ライフサイエンスコーパス: neuroectoderm

1 a key regulator in the development of human neuroectoderm.

2 tional diversity after delamination from the neuroectoderm.

3 expression throughout the entire presumptive neuroectoderm.

4 id/rhabdoid tumors may originate outside the neuroectoderm.

5 l expression domains within the plane of the neuroectoderm.

6 ities of wnt8 in patterning the mesoderm and neuroectoderm.

7 loss of epithelial structure of ectoderm and neuroectoderm.

8 erning of regional fates within the anterior neuroectoderm.

9 nic cardiac and skeletal muscle mesoderm and neuroectoderm.

10 Wnt1 expression by Six3 within the anterior neuroectoderm.

11 ndodermal inductive signals to the overlying neuroectoderm.

12 ptosis occurs in head mesenchyme and ventral neuroectoderm.

13 to regulate absolute cell numbers within the neuroectoderm.

14 ed by the patterning and segmentation of the neuroectoderm.

15 activation of Hh target genes in the ventral neuroectoderm.

16 ulates the anteroposterior patterning of the neuroectoderm.

17 g ectoderm, leading to expression of Ganf in neuroectoderm.

18 r, less likely, of the disorganized adjacent neuroectoderm.

19 late, cardiac mesoderm, endoderm and ventral neuroectoderm.

20 ive to regulate pattern and cell fate in the neuroectoderm.

21 ling controls self-patterning in ESC-derived neuroectoderm.

22 post-transcriptional control in epiblast and neuroectoderm.

23 -localized in a broad anterior region of the neuroectoderm.

24 reduction and subsequent posteriorization of neuroectoderm.

25 tiation and an expansion of undifferentiated neuroectoderm.

26 that specify cell fates in the mesoderm and neuroectoderm.

27 llel to specify dorsal mesoderm and anterior neuroectoderm.

28 r populations within specific regions of the neuroectoderm.

29 hing and sprouting of blood vessels into the neuroectoderm.

30 AX6 promoter and improves differentiation to neuroectoderm.

31 in dorsoventral patterning in the Drosophila neuroectoderm.

32 g mesoderm as well as originating within the neuroectoderm.

33 aracteristics of the intermediate and dorsal neuroectoderm.

34 d (ptc) during the patterning of the ventral neuroectoderm.

35 nterior axial mesoderm, endoderm and ventral neuroectoderm.

36 centrations it stimulates differentiation to neuroectoderm.

37 fted with XFD-expressing ACs in the place of neuroectoderm.

38 itors (NMPs) into mesoderm at the expense of neuroectoderm.

39 e neural retina arise from a single layer of neuroectoderm.

40 , rather than at restricted locations of the neuroectoderm.

41 uring embryogenesis, in specific foci of the neuroectoderm.

42 o can perform both of these functions in the neuroectoderm.

43 stoderm embryo to oppose Dpp activity in the neuroectoderm.

44 d in a variety of human cancers derived from neuroectoderm.

45 with peaks at the dorsal midline and ventral neuroectoderm.

46 d PTK7, and disrupted planar polarity in the neuroectoderm.

47 edly, activation of pluripotency factors and neuroectoderm.

48 lineage genes, specifically in the anterior neuroectoderm.

49 inct from those arising within the segmental neuroectoderm.

50 nomous requirement for Geminin in developing neuroectoderm.

51 trunk expression extending into somites and neuroectoderm.

52 hanism to define the ventral boundary of the neuroectoderm.

53 or binary cell fate decisions in the ventral neuroectoderm.

54 e attachment, as well as cohesion within the neuroectoderm.

55 idline but in the median area of the ventral neuroectoderm.

56 ng pharynx drives involution of the adjacent neuroectoderm.

57 rmed along the ventro-lateral surface of the neuroectoderm.

58 in the Drosophila dorsomedial protocerebral neuroectoderm.

59 lthough they are still capable of generating neuroectoderm.

60 in triggered differentiation of hESCs toward neuroectoderm.

61 ng from the underlying mesoderm and adjacent neuroectoderm.

62 , one of the earliest genes expressed in the neuroectoderm.

