ライフサイエンスコーパス: neurofilament

1 in neurons resulted in a decreased amount of neurofilament.

2 erity but not with the survival time, as did neurofilaments.

3 ion and bundling of perikaryal and dendritic neurofilaments.

4 determines axonal diameter in the absence of neurofilaments.

5 E revealed a 3-fold reduction in optic nerve neurofilaments.

6 ms as well as other proteins associated with neurofilaments.

7 along axons, with only minor roles played by neurofilaments.

8 peptidergic nociceptor marker; CGRP), and/or neurofilament 200 (myelinated axon marker; NF200).

9 ing femurs for tyrosine hydroxylase (TH) and neurofilament 200 (NF-200).

10 receptor potential vanilloid type 1 (TRPV1), neurofilament 200 (NF200), or vesicular glutamate transp

11 Using neurofilament-200 immunohistochemistry, we also detected

12 -like receptor 5 (TLR5) is co-expressed with neurofilament-200 in large-diameter A-fiber neurons in t

13 marrow denervation, demonstrating a loss of neurofilament-200 staining.

14 major autonomic source of axons labeled with neurofilament-200, which is commonly used to identify my

15 (SP), neuronal nitric oxide synthase (nNOS), neurofilament 200kDa (NF200), transient receptor potenti

16 which has implications for the mechanism of neurofilament accumulation in development and disease.

17 regation precedes the abnormal and excessive neurofilament accumulation in these diseases, which in t

18 While neurofilament accumulation suggests an impairment of neu

19 using was sufficient to explain the observed neurofilament accumulation.

20 ain the vulnerability of nodes of Ranvier to neurofilament accumulations in animal models of neurotox

21 Neurofilament accumulations were observed only in the my

22 onal cytoskeletal polymers, microtubules and neurofilaments, align longitudinally in axons and are in

23 c nerves showed a reduction in the number of neurofilaments, an increase in the number of microtubule

24 uds, as evidenced by elevated expressions of neurofilament and P2X(3) at the injury areas.

25 mentous proteins of the cytoskeleton such as neurofilaments and alpha-internexin.

26 orthogonal immunodetection showed changes in neurofilaments and ApoE in bulbar versus limb onset fast

27 erity of glaucoma by staining the retina for neurofilaments and counting the neurons of the retinal g

28 The myelinated segments contained more neurofilaments and had a larger cross-sectional area tha

29 imentally reported numbers and densities for neurofilaments and microtubules in nodes and internodes,

30 The model describes microtubules, neurofilaments and organelles as interacting particles i

31 t incorporates the longitudinal transport of neurofilaments and organelles through this domain by all

32 tion, a consequent increase in ubiquitinated neurofilaments and other proteins, and decrease the expr

33 this coordinated gene expression extended to neurofilaments and specific presynaptic molecules, provi

34 We have shown previously that neurofilaments and vimentin filaments expressed in nonne

35 The degree of GFP expression by neurofilament(+) and peripherin(+) DRG neurons was simil

36 markers such as nestin, doublecortin, GFAP, neurofilament, and vimentin.

37 Neurofilaments are abundant space-filling cytoskeletal p

38 Neurofilaments are elevated in the cerebrospinal fluid (

39 Neurofilaments are intermediate cytoskeletal proteins th

40 Neurofilaments are intermediate filaments assembled from

41 In this way, neurofilaments are prevented from piling up in the flank

42 The data suggest that neurofilaments are sensitive and specific blood markers

43 -domains, and ubiquitin-like domain modified neurofilament assembly in vivo.

44 identifies important domains for alleviating neurofilament bundles in neurons lacking sacsin.

45 ression of heat shock proteins also resolved neurofilament bundles, indicating that this endogenous c

46 the SIRPT1 and J-domain resolved preexisting neurofilament bundles.

47 ucture arising from interactions between the neurofilaments' C-terminal sidearms.

48 and that specific neuronal markers (Brn3 and neurofilament) can partly distinguish between different

49 ese polymers, which collectively bring nodal neurofilaments closer to their microtubule tracks.

50 review critically evidence supporting use of neurofilament concentration measures as biomarkers of ne

51 ng studies with antibodies to phosphorylated neurofilaments confirmed the axonal location of full-len

52 pose that myelinating cells can regulate the neurofilament content and morphology of axons locally by

53 emerging understanding of the mechanisms of neurofilament degradation and clearance and review new m

54 male mice of this strain ex vivo Fluorescent neurofilaments departed the activated region more rapidl

55 embranous organelles clustered centrally and neurofilaments displaced to the periphery.

