ライフサイエンスコーパス: neuronal NO synthase

1 ivated receptor-gamma coactivator-1alpha and neuronal NO Synthase.

2 evels, in retinas of transgenic mice lacking neuronal NO synthase.

3 through generation of nitric oxide (NO) via neuronal NO synthase.

4 e Ras in neuronal cultures from mice lacking neuronal NO synthase.

5 NO synthase (endothelial NO synthase and/or neuronal NO synthase) activity.

6 s not activated in mice lacking the gene for neuronal NO synthase after NMDA administration.

7 nis, nitric oxide (NO) can be formed by both neuronal NO synthase and endothelial NOS (eNOS).

8 Neuronal NO synthase contains a modular protein-protein

9 e fibers remain intact while they lose their neuronal NO synthase content.

10 used two models of nitroso-redox imbalance, neuronal NO synthase-deficient (NOS1(-/-)) mice and spon

11 A ferrous heme-NO complex builds up in rat neuronal NO synthase during catalysis and lowers its act

12 thylphenyl)imidazole (TRIM), an inhibitor of neuronal NO synthase, eliminated the light-evoked increa

13 e and primates have shown that inhibition of neuronal NO synthase exerts neuroprotective effects.

14 ive oxygen species activity is increased and neuronal NO synthase expression in the brain is elevated

15 ld elevations of endothelial NO synthase and neuronal NO synthase expression, as compared with beta-a

16 The neuronal NO synthase inhibitor 7-nitroindazole attenuate

17 Intrastriatal infusion of a neuronal NO synthase inhibitor or a NO scavenger via rev

18 Antioxidants such as LY231617 or neuronal NO synthase inhibitors can prevent the ischaemi

19 t that excitatory amino acid antagonists for neuronal NO synthase inhibitors might be useful in the t

20 The neuronal NO synthase inhibitors, 3-bromo-7-nitroindazole

21 on may serve to treat AD, where we find that neuronal NO synthase is profoundly reduced early in dise

22 of Ca-dependent endothelial NO synthase and neuronal NO synthase isoforms and absence of Ca-independ

23 genetic approach, we generated a null mutant neuronal NO synthase knockout mouse line by targeting th

24 Besides NO, neuronal NO synthase (nNOS) also produces superoxide (O(

25 e is associated with decreased expression of neuronal NO synthase (nNOS) and concomitant reduction in

26 on of their respective biosynthetic enzymes, neuronal NO synthase (nNOS) and heme oxygenase-2 (HO2),

27 MNs in mice deficient in neuronal NO synthase (nNOS) and inducible NOS (iNOS) res

28 in beating cardiac myocytes, we identified a neuronal NO synthase (nNOS) as the most relevant source

29 Importantly, inhibition of neuronal NO synthase (nNOS) by 7-NI normalized autophagy

30 des synthesizing nitric oxide (NO), purified neuronal NO synthase (nNOS) can produce superoxide (.O2-

31 Neuronal NO synthase (nNOS) consists of a reductase doma

32 Rat neuronal NO synthase (nNOS) contains an Akt-dependent ph

33 ly shown that nitric oxide (NO) derived from neuronal NO synthase (nNOS) does not contribute to the h

34 the influence of EA stimulation of ST 36 on neuronal NO synthase (nNOS) expression in the brainstem

35 njury-induced tactile allodynia, we examined neuronal NO synthase (nNOS) expression in the spinal cor

36 NO levels are elevated by the activity of neuronal NO synthase (nNOS) following Ca(2+) entry throu

37 resent study, we investigated the effects of neuronal NO synthase (nNOS) gene transfer on CB chemorec

38 Nitric oxide (NO) synthesized by neuronal NO synthase (nNOS) has long been implicated in

39 The neuronal NO synthase (nNOS) heme binds self-generated NO

40 Neuronal NO synthase (nNOS) immunoreactivity and nicotin

41 roliferation and increased the expression of neuronal NO synthase (nNOS) in differentiating neurons.

42 In addition, nitric oxide (NO) produced via neuronal NO synthase (nNOS) in MD cells attenuates MD-TG

43 salis (ND) that normally lacks expression of neuronal NO synthase (nNOS) in opposition to those in th

44 ed transmitter NO, through the activation of neuronal NO synthase (nNOS) in these neurons.

45 Nitric oxide (NO) generated by neuronal NO synthase (nNOS) initiates penile erection, b

46 Neuronal NO synthase (nNOS) is activated by Ca(2+)/calmo

47 It is established that neuronal NO synthase (nNOS) is associated with the chape

48 Rat neuronal NO synthase (nNOS) is comprised of a flavin-con

49 that produce NO, the ubiquitously expressed neuronal NO synthase (nNOS) is responsible for a large p

50 It is established that neuronal NO synthase (nNOS) is ubiquitinated and proteas

51 nsistent with these observations, studies in neuronal NO synthase (nNOS) knock-out (KO) mice confirme

52 heme oxygenase (HO)-2 knockout (HO-2-/-) and neuronal NO synthase (nNOS) knockout (nNOS-/-) mice.