63 ke overexpression of wnt8, posteriorizes the neuroectoderm, (2) sp5-like morpholino-mediated knockdow

64 at embryonic day (E)9.0 in the yolk sac and neuroectoderm; 2) at E10.5, CX3CR1 single-positive micro

65 t Wnt11R, a Wnt protein that is expressed in neuroectoderm adjacent to the NC territory, is required

66 protein, expressed initially in the ventral neuroectoderm adjacent to the ventral midline, in the do

67 Patterning the neuroectoderm along the anterior-posterior (AP) axis is

68 the dorso-ventral axis and patterning of the neuroectoderm along the anterior-posterior axis during g

69 ook also plays a crucial role to pattern the neuroectoderm along the DV axis.

70 ntiation where B6 showed a propensity toward neuroectoderm and D2 toward definitive endoderm.

71 oups of neural precursors segregate from the neuroectoderm and directly differentiate into neurons an

72 ells, but also cells with visceral mesoderm, neuroectoderm and endoderm characteristics in vitro.

73 ias arising from the embryonic neural crest, neuroectoderm and endoderm.

74 roviding an instructive signal for posterior neuroectoderm and foregut endoderm and a permissive sign

75 embryos have increased cell death in ventral neuroectoderm and foregut endoderm, but normal cranial n

76 eage reflected alterations in SOX1(+)PAX6(+) neuroectoderm and FOXG1(+) cortical neuron marker expres

77 with reduced cell proliferation in forebrain neuroectoderm and frontonasal mesenchyme.

78 e earliest markers specific for the anterior neuroectoderm and it may play a role in forebrain develo

79 o-/- embryos that mostly consist of anterior neuroectoderm and lack posterior structures, thus resemb

80 the inductive interaction with the anterior neuroectoderm and LHX1 also regulates the expression of

81 Instead, Delta is required for neuroectoderm and mesectoderm formation; embryos missing

82 his negative-feedback loop imposes stasis in neuroectoderm and mesendoderm differentiation, thereby m

83 Cell lineage analyses showed that neuroectoderm and mesoderm along the secondary axis were

84 tion and prevents premature specification of neuroectoderm and mesoderm.

85 yos, Amer2 is expressed mainly in the dorsal neuroectoderm and neural tissues.

86 ish ventral, intermediate, and dorsal column neuroectoderm and neuroblasts, and a cell lineage marker

87 Vnd protein is restricted to ventral column neuroectoderm and neuroblasts; later it is detected in a

88 confocal and two-photon images of zebrafish neuroectoderm and paraxial mesoderm by comparing its res

89 een sog and dpp determines the extent of the neuroectoderm and subdivides the dorsal ectoderm into tw

90 ast, a tissue normally fated to give rise to neuroectoderm and surface ectoderm, in a serum-free, che

91 mitive streak act on the rostral prospective neuroectoderm and the latter gains potency (i.e., is spe

92 e the embryonic neural fields - the anterior neuroectoderm and the more posterior ciliary band neuroe

93 dline, in the dorsoventral patterning of the neuroectoderm and the neuroblasts.

94 ng neurulation to induce and regionalize the neuroectoderm and to produce the morphogenetic forces th

95 no additional signaling between NBs and the neuroectoderm and/or mesoderm is required to trigger the

96 at the early head-fold stage in the midline neuroectoderm, and consequently is an early marker for t

97 ereby establishing the presumptive mesoderm, neuroectoderm, and dorsal ectoderm.

98 of precellular Drosophila embryos: mesoderm, neuroectoderm, and dorsal ectoderm.

99 t that initiates separation of the mesoderm, neuroectoderm, and ectoderm.

100 ant regulator of dorsoventral pattern in the neuroectoderm, and indicate that Dichaete acts in concer

101 ponding intermediate region of the embryonic neuroectoderm, and is essential for the correct specific

102 n the medial and intermediate columns of the neuroectoderm, and mutant analysis indicates that Dichae

103 not Twist1, preferentially expressed in the neuroectoderm, and regulates beta-catenin-mediated gene

104 tterns in the ventral proneural clusters and neuroectoderm, and that its action in neuroblast formati

105 tor (bFGF) is an important growth factor for neuroectoderm- and mesoderm-derived cells.

106 r-to-anterior downregulation of the anterior neuroectoderm (ANE) gene regulatory network (GRN) by can

107 help specify and pattern the early anterior neuroectoderm (ANE) in many deuterostomes.

108 Remarkably, the anterior neuroectoderm (ANE) of the deuterostome sea urchin embry

109 anterior definitive endoderm (ADE), anterior neuroectoderm (ANE), anterior mesendoderm (AME), headfol

110 late the specification and patterning of the neuroectoderm are incompletely understood.