56 focal swellings of retinal nerve fibres with neurofilament disruption.

57 tion, axons have a reduced-caliber, abnormal neurofilament distribution and an increase in mitochondr

58 n the flanking internodes, ensuring a stable neurofilament distribution and uniform axonal morphology

59 Anti-neurofilament factor staining showed axon loss in the co

60 cceleration functions to maintain a constant neurofilament flux across nodal constrictions, much as t

61 In axons, parallel neurofilaments form a nematic liquid-crystal hydrogel wi

62 ltured rat cortical neurons with fluorescent neurofilament fusion proteins and then used photoconvers

63 The neurofilament gene NEFL harbored three SNPs associated w

64 yed for the presence of serum phosphorylated neurofilament H (pNF-H).

65 ng for vesicular glutamate transporter 2 and neurofilament H indicate that the granule cell layer was

66 uscle strength, plasma phosphorylated axonal neurofilament H subunit levels, and the slow vital capac

67 DRG neuronal populations were identified by neurofilament H-chain 200, I-B(4) isolectin (IB4), or tr

68 staining against Protein-Gene-Product-9.5 or Neurofilament-H in combination with antigen retrieval pr

69 Interest in neurofilaments has risen sharply in recent years with re

70 ess-stiffening response of the soma, whereas neurofilaments have a predominant contribution in the vi

71 (Syt2) and complexin 1 (Cplx1)], structural [neurofilament heavy chain (Nefh)], and metabolic [neutra

72 ther the measurement of serum phosphorylated neurofilament heavy chain (pNF-H) titre is likely to be

73 els of CHIT1, CHI3L1, CHI3L2, phosphorylated neurofilament heavy chain (pNFH) and C-reactive protein

74 We show that levels of phosphorylated neurofilament heavy chain (pNFH) in cerebrospinal fluid

75 Phosphorylated neurofilament heavy chain (pNfH) levels are elevated in

76 o quantify Chit-1, CHI3L1 and phosphorylated neurofilament heavy chain levels in longitudinal CSF and

77 The phosphorylated neurofilament heavy subunit (pNF-H), a major structural

78 carry distinct frameshift variants in NEFH (neurofilament heavy), leading to a loss of the terminati

79 phingomyelin phosphodiesterase 3 (SMPD3) and neurofilament, heavy polypeptide (NEFH), which we found

80 ament-light chain) and pNF-H (phosphorylated neurofilament-heavy chain) are normal before symptom ons

81 This suggests a dominant regulatory role for neurofilament-high sidearms in filament reorientation pl

82 neurofilament-low, neurofilament-medium and neurofilament-high.

83 nvolved in the degradation of peripherin and neurofilament IF proteins in neurons.

84 Myelin basic protein and neurofilament immunolabelling demonstrates that axons in

85 A group of morphologically distinct, 200-kD neurofilament-immunopositive myelinated afferent fibers,

86 ceiving GAS6 for 28 d had preserved SMI31(+) neurofilament immunoreactivity, significantly fewer SMI3

87 Although phosphorylated neurofilament immunostaining revealed a few dystrophic n

88 The loss of neurofilament in juveniles exposed to darkness prior to

89 uses on the organization of microtubules and neurofilaments in axon shafts in both vertebrate and inv

90 s-sectional distribution of microtubules and neurofilaments in axons.

91 A prominent feature is abnormal bundling of neurofilaments in many neuronal populations.

92 lysis indicated an increase in ubiquitinated neurofilaments in midbrain of KO mice, whereas 20S prote

93 annealing." To test if this also occurs for neurofilaments in neurons, we transfected cultured rat c

94 indings, along with an increase of levels of neurofilaments in patients' cerebrospinal fluid, suggest

95 ts, new recognition of specialized roles for neurofilaments in synapses and a developing understandin

96 Primary roles of neurofilaments in the pathogenesis of human diseases wil

97 otic vesicles possessing sensory hair cells, neurofilament innervation in a thickened sensory epithel

98 Neurofilament-inspired biomimetic hydrogels should there

99 Neurofilament is a biomarker of axonal injury proposed a

100 ons expressing nonphosphorylated heavy-chain neurofilaments (labeled by SMI-32 antibody) were analyze

101 we observed no alteration in neuron size or neurofilament labeling within the dLGN.

