ライフサイエンスコーパス: neuromodulatory

1 xis can be approximately doubled through the neuromodulatory action of beta-adrenergic receptors (bet

2 c and postsynaptic mechanisms underlying the neuromodulatory action of picomolar amounts of oligomeri

3 rocytes are emerging as cells with important neuromodulatory actions in brain physiology.

4 These results suggest that the neuromodulatory actions of NA and 5-HT are compartmental

5 Our results reveal distinct neuromodulatory actions of striatal dopamine that extend

6 rovide a better understanding of the role of neuromodulatory actions on HPC place map plasticity.

7 stingly, despite the striking differences in neuromodulatory actions on output neurons, chemogenetic

8 rates the motor pattern through synaptic and neuromodulatory actions, thereby differing from its homo

9 lts revealed that the kinetics emerging from neuromodulatory activation of the signaling network were

10 new structural class of compounds exhibiting neuromodulatory activities from marine cyanobacteria.

11 in a nutritionally sensitive metabolite with neuromodulatory activity rather than indirect or seconda

12 acterial metabolites with known or suspected neuromodulatory activity, define mechanisms of signallin

13 ts from extrinsic and intrinsic sources, and neuromodulatory afferents from cholinergic and monoamine

14 eruleus complex, auditory system, and motor, neuromodulatory and autonomic systems involved in feedin

15 Rather, the neuromodulatory and electrophysiological events that cha

16 tin 2A receptor (sst2A) mediates many of the neuromodulatory and neuroendocrine actions of somatostat

17 Multiple points of interaction with other neuromodulatory and signaling systems have now been iden

18 serve as novel targets for pharmacological, neuromodulatory, and behavioral interventions.

19 cranial direct current stimulation (tDCS), a neuromodulatory approach that has previously been demons

20 tend the optogenetic toolset by developing a neuromodulatory approach using a rationale-based design

21 ts, and demonstrates the utility of chronic, neuromodulatory approaches in ameliorating AD pathology

22 the safety and efficacy of neuroleptics and neuromodulatory approaches in treatment-resistant cases

23 hasic, pupil-linked responses of a number of neuromodulatory brainstem centers involved in the contro

24 We identify orthogonal neuromodulatory cascades that oppositely control periphe

25 sed this method (MultiMAP) to record from 22 neuromodulatory cell types in behaving zebrafish during

26 next recorded from and controlled homologous neuromodulatory cells in mice; alertness-related cell-ty

27 stematic evaluation of mouse lines targeting neuromodulatory cells in the DR.

28 he first causal demonstration of the role of neuromodulatory centers in VPL in primates.

29 erceptual learning through the activation of neuromodulatory centers, but this has not been directly

30 ons through the influence of the amygdala on neuromodulatory centers.

31 lectric medicine due to its direct access to neuromodulatory centers.

32 through global projections, arousal-related neuromodulatory changes can rapidly alter coordination o

33 c sleep restriction likely induces long-term neuromodulatory changes in brain physiology that could e

34 The slow temporal dynamics of this neuromodulatory circuit supplement fast motor circuits t

35 Here, we characterize a neuromodulatory circuit that generates long-lasting roam

36 s, the iTango platform allows for control of neuromodulatory circuits in a genetically and functional

37 ionship between the circadian system and the neuromodulatory circuits that govern motivational behavi

38 These findings provide insight into neuromodulatory circuits that regulate motivated behavio

39 er nudibranch, Dendronotus iris, serves as a neuromodulatory command neuron for the CPG of a homologo

40 fort, delineating transmission properties of neuromodulatory communication remains a daunting task du

41 Mapping neuromodulatory connections in this system thus defines

42 Here, we systematically map the patterns of neuromodulatory connectivity in a network that governs a

43 will be highlighted concerning the roles of neuromodulatory control and postsynaptic long-range proj

44 ong experimental evidence that STDP is under neuromodulatory control by acetylcholine, monoamines, an

45 Neuromodulatory control by oxytocin is essential to a wi

46 These results provide evidence for top-down, neuromodulatory control of entropy in neural state model

47 the motion pathway or whether they are under neuromodulatory control to impart functional plasticity

48 timing-dependent plasticity (STDP) is under neuromodulatory control, which is correlated with distin

49 le courtship drive is complex and subject to neuromodulatory control.