111 s absence led to massive apoptosis in dorsal neuroectoderm around the FB-MB boundary and in a restric

112 igodendrocytes are widespread throughout the neuroectoderm as early as E10.5.

113 s also associated with limited growth of the neuroectoderm, as revealed by morphological observation,

114 d expression of mesoderm-associated, but not neuroectoderm-associated, genes.

115 PV.1 is expressed in the prospective neuroectoderm at the time of ectodermal fate determinati

116 Furthermore, in the embryonic neuroectoderm, Barbu expression is inducible by activate

117 am of wnt8 in patterning of the mesoderm and neuroectoderm because (1) overexpression of sp5-like, li

118 for the establishment of the sharp mesoderm/neuroectoderm boundary in the early embryo.

119 on and for the establishment of the mesoderm/neuroectoderm boundary, respectively.

120 the epiblast, axial mesendoderm and anterior neuroectoderm but not in the visceral endoderm.

121 trulation movements in both the mesoderm and neuroectoderm, but how or whether molecular regulation o

122 able at the anterior edge of the presumptive neuroectoderm by 70% epiboly.

123 ose that boz specifies formation of anterior neuroectoderm by regulating BMP and Wnt pathways in a fa

124 le by molecular markers, is conferred on the neuroectoderm by signals from the endomesoderm that are

125 Here we investigate the subdivision of the neuroectoderm by three conserved homeobox genes, ventral

126 k stage (i.e., stage 3c/3+), the prospective neuroectoderm cannot self-differentiate (i.e. , express

127 Initial opposing flows lead to neuroectoderm cell internalisation and progressive multi

128 y reduced the generation of NESTIN(+)SOX1(+) neuroectoderm cells from 70% in wild-type cells to 20% i

129 rm cells examined, but not in any of the 165 neuroectoderm cells.

130 multiple regulatory nodes of hESC identity, neuroectoderm commitment and neurogenesis.

131 specification, and these changes heralded a neuroectoderm decision before any neural precursor marke

132 n achaete expression within the intermediate neuroectoderm demonstrates that each protein also has re

133 rate abnormal planar polarity in the Xenopus neuroectoderm depleted of FGFR1, suggesting a mechanisti

134 s issue of Immunity, Kang et al. report that neuroectoderm-derived astrocytes are the critical cellul

135 FGF-1) is a potent mitogen for mesoderm- and neuroectoderm-derived cell types in vitro.

136 is a mitogen for a variety of mesoderm- and neuroectoderm-derived cells, as well as an angiogenic fa

137 is a mitogen for a variety of mesoderm- and neuroectoderm-derived cells, as well as an angiogenic fa

138 However, targeted Act1 deficiency in neuroectoderm-derived CNS-resident cells resulted in mar

139 How the neuroectoderm-derived eye field breaks symmetry to speci

140 clear RNA sequencing (RNA-seq) census of all neuroectoderm-derived glia in the adult C. elegans nervo

141 hing the usefulness of the model in studying neuroectoderm-derived iris muscle specification, and rel

142 with no detectable contribution by migratory neuroectoderm-derived populations.

143 Two isoforms are specifically expressed in neuroectoderm-derived tissues, but not in tumors or canc

144 f the vertebrate brain, we compared anterior neuroectoderm development across deuterostome species, u

145 During vertebrate embryogenesis, the neuroectoderm differentiates into neural tissues and als

146 d endoderm, with a concomitant inhibition of neuroectoderm differentiation by Nodal itself.

147 n PSCs with PCGF6 depletion display impaired neuroectoderm differentiation coupled with increased mes

148 cell crowding derepresses the potential for neuroectoderm differentiation in human embryonic stem ce

149 Nanog in turn prevents neuroectoderm differentiation induced by FGF signalling

150 -regulatory element phenocopies the impaired neuroectoderm differentiation, while overexpressing SOX2

151 which likely accounts for the regulation in neuroectoderm differentiation.

152 ishment of this molecular program in nascent neuroectoderm directly links early neural cell fate acqu

153 re among the earliest genes expressed in the neuroectoderm, dividing it into anterior and posterior d

154 transfer experiments using both endoderm and neuroectoderm donor cells, we have observed substantial

155 BMPs initially inhibit the formation of neuroectoderm during gastrulation while, within the neur

156 ectoderm and the more posterior ciliary band neuroectoderm - during development.

157 zygotically for the formation of the ventral neuroectoderm, endoderm, and prechordal plate.

