ライフサイエンスコーパス: neurologic disease

1 g. cardiovascular complications, cancer, and neurologic disease).

2 a novel biological therapy for a progressive neurologic disease.

3 r's disease than the brains of women without neurologic disease.

4 t with a role for SIV in the pathogenesis of neurologic disease.

5 linked and may play a combined role in human neurologic disease.

6 r half of the macaques developed SIV-induced neurologic disease.

7 possibly induce, aggravate, and/or maintain neurologic disease.

8 e stroke patients and 17 individuals free of neurologic disease.

9 implementation may help identify unsuspected neurologic disease.

10 ylation and splicing, and potential links to neurologic disease.

11 release of proinflammatory mediators causes neurologic disease.

12 broader functional deficits associated with neurologic disease.

13 mportant consideration for the patients with neurologic disease.

14 presents as uveitis, arthritis, myositis or neurologic disease.

15 iated with leukemia/lymphoma and progressive neurologic disease.

16 tering disease that is often associated with neurologic disease.

17 ted with the development of life-threatening neurologic disease.

18 portant roles in acute and chronic models of neurologic disease.

19 ng that extracellular Tax may be relevant to neurologic disease.

20 d with the pathogenesis of HTLV-I-associated neurologic disease.

21 ost factors that contribute to virus-induced neurologic disease.

22 eath that may contribute to HIV-1-associated neurologic disease.

23 phenotype of BP is not affected by preceding neurologic disease.

24 %) of 41 samples from patients without known neurologic disease.

25 d cell death may play a role in degenerative neurologic disease.

26 ce the incidence and severity of genital and neurologic disease.

27 neurobiology, tumor immunity, and autoimmune neurologic disease.

28 the role of CCR2 in a model of viral-induced neurologic disease.

29 not completely protected against genital and neurologic disease.

30 ficantly older than patients with BP without neurologic disease.

31 to the neuropathogenesis of HIV-1 associated neurologic disease.

32 assembly, and the emergence of diabetes and neurologic disease.

33 in humans at Xq13, a region associated with neurologic disease.

34 tein cause glutaric acidemia type I, a fatal neurologic disease.

35 ith end-stage pulmonary, cardiac, renal, and neurologic disease.

36 ) is expressed in the brain of patients with neurologic disease.

37 tric disease, or a movement-disorder type of neurologic disease.

38 tigating the mechanism of lentivirus-induced neurologic disease.

39 genome stability pathways that prevent human neurologic disease.

40 usceptibility of SJL mice to immune-mediated neurologic disease.

41 eir pivotal role in the pathogenesis of this neurologic disease.

42 he CNS but fails to induce clinical signs of neurologic disease.

43 ls may be required for induction of clinical neurologic disease.

44 es including infection, atherosclerosis, and neurologic disease.

45 cell vaccines do not cause infant deaths or neurologic disease.

46 e from the CNS but not for demyelination and neurologic disease.

47 issue is the use of this medical therapy in neurologic disease.

48 ents as early-onset progressive visceral and neurologic disease.

49 n reports, or investigations for undiagnosed neurologic disease.

50 clusions formed by FUS and other proteins in neurologic disease.

51 to this process in a model of viral-induced neurologic disease.

52 ease cases were identified; none experienced neurologic disease.

53 ed diagnosis of vision- and life-threatening neurologic disease.

54 controversial in patients with pre-existing neurologic disease.

55 ule organization, cell motility, cancer, and neurologic disease.

56 thout prior systemic treatment, dementia, or neurologic disease.

57 in attenuated derivatives that do not cause neurologic disease.

58 lay an important role in preventing onset of neurologic disease.

59 o control of viral replication as well as to neurologic disease.

60 rs have emerged as major causes of inherited neurologic disease.

61 isms attributed to progesterone treatment in neurologic disease.

62 studies using progesterone to treat several neurologic diseases.

63 nnitus, Williams syndrome, autism, and other neurologic diseases.

64 cur as part of the pathology of a variety of neurologic diseases.

65 in caregivers of patients with debilitating neurologic diseases.