102 Thus, blood and CSF neurofilament levels are linked to the symptomatic phase

103 Furthermore, nonphosphorylated neurofilament levels were decreased, indicating neuropro

104 CHIT1 and neurofilament levels were determined in cerebrospinal fl

105 Plasma neurofilament light (NEFL) levels, a clinically relevant

106 ing pathways, resulting in reduced levels of neurofilament light (NF-L) protein in distal axons and m

107 n of the blood biomarkers total tau (t-tau), neurofilament light (Nf-L), and glial fibrillary acidic

108 tin carboxyl-terminal hydrolase L1 (UCH-L1), neurofilament light (NF-L), and glial fibrillary acidic

109 CSF neurogranin, total tau, neurofilament light (NFL) and 14-3-3 protein were measur

110 thyl fumarate (DMF), we examined dynamics of neurofilament light (NFL) chain in serum, plasma and cer

111 We also observed elevated levels of neurofilament light (NfL) chain protein in the plasma of

112 Cerebrospinal fluid (CSF) neurofilament light (NFL) concentration is a general mar

113 Plasma neurofilament light (NFL) has recently been proposed as

114 Neurofilament light (NfL) is a marker of neuroaxonal inj

115 The neurofilament light (NFL) subunit is considered as an ob

116 , chemokine (C-C motif) ligand 2 (CCL2), and neurofilament light (NFL) were determined by commercial

117 s a nonspecific marker of neurodegeneration (neurofilament light [NfL]) were also examined.

118 amined the relationship between p-tau181 and neurofilament light and estimated years to/from symptom

119 a42), total tau (T-tau), phosphorylated tau, neurofilament light and monocyte chemoattractant protein

120 is associated with exaggerated increases in neurofilament light and that this putative neurotoxicity

121 ures of disease severity and CSF biomarkers (neurofilament light and the soluble fraction beta of the

122 Fluid biomarkers such as neurofilament light can complement neuroimaging, represe

123 similar to immunoglobulin G (IgG) index and neurofilament light chain (area under the curve [AUC] =

124 nd PD cases, and controls, were analysed for neurofilament light chain (NF-L) and Olink Neurology and

125 Here, we assessed the utility of serum neurofilament light chain (NF-L) and tau protein in comp

126 We have used a recombinant neurofilament light chain (NF-L) protein for the ELISA d

127 a that reveals the ability of CSF and plasma neurofilament light chain (NF-L) to predict and track cl

128 The concentrations of neurofilament light chain (NF-L), myelin basic protein (

129 tly higher accuracy than plasma P-tau181 and neurofilament light chain (NfL) (AUC range, 0.50-0.72; P

130 CSF biomarkers, including total-tau, neurofilament light chain (NfL) and amyloid-beta, are in

131 A clearer definition of the role of neurofilament light chain (NFL) as a biomarker in amyotr

132 Establishment of neurofilament light chain (NfL) as a reliable biomarker

133 Cerebrospinal fluid (CSF) neurofilament light chain (NfL) concentration is elevate

134 Plasma GFAP and neurofilament light chain (NfL) concentration were measu

135 As a marker of axonal damage, neurofilament light chain (NfL) has been suggested a mar

136 Neurofilament light chain (NfL) is a neuronal cytoplasmi

137 Neurofilament light chain (NfL) is a promising biomarker

138 Neurofilament light chain (NfL) is a promising blood bio

139 Neurofilament light chain (NfL) is a promising fluid bio

140 In different FTLD subtypes, neurofilament light chain (NfL) is a promising marker, t

141 s of case-control studies that have measured neurofilament light chain (NfL) levels in cerebrospinal

142 Neurofilament light chain (NFL) measurement has been gai

143 Neurofilament light chain (NfL) represents a promising b

144 nd neuroimaging datasets as well as with CSF neurofilament light chain (NfL) using linear regression

145 Cerebrospinal fluid (CSF) neurofilament light chain (NFL), a measure of axonal inj

146 ed tau (p-tau), beta-amyloid 1-42 (Abeta42), neurofilament light chain (NFL), alpha-synuclein (alpha-

147 t of HIV- subjects (n = 17) to CSF levels of neurofilament light chain (NFL), reflective of axonal da

148 The CSF biomarkers neurofilament light chain (NFL), S100B, glial fibrillary

149 ations between the QAlb and the CSF level of neurofilament light chain (NFL), the ratio of N-acetylas