50 hese data establish a molecular basis of the neuromodulatory deficiency in BN rats, and further sugge

51 cortical populations and the crucial role of neuromodulatory drive in specific inhibitory-excitatory

52 aracterized biochemicals, and derivatives of neuromodulatory drugs as important areas for assessing m

53 with psychiatric disorders, where a putative neuromodulatory dysregulation provides the rationale for

54 ompared with stDCS, reflecting the preserved neuromodulatory effect of atDCS in older adults.

55 A neuromodulatory effect of creatine via increased energy

56 thermal sensitivity were used to assess the neuromodulatory effect of glial Gq-GPCR activation in aw

57 (Cajal cells) of the olfactory bulb and its neuromodulatory effect on mitral cell (MC) first-order n

58 efits of DBS are, at least in part, due to a neuromodulatory effect on the SNpc neurons.

59 n if the patient believes there is an actual neuromodulatory effect.

60 Such rapid neuromodulatory effects are likely mediated via membrane

61 Neuromodulatory effects can vary with their mode of tran

62 We then quantified the neuromodulatory effects of DBS and compared sixteen dyna

63 In this study, we investigate the neuromodulatory effects of dopaminergic and serotonergic

64 g PLE to neurons, VF-EX2 can interrogate the neuromodulatory effects of serotonin in cultured hippoca

65 parator lorazepam (LZP) with regard to their neuromodulatory effects on local and network responses t

66 sitions and how state-encoding neurons exert neuromodulatory effects on sensory perception and decisi

67 w approach for quantitative investigation of neuromodulatory effects on signaling and electrophysiolo

68 in signaling and integrate how these various neuromodulatory effects shape and protect synapses.

69 his assessment of dopamine and noradrenaline neuromodulatory effects we reveal their specific contrib

70 TUS neuromodulatory effects were measured by examining relat

71 To date, investigations report short-lived neuromodulatory effects, but to deliver on its full pote

72 se inhibitor, did not block norepinephrine's neuromodulatory effects.

73 n the brain, thought to mediate a variety of neuromodulatory effects.

74 ility to distinguish sensory processing from neuromodulatory effects.

75 incorporating both nicotinic and muscarinic neuromodulatory effects.

76 Here we show that neuromodulatory electrical stimulation of the supplement

77 nectome provides a minimal structure and the neuromodulatory environment constructs and specifies the

78 Loss of tonic neuromodulatory excitation, mediated by nicotinic acetyl

79 consolidation process is thought to require neuromodulatory factors such as dopamine, noradrenaline,

80 dependent of all known forms of synaptic and neuromodulatory feedback-maintains most channel mRNA rel

81 e rapid recruitment of presynaptic proteins, neuromodulatory forms of plasticity, such as facilitatio

82 is clarified when considered within a larger neuromodulatory framework.

83 mpelling evidence that prefrontal control of neuromodulatory function can have a dramatic effect on m

84 cessing and reveal fundamental principles of neuromodulatory function.

85 This RFamide neuropeptide has neuromodulatory functions and controls the synthesis and

86 nnels, they are most adept at mediating slow neuromodulatory functions that are more widespread and m

87 .Certain neuropeptides, in addition to their neuromodulatory functions, display antibacterial activit

88 -stimulating hormone (TSH) levels as well as neuromodulatory functions.

89 enosine serves important neuroprotective and neuromodulatory functions.

90 of GnRH release, providing insight into its neuromodulatory functions.

91 pted in developing neurons by overexpressing neuromodulatory G-protein-coupled receptors GPCRs or by

92 disruption of glutamatergic, potassium, and neuromodulatory homoeostasis, resulting in dysregulated

93 Exogenous application of the neuromodulatory hormone oxytocin (OT) promotes prosocial

94 Thus, the PAG represents a neuromodulatory hub that regulates both the sensory and

95 rom competition between leucokinin and other neuromodulatory hunger signals at the level of the DANs.