66 prove the treatment, diagnosis, and study of neurologic diseases.

67 is now applicable for the study of selected neurologic diseases.

68 s have identified genetic variants linked to neurologic diseases.

69 patients with MS and 34 patients with other neurologic diseases.

70 of splicing may underlie many types of human neurologic diseases.

71 uding two (CACNA1A and PTPRZ1) implicated in neurologic diseases.

72 tment of patients with refractory autoimmune neurologic diseases.

73 thy brains, and brains of persons with other neurologic diseases.

74 ith ALS and only 1 of 29 subjects with other neurologic diseases.

75 s to the pathogenesis of a broad spectrum of neurologic diseases.

76 30%) had findings attributable to coexisting neurologic diseases.

77 cruitment to the brain is a hallmark of many neurologic diseases.

78 ntion of a broad spectrum of different human neurologic diseases.

79 l control subjects or in patients with other neurologic diseases.

80 emerged as an important therapy for various neurologic diseases.

81 on glial cells has been observed in several neurologic diseases.

82 on and the molecular pathophysiology of many neurologic diseases.

83 ay provide a novel therapy for TBI and other neurologic diseases.

84 main (NTD) aims for the treatment of various neurologic diseases.

85 nodeficiency virus, autoimmune diseases, and neurologic diseases.

86 Abs are beneficial as therapeutic agents for neurologic diseases.

87 fication of human mutations and treatment of neurologic diseases.

88 oles in dendrites and dysregulation in major neurologic diseases.

89 ailable for studying RNA gain-of-function in neurologic diseases.

90 of cardiovascular, liver, kidney, bone, and neurologic diseases.

91 osis (46.9%), in 3 of 329 persons with other neurologic diseases (0.9%), and in none of the 59 health

92 epidemiology and association with different neurologic diseases, 3) clinical presentation, 4) impact

93 For neurologic disease, 88% of patients received AMB, 78% wi

94 ychiatric disease, and numerous degenerative neurologic diseases, affect only the brain.

95 f PrP(d) accumulation in sheep succumbing to neurologic disease after blood transfusion from donors e

96 s as the pathogenic cell in the induction of neurologic disease after demyelination.

97 vasculature rather than on the phenotype of neurologic disease analyzed.

98 IV-infected PML patients who had progressive neurologic disease and an eventual fatal outcome.

99 Neurologic disease and bone disease are intriguing compl

100 h and arthritis, occasionally complicated by neurologic disease and chronic arthritis.

101 (PBMCs) from patients with HTLV-I-associated neurologic disease and defined a new CD8+ T-cell epitope

102 irulent HSV-2 showed more severe genital and neurologic disease and higher mortality rates than their

103 Somatic mutation in neurons is linked to neurologic disease and implicated in cell-type diversifi

104 of copper and iron roles in neurobiology and neurologic disease and may allow for the development of

105 ere is no question that it can also occur in neurologic disease and models thereof.

106 We investigated an outbreak of severe neurologic disease and pneumonia that occurred among stu

107 cription of an HTLV-II-infected patient with neurologic disease and presents the clinical and immunol

108 sitive results of the National Institutes of Neurologic Disease and Stroke tissue plasminogen activat

109 Stroke is the most common life-threatening neurologic disease and the leading cause of serious long

110 namics of brain physiology in the context of neurologic disease and therapeutic interventions, which

111 death primarily resulted from the underlying neurologic disease and withdrawal of life-sustaining tre

112 nic Th17 cells enter the CNS at the onset of neurologic disease and, in the absence of IL-10, appear

113 is by far the most important risk factor for neurologic disease and, once disease develops, for worse

114 chronic infections, autoimmune diseases, or neurologic diseases and 99 serum specimens from hospital

115 ne samples obtained from patients with other neurologic diseases and from healthy controls, resulting

116 ultiple sclerosis than in persons with other neurologic diseases and healthy donors (P<0.001 for both

117 ng on human disorders ranging from cancer to neurologic diseases and immunity.