150 M2), as well as a marker of neuronal damage, neurofilament light chain (NfL), using enzyme-linked imm

151 1, as well as the neuronal damage biomarker, neurofilament light chain (NFL), were elevated compared

152 o (Abeta(1-42/1-40)), total tau protein, and neurofilament light chain (NFL); tau phosphorylated at t

153 Serum neurofilament light chain (sNfL) and its ability to expo

154 Elevated neurofilament light chain and its correlation with MRS-b

155 kers, such as proxies of neuronal integrity (Neurofilament light chain and phosphorylated heavy chain

156 sphatase 2B catalytic subunit gamma isoform, neurofilament light chain and vesicular glutamate transp

157 bo in changes from baseline in CSF levels of neurofilament light chain at Week 78 (increases of 7.2 a

158 Neurofilament light chain correlated with decreased N-ac

159 tion, and in particular, multiple studies of neurofilament light chain have highlighted its importanc

160 dendritic spine loss around plaque and more neurofilament light chain in CSF.

161 Neurofilament light chain in the CSF was assessed as a b

162 ssociated with the concentrations of tau and neurofilament light chain in the CSF, suggesting a neuro

163 samples of PCB exposed humans, levels of the neurofilament light chain increase after LC-PCB exposure

164 enlarging lesions on T2-weighted MRI, serum neurofilament light chain levels at month 3, and change

165 ate of lesions on T2-weighted MRI, and serum neurofilament light chain levels, but not the change in

166 Cerebrospinal fluid concentrations of neurofilament light chain protein, Abeta1-42, total tau,

167 In PD, high neurofilament light chain protein, low Abeta1-42, and hi

168 In PD, high neurofilament light chain protein, low Abeta1-42, and hi

169 highlight the potential role of serum or CSF neurofilament light chain to differentiate bvFTD from pr

170 showed that expression of disease-associated neurofilament light chain variants results in abnormal i

171 Neurofilament light chain was elevated in primary HIV in

172 e, amyloid-beta, tau, phosphorylated tau and neurofilament light chain, are likely to be relevant to

173 We compared CSF concentrations of neurofilament light chain, t-tau, p-tau, amyloid precurs

174 and positively correlated with the levels of neurofilament light chain.

175 Neurofilament light chains (NfL) are unique to neuronal

176 This study analyzed serum neurofilament light chains (NfL) in 2 European cohorts o

177 on, Bacioglu, Maia, and colleagues show that neurofilament light concentrations in body fluids reflec

178 Therefore, we tested whether the change in neurofilament light contributed to delirium severity ind

179 that surgery was associated with increasing neurofilament light from preoperative levels [mean diffe

180 Initially we confirmed prior reports that neurofilament light levels correlated with markers of ne

181 olecular architecture and reduction of blood neurofilament light levels, a clinically relevant biomar

182 We identified a novel neurofilament light polypeptide (NEFL) nonsense mutation

183 oth disease (CMT) caused by mutations in the neurofilament light polypeptide gene (NEFL).

184 Multiple mutations in the neurofilament light polypeptide gene, NEFL, cause CMT2E.

185 We hypothesized that measurement of neurofilament light protein (NF-L), a protein found in l

186 CSF neurofilament light protein (NfL), plasma NfL, and CSF Y

187 Furthermore, neurofilament light protein concentrations correlated wi

188 We investigated whether neurofilament light protein NfL (also known as NF-L) in

189 Main Outcomes and Measures: Neurofilament light protein, total tau, glial fibrillary

190 and Relevance: Increased cerebrospinal fluid neurofilament light proteins and reduced amyloid beta we

191 Neurofilament light proteins were significantly increase

192 Neurofilament light rose more sharply in participants wi

193 lationship showed dose-dependence, such that neurofilament light rose proportionately to delirium sev

194 acid aggregate colocalizes and binds to the neurofilament light subunit protein that is associated w

195 Neurofilament light was independently associated with de

196 ilar aggregation-inducing mechanism in NEFL (neurofilament light) and FUS (fused in sarcoma), in whic

197 derwent perioperative testing for changes in neurofilament light, a neuronal injury biomarker, as wel

198 stoperative delirium, next we tested whether neurofilament light, as a potential marker of neurotoxic

199 Neurofilaments light chain (Nf-L), an integral part of t

200 protein FUS, superoxide dismutase Cu-Zn and neurofilaments light polypeptide) alongside newly identi