96 To examine the neuromodulatory influence of brain extracellular fluid o

97 ovel framework for inferring, noninvasively, neuromodulatory influences on ion channel signaling via

98 This review describes unique neuromodulatory influences on working memory prefrontal

99 Neuromodulatory influences, exemplified by the effects o

100 he interaction of multiple physiological and neuromodulatory influences, the PLR reflects the action

101 solidation in the BLA is mediated in part by neuromodulatory inhibition of the M-current, which is co

102 ntified GABAergic interneurons as targets of neuromodulatory input and mediators of state-dependent g

103 Thus, variation between individuals in neuromodulatory input contributes to individuality in a

104 e find that variation between individuals in neuromodulatory input contributes to individuality in sh

105 pensation was achieved by stronger extrinsic neuromodulatory input from projection neurons or by augm

106 This is partly due to fluctuations in neuromodulatory input from regions such as the noradrene

107 t can be conditionally provided by extrinsic neuromodulatory input that counterbalances temperature-i

108 Neuromodulatory input, acting on G protein-coupled recep

109 tonomously in vivo, but is likely induced by neuromodulatory input, which is consistent with the idea

110 ional and arousal states, motor activity and neuromodulatory input.

111 in response to diverse sensory and top-down neuromodulatory input.

112 hreat (fear) conditioning (PTC), sensory and neuromodulatory inputs converge on post-synaptic neurons

113 could be stabilized by activating extrinsic neuromodulatory inputs from descending projection neuron

114 Their activity is also sensitive to neuromodulatory inputs from multiple respiratory centers

115 onally influenced by inhibition and possibly neuromodulatory inputs, albeit their functional role is

116 f not all, sensory networks receive multiple neuromodulatory inputs, and the mechanisms by which sens

117 y influenced by nonlocal corticocortical and neuromodulatory inputs.

118 rties, likely reflecting corticocortical and neuromodulatory inputs.

119 the first evidence of a clinical effect of a neuromodulatory intervention in the subacute phase of st

120 sting plastic and restorative changes when a neuromodulatory intervention is coupled with visual trai

121 for long-lasting plastic changes promoted by neuromodulatory intervention.

122 ranslation of neuroimaging findings to novel neuromodulatory interventions capable of enhancing the t

123 s-level view also provides insights into how neuromodulatory interventions might target pathological

124 tigating effects of both pharmacological and neuromodulatory interventions on excitatory/inhibitory b

125 findings may be relevant for rehabilitative neuromodulatory interventions.

126 ch enables the direct overlaying of chemical neuromodulatory maps onto synaptic connectomic maps in t

127 synapses in the olfactory bulb, revealing a neuromodulatory mechanism for continued circuit plastici

128 ur findings illustrate a simple yet powerful neuromodulatory mechanism to shift the balance between b

129 r this effect is unclear, and the underlying neuromodulatory mechanisms are unknown.

130 We describe and test the synaptic and neuromodulatory mechanisms by which the command neuron i

131 Furthermore, the roles played by neuromodulatory mechanisms can be addressed directly thr

132 These data reveal circuit-level and neuromodulatory mechanisms regulating social function re

133 stigations of spatiotemporal dynamics in the neuromodulatory microcircuits involved in perceptual lea

134 I suggest a consensus effect of each neuromodulatory molecule on Drosophila aggression, as we

135 LPFC and thalamus, two key components of the neuromodulatory network.

136 echanism for behavioral flexibility in which neuromodulatory networks act with synaptic precision to

137 estable predictions regarding 37 peptidergic neuromodulatory networks that may play prominent roles i

138 w work in Drosophila melanogaster shows that neuromodulatory neurons active during flight boost respo

139 r may illustrate a general strategy by which neuromodulatory neurons orchestrate behavior.

140 -motor task, glia integrate information from neuromodulatory neurons to stop motor output.

141 uit flies is coordinated by a single pair of neuromodulatory neurons with command-like function.

142 ies lacking the function of the command-like neuromodulatory neurons.

143 The cholinergic system is a neuromodulatory neurotransmitter system involved in a va

144 For example, damage to neuromodulatory neurotransmitter systems is common after

145 ortex and from the locus coeruleus (LC) (the neuromodulatory nucleus releasing norepinephrine) in ure

146 eus (LC) is a seemingly singular and compact neuromodulatory nucleus that is a prominent component of

147 These neuromodulatory or gain control processes are central to

148 or controlling neuronal activity that shapes neuromodulatory outcomes.

149 However, the translation of neuromodulatory OXT effects to novel treatment approache

150 functional asymmetry in a major cholinergic neuromodulatory pathway of the vertebrate brain.