158 In contrast, the rho neuroectoderm enhancer (NEE) does not discriminate betwe

159 In the multilayered neuroectoderm, epidermal precursors, neuroblasts and gan

160 from discrete subdomains of rhombencephalic neuroectoderm expressing Wnt1; that choroid plexus, a se

161 pattern which is rapidly replaced by strong neuroectoderm expression.

162 y for endoderm specification while promoting neuroectoderm factors.

163 neither of which is expressed in the dorsal neuroectoderm, failed to induce neural crest markers.

164 nsformation of intermediate to dorsal column neuroectoderm fate, and only 10% of the intermediate col

165 cerebral organoids (enCORs) display enhanced neuroectoderm formation and improved cortical developmen

166 w that the PTEN(G132D) allele disrupts early neuroectoderm formation during the first several days of

167 rosa and dorsal epidermis, and also inhibits neuroectoderm formation.

168 s in endoderm, prechordal plate, and ventral neuroectoderm formation.

169 the mesendodermal lineage at the expense of neuroectoderm formation.

170 We propose that Sog protects the neuroectoderm from an invasive positive feedback loop cr

171 orsally limited by Bozozok, acts on anterior neuroectoderm from the lateral mesoderm to produce the A

172 l precursor groups (NPGs) segregate from the neuroectoderm generating the nervous system, whereas in

173 ed by expression of both endoderm as well as neuroectoderm genes suggesting lineage potential towards

174 spatially co-localized with the prospective neuroectoderm immediately rostral to the primitive strea

175 e the earliest known markers for presumptive neuroectoderm in amphioxus.

176 The posteriorization of neuroectoderm in boz was correlated with ectopic dorsal

177 nd for conferring competence to the anterior neuroectoderm in responding to forebrain-, midbrain- and

178 The establishment of mesoderm and neuroectoderm in the early Drosophila embryo relies on i

179 xpression border separating the mesoderm and neuroectoderm in the early Drosophila embryo.

180 m the bilateral median domain of the ventral neuroectoderm in the last common ancestor of Mandibulata

181 zer formation and limits posteriorization of neuroectoderm in the late gastrula.

182 on, a complete failure of evagination of the neuroectoderm in the ventral diencephalon, and defects i

183 bulum, which is formed by evagination of the neuroectoderm in the ventral diencephalon.

184 OTX2 functions to specify the fate of neuroectoderm in various regions of the developing brain

185 hat expression of slp genes is lost from the neuroectoderm in wg mutants and that ectopic expression

186 y transcription factors expressed in nascent neuroectoderm, including Geminin and members of the Zic

187 rmation and the early development of ventral neuroectoderm, including the floor plate.

188 ripotent stem cells (PSCs) resembles in vivo neuroectoderm induction in the temporal course, morphoge

189 patterning genes that subdivide the ventral neuroectoderm into a grid-like structure.

190 tablished independent of the division of the neuroectoderm into an anterior Otx2-positive domain and

191 The process of folding the flat neuroectoderm into an elongated neural tube depends on t

192 (en) allow one to subdivide the procephalic neuroectoderm into tritocerebral, deuterocerebral, and p

193 sues driving involution, which suggests that neuroectoderm involution in C. elegans is potentially ho

194 2-4 is inducing, rather than repressing, the neuroectoderm is a surprising difference that may be con

195 DV columnar homeobox gene expression in the neuroectoderm is an early, essential, and evolutionarily

196 ers including itself (autoactivation) in the neuroectoderm is blocked by sog.

197 Patterning of the prospective neuroectoderm is greatly perturbed in the mutant embryos

198 The Drosophila neuroectoderm is initially subdivided into three longitu

199 Msx, Nkx and Gsx families in the Drosophila neuroectoderm is not conserved between their homologues

200 The neuroectoderm is patterned along a rostral-caudal axis i

201 orming placode, a diffusible signal from the neuroectoderm is required for induction and/or maintenan

202 he induction of three intermediate lineages: neuroectoderm, lateral plate mesoderm and paraxial mesod

203 n which hPSCs were initially induced to form neuroectoderm, lateral plate mesoderm or paraxial mesode

204 conditional Porcn depletion in optic vesicle neuroectoderm, lens, and neural crest-derived periocular

205 in mouse embryoid bodies (EBs) undergoing a neuroectoderm-like state.