201 Neurofilaments NF-L (neurofilament-light chain) and pNF-H (phosphorylated neu

202 ogels a narrow ionic strength range, whereas neurofilament-low hydrogels lack the isotropic gel phase

203 ediate filaments assembled from the subunits neurofilament-low, neurofilament-medium and neurofilamen

204 ic gel phase stability is sidearm-dependent: neurofilament-low-high hydrogels exhibit a wide ionic st

205 ometry, that with decreasing ionic strength, neurofilament-low-high, neurofilament-low-medium and neu

206 sing ionic strength, neurofilament-low-high, neurofilament-low-medium and neurofilament-low-medium-hi

207 drogels exhibit a wide ionic strength range, neurofilament-low-medium hydrogels a narrow ionic streng

208 ament-low-high, neurofilament-low-medium and neurofilament-low-medium-high hydrogels transition from

209 d in significant upregulation of Oct4, SSEA, Neurofilament M and GFAP with significant decreases in b

210 differentiated cells (Oct4, SSEA4), neurons (Neurofilament M), astrocytes (GFAP) or cell cycle phase,

211 h peak cell cycle exit at E11.5, followed by neurofilament-M neurons, calcitonin gene-related peptide

212 loads, changes at the substructural level of neurofilaments may precede microtubule rupture and degen

213 precise use and confident interpretation of neurofilament measures as biomarkers of neurodegeneratio

214 well as an epitope within the axonal protein neurofilament medium (NF-M15-35) in H-2(b) mice.

215 te glycoprotein epitope 35-55 (MOG35-55) and neurofilament medium protein epitope 15-35 (NFM15-35).

216 hnRNP K-regulated cytoskeletal RNAs (tau and neurofilament medium), effects that were alleviated by e

217 sembled from the subunits neurofilament-low, neurofilament-medium and neurofilament-high.

218 Neurofilaments move bidirectionally along axons, alterna

219 The model assumes that the probability of a neurofilament moving is dependent on its distance from t

220 To investigate how neurofilaments navigate these constrictions, we develope

221 Consequences of its loss include neurofilament network abnormalities, specifically accumu

222 t protein that is associated with pathologic neurofilament network disorganization and degeneration o

223 , we show that the macroscopic properties of neurofilament networks are tuned by enzymatic regulation

224 , CHX10(+) cells expressed neuronal markers [neurofilament, NeuN, and vesicular glutamate transporter

225 ), synaptic (PSD-95; synaptophysin), axonal (neurofilament/neurofilament light chain [NFL]), inflamma

226 on for the complexity of the neurobiology of neurofilaments, new recognition of specialized roles for

227 Neurofilaments NF-L (neurofilament-light chain) and pNF-

228 at spinal MNs, but rarely non-MNs, exhibited neurofilament (NF) aggregation followed by neurite degen

229 Neurofilament (NF) proteins detection in biological flui

230 Synaptic roles for neurofilament (NF) proteins have rarely been considered.

231 leads to the hyperphosphorylation of Tau and neurofilament (NF) proteins in ALS transgenic mouse mode

232 ude low-, middle-, and high-molecular-weight neurofilament (NF) triplet proteins, designated NFL, NFM

233 n family, which also includes peripherin and neurofilament (NF) triplet proteins.

234 uronal intermediate filaments comprising the neurofilament (NF) triplet proteins.

235 iated from GAN iPSCs exhibit accumulation of neurofilament (NF-L) and peripherin (PRPH) protein and f

236 Neurofilaments (Nf) are major structural proteins that o

237 terized by impaired myelin basic protein and neurofilament NF200, the reduced thickness of corpus cal

238 Brn3 transcription factor and the different neurofilaments (NF68, NF160, NF200) were able to discrim

239 additional study to investigate the value of neurofilament (NfH) and other biomarkers in predicting p

240 on at nodes is accompanied by a reduction in neurofilament number that can be as much as 10-fold in t

241 ctions are accompanied by sharp decreases in neurofilament number, no decreases in microtubule number

242 ier, resulting in a marked local decrease in neurofilament number.

243 Transfected microtubules and neurofilaments of E17 rat neuronal axons are imaged befo

244 anism gradually segregates microtubules from neurofilaments on a time scale of hours, similar to that

245 tissue interface was uniform and neurons and neurofilaments penetrated through the mesh by 3 mo posti

246 rs TrkA, TrkB, TrkC, and RET and the sensory neurofilament peripherin.