53 se 2 (HO2) and nitric oxide (NO) produced by neuronal NO synthase (nNOS) mediate nonadrenergic/noncho

54 stration; endothelial NO synthase (eNOS) and neuronal NO synthase (nNOS) mRNA, phospho-eNOS protein,

55 However, excess NO produced from neuronal NO synthase (nNOS) or inducible NOS (iNOS) duri

56 After initiating NO synthesis a majority of neuronal NO synthase (nNOS) quickly partitions into a fe

57 ytes, accompanied by loss of stretch-induced neuronal NO synthase (nNOS) S1412 phosphorylation.

58 be enhanced by adaptor proteins that couple neuronal NO synthase (nNOS) to specific target proteins.

59 l established, but the relative roles of the neuronal NO synthase (nNOS) versus endothelial forms of

60 (WT) mice and 24 mice in which the gene for neuronal NO synthase (nNOS) was absent (nNOS-/- mice).

61 reased at 72 hours; instead, upregulation of neuronal NO synthase (nNOS) was evident at both the mRNA

62 mice with muscle-specific over-expression of neuronal NO synthase (nNOS) were generated in which tran

63 ined in part by the precise localizations of neuronal NO synthase (nNOS) within the cell.

64 tivated neurocircuitries that express either neuronal NO synthase (nNOS), a constitutive enzyme respo

65 how the NO-synthesizing enzyme within brain, neuronal NO synthase (nNOS), and NMDA receptors are func

66 o the mouse neocortex were both dependent on neuronal NO synthase (nNOS), cGMP, and the cGMP effector

67 neuron-derived NO, produced primarily by the neuronal NO synthase (nNOS), excess nNOS activity mediat

68 Mice with a defective form of the gene for neuronal NO synthase (nNOS), however, exhibit normal LTP

69 cular tone in vivo is tonically regulated by neuronal NO synthase (nNOS), in contrast to an acetylcho

70 nitric oxide (NO), synthesized by the enzyme neuronal NO synthase (nNOS), is essential for the format

71 ation of nitric oxide (NO) via activation of neuronal NO synthase (nNOS), is modulated by neurotrophi

72 forms of a well-established client protein, neuronal NO synthase (nNOS), to identify compounds that

73 odel, we demonstrate that neurons containing neuronal NO synthase (nNOS), which are morphologically a

74 A10 neurofilament-associated antigen; and 4) neuronal NO synthase (nNOS)-containing neurons and fiber

75 In this study, we report a novel role for neuronal NO synthase (nNOS)-mediated NO generation in li

76 flux, and formation of nitric oxide (NO) via neuronal NO synthase (nNOS).

77 ) regulate nitric oxide (NO) production from neuronal NO synthase (nNOS).

78 a specific link between these receptors and neuronal NO synthase (nNOS).

79 hus inducing NO production via activation of neuronal NO synthase (nNOS).

80 ated by the calcium/calmodulin dependence of neuronal NO synthase (nNOS).

81 r CO synthesis) types 1 (HO-1) and 2 (HO-2), neuronal NO synthase (nNOS, for NO synthesis), and VIP.

82 on of mice lacking endothelial (eNOS-/-) and neuronal NO synthase (nNOS-/-) showed that longitudinal

83 Neuronal NO(*) Synthase (nNOS) was examined for levels a

84 is study, mutant mice with disrupted type I (neuronal) NO synthase (nNOS) were compared with wild-typ

85 ng primary cortical cultures from transgenic neuronal NO synthase (NOS) null (nNOS-) mice, we definit

86 NO synthesis by inducible, endothelial, and neuronal NO synthase (NOS).

87 in the myenteric plexus possess both HO2 and neuronal NO synthase (NOS).

88 We hypothesized that a disruption of neuronal NO synthase (NOS1) activity underlies some form

89 Neuronal NO synthase (NOS1), however, is targeted to car

90 betaGal (recombinant adenoviruses expressing neuronal NO synthase or beta-galactosidase, respectively

91 inhibitor NG-nito-L-arginine (L-NNA) and the neuronal NO synthase selective inhibitor 1-(2-trifluorme

92 c oxide (NO) production from tumor cells via neuronal NO synthase silencing or inhibition establishes

93 ed by a cascade involving NMDA activation of neuronal NO synthase to form NO, leading to S-nitrosylat

94 ) and mice lacking either the endothelial or neuronal NO synthase, we obtained evidence that hyperten