206 nt cells are efficiently specified along the neuroectoderm lineage toward p75(+) Hnk1(+) Ap2(+) neura

207 Thus, distinct FSCs exist for the four neuroectoderm lineages, and dermal fibroblasts are not p

208 Posterior neuroectoderm markers are not expressed, presumably beca

209 Anterior neuroectoderm markers are widely expressed, at least in

210 ressing hESCs showed increased expression of neuroectoderm markers Sox1, Sox3, and Nestin.

211 progressively decreased, while expression of neuroectoderm markers was strongly upregulated, thus rev

212 otency marker genes and reduced induction of neuroectoderm markers.

213 ssed in a spatiotemporal specific pattern in neuroectoderm, mesoderm and gut endoderm during developm

214 corepressors and coactivator complexes onto neuroectoderm, mesoderm, and endoderm genes.

215 hat translation of Otx2 mRNA in epiblast and neuroectoderm might require a cell type-specific post-tr

216 was abnormal in embryos deficient in primary neuroectoderm (N lineage).

217 can be directed toward a mesendoderm (ME) or neuroectoderm (NE) fate, the first decision during hESC

218 llel, robust, and reproducible derivation of neuroectoderm, neural crest (NC), cranial placode (CP),

219 d immunostaining characteristics, resembling neuroectoderm, neural crest, ocular-surface ectoderm, or

220 helial cells, macrophages and microglia, and neuroectoderm (neurons, astrocytes, and oligodendrocytes

221 ither mesendoderm underlying the prospective neuroectoderm nor a morphologically normal node to provi

222 lf of the embryos prepared from transplanted neuroectoderm nuclei overexpressed the neuroectodermal m

223 ontrol, but mRNA translation in epiblast and neuroectoderm occurred only in otd(2FL) mutants.

224 development, neuroblasts delaminate from the neuroectoderm of each hemisegment in a stereotypic ortho

225 Notch signalling has diverged in the ventral neuroectoderm of insects and crustaceans accompanied by

226 iew, we revisit the molecular mapping of the neuroectoderm of insects and vertebrates to reconsider h

227 Cell tracing experiments show that the neuroectoderm of Nodal-deficient embryos undergoes a rap

228 We find that the neuroectoderm of Nodal-deficient zebrafish gastrulae exh

229 ssed in broad lateral stripes comprising the neuroectoderm of the Drosophila blastoderm embryo.

230 ryogenesis, ASPN is broadly expressed in the neuroectoderm of the embryo.

231 ngle domain protein already expressed in the neuroectoderm of the prevertebrate ancestor.

232 The neuroectoderm of the vertebrate gastrula was proposed by

233 Overexpression of Wnt-1 or Wnt-3a in the neuroectoderm of whole embryos led to a dramatic increas

234 ary neurogenesis, PCD takes place within the neuroectoderm of Xenopus embryos in a reproducible stere

235 is study, we focused on PCP in the posterior neuroectoderm of Xenopus laevis and investigated how mec

236 sed differentiation potentials toward either neuroectoderm or mesendoderm depending on their G1 lengt

237 and predicts differentiation outcome toward neuroectoderm or mesendoderm lineages.

238 huckebein expression in specific regions of neuroectoderm or neuroblasts.

239 nizer and the Notum deacylase in presumptive neuroectoderm orchestrate vertebrate brain development.

240 g the formation of a balanced rostral-caudal neuroectoderm pattern.

241 to provide precise spatiotemporal control of neuroectoderm patterning along its AP axis.

242 nockdown reduces the defects in mesoderm and neuroectoderm patterning caused by wnt8 overexpression,

243 d for proper anteroposterior axis formation, neuroectoderm patterning, and somitogenesis.

244 ation, while overexpressing SOX2 rescues the neuroectoderm phenotype caused by PCGF6-depletion.

245 m, which become corneal epithelium and lens, neuroectoderm (posterior iris and ciliary body) and cran

246 In contrast, the regionalized neuroectoderm posterioriorization phenotype is selective

247 e G1, resulting in a switch from endoderm to neuroectoderm potential in pluripotent stem cells.

248 , single neural precursors are formed in the neuroectoderm, potentially supporting the Myriochelata h

249 trinsic ability of hESCs to differentiate to neuroectoderm, presumably by decreasing the expression o

250 neuroblast identities takes place within the neuroectoderm, prior to neuroblast delamination.

251 The Drosophila ventral neuroectoderm produces a stereotyped array of central ne

252 olates containing non-specified, prospective neuroectoderm provide an improved model system for analy

253 e report that Lhx5, expressed in the rostral neuroectoderm, regulates the local inhibition of Wnts.

254 ern neural and non-neural tissues within the neuroectoderm remain unknown.