247 Neurofilament phosphorylation was also observed to incre

248 amyelin loops) and axonopathy (i.e., altered neurofilament phosphorylation, paranodal defects, and ch

249 mature myelinated axons ex vivo reveals that neurofilament polymers navigate these nodal axonal const

250 hat expresses a photoactivatable fluorescent neurofilament protein in neurons.

251 We also noted that neurofilament protein SMI31 immunoreactivity was increas

252 0 days of darkness also enhanced the loss of neurofilament protein within deprived dLGN layers.

253 e, and also reversed the significant loss of neurofilament protein within originally deprived dLGN la

254 rofibrillary tangles such as tau, ubiquitin, neurofilament proteins and apolipoprotein E.

255 Colocalization of 3-NT staining with neurofilament proteins and evidence of decreased tyrosin

256 , serum levels of glial fibrillar acidic and neurofilament proteins and S100B.

257 ation, whereas 3-NT modification of striatal neurofilament proteins likely points to the ensuing dopa

258 These include neurofilament proteins that constitute the stress-respon

259 entin(+) SW13 cells, and with peripherin and neurofilament proteins when transfected into N2a cells.

260 ed by significant reduction in the levels of neurofilament proteins, and alterations in axonal fiber

261 Here we will review the neurobiology of neurofilament proteins, describing current understanding

262 ar calcium signaling, and down-regulation of neurofilament proteins, with DLG4 and MAPT as major hub

263 enous Nes-S co-assembles with peripherin and neurofilament proteins.

264 Accumulation of the heavy-chain neurofilaments reflects the maturation status of neurona

265 al analysis of renal arteries yielded a mean neurofilament score of healthy nerves that was significa

266 eurodegenerative disorders, microtubules and neurofilaments segregate apart from each other, with mic

267 This suggests that the microtubule-neurofilament segregation can be a consequence of the se

268 t (i.e., the proportion of the time that the neurofilaments spend moving).

269 rease in the proportion of the time that the neurofilaments spent pausing and that this increase in p

270 sions colocalize with the low-molecular-mass neurofilament subunit (NFL) or peripherin staining.

271 evealed plentiful mRNA for the low molecular neurofilament subunit and beta-tubulin, but very little

272 a concentrations of the phophorylated axonal neurofilament subunit H, indicating that axonal integrit

273 the first time in human lung tissue, 200-kD neurofilament subunit.

274 to neuron structure and function, and three neurofilament subunits different in their molecular mass

275 or example, the homeodomain TF DACH1 and the neurofilament subunits NF-L (NFEL) and NF-M (NFEM) were

276 her proteins, and decrease the expression of neurofilaments that could be relevant to the mechanism o

277 ely by a local increase in the duty cycle of neurofilament transport (i.e., the proportion of the tim

278 ament accumulation suggests an impairment of neurofilament transport along axons, the underlying mech

279 cape kinetics, we found that this slowing of neurofilament transport could be explained by an increas

280 microtubule tracks may be a key regulator of neurofilament transport in axons, which has implications

281 -escape technique to compare the kinetics of neurofilament transport in contiguous myelinated and unm

282 Imaging of neurofilament transport in mature myelinated axons ex vi

283 escence photoactivation technique to analyze neurofilament transport in mature myelinated axons of ti

284 Neurofilament transport is accelerated at nodes of Ranvi

285 than in flanking internodes, indicating that neurofilament transport is faster in nodes.

286 est this, we developed a stochastic model of neurofilament transport that tracks their number, kineti

287 that this regulatory mechanism may influence neurofilament transport within axons.

288 microtubules together, and in the absence of neurofilament transport, this mechanism gradually segreg

289 a consequence of the selective impairment of neurofilament transport.

290 and this correlated with a local slowing of neurofilament transport.

291 axons locally by modulating the kinetics of neurofilament transport.

292 is accumulation is a decrease in the rate of neurofilament transport.

293 bodies against choline-acetyltransferase and neurofilament was performed to differentiate motor and s

294 CSF neurofilaments were increased before symptom onset, whil

295 All three neurofilaments were primarily expressed in large M2 cell

296 By contrast, neurofilaments were significantly decreased in SN of KO

297 One type of cargo are neurofilaments, which are abundant space-filling cytoske

298 f space-filling cytoskeletal polymers called neurofilaments, which are cargoes of axonal transport.

299 tial bottlenecks for the axonal transport of neurofilaments, which move along axons in a rapid interm

300 ficient to explain the local acceleration of neurofilaments within nodes of Ranvier.