151 g their neuromodulatory state: activation of neuromodulatory pathways establishes a dynamic coregulat

152 on, indicating differentiated involvement of neuromodulatory pathways in the ripple phenomenon mediat

153 for conveying neural activity downstream via neuromodulatory pathways that are distinct from classica

154 ic methods to stimulate prefrontal-brainstem neuromodulatory pathways while animals face environmenta

155 ured when isolating the functions of various neuromodulatory peptide systems within the striatum.

156 This suggests structural dependence by the neuromodulatory process to induce analgesia with potenti

157 It is therefore crucial to understand the neuromodulatory processes that regulate the function of

158 The neuromodulatory processes underlying these different phe

159 ved little or no transport, however, through neuromodulatory projections (e.g., serotonergic, choline

160 re effectors of alpha7-nAChRs and that their neuromodulatory properties depend on phosphorylation of

161 ion can exhibit unique circuit functions and neuromodulatory properties dictated by disparate develop

162 However, because of their neuromodulatory properties, the kynurenines are not just

163 signaling molecules, these G-protein-coupled neuromodulatory receptors are capable of recruiting a di

164 ulation are made complex by the diversity of neuromodulatory receptors expressed within a neural netw

165 memories of post-traumatic stress disorder, neuromodulatory receptors provide a potential pharmacolo

166 gered by activation of Hebbian processes and neuromodulatory receptors, interact to produce neural pl

167 with regional differences in the density of neuromodulatory receptors, which in turn relate to disti

168 anization of neurons that express individual neuromodulatory receptors.

169 tethered photoswitchable ligands to control neuromodulatory receptors.

170 acetylcholine system plays a central role in neuromodulatory regulation of cognitive control processe

171 These results support the idea that neuromodulatory regulation of ion channel activity and n

172 gnaling and may function in the DCV-mediated neuromodulatory regulation of locomotion rate.

173 iduals within a species, result in part from neuromodulatory regulation of these neural circuits, whi

174 actory conditioned stimulus (CS) inputs with neuromodulatory reinforcement (unconditioned stimuli, US

175 ia (AIH) leads to fundamental changes in the neuromodulatory response of the respiratory network loca

176 y exhibit homogeneous developmental origins, neuromodulatory response profiles, morphological charact

177 external circumstances; both the rhythm and neuromodulatory responses of breathing are controlled by

178 data show that P2X receptors often underlie neuromodulatory responses on slower time scales of secon

179 ophysiological properties, excitability, and neuromodulatory responses to serotonin (5-HT) in mouse l

180 d receptor activation and by startle-induced neuromodulatory responses.

181 A fast, neuromodulatory role for estrogen signaling has been rep

182 Together, our data describe a novel neuromodulatory role for VAV-1-dependent signalling in t

183 et al. (2017) demonstrate that IL-17 plays a neuromodulatory role in Caenorhabditis elegans by acting

184 /hypocretin peptide signaling system plays a neuromodulatory role in motivation and stress; two criti

185 previously thought, and that GABA may play a neuromodulatory role in the control of lens or pupil fun

186 g adds to the complex picture of the central neuromodulatory role of aggression in human subjects.

187 g adds to the complex picture of the central neuromodulatory role of aggression in humans.

188 g adds to the complex picture of the central neuromodulatory role of impulsive aggression in human su

189 s adds to the complex picture of the central neuromodulatory role of impulsive aggression in human su

190 on neuronal circuits where DAAO can exert a neuromodulatory role.

191 Collectively, these data uncover important neuromodulatory roles for TAAR1 and suggest that agonist

192 Collectively, these data uncover essential neuromodulatory roles of TAAR 1 on cocaine abuse, and su

193 panded to include multiple postdevelopmental neuromodulatory roles, revealing an ever increasing body

194 tool for studying how endogenous subcortical neuromodulatory signaling affects human cognition, inclu

195 ical models of the effects of stress-related neuromodulatory signaling at the cellular level to large

196 echolaminergic hyperactivation alters phasic neuromodulatory signaling in memory-related circuits, re

197 naling by Pigment-dispersing factor (PDF), a neuromodulatory signaling peptide produced only by circa

198 ur work elucidates the interplay between two neuromodulatory signaling systems in the brain through w

199 Elucidating brain circuits and neuromodulatory signaling systems that regulate sociabil

200 however, about the neural substrates or the neuromodulatory signaling that govern ELS-induced social

201 Pair-bond formation depends vitally on neuromodulatory signaling within the nucleus accumbens,

202 es noradrenaline and other arousal-promoting neuromodulatory signaling, and mimics invasive VNS.SIGNI

203 epresents a dynamic process that may require neuromodulatory signaling.