118 Seropositivity is associated with neurologic diseases and malignancies.

119 17 [standard deviation]; 113 women) with 35 neurologic diseases and normal brain MRI scans obtained

120 arison group (normal MR images and no proved neurologic disease); and were expressed as a ratio.

121 rimary diagnosis of pulmonary disease, 14.2% neurologic disease, and 8.9% cardiac disease.

122 iruses that cause hemorrhagic, edematous, or neurologic disease, and as a result, our findings sugges

123 exerts a profound influence on development, neurologic disease, and cell stress.

124 h is associated with cardiovascular disease, neurologic disease, and early aging, is likely to be a m

125 ice had more neuronal apoptosis, more severe neurologic disease, and higher mortality than Bc mice.

126 ost often develops as a result of nongenetic neurologic disease, and it manifests in a variety of pat

127 roximal aortic atherosclerosis, a history of neurologic disease, and older age; predictors of type II

128 ctions are associated with birth defects and neurologic disease, and that the virus can be sexually t

129 Mortality, neurologic disease, and visceral dissemination of virus

130 es with both the severity of virally induced neurologic disease, and with the generation of neurotoxi

131 ide unique insights into the pathogenesis of neurologic diseases, and identify potential targets for

132 in patients with spinal cord injury or other neurologic diseases, and in critical care or perioperati

133 deaths attributed to cardiovascular disease, neurologic diseases, and suicide.

134 included asthma; diabetes; heart, lung, and neurologic diseases; and pregnancy.

135 ent enterovirus 71 strain that causes severe neurologic disease are highlighted.

136 Animal models to study development of neurologic disease are needed.

137 Autoimmune neurologic diseases are being increasingly recognized, a

138 r brain, possibilities for new treatments of neurologic diseases are bound to emerge.

139 BAF subunits underlie widely different human neurologic diseases arising in different neuronal types,

140 retroviral therapy in reducing viral burden, neurologic disease associated with HIV-1 infection of th

141 paraparesis is a demyelinating inflammatory neurologic disease associated with HTLV-1 infection.

142 tic paraparesis (HAM/TSP) is an inflammatory neurologic disease associated with HTLV-I infection, in

143 The spectrum of neurologic disease associated with mutations in NBIA gen

144 he Notch pathway are involved in a number of neurologic diseases associated with mental retardation o

145 s, a group of rare, transmissible, and fatal neurologic diseases associated with the accumulation of

146 erlying pathology (such as cancer or serious neurologic disease) associated with urinary incontinence

147 iratory tract by PCR, 42 (11.5%) of whom had neurologic disease attributable to M. pneumoniae.

148 The spectrum of neurologic disease attributable to Mycoplasma pneumoniae

149 these mice eventually developed a late-onset neurologic disease because of accumulation of another cl

150 ciated conditions, including psychiatric and neurologic disease, brain lesions, drug effect, and hear

151 s parenteral immunizations protected against neurologic disease but did not entirely prevent infectio

152 e HS binding increased brain replication and neurologic disease but reduced lymphoid tissue replicati

153 e a target for pharmacologic intervention in neurologic disease, but compounds that promote this acti

154 tion less than 45%, atrial fibrillation, and neurologic disease, but not the type of TTS, were indepe

155 ith IVIg is effective for certain autoimmune neurologic diseases, but its spectrum of efficacy has no

156 munoglobulin is effective in many autoimmune neurologic diseases, but its spectrum of efficacy, espec

157 apoptosis is a key aspect of many different neurologic diseases, but the mechanisms remain unresolve

158 confer both susceptibility to infection and neurologic disease by this human virus.