255 neurogenic genes in the mesoderm and ventral neuroectoderm, respectively.

256 ventral, intermediate, and dorsal columns of neuroectoderm, respectively.

257 triking regional posteriorization within the neuroectoderm, resulting in a reduction in anterior fate

258 s of defined target genes in the presumptive neuroectoderm, resulting in their histone acetylation an

259 nts from the embryonic lateral telencephalic neuroectoderm reveal that exogenous BMP proteins (BMP4 a

260 with organizing activity and the prospective neuroectoderm rostral to the streak separate.

261 stem cell (ESC), we report that ESC-derived neuroectoderm self-generates a Six3(+) rostral and a Irx

262 ired to establish chromatin accessibility at neuroectoderm-specific enhancers.

263 ) are severely reduced, correlating with the neuroectoderm-specific expression phase of pou2.

264 fferentiation of hESCs to neuroepithelium, a neuroectoderm-specific subset of poised enhancers acquir

265 at overexpression of PV.1 in the prospective neuroectoderm specifically blocks neurogenesis in intact

266 ggest a connection between ARID1B mutations, neuroectoderm specification and a pathogenic mechanism f

267 The role of miRNAs in neuroectoderm specification is largely unknown.

268 Here, we report that PCGF6 controls neuroectoderm specification of human pluripotent stem ce

269 ival of neural crest cells that arise at the neuroectoderm/surface ectoderm border, but not for their

270 toderm culminating in a lateral shift of the neuroectoderm/surface ectoderm border.

271 esult of reciprocal interactions between the neuroectoderm that forms the retina and surface ectoderm

272 ited Sonic hedgehog (Shh) signaling from the neuroectoderm then examined the molecular changes and th

273 neurogenesis: within distinct regions of the neuroectoderm, they are required both for neuroblast for

274 , immature neurons migrate radially from the neuroectoderm to defined locations, giving rise to chara

275 xperiments, we propose that Six3 acts in the neuroectoderm to establish a prepattern of bilateral rep

276 entiation of human embryonic stem cells into neuroectoderm to perform a whole-genome CRISPR-Cas9 knoc

277 The competence of neuroectoderm to respond to anteriorizing signals declin

278 th posteriorizing signals and the ability of neuroectoderm to respond to them persist after this stag

279 ental events: migration from the rhombomeric neuroectoderm to the pharyngeal arches, proliferation as

280 t to define the specific contribution of the neuroectoderm to this inductive process in Xenopus.

281 These results suggest the use of a neuroectoderm-to-mesoderm signaling pathway in the speci

282 Importantly, epiblast and neuroectoderm translation of otd(2FL) mRNA rescued maint

283 he expression of three homeobox genes in the neuroectoderm-ventral nervous system defective (vnd), in

284 The retina, for example, develops from neuroectoderm via the optic vesicle, the corneal epithel

285 planar polarity of endogenous Vangl2 in the neuroectoderm was similarly redirected by an ectopic Wnt

286 chanisms for establishing and patterning the neuroectoderm, we cloned and determined the embryonic ex

287 By performing RNA-seq and ATAC-seq in neuroectoderm, we find that un(der)phosphorylated ASCL1

288 In addition to changes in the forebrain neuroectoderm, we observed altered gene expression patte

289 TFAP2B, a transcription factor expressed in neuroectoderm, we studied eight patients with Char syndr

290 Markers of neuroectoderm were not upregulated during development of

291 that Sog diffuses dorsally from the lateral neuroectoderm where it is produced, and is cleaved and d

292 hord, in contrast to its effects on adjacent neuroectoderm where SHH expression is induced, represses

293 n within a zone of the mesoderm abutting the neuroectoderm, where Sna levels are graded.

294 NS development in DROSOPHILA: In the lateral neuroectoderm, where SoxNeuro is uniquely expressed, Sox

295 By contrast, in the medial neuroectoderm, where the expression of SoxNeuro and Dich

296 tion of mediolaterally oriented cells in the neuroectoderm, whereas the overexpression of Pk2 or Pk1

297 originate as neighboring cells from anterior neuroectoderm, which expresses genes orthologous to thos

298 n in hESCs begins by initiation of primitive neuroectoderm, which is manifested by rosette formation,

299 step, the Spemann gastrula organizer induces neuroectoderm with anterior character, followed by poste

300 nk reveals RALDH-2 mRNA both in mesoderm and neuroectoderm, with highest neuroectodermal expression i