204 dopamine transients are accompanied by other neuromodulatory signals, such as acetylcholine and adeno

205 striatal circuits and ascending dopaminergic neuromodulatory signals.

206 es delta rhythms in conditions mimicking the neuromodulatory state during deep sleep (low cholinergic

207 Pupil diameter, which indexes neuromodulatory state including noradrenaline release, p

208 ionally and dysfunctionally regulated by the neuromodulatory state of the brain.

209 coupled activity, synaptic connectivity, and neuromodulatory state, we determined that correlated cha

210 l networks are compensated by changing their neuromodulatory state: activation of neuromodulatory pat

211 s a simple, tractable model for studying how neuromodulatory states like stress alter behavioral resp

212 connectivity between these neurons, and the neuromodulatory status of the circuits at the time they

213 Although neuromodulatory strategies have targeted different sites

214 autonomic testing, risk stratification, and neuromodulatory strategies to mitigate the progression o

215 xus between diverse multisensory, motor, and neuromodulatory streams.

216 e precise homeostatic control by subcortical neuromodulatory structures(2).

217 as allowed the systematic exploration of how neuromodulatory substances and the neurons that release

218 ir function in vivo is likely to be tuned by neuromodulatory substances in the brain extracellular fl

219 urons and alter effective synaptic strength, neuromodulatory substances reconfigure neuronal circuits

220 known to contain a wide range of endogenous neuromodulatory substances, but their collective influen

221 Nevertheless, the neuromodulatory substrates of rejection experiences are

222 s the enhancement of prefrontal cortex (PFC)-neuromodulatory subsystem connectivity in ketamine-treat

223 age-dependent and -independent channels, and neuromodulatory synapses on the dendritic tree.

224 report suggestive of presynaptically silent neuromodulatory synapses.

225 forming symmetrical (putative inhibitory or neuromodulatory) synapses were unlabeled perikarya and M

226 on at three different levels: (i) underlying neuromodulatory (synaptic) mechanisms; (ii) cognitive an

227 brain cholinergic neurons constitute a major neuromodulatory system implicated in normal cognition an

228 abis exposure affects the maturation of this neuromodulatory system remains limited.

229 e DDT represents an evolutionarily conserved neuromodulatory system that is necessary for normal vert

230 endocannabinoid system (ECS) is a widespread neuromodulatory system that plays important roles in cen

231 s provide novel insight into an understudied neuromodulatory system within the NAc and implicate HA i

232 The most common chemogenetic neuromodulatory system, designer receptors exclusively a

233 As a diffuse neuromodulatory system, noradrenaline affects learning a

234 The endogenous opioid system, a complex neuromodulatory system, sits at the neurobiological conv

235 differences in molecular regulation of a key neuromodulatory system, the endocannabinoid system, in t

236 the locus coeruleus (LC)-norepinephrine (NE) neuromodulatory system, which mediates relationships bet

237 is powerfully controlled by the cholinergic neuromodulatory system.

238 imuli with activation of the nucleus basalis neuromodulatory system.

239 It has been proposed that pupil-linked neuromodulatory systems are activated by the termination

240 Neuromodulatory systems are essential for remodeling glu

241 Genetic components of neuromodulatory systems are highly conserved across anim

242 ections between these networks and brainstem neuromodulatory systems are likely to provide the signal

243 vo These results elucidate pathways by which neuromodulatory systems can dynamically regulate brain c

244 ve cues, but little is known about how other neuromodulatory systems contribute to cue-motivated beha

245 We conclude that the central neuromodulatory systems controlling pupil size are conti

246 Thus we show parallel neuromodulatory systems functionally reconfigure early o

247 netic bases of behaviors and in recent years neuromodulatory systems have been shown to play a major

248 However, it is unknown how neuromodulatory systems impact on the generation of opti

249 One speculation is that the brain employs neuromodulatory systems implicated in primary reward-see

250 ight into the organization and regulation of neuromodulatory systems in anuran amphibians, tracing an

251 tions for thinking about the role of related neuromodulatory systems in mammals.