159 type I (HTLV-I) is associated with a chronic neurologic disease called HTLV-I-associated myelopathy/t

160 seases including inflammatory bowel disease, neurologic diseases, cardiovascular disorders, and cance

161 Many neurologic diseases cause discrete episodic impairment i

162 tic paraparesis (HAM/TSP) is an inflammatory neurologic disease caused by HTLV-I infection and has be

163 Fragile X syndrome (FXS) is an inherited neurologic disease caused by loss of fragile X mental re

164 lonus myoclonus ataxia (POMA), an autoimmune neurologic disease characterized by abnormal motor inhib

165 Guillain-Barre syndrome (GBS), a neurologic disease characterized by acute paralysis, is

166 nally identified as targets in an autoimmune neurologic disease characterized by failure of motor inh

167 Both Fr98 and Fr98/SE induce a clinical neurologic disease characterized by hyperexcitability an

168 t VEGF may be a viable therapeutic target in neurologic disease characterized by inflammation-induced

169 ssociated myelopathy is a slowly progressive neurologic disease characterized by inflammatory infiltr

170 aparesis (HAM/TSP) is a chronic, progressive neurologic disease characterized by marked degeneration

171 Multiple sclerosis (MS) is a multifactorial neurologic disease characterized by modest but tractable

172 phalopathy (CADASIL) is a genetically linked neurologic disease characterized by recurrent strokes an

173 These results have implications for treating neurologic diseases characterized by inherited single ge

174 subtype dysfunction is a key contributor to neurologic disease circuits, but identifying associated

175 ildren with AFM (n = 42) and other pediatric neurologic disease controls (n = 58) were investigated f

176 as seen in two of the 34 patients with other neurologic diseases, corresponding to the low percentage

177 White matter from other inflammatory neurologic diseases displayed glutaminase reactivity, wh

178 orsinA is the causative protein in the human neurologic disease early onset torsin dystonia, a moveme

179 evidence for the use of progesterone in each neurologic disease family.

180 athways has been suggested to play a role in neurologic diseases featuring cell death.

181 -third of CD4-depleted mice developed severe neurologic disease following infection, in contrast to v

182 rare variants identified in individuals with neurologic disease had complex, and sometimes opposing,

183 r periods of many years in the prevention of neurologic diseases has not been adequately explored.

184 udy are that patients with BP with preceding neurologic disease have a shorter elapsed time between o

185 ion is a key pathologic hallmark of numerous neurologic diseases, however, its exact role in vivo is

186 ters, is neuroinvasive, and induces clinical neurologic disease in 100% of neonatally inoculated mice

187 opment of a novel virus isolate that induces neurologic disease in a high proportion of rhesus macaqu

188 orts including inflammatory and degenerative neurologic disease in a multicenter study involving 220

189 iled macaques resulted in the development of neurologic disease in addition to AIDS.

190 g severe and often lethal respiratory and/or neurologic disease in animals and humans.

191 es severe and often fatal respiratory and/or neurologic disease in both animals and humans.

192 ral infarct (SCI) is the most common form of neurologic disease in children with sickle cell anemia (

193 cosis is now recognized as a common cause of neurologic disease in developing countries and the Unite

194 Outbreaks of neurologic disease in humans and horses were reported in

195 ue may have applications in the treatment of neurologic disease in humans.

196 arasitic nematode that causes a debilitating neurologic disease in many North American cervids and do

197 quent cause of hearing loss and debilitating neurologic disease in newborn infants.

198 s were found in brains from subjects without neurologic disease in similar proportions to those repor

199 everal murine leukemia viruses (MuLV) induce neurologic disease in susceptible mice.

200 The frequency of severe neurologic disease in the current epidemic suggests a mo

201 LV FB29 induces both syncytium formation and neurologic disease in vivo.

202 Multiple sclerosis (MS) is a common cause of neurologic disease in young adults that is primarily tre

203 sheath has been associated with a variety of neurologic diseases in which repair is limited, despite

204 rain atrophy is a common feature of numerous neurologic diseases in which the role of neuroinflammati

205 ted calcium channel, cause a number of human neurologic diseases including familial hemiplegic migrai

206 n activated brain endothelium contributes to neurologic disease, including cerebral ischemia and mult

207 Rare mitochondrial mutations cause neurologic disease, including ischemic stroke and MRI wh

208 nflammation has been associated with various neurologic diseases, including Alzheimer disease (AD).

