal devel

274 s a transcription factor essential in dorsal neural tube progenitors for specification of these inhib

275 echanisms that position motor neurons in the neural tube remain poorly understood.

276 Formation of the vertebrate neural tube represents one of the premier examples of mo

277 Failure to close the neural tube results in birth defects, with severity rang

278 eased Hedgehog signaling and completely open neural tubes showing co-expansion of all ventral neuropr

279 In the ventral neural tube, sonic hedgehog (Shh) signaling, together wi

280 ly, PRDM13 also ensures a battery of ventral neural tube specification genes such as Olig1, Olig2 and

281 orsal midline Bmp signaling to drop at early neural tube stages.

282 es is the unique presence of a dorsal hollow neural tube that forms by internalization of the ectoder

283 ctional complexes.SIGNIFICANCE STATEMENT The neural tube, the CNS precursor, is shaped during neurula

284 ory along the anterior-posterior axis of the neural tube, the mechanisms establishing the cerebellar

285 In the vertebrate neural tube, the morphogen Sonic Hedgehog (Shh) establis

286 After closure of the neural tube, these cells undergo an epithelial-to-mesenc

287 ry showed strong expression of hFOXA2 in the neural tube, third ventricle, diencephalon and pancreas.

288 that Inpp5e attenuates Shh signaling in the neural tube through regulation of the relative timing of

289 of the vertebrate trunk but predisposes the neural tube to convergence defects that lead to spina bi

290 wo mechanisms are combined in the vertebrate neural tube to increase the range of cell types and deli

291 neural crest cells (crNCCs) migrate from the neural tube to the pharyngeal arches (PAs) of the develo

292 racellular matrix of Fibronectin adheres the neural tube to the two flanking columns of paraxial meso

293 rvous system migrate ventrally away from the neural tube toward and along the primitive gut.

294 l targets genome-wide in the embryonic mouse neural tube using ChIP-Seq and RNA-Seq.

295 of Sox2 or Pax7 alters the apportionment of neural tube versus neural crest fates.

296 e border, and subsequent emigration from the neural tube via canonical Wnt signaling.

297 on affect cell arrangement and growth of the neural tube, we used experimental measurements to develo

298 sonic hedgehog, and Notch) that pattern the neural tube were sequentially perturbed to identify an o

299 to anteriorize 5 Hoxa gene expression in the neural tube when inserted into a HoxA BAC reporter.

300 ronal lineages when they delaminate from the neural tube, whereas cranial neural crest cells acquire