252 sely, but the specific role of the different neuromodulatory systems in motivation remains unclear.

253 Deciphering the role of neuromodulatory systems in motor network development has

254 Several neuromodulatory systems increase or decrease the degree

255 the hypothesis that subcortical and cortical neuromodulatory systems interact to guide aspects of goa

256 in pupil diameter, suggesting that ascending neuromodulatory systems may govern the transition betwee

257 These studies elucidate how different neuromodulatory systems regulate aversive emotional proc

258 Neuromodulatory systems such as noradrenaline (NE), acet

259 Diffuse neuromodulatory systems such as norepinephrine (NE) cont

260 are embodied in complex circuits, including neuromodulatory systems such as the noradrenergic locus

261 he olfactory map is mediated by two parallel neuromodulatory systems that act in opposing directions

262 l an evolutionarily conserved set of diverse neuromodulatory systems that collectively govern interna

263 Evolutionarily conserved neuromodulatory systems that define neural states of nut

264 lineage, dopaminergic neurons form important neuromodulatory systems that influence motor behavior, m

265 d distribution of synapses from two powerful neuromodulatory systems that originate from noradrenergi

266 their receptors are evolutionarily conserved neuromodulatory systems that profoundly influence behavi

267 ive development of cortical oscillations and neuromodulatory systems that underlie them.

268 els, from work linking neural structures and neuromodulatory systems to specific aspects of motivated

269 izing the interface between neural activity, neuromodulatory systems, and cognitive function.

270 nd, in connection, the adequate formation of neuromodulatory systems, particularly serotonergic signa

271 te factors are subcortical catecholaminergic neuromodulatory systems, such as the locus ceruleus-nore

272 egregation is under the control of ascending neuromodulatory systems, such as the noradrenergic syste

273 hanges in pupil size are mediated by central neuromodulatory systems, which also influence the intern

274 motor networks that can also be affected by neuromodulatory systems.

275 ase is emerging as a common theme of central neuromodulatory systems.

276 l habenula to increase the inhibition of the neuromodulatory systems.

277 ith a particular emphasis on the subcortical neuromodulatory systems.

278 , many of which involve changes in brainstem neuromodulatory systems.

279 epresented in the brain by shared and unique neuromodulatory systems.

280 ossibility that these circuits might provide neuromodulatory targets for the treatment of ASD.

281 anscranial electrical stimulation (tES) is a neuromodulatory technique in which low voltage constant

282 ranial direct current stimulation is a novel neuromodulatory technique with emerging evidence of pote

283 Noninvasive neuromodulatory techniques such as transcranial direct c

284 ABSTRACT: Contemporary non-invasive neuromodulatory techniques, such as transcranial direct

285 Contemporary non-invasive neuromodulatory techniques, such as transcranial direct

286 with many conventional peripherally-focused neuromodulatory therapies.

287 Different levels of cholinergic neuromodulatory tone have been hypothesized to set the s

288 (DREADDs) have proven to be highly effective neuromodulatory tools for the investigation of neural ci

289 ct of rapid advances in the understanding of neuromodulatory transmission essential for resolving the

290 ncluding novel taste, requires activation of neuromodulatory transmission mediated, for example, by t

291 resolves fundamental synaptic properties of neuromodulatory transmission, and the new data unveil un

292 irst micro- and nano-scopic visualization of neuromodulatory transmission.

293 Together, our findings identify NA as a neuromodulatory transmitter capable of triggering epigen

294 Acetylcholine (ACh) is a neuromodulatory transmitter implicated in perception and

295 o sensitively track the activity in multiple neuromodulatory transmitter systems as they control the

296 Acetylcholine is a neuromodulatory transmitter that controls synaptic plast

297 The neuromodulatory transmitters, biogenic amines, have prof

298 ure and offer a migraine-specific target for neuromodulatory treatment.

299 Psychotherapeutic, pharmacological, or neuromodulatory treatments of mental disorders can often

300 recruitment of presynaptic proteins, whereas neuromodulatory types of plasticity involve more delayed