209 issue suggests it may play a role in diverse neurologic diseases, including Alzheimer's disease, mult

210 disease and cognitive status in people with neurologic diseases, including Alzheimer's; disease and

211 eurotransmission has been implicated in many neurologic diseases, including epilepsy, intellectual di

212 e therapeutic benefit of a ketogenic diet in neurologic diseases, including epilepsy.

213 Reactive astrocytosis develops in many neurologic diseases, including epilepsy.

214 ove outcomes in animal models of a number of neurologic diseases, including traumatic brain injury, i

215 se virus, our findings may have relevance to neurologic disease induced by MCF retroviruses in mice.

216 ated neuroinvasiveness, and induces clinical neurologic disease infrequently, with a relatively long

217 Neurologic disease is correlated with the relative numbe

218 re related to the pathogenesis of autoimmune neurologic disease is discussed.

219 An increasing number of neurologic diseases is associated with autoimmunity.

220 ygenase (COX-2) activity in stroke and other neurologic diseases is complex, as both activation and s

221 nd in the brain, and it is hypothesized that neurologic disease leads to the production of autoantibo

222 ST-segment depression, higher prevalence of neurologic diseases, less pronounced reduction in left v

223 risk factors for reintubation included acute neurologic disease, lower aPiMax, postextubation upper a

224 nduction, this restriction directly promotes neurologic disease manifestations characteristic of east

225 This study demonstrates that distinct neurologic disease manifestations develop during relapsi

226 BDV causes neurologic disease manifested by behavioral abnormalitie

227 ous variegate porphyria is a severe skin and neurologic disease manifesting in early infancy, and cha

228 intensive care monitoring for patients with neurologic disease may change patterns of intensive care

229 Minocycline is broadly protective in neurologic disease models featuring cell death and is be

230 ologic hallmark of the human immune-mediated neurologic disease multiple sclerosis, which may be trig

231 sified as having either hepatic (n = 711) or neurologic disease (n = 461).

232 of MS (n=13), donors without any history of neurologic disease (n=20), and in platelets from healthy

233 n without clinical or pathologic evidence of neurologic disease (n=26), or women who had Alzheimer's

234 iseases (OIND; n = 19), and non-inflammatory neurologic diseases (NIND; n = 41).

235 ensive literature on innate inflammation and neurologic disease notwithstanding, three fundamental qu

236 xpressing mice showed no signs of the severe neurologic disease observed in completely deficient mice

237 dilatation disease (PDD), a frequently fatal neurologic disease of captive parrots.

238 ry systems, but the public health impact for neurologic disease of moderately low vitamin B-12 status

239 le sclerosis (MS), the most common disabling neurologic disease of young adults, is considered a clas

240 clerosis (PP-MS; n = 21), other inflammatory neurologic diseases (OIND; n = 19), and non-inflammatory

241 13 late Lyme disease patients, and 19 other neurologic disease (OND) controls.

242 c progressive MS (CPMS), patients with other neurologic disease (OND), patients with other autoimmune

243 is (SSPE), multiple sclerosis (MS), or other neurologic diseases (OND) by ELISA.

244 relapsing-remitting MS (RRMS; n = 12), other neurologic diseases (ONDs; n = 1), and healthy controls

245 n=17) were compared with patients with other neurologic diseases (ONDs; n=13) with respect to cerebro

246 etic mechanisms for M. pneumoniae-associated neurologic disease, one related to direct infection of t

247 Excluded were children with systemic neurologic disease, optic nerve or retinal disease (even

248 are innate inflammatory responses a cause of neurologic disease or merely a more sophisticated means

249 rains have seldom been associated with human neurologic disease or mortality, despite serological evi

250 stic disease (OR = 2.8; 95% CI, 2.4 to 3.1), neurologic disease (OR = 4.6; 95% CI, 2.3 to 8.9), bacte

251 flammatory agents effectively treat existing neurologic disease, or is a protective strategy in high-

252 of tarsal coalition, collagen abnormalities, neurologic disease, or other underlying condition.

253 itable bowel syndrome, anemia, osteoporosis, neurologic diseases, or malignancy.

254 of persons with multiple sclerosis or other neurologic diseases (P<0.001 for both comparisons).

255 ons in GABA receptor genes being involved in neurologic diseases, particularly the epilepsies.

256 A plethora of neurologic disease presents with brain iron accumulation

257 had been presumptively diagnosed with other neurologic diseases prior to organ procurement.

258 Metallothioneins are potential markers of neurologic disease processes and treatment response in L

259 owever, their contribution to autoimmune and neurologic disease processes has not been investigated.

260 pper deficiency, the mechanisms resulting in neurologic disease remain unknown.

261 tion might fail in the setting of autoimmune neurologic disease remains to be explored.

262 he prion protein promoter develop widespread neurologic disease, reminiscent of juvenile forms of oth

263 African Americans were more likely to have neurologic disease, renal disease, and a higher SLAM sco

264 more than half received funding; cancer and neurologic disease research is relatively well funded.

265 ted diet during gestation developed a severe neurologic disease resulting from extensive myelin vacuo

266 This neurologic disease results from a defect in the lysosoma

267 using visual fields from subjects with known neurologic disease, subjects with glaucoma, and glaucoma

268 the prevalence of congestive heart failure, neurologic diseases such as dementia and stroke, renal a

269 atrophy is prominent in chronic progressive neurologic diseases such as human T-cell lymphotropic vi

270 to ALS but also to other fatal, progressive neurologic diseases such as Huntington's chorea and late

271 ce in healthy CNS, its role in BBB repair in neurologic diseases such as MS remains unclear.

272 vel approach for immunotherapy of autoimmune neurologic diseases, such as multiple sclerosis.

273 Neural activity in the pallidum goes awry in neurologic diseases, such as Parkinson's disease.

274 Guillain-Barre syndrome (GBS), a neurologic disease that produces ascending paralysis, af

275 n and South American strains of EEEV produce neurologic disease that resembles that associated with h

276 bules, has been associated with several rare neurologic diseases that clinically include parkinsonian

277 ay critical roles in synaptic modulation and neurologic disease, the nature of its substrates has not

278 homocysteine has been associated with other neurologic diseases, these pathways have not been evalua

279 ses consists primarily of viruses that cause neurologic disease; these viruses include Omsk hemorrhag

280 s play a key role in pathophysiology of many neurologic diseases/trauma, but the effect of immune cel

281 In biopsy specimens of patients with neurologic diseases, vascular EGFL7 expression rose with

282 To investigate the role of SIV in neurologic disease, virus was isolated from a lymph node

283 romaius novaehollandiae (emu), a progressive neurologic disease was recently discovered, which was ch

284 For initial therapy of patients with neurologic disease we use tetrathiomolybdate.

285 responses that may contribute to autoimmune neurologic disease, we compared the responses of SJL and

286 To better understand the link between BP and neurologic disease, we evaluated primary demographic fea

287 es, anthropomorphic measurements, cancer and neurologic disease were also observed.

288 ies of trauma, intracerebral hemorrhage, and neurologic disease were associated with lower hospital s

289 Patients with a prior history of neurologic disease were excluded.

290 Interestingly, similar neurologic diseases were associated with both gain- and

291 pe develop severe demyelination with minimal neurologic disease when chronically infected with TMEV.

292 ting a broad range of acquired and inherited neurologic diseases, where the causative gene defect or

293 bigenic for the p35 and p40 genes, developed neurologic disease which correlated with the levels and

294 icing plays a particularly important role in neurologic disease, which is perhaps not surprising give

295 adult mice, nectin-1 is a major mediator of neurologic disease, while the absence of either receptor

296 re than 110 patients with various autoimmune neurologic diseases who received IVIg during the past 6

297 M83(+/-) mice developed progressive signs of neurologic disease with an incubation period of approxim

298 preclinical and clinical studies of several neurologic diseases with varying degrees of success.

299 brain tissue from donors with no history of neurologic disease, with TSPO-binding PET ligands other

300 Epilepsy is one of the most common chronic neurologic diseases, yet approximately one